AR001816A1 - Método para producir esteres de 3,3-dietil-4-Ä(4-carboxi)fenoxiÜ-2-azetidinona opticamente activos - Google Patents

Método para producir esteres de 3,3-dietil-4-Ä(4-carboxi)fenoxiÜ-2-azetidinona opticamente activos

Info

Publication number
AR001816A1
AR001816A1 AR33634296A AR33634296A AR001816A1 AR 001816 A1 AR001816 A1 AR 001816A1 AR 33634296 A AR33634296 A AR 33634296A AR 33634296 A AR33634296 A AR 33634296A AR 001816 A1 AR001816 A1 AR 001816A1
Authority
AR
Argentina
Prior art keywords
azetidinone
carboxy
diethyl
esters
phenoxyü
Prior art date
Application number
AR33634296A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of AR001816A1 publication Critical patent/AR001816A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/10—Nitrogen as only ring hetero atom
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y10S435/875—Pseudomonas aeruginosa

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Analytical Chemistry (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se relaciona con un proceso para convertir una mezcla racémica de ésteres de 3,3-dietil-4-[(4-carboxi)fenoxi]-2-azetidinona en lacorrespondiente (S)-azetidinona ácida usando lipasa derivada de Pseudomonas sp. El proceso provee el producto deseado ácido con un alto exceso enantiomérico.
AR33634296A 1995-05-03 1996-04-29 Método para producir esteres de 3,3-dietil-4-Ä(4-carboxi)fenoxiÜ-2-azetidinona opticamente activos AR001816A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/433,586 US5523233A (en) 1995-05-03 1995-05-03 Enzymatic hydrolysis of 3,3-diethyl-4-[(4-carboxy)phenoxy]-2-azetidinone esters

Publications (1)

Publication Number Publication Date
AR001816A1 true AR001816A1 (es) 1997-12-10

Family

ID=23720700

Family Applications (1)

Application Number Title Priority Date Filing Date
AR33634296A AR001816A1 (es) 1995-05-03 1996-04-29 Método para producir esteres de 3,3-dietil-4-Ä(4-carboxi)fenoxiÜ-2-azetidinona opticamente activos

Country Status (9)

Country Link
US (1) US5523233A (es)
EP (1) EP0826065A1 (es)
JP (1) JP2939342B2 (es)
AR (1) AR001816A1 (es)
AU (1) AU694358B2 (es)
CA (1) CA2218881A1 (es)
HR (1) HRP960211A2 (es)
WO (1) WO1996034975A1 (es)
YU (1) YU25996A (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999041405A1 (en) 1998-02-17 1999-08-19 G.D. Searle & Co. Process for the enzymatic resolution of lactams
DE19931847A1 (de) * 1999-07-09 2001-01-11 Basf Ag Immobilisierte Lipase
AT502395B1 (de) 2005-07-27 2007-03-15 Iep Gmbh Oxidoreduktasen zur stereoselektiven reduktion von ketoverbindungen
AT503486B1 (de) * 2006-04-11 2008-05-15 Iep Gmbh Verfahren zur enantioselektiven reduktion von steroiden

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5229381A (en) * 1983-12-01 1993-07-20 Merck & Co., Inc. Substituted azetidinones as anti-inflammatory and antidegenerative agents
NZ228600A (en) * 1988-04-11 1992-02-25 Merck & Co Inc 1-(benzylaminocarbonyl)-4-phenoxy-azetidin-2-one derivatives
US5241064A (en) * 1989-10-02 1993-08-31 Fujisawa Pharmaceutical Co., Ltd. Enzymatic process for preparing optically active 3-substituted azetidinones
ES2230790T3 (es) * 1992-01-15 2005-05-01 E.R. SQUIBB & SONS, INC. Procedimientos enzimaticos para la resolucion de mezclas enantiomericas de compuestos utiles como intermedios en la preparacion de taxanos.
MY128261A (en) * 1992-10-27 2007-01-31 Merck Sharp & Dohme New substituted azetidinones as anti-inflammatory and antidegenerative agents

Also Published As

Publication number Publication date
HRP960211A2 (en) 1998-02-28
CA2218881A1 (en) 1996-11-07
JPH10507932A (ja) 1998-08-04
US5523233A (en) 1996-06-04
YU25996A (sh) 1998-11-05
EP0826065A1 (en) 1998-03-04
WO1996034975A1 (en) 1996-11-07
AU5633096A (en) 1996-11-21
AU694358B2 (en) 1998-07-16
JP2939342B2 (ja) 1999-08-25

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