AR004488A1 - Un conjugado de polimixina, y sales solubles del mismo, proceso para producir dicho conjugado, composicion farmaceutica que incluye dicho conjugado y uso del mismo para la preparacion de medicamentos - Google Patents
Un conjugado de polimixina, y sales solubles del mismo, proceso para producir dicho conjugado, composicion farmaceutica que incluye dicho conjugado y uso del mismo para la preparacion de medicamentosInfo
- Publication number
- AR004488A1 AR004488A1 ARP960102707A AR10270796A AR004488A1 AR 004488 A1 AR004488 A1 AR 004488A1 AR P960102707 A ARP960102707 A AR P960102707A AR 10270796 A AR10270796 A AR 10270796A AR 004488 A1 AR004488 A1 AR 004488A1
- Authority
- AR
- Argentina
- Prior art keywords
- conjugate
- same
- polymixine
- medicines
- preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/61—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule the organic macromolecular compound being a polysaccharide or a derivative thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Toxicology (AREA)
- Communicable Diseases (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicinal Preparation (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Abstract
La presente invención se refiere a conjugados de polimixina B/dextrano o sales de los mismos, solubles en agua, que tienen una actividadantiendotoxínica o en contra de las endotoxinas, mayor que la de polimixina B no conjugada, útiles en eltrata miento profiláctico o curativo del síndrome derespuesta inflamatoria sistémica o choque séptico. Estos conjugados se pueden preparar mediante la reacción de la polimixina B o una sal de la misma, condextrano, en un medio acuoso a un pH desdeaproxi madamente 9,3 hasta aproximadamente 10, y a una temperatura desde aproximadamente 30°C hastaaproximadamente 35°C.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/449,436 US5691304A (en) | 1995-05-25 | 1995-05-25 | Improved process for preparing polymyxin B/dextran conjugates |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR004488A1 true AR004488A1 (es) | 1998-12-16 |
Family
ID=23784156
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP960102707A AR004488A1 (es) | 1995-05-25 | 1996-05-24 | Un conjugado de polimixina, y sales solubles del mismo, proceso para producir dicho conjugado, composicion farmaceutica que incluye dicho conjugado y uso del mismo para la preparacion de medicamentos |
Country Status (24)
| Country | Link |
|---|---|
| US (1) | US5691304A (es) |
| EP (1) | EP0830147A1 (es) |
| JP (1) | JPH11505216A (es) |
| KR (1) | KR19990021926A (es) |
| CN (1) | CN1185115A (es) |
| AR (1) | AR004488A1 (es) |
| AU (1) | AU711200B2 (es) |
| BR (1) | BR9609130A (es) |
| CA (1) | CA2219778A1 (es) |
| CO (1) | CO4700478A1 (es) |
| CZ (1) | CZ288830B6 (es) |
| FI (1) | FI974004A (es) |
| HU (1) | HUP9801750A3 (es) |
| IL (1) | IL118407A (es) |
| NO (1) | NO975329D0 (es) |
| NZ (1) | NZ309764A (es) |
| PE (1) | PE5398A1 (es) |
| PL (1) | PL323186A1 (es) |
| RU (1) | RU2164149C2 (es) |
| SK (1) | SK157997A3 (es) |
| TR (1) | TR199701426T1 (es) |
| TW (1) | TW426517B (es) |
| WO (1) | WO1996037233A1 (es) |
| ZA (1) | ZA964210B (es) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2263164A1 (en) * | 1996-08-15 | 1998-02-19 | Southern Illinois University | Enhancement of antimicrobial peptide activity by metal ions |
| US20080287633A1 (en) * | 2007-05-18 | 2008-11-20 | Drumheller Paul D | Hydrogel Materials |
| US20180028684A1 (en) | 2010-11-01 | 2018-02-01 | Nanoderm Sciences, Inc. | Targeted nanoparticles |
| US9161962B2 (en) | 2010-11-01 | 2015-10-20 | Nanoderm Sciences, Inc. | Targeted therapeutic nanoparticles |
| EP2872120B1 (en) * | 2012-07-16 | 2017-05-03 | Nanoderm Sciences, Inc. | Therapeutic nanoparticles with a polymyxin b as targeting agent |
| CN115321819B (zh) * | 2022-08-15 | 2024-02-13 | 希诺股份有限公司 | 一种高钢化抗菌玻璃杯及其制造方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2063326T3 (es) * | 1989-11-15 | 1995-01-01 | Sandoz Ltd | Conjugados de polimixina. |
| US5177059A (en) * | 1989-11-15 | 1993-01-05 | Sandoz Ltd. | Polymyxin B conjugates |
-
1995
- 1995-05-25 US US08/449,436 patent/US5691304A/en not_active Expired - Fee Related
-
1996
- 1996-05-23 TW TW085106100A patent/TW426517B/zh active
- 1996-05-23 IL IL11840796A patent/IL118407A/xx not_active IP Right Cessation
- 1996-05-23 PE PE1996000379A patent/PE5398A1/es not_active Application Discontinuation
- 1996-05-24 PL PL96323186A patent/PL323186A1/xx unknown
- 1996-05-24 ZA ZA9604210A patent/ZA964210B/xx unknown
- 1996-05-24 NZ NZ309764A patent/NZ309764A/en unknown
- 1996-05-24 AU AU60007/96A patent/AU711200B2/en not_active Ceased
- 1996-05-24 CZ CZ19973721A patent/CZ288830B6/cs not_active IP Right Cessation
- 1996-05-24 CN CN96194171A patent/CN1185115A/zh active Pending
- 1996-05-24 EP EP96917430A patent/EP0830147A1/en not_active Withdrawn
- 1996-05-24 CO CO96026735A patent/CO4700478A1/es unknown
- 1996-05-24 SK SK1579-97A patent/SK157997A3/sk unknown
- 1996-05-24 WO PCT/EP1996/002256 patent/WO1996037233A1/en not_active Application Discontinuation
- 1996-05-24 RU RU97120930/14A patent/RU2164149C2/ru active
- 1996-05-24 BR BR9609130A patent/BR9609130A/pt unknown
- 1996-05-24 HU HU9801750A patent/HUP9801750A3/hu unknown
- 1996-05-24 CA CA002219778A patent/CA2219778A1/en not_active Abandoned
- 1996-05-24 KR KR1019970708401A patent/KR19990021926A/ko not_active Application Discontinuation
- 1996-05-24 JP JP8532821A patent/JPH11505216A/ja active Pending
- 1996-05-24 TR TR97/01426T patent/TR199701426T1/xx unknown
- 1996-05-24 AR ARP960102707A patent/AR004488A1/es unknown
-
1997
- 1997-10-20 FI FI974004A patent/FI974004A/fi not_active Application Discontinuation
- 1997-11-20 NO NO975329A patent/NO975329D0/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| NO975329L (no) | 1997-11-20 |
| PE5398A1 (es) | 1998-02-16 |
| CO4700478A1 (es) | 1998-12-29 |
| PL323186A1 (en) | 1998-03-16 |
| CA2219778A1 (en) | 1996-11-28 |
| FI974004A0 (fi) | 1997-10-20 |
| EP0830147A1 (en) | 1998-03-25 |
| CZ288830B6 (cs) | 2001-09-12 |
| HUP9801750A3 (en) | 1998-12-28 |
| MX9709003A (es) | 1998-03-31 |
| BR9609130A (pt) | 1999-02-23 |
| US5691304A (en) | 1997-11-25 |
| IL118407A0 (en) | 1996-09-12 |
| WO1996037233A1 (en) | 1996-11-28 |
| CN1185115A (zh) | 1998-06-17 |
| ZA964210B (en) | 1997-11-24 |
| TR199701426T1 (xx) | 1998-02-21 |
| AU6000796A (en) | 1996-12-11 |
| TW426517B (en) | 2001-03-21 |
| KR19990021926A (ko) | 1999-03-25 |
| SK157997A3 (en) | 1998-04-08 |
| RU2164149C2 (ru) | 2001-03-20 |
| NZ309764A (en) | 1999-04-29 |
| HUP9801750A2 (hu) | 1998-11-30 |
| FI974004A (fi) | 1997-11-25 |
| NO975329D0 (no) | 1997-11-20 |
| CZ372197A3 (cs) | 1998-03-18 |
| IL118407A (en) | 2000-10-31 |
| JPH11505216A (ja) | 1999-05-18 |
| AU711200B2 (en) | 1999-10-07 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FB | Suspension of granting procedure |