AR004169A1 - Forma de solvato alcoholico de 2-metil-4-(4-metil-1-piperacinil)-10 h-tieno(2,3-b)(1,5) benzodiacepina (olanzapina) - Google Patents

Forma de solvato alcoholico de 2-metil-4-(4-metil-1-piperacinil)-10 h-tieno(2,3-b)(1,5) benzodiacepina (olanzapina)

Info

Publication number
AR004169A1
AR004169A1 ARP960101882A AR10188296A AR004169A1 AR 004169 A1 AR004169 A1 AR 004169A1 AR P960101882 A ARP960101882 A AR P960101882A AR 10188296 A AR10188296 A AR 10188296A AR 004169 A1 AR004169 A1 AR 004169A1
Authority
AR
Argentina
Prior art keywords
methyl
benzodiacepine
piperacinyl
theno
olanzapine
Prior art date
Application number
ARP960101882A
Other languages
English (en)
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27020696&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR004169(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US08/410,474 external-priority patent/US5631250A/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of AR004169A1 publication Critical patent/AR004169A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

La invención proporciona solvatos metanólicos, etanólicos y 1-propanólicos de olazanpina y un procedimiento para usar dichos solvatos.
ARP960101882A 1995-03-24 1996-03-22 Forma de solvato alcoholico de 2-metil-4-(4-metil-1-piperacinil)-10 h-tieno(2,3-b)(1,5) benzodiacepina (olanzapina) AR004169A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US40956695A 1995-03-24 1995-03-24
US08/410,474 US5631250A (en) 1995-03-24 1995-03-24 Process and solvate of 2-methyl-thieno-benzodiazepine

Publications (1)

Publication Number Publication Date
AR004169A1 true AR004169A1 (es) 1998-11-04

Family

ID=27020696

Family Applications (2)

Application Number Title Priority Date Filing Date
ARP960101881A AR002721A1 (es) 1995-03-24 1996-03-22 Proceso para preparar 2- metil-4-(4-metil-1-piperacinil)-10h-tieno [2,3-b][1,5]benzodiacepina(olanzapina) que contiene menos de 5 % de substancias relacionadas indeseables
ARP960101882A AR004169A1 (es) 1995-03-24 1996-03-22 Forma de solvato alcoholico de 2-metil-4-(4-metil-1-piperacinil)-10 h-tieno(2,3-b)(1,5) benzodiacepina (olanzapina)

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ARP960101881A AR002721A1 (es) 1995-03-24 1996-03-22 Proceso para preparar 2- metil-4-(4-metil-1-piperacinil)-10h-tieno [2,3-b][1,5]benzodiacepina(olanzapina) que contiene menos de 5 % de substancias relacionadas indeseables

Country Status (17)

Country Link
EP (1) EP0733634B1 (es)
AR (2) AR002721A1 (es)
AT (1) ATE197711T1 (es)
AU (1) AU5257896A (es)
CO (1) CO4700300A1 (es)
DE (1) DE69611003T2 (es)
DK (1) DK0733634T3 (es)
EG (1) EG24221A (es)
ES (1) ES2151991T3 (es)
GR (1) GR3035355T3 (es)
IL (1) IL117613A (es)
MY (1) MY116503A (es)
PE (1) PE38197A1 (es)
PT (1) PT733634E (es)
SI (1) SI0733634T1 (es)
WO (1) WO1996030374A1 (es)
YU (1) YU49276B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA978515B (en) * 1996-09-23 1999-03-23 Lilly Co Eli Intermediates and process for preparing olanzapine
EA001881B1 (ru) 1996-09-23 2001-10-22 Эли Лилли Энд Компани Форма d дигидрата оланзапина
FR2802101B1 (fr) 1999-12-10 2003-02-28 Aventis Pharma Sa Association de cymemazine et d'un neuroleptique atypique
AU2003237305A1 (en) 2002-05-31 2003-12-19 Geneva Pharmaceuticals, Inc. Process of preparation of olanzapine form i
SI21270A (sl) 2002-07-15 2004-02-29 Krka, Tovarna Zdravil, D.D., Novo Mesto Kristalne oblike olanzapina in postopki za njihovo pripravo
US7323459B2 (en) 2002-12-24 2008-01-29 Teva Pharmaceutical Industries Ltd. Crystal forms, methods for their preparation and method for preparation of olanzapine
CN1906201A (zh) 2003-12-22 2007-01-31 特瓦制药工业有限公司 合成奥氮平的方法
EP1716154A1 (en) * 2004-02-19 2006-11-02 Neuland Laboratories Ltd Process for the preparation of olanzapine form 1 useful as antipsychotic drug
ES2253091B1 (es) * 2004-07-27 2007-02-01 Inke, S.A. Solvato mixto de olanzapina, procedimiento para su obtencion y procedimiento de obtencion de la forma i de olanzapina a partir del mismo.
EP1838716B1 (en) 2005-01-05 2011-06-01 Eli Lilly And Company Olanzapine pamoate dihydrate
CA2593407A1 (en) * 2007-06-22 2008-12-22 Apotex Pharmachem Inc. Improved processes for the synthesis of olanzapine
CU20090172A7 (es) 2009-10-09 2011-10-05 Ct De Investigación Y Desarrollo De Medicamentos Sistemas tricíclicos y tetracíclicos con actividad sobre el sistema nervioso central y vascular
EP2486913A1 (en) 2011-02-14 2012-08-15 Labtec GmbH Rapidly disintegrating oral film formulation for Olanzapin

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237279A (en) * 1979-07-27 1980-12-02 Eli Lilly And Company Crystalline 3-hydroxycephalosporin solvates
GB9009229D0 (en) * 1990-04-25 1990-06-20 Lilly Industries Ltd Pharmaceutical compounds
US5229382A (en) * 1990-04-25 1993-07-20 Lilly Industries Limited 2-methyl-thieno-benzodiazepine
TW268005B (es) * 1992-05-29 1996-01-11 Lilly Industries Ltd
US5439888A (en) * 1994-03-04 1995-08-08 Eli Lilly And Company Antithrombotic agents
US5457101A (en) * 1994-06-03 1995-10-10 Eli Lilly And Company Thieno[1,5]benzoidiazepine use

Also Published As

Publication number Publication date
SI0733634T1 (en) 2001-06-30
GR3035355T3 (en) 2001-05-31
DK0733634T3 (da) 2000-12-11
EG24221A (en) 2008-11-10
YU17696A (sh) 1998-07-10
IL117613A0 (en) 1996-07-23
MY116503A (en) 2004-02-28
DE69611003D1 (de) 2000-12-28
EP0733634A1 (en) 1996-09-25
YU49276B (sh) 2005-03-15
IL117613A (en) 2000-07-16
AR002721A1 (es) 1998-04-29
EP0733634B1 (en) 2000-11-22
DE69611003T2 (de) 2001-05-10
WO1996030374A1 (en) 1996-10-03
ATE197711T1 (de) 2000-12-15
AU5257896A (en) 1996-10-16
PT733634E (pt) 2001-04-30
ES2151991T3 (es) 2001-01-16
CO4700300A1 (es) 1998-12-29
PE38197A1 (es) 1997-10-16

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