HUP9903706A2 - 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity, process for their preparation and pharmaceutical compositions containing the same - Google Patents
4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity, process for their preparation and pharmaceutical compositions containing the sameInfo
- Publication number
- HUP9903706A2 HUP9903706A2 HU9903706A HUP9903706A HUP9903706A2 HU P9903706 A2 HUP9903706 A2 HU P9903706A2 HU 9903706 A HU9903706 A HU 9903706A HU P9903706 A HUP9903706 A HU P9903706A HU P9903706 A2 HUP9903706 A2 HU P9903706A2
- Authority
- HU
- Hungary
- Prior art keywords
- atom
- tube powder
- hydroxy
- group
- alkyl
- Prior art date
Links
- 230000000694 effects Effects 0.000 title abstract 2
- IHHJKWJJZUXWFI-UHFFFAOYSA-N 4,5-dihydrobenzo[g][2,1]benzoxazole Chemical class C1=CC=C2C3=NOC=C3CCC2=C1 IHHJKWJJZUXWFI-UHFFFAOYSA-N 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 239000000843 powder Substances 0.000 abstract 5
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 125000005843 halogen group Chemical group 0.000 abstract 2
- 201000004384 Alopecia Diseases 0.000 abstract 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- 206010028813 Nausea Diseases 0.000 abstract 1
- 206010047700 Vomiting Diseases 0.000 abstract 1
- 239000000654 additive Substances 0.000 abstract 1
- 230000000996 additive effect Effects 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000003277 amino group Chemical group 0.000 abstract 1
- 125000004429 atom Chemical group 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 208000024963 hair loss Diseases 0.000 abstract 1
- 230000003676 hair loss Effects 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000008693 nausea Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- 125000004433 nitrogen atom Chemical group N* 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 208000020016 psychiatric disease Diseases 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 201000000980 schizophrenia Diseases 0.000 abstract 1
- 239000003369 serotonin 5-HT3 receptor antagonist Substances 0.000 abstract 1
- 125000003107 substituted aryl group Chemical group 0.000 abstract 1
- 230000008673 vomiting Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/08—Drugs for disorders of the alimentary tract or the digestive system for nausea, cinetosis or vertigo; Antiemetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
- C07D261/20—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings condensed with carbocyclic rings or ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
Abstract
A találmány tárgya az (I) általánős képletű vegyületek, ahől A jelentése hidrőgénatőm, hidrőxilcsőpőrt, (a), (b) (c), vagy (d)képletű csőpőrt, ahől R1 jelentése hidrőgénatőm, adőtt esetbenhidrőxilcsőpőrttal, alkőxi- vagy aminőcsőpőrttal szűbsztitűált 1-6szénatőmős alkilcsőpőrt, adőtt esetben halőgénatőmmal, hidrőxi- vagyalkőxicsőpőrttal szűbsztitűált aril- vagy heterőarilcsőpőrt; vagyadőtt esetben halőgénatőmmal, hidrőxi- vagy alkőxicsőpőrttalszűbsztitűált benzilcsőpőrt; n jelentése egész szám, melynek értéke 1 vagy 2, Z jelentése nitrőgénatőm, -CH- vagy -C(OH)-csőpőrt, m jelentése egész szám, melynek értéke 1-3 X jelentése hidrőgénatőm, hidrőxi- vagy alkőxicsőpőrt, vagy gyógyászatilag alkalmazható addíciós sóik, vagy adőtt esetbengeőmetriai vagy őptikai izőmerjeik vagy ezek racém keverékei. Atalálmány szerinti vegyületek 5-HT3 antagőnista hatásűk következtébenszőrőngás, pszichiátriai rendellenességek, skizőfrénia, émelygés,hányás gyógyszerfüggés kezelésében alkalmazhatók. ŕThe subject of the invention is the compounds of the general formula (I), where A is a hydrogen atom, a hydroxyl group, a group of the formula (a), (b), (c), or (d), where R1 is a hydrogen atom, optionally substituted with a hydroxyl group, an alkyl group, or an amino group 1 - 6 carbon atomized alkyl tube powder, optionally substituted aryl or heteroaryl tube powder with a halogen atom, hydroxy- or alkyloxy tube powder; or, where appropriate, benzyl tube powder substituted with a halogen atom, hydroxy or aldehyde tube powder; n is an integer with a value of 1 or 2, Z is a nitrogen atom, -CH- or -C(OH) atom, m is an integer with a value of 1-3 X is a hydrogen atom, a hydroxy or alkyl atom, or a medically applicable additive their salts, or, where appropriate, their geometric or optical derivatives or their racemic mixtures. Due to their 5-HT3 antagonist effect, the compounds according to the invention can be used in the treatment of hair loss, psychiatric disorders, schizophrenia, nausea, and vomiting. ŕ
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58331996A | 1996-01-05 | 1996-01-05 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| HUP9903706A2 true HUP9903706A2 (en) | 2000-08-28 |
| HUP9903706A3 HUP9903706A3 (en) | 2000-09-28 |
Family
ID=24332609
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HU9903706A HUP9903706A3 (en) | 1996-01-05 | 1996-12-12 | 4,5-dihydronaphth[1,2-c]isoxazoles and derivatives thereof having cns activity, process for their preparation and pharmaceutical compositions containing the same |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP0874833A1 (en) |
| JP (1) | JP3161737B2 (en) |
| KR (1) | KR100308748B1 (en) |
| CN (1) | CN1214046A (en) |
| AR (1) | AR005347A1 (en) |
| AU (1) | AU710059B2 (en) |
| BR (1) | BR9612578A (en) |
| CA (1) | CA2241845C (en) |
| HU (1) | HUP9903706A3 (en) |
| IL (1) | IL125197A0 (en) |
| NO (1) | NO983100L (en) |
| NZ (1) | NZ325587A (en) |
| WO (1) | WO1997025317A1 (en) |
| ZA (1) | ZA9725B (en) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU8656101A (en) * | 2000-08-21 | 2002-03-04 | Univ Georgetown | 2-3-disubstituted quinuclidines as modulators of monoamine transporters and therapeutic and diagnostic methods based thereon |
| EA008189B1 (en) * | 2002-04-02 | 2007-04-27 | Янссен Фармацевтика Н.В. | Substituted amino isoxazoline derivatives and their use as anti-depressants |
| AR040967A1 (en) * | 2002-08-12 | 2005-04-27 | Janssen Pharmaceutica Nv | TRICYCLIC C-SUBSTITUTED ISOXAZOLINE DERIVATIVES AND ITS USE AS ANTI-DEPRESSIVE |
| ES2339444T3 (en) | 2002-08-15 | 2010-05-20 | Janssen Pharmaceutica Nv | CONDENSED HETEROCICLIC ISOXAZOLINE DERIVATIVES AND ITS USE AS ANTIDEPRESSANTS. |
| MY134287A (en) | 2002-08-21 | 2007-11-30 | Janssen Pharmaceutica Nv | C6- and c9-substituted isoxazoline derivatives and their use as anti-depressants |
| US8025859B2 (en) | 2007-05-18 | 2011-09-27 | Cesl Limited | Process for gold and silver recovery from a sulphide concentrate |
| EP2597089A1 (en) | 2009-10-29 | 2013-05-29 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
| CN110234633A (en) | 2016-09-02 | 2019-09-13 | 百时美施贵宝公司 | Substituted tricyclic heterocyclic compounds |
| WO2019032632A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
| WO2019032631A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | Oxime ether compounds |
| KR102002633B1 (en) | 2018-07-19 | 2019-07-22 | 김태효 | Non slip foot wear with separating cushion part |
| KR102429797B1 (en) | 2019-12-31 | 2022-08-05 | 주식회사 제이패션 | Functional non-sewn overshoes and manufacturing method thereof |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2119977A1 (en) * | 1971-04-23 | 1971-12-16 | Teikoku Hormone Manufacturing Co , Ltd, Tokio | Antiphlogistic and antisecretory napththisoxazoles - from 1-hydroxyim - 2-carbonyl derivs by intramolecular condensation |
| DE69021645T2 (en) * | 1989-05-19 | 1996-02-22 | Hoechst Roussel Pharma | N- (aryloxyalkyl) heteroarylpiperidines and heteroarylpiperazines, processes for their preparation and their use as medicaments. |
| US5670522A (en) * | 1992-10-23 | 1997-09-23 | Merck Sharp & Dohme Limited | Dopamine receptor subtype ligands |
-
1996
- 1996-12-12 WO PCT/US1996/019569 patent/WO1997025317A1/en not_active Application Discontinuation
- 1996-12-12 AU AU14126/97A patent/AU710059B2/en not_active Ceased
- 1996-12-12 CA CA002241845A patent/CA2241845C/en not_active Expired - Fee Related
- 1996-12-12 CN CN96180175A patent/CN1214046A/en active Pending
- 1996-12-12 JP JP52519797A patent/JP3161737B2/en not_active Expired - Fee Related
- 1996-12-12 NZ NZ325587A patent/NZ325587A/en unknown
- 1996-12-12 KR KR1019980705166A patent/KR100308748B1/en not_active IP Right Cessation
- 1996-12-12 BR BR9612578A patent/BR9612578A/en not_active Application Discontinuation
- 1996-12-12 EP EP96944274A patent/EP0874833A1/en not_active Withdrawn
- 1996-12-12 IL IL12519796A patent/IL125197A0/en unknown
- 1996-12-12 HU HU9903706A patent/HUP9903706A3/en unknown
-
1997
- 1997-01-02 ZA ZA9725A patent/ZA9725B/en unknown
- 1997-01-03 AR ARP970100015A patent/AR005347A1/en unknown
-
1998
- 1998-07-03 NO NO983100A patent/NO983100L/en not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO983100D0 (en) | 1998-07-03 |
| CA2241845A1 (en) | 1997-07-17 |
| AR005347A1 (en) | 1999-04-28 |
| AU1412697A (en) | 1997-08-01 |
| ZA9725B (en) | 1997-07-07 |
| KR19990077033A (en) | 1999-10-25 |
| CN1214046A (en) | 1999-04-14 |
| BR9612578A (en) | 1999-07-27 |
| JP3161737B2 (en) | 2001-04-25 |
| CA2241845C (en) | 2002-10-01 |
| HUP9903706A3 (en) | 2000-09-28 |
| AU710059B2 (en) | 1999-09-09 |
| IL125197A0 (en) | 1999-03-12 |
| NO983100L (en) | 1998-09-04 |
| NZ325587A (en) | 1999-02-25 |
| WO1997025317A1 (en) | 1997-07-17 |
| KR100308748B1 (en) | 2001-12-12 |
| EP0874833A1 (en) | 1998-11-04 |
| JPH11510816A (en) | 1999-09-21 |
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