AR003964A1 - Nuevos azepanos y homologos de su anillo, compuestos de partida para su preparacion, procedimiento para la elaboracion de dichos azepanos y sushomologos de anillo y composiciones farmaceuticas que los contienen. - Google Patents

Nuevos azepanos y homologos de su anillo, compuestos de partida para su preparacion, procedimiento para la elaboracion de dichos azepanos y sushomologos de anillo y composiciones farmaceuticas que los contienen.

Info

Publication number
AR003964A1
AR003964A1 ARP960103426A AR10342696A AR003964A1 AR 003964 A1 AR003964 A1 AR 003964A1 AR P960103426 A ARP960103426 A AR P960103426A AR 10342696 A AR10342696 A AR 10342696A AR 003964 A1 AR003964 A1 AR 003964A1
Authority
AR
Argentina
Prior art keywords
ring
preparation
azepanos
pharmaceutical compositions
new
Prior art date
Application number
ARP960103426A
Other languages
English (en)
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of AR003964A1 publication Critical patent/AR003964A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/18—Dibenzazepines; Hydrogenated dibenzazepines
    • C07D223/22—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines
    • C07D223/24—Dibenz [b, f] azepines; Hydrogenated dibenz [b, f] azepines with hydrocarbon radicals, substituted by nitrogen atoms, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/12—Nitrogen atoms not forming part of a nitro radical

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Nuevos azepanos y homólogos de su anillo, según fórmula (I), en donde: R1 es fenilo o alfa o beta-naftilo, los cuales pueden estar substituidos conhidroxilo, alquilo inferior, alcoxilo inferior, alcoxi-carbonilo inferior, fenoxilo, aciloxilo,hidroxifenoxi-sulfonilo, halógeno, nitro, amino, acilamino o n-alquilacilamino inferior; R2 es fenilo o fenilo substituido con hidroxilo o aciloxilo; Y es un enlace carbono-carbono o es vinileno; y n es1,2 ó 3; y las sales de adición de ácidof armacéuticamente aceptables de los mismos. Dichos compuestos son útiles para la terapia profilaxis de condicionesque están inducidas por proteína quinasas. Asimismo, la invención también se refiere a compuestos de partida para la preparaciónde dichos azepanos y sushomólogos de anillo, a composiciones farmacéuticas que los contienen y a un procedimiento para la elaboración de tales azepanos y sus homólogos de anillo.
ARP960103426A 1995-07-05 1996-07-03 Nuevos azepanos y homologos de su anillo, compuestos de partida para su preparacion, procedimiento para la elaboracion de dichos azepanos y sushomologos de anillo y composiciones farmaceuticas que los contienen. AR003964A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95110473 1995-07-05

Publications (1)

Publication Number Publication Date
AR003964A1 true AR003964A1 (es) 1998-09-30

Family

ID=8219416

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP960103426A AR003964A1 (es) 1995-07-05 1996-07-03 Nuevos azepanos y homologos de su anillo, compuestos de partida para su preparacion, procedimiento para la elaboracion de dichos azepanos y sushomologos de anillo y composiciones farmaceuticas que los contienen.

Country Status (14)

Country Link
US (2) US5907038A (es)
EP (1) EP0836592A1 (es)
JP (1) JPH10510296A (es)
KR (1) KR100264185B1 (es)
CN (1) CN1199396A (es)
AR (1) AR003964A1 (es)
AU (1) AU716996B2 (es)
BR (1) BR9609650A (es)
CA (1) CA2225616A1 (es)
CO (1) CO4700450A1 (es)
TR (1) TR199701757T1 (es)
TW (1) TW339325B (es)
WO (1) WO1997002249A1 (es)
ZA (1) ZA965540B (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TW339325B (en) * 1995-07-05 1998-09-01 Hoffmann La Roche Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same
US5902882A (en) * 1996-04-17 1999-05-11 Hoffmann-La Roche Inc. Assymetric synthesis of azepines
US6914140B1 (en) 1996-04-17 2005-07-05 Hoffmann-La Roche Inc. Asymmetric synthesis process
SE0100374D0 (sv) * 2001-02-07 2001-02-07 Pharmacia Ab Novel compositions of potassium channel openers and protein kinase c inhibitors and use thereof
WO2003074970A2 (en) * 2002-03-01 2003-09-12 American Tool Companies, Inc. Manual leveling rotating laser with swivel head
US6887864B2 (en) 2002-03-12 2005-05-03 Hoffmann-La Roche Inc. Azepane derivatives

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4254134A (en) * 1978-03-17 1981-03-03 Endo Laboratories, Inc. Antidepressant 2-amino- and -2-(substituted amino)-cis-hexahydro-carbazoles
US4254135A (en) * 1979-10-16 1981-03-03 A. H. Robins Company, Inc. 3-Amino-4-hydroxypyrrolidines
CA2115994A1 (en) * 1991-08-22 1993-03-04 Yali F. Hallock Protein kinase c inhibition and novel compound balanol
EP0687249A1 (en) * 1993-03-03 1995-12-20 Eli Lilly And Company Balanoids
AU686691B2 (en) * 1994-01-12 1998-02-12 F. Hoffmann-La Roche Ag Novel azepanes and homologs thereof
TW339325B (en) * 1995-07-05 1998-09-01 Hoffmann La Roche Novel azepane derivatives, process for the preparation thereof and pharmaceutical composition containing the same

Also Published As

Publication number Publication date
MX9710257A (es) 1998-03-29
WO1997002249A1 (en) 1997-01-23
JPH10510296A (ja) 1998-10-06
EP0836592A1 (en) 1998-04-22
KR100264185B1 (ko) 2001-01-15
BR9609650A (pt) 1999-03-02
US6136969A (en) 2000-10-24
CN1199396A (zh) 1998-11-18
ZA965540B (en) 1997-01-06
TR199701757T1 (xx) 1998-04-21
CA2225616A1 (en) 1997-01-23
KR19990028740A (ko) 1999-04-15
US5907038A (en) 1999-05-25
TW339325B (en) 1998-09-01
AU6305196A (en) 1997-02-05
AU716996B2 (en) 2000-03-16
CO4700450A1 (es) 1998-12-29

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