AR005865A1 - Derivados de oxidación de indolilalquilaminas; su uso para preparar medicamentos; y composiciones farmacéutica y cosmética. - Google Patents

Derivados de oxidación de indolilalquilaminas; su uso para preparar medicamentos; y composiciones farmacéutica y cosmética.

Info

Publication number
AR005865A1
AR005865A1 ARP960104398A AR10439896A AR005865A1 AR 005865 A1 AR005865 A1 AR 005865A1 AR P960104398 A ARP960104398 A AR P960104398A AR 10439896 A AR10439896 A AR 10439896A AR 005865 A1 AR005865 A1 AR 005865A1
Authority
AR
Argentina
Prior art keywords
alkyl
radical
aryl
amino
perhalogen
Prior art date
Application number
ARP960104398A
Other languages
English (en)
Original Assignee
Cemaf
Besins Iscovesco Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cemaf, Besins Iscovesco Lab filed Critical Cemaf
Publication of AR005865A1 publication Critical patent/AR005865A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • C07D209/34—Oxygen atoms in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
    • A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
    • A61K8/492—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid having condensed rings, e.g. indol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00—Preparations for affecting hair growth

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Birds (AREA)
  • Epidemiology (AREA)
  • Anesthesiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Cosmetics (AREA)

Abstract

Derivados de oxidación de indolilalquilaminas que comprende la fórmula general (I), en la cual (II) es uno de los tres radicales (1a)(1b) o (1c);n es igual a 1, 2 o 3, de preferencia 2; R1, R2, R3 y R4 son independientemente u no del otro un átomode hidrógeno, un radical hidroxilo,un radical alquilo inferior, cicloalquilo, alcoxi inferior, ariloxi, aralcoxi inferior, perhalógeno alquilo inferior, perhalógenoalcoxi inferior, halógeno,nitro, o una cadena alifática insatur ada; R5 es un átomode hidrógeno, un radical alquilo inferior, arilo, aralquilo inferior, cada uno de elloseventualmente substituido por uno o varios halógenos, un radical amino, alquil-(inferior)-amino o dialquilo(inferior)-amino, aril o-alquilo-amino,aralquilamino odiaralquilamino, un radical alcoxi inferior, alquilo(inferior) -oxicarbonilo, ariloxicarbonilo o aralquiloxicarbonilo; R6 y R8 sonindependientemente uno del otro un átomo de hidrógeno, un radical alquilo inferio r, arilo, aralquilo inferior, alcoxiinferior, ariloxi, aralcoxiinferior, perhalógenoalquilo inferior, perhalógeno-alquil-(inferior)- perhalógenoalquil-(inferior)-carboniloxi, halógeno, alquilsulfonilo,arilsulfonilo, aralquilsulfonilo, perh alógenoalquil-(inferior)-sulfonilo; W y R7son independientemente uno del otro un átomo de oxígeno o un átomo deazufre; R9 es un radical alquilo inferior, arilo, aralquilo, eventualmente substituido por uno o varios halógenos, un radical alqui lcarbonilo,arilcarbonilo, aralquilcarbonil,perhalógenoalquil-(inferior)-carbonilo, perhalógenoaralquilcarbonilo, o un radical alquilo-(inferior)-sulfonilo oarilsulfonil, o aralquilsulfonilo o perhalógenoalquilo-(inferior)-sulfonilo perhal ógenoaralquilsulfonilo; R5 y R6, R5 y R8, R6 y R8 yR8 y R9 pueden estar
ARP960104398A 1995-09-18 1996-09-18 Derivados de oxidación de indolilalquilaminas; su uso para preparar medicamentos; y composiciones farmacéutica y cosmética. AR005865A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9510900A FR2738818B1 (fr) 1995-09-18 1995-09-18 Nouveaux derives d'oxydation d'indolylalkylamines, et leur utilisation a titre de medicament

Publications (1)

Publication Number Publication Date
AR005865A1 true AR005865A1 (es) 1999-07-21

Family

ID=9482641

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960104398A AR005865A1 (es) 1995-09-18 1996-09-18 Derivados de oxidación de indolilalquilaminas; su uso para preparar medicamentos; y composiciones farmacéutica y cosmética.

Country Status (13)

Country Link
US (1) US6066663A (es)
EP (1) EP0851856B1 (es)
JP (1) JP3513876B2 (es)
AR (1) AR005865A1 (es)
AT (1) ATE210117T1 (es)
AU (1) AU7088396A (es)
DE (1) DE69617712T2 (es)
DK (1) DK0851856T3 (es)
ES (1) ES2169264T3 (es)
FR (1) FR2738818B1 (es)
PT (1) PT851856E (es)
WO (1) WO1997011056A1 (es)
ZA (1) ZA967870B (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004529110A (ja) 2001-03-06 2004-09-24 アストラゼネカ アクチボラグ 脈管損傷活性を有するインドール誘導体
TW200508197A (en) * 2003-03-31 2005-03-01 Ucb Sa Indolone-acetamide derivatives, processes for preparing them and their uses
FR2857011B1 (fr) * 2003-07-04 2005-09-16 Servier Lab Nouveaux derives du benzothiophene 2-thiosubstitues, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
BR102016024814A2 (pt) 2016-10-24 2018-05-08 Aché Laboratórios Farmacêuticos S.A. composto, processo de obtenção do composto, composição farmacêutica, uso do composto e método de tratamento de desordens psiquiátricas e/ou distúrbios do sono

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2680366B1 (fr) * 1991-08-13 1995-01-20 Adir Nouveaux derives d'arylethylamines, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent.
AU672224B2 (en) * 1992-08-06 1996-09-26 Warner-Lambert Company 2-thioindoles (selenoindoles) and related disulfides (selenides) which inhibit protein tyrosine kinases and whichhave antitumor properties
WO1995027712A1 (fr) * 1994-04-07 1995-10-19 Cemaf Nouveaux derives de spiro[indole-pyrrolidine] agonistes melatoninergiques, leur procede de preparation et leur utilisation a titre de medicament
FR2737725B1 (fr) * 1995-08-08 1997-10-31 Valentonine Nouveaux derives acyles de la melatonine et d'analogues melatoninergiques, leur procede de preparation et leur utilisation en tant que medicament

Also Published As

Publication number Publication date
ES2169264T3 (es) 2002-07-01
WO1997011056A1 (fr) 1997-03-27
DE69617712D1 (de) 2002-01-17
FR2738818A1 (fr) 1997-03-21
JPH11512450A (ja) 1999-10-26
FR2738818B1 (fr) 1997-12-05
EP0851856B1 (fr) 2001-12-05
AU7088396A (en) 1997-04-09
ATE210117T1 (de) 2001-12-15
DK0851856T3 (da) 2002-04-02
DE69617712T2 (de) 2004-05-06
US6066663A (en) 2000-05-23
JP3513876B2 (ja) 2004-03-31
ZA967870B (en) 1997-04-07
EP0851856A1 (fr) 1998-07-08
PT851856E (pt) 2002-05-31

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