AR001629A1 - Proceso para fabricar 1-hidroxibisfosfonatos - Google Patents

Proceso para fabricar 1-hidroxibisfosfonatos

Info

Publication number
AR001629A1
AR001629A1 AR33617596A AR33617596A AR001629A1 AR 001629 A1 AR001629 A1 AR 001629A1 AR 33617596 A AR33617596 A AR 33617596A AR 33617596 A AR33617596 A AR 33617596A AR 001629 A1 AR001629 A1 AR 001629A1
Authority
AR
Argentina
Prior art keywords
hydroxybisphosphonates
make
substituted
reaction
adialkyl
Prior art date
Application number
AR33617596A
Other languages
English (en)
Original Assignee
Merck & Co Inc
Merck Frosst Canada Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck & Co Inc, Merck Frosst Canada Inc filed Critical Merck & Co Inc
Publication of AR001629A1 publication Critical patent/AR001629A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/3873—Polyphosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3839—Polyphosphonic acids
    • C07F9/386—Polyphosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/404—Esters of poly(thio)phosphonic acids containing hydroxy substituents in the hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4025—Esters of poly(thio)phosphonic acids
    • C07F9/405—Esters of poly(thio)phosphonic acids containing nitrogen substituent, e.g. N.....H or N-hydrocarbon group which can be substituted by halogen or nitro(so), N.....O, N.....S, N.....C(=X)- (X =O, S), N.....N, N...C(=X)...N (X =O, S)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
    • C07F9/5537—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom the heteroring containing the structure -C(=O)-N-C(=O)- (both carbon atoms belong to the heteroring)

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Esta invención se relaciona con una reacción de adición entre aniones de dialquilfosfitos y haluros ácidos, para producir 1-hidroxibisfosfonatos ehidroxibisfosfonatos substituidos. Se prefiere que la reacción se efectúe a baja temperatura en una base, de manera que se minimiza el rearreglo adialquil(dialcoxifosfinil)fosfatos.
AR33617596A 1995-04-20 1996-04-15 Proceso para fabricar 1-hidroxibisfosfonatos AR001629A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US42596695A 1995-04-20 1995-04-20

Publications (1)

Publication Number Publication Date
AR001629A1 true AR001629A1 (es) 1997-11-26

Family

ID=23688754

Family Applications (2)

Application Number Title Priority Date Filing Date
AR33617596A AR001629A1 (es) 1995-04-20 1996-04-15 Proceso para fabricar 1-hidroxibisfosfonatos
ARP970100722A AR005965A1 (es) 1995-04-20 1997-02-21 Proceso para fabricar amino alquil-hidroxibisfosfonatos

Family Applications After (1)

Application Number Title Priority Date Filing Date
ARP970100722A AR005965A1 (es) 1995-04-20 1997-02-21 Proceso para fabricar amino alquil-hidroxibisfosfonatos

Country Status (6)

Country Link
AR (2) AR001629A1 (es)
AU (1) AU5485596A (es)
HR (1) HRP960171A2 (es)
TW (1) TW393488B (es)
WO (1) WO1996033199A1 (es)
YU (1) YU24396A (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20011061A1 (es) 2000-02-01 2001-11-20 Procter & Gamble Cristalizacion selectiva del acido 3-piridil-1-hidroxi-etiliden-1,1-bisfosfonico sodio como el hemipentahidrato o el monohidrato
PE20011065A1 (es) 2000-02-01 2001-11-21 Procter & Gamble Proceso para fabricar bisfosfonatos geminales

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB777718A (en) * 1953-04-20 1957-06-26 Ciba Ltd New organic compounds containing phosphorus and process for making them
DE3365492D1 (en) * 1982-01-27 1986-10-02 Schering Ag Diphosphonic acid derivatives and pharmaceutical preparations containing them
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
GB2248061A (en) * 1990-09-18 1992-03-25 Merck & Co Inc Amino-hydroxy-alkylidene bis phosphonic acids

Also Published As

Publication number Publication date
HRP960171A2 (en) 1997-08-31
AU5485596A (en) 1996-11-07
WO1996033199A1 (en) 1996-10-24
YU24396A (sh) 1998-11-05
TW393488B (en) 2000-06-11
AR005965A1 (es) 1999-07-21

Similar Documents

Publication Publication Date Title
BR9407563A (pt) Composto e processo para a produçao continua do mesmo
ATE12236T1 (de) Phosphoramiditderivate und ihre verwendung fuer die produktion von oligonukleotiden.
MX9202450A (es) Vidrios de baja temperatura de fosfato de zinc.
DE69834562D1 (de) Verfahren für die produktion von malonsäure-derivaten.
ES2159919T3 (es) Procedimiento para la preparacion de compuestos de tipo ceramidas.
CA2235470A1 (en) Dentifrice compositions containing .beta.-phase calcium pyrophosphate, an anticalculus agent, and fluoride
BG101893A (en) Nodulosporic acid derivatives
ES2119283T3 (es) Proceso para producir 2-metil-1,4-naftoquinona.
ES2088430T3 (es) Sistema para desinfectar lentes de contacto.
ES2108482T3 (es) Productos solidos de cloruro de mepicuato y cloruro de clormecuato altamente concentrados.
AR001629A1 (es) Proceso para fabricar 1-hidroxibisfosfonatos
ES2034323T3 (es) Procedimiento de produccion de oligomeros de olefinas, utilizando un catalizador a base mordenita modificada.
ES2145969T3 (es) Metodo de activacion o regeneracion de un catalizador utilizado en la produccion de peroxido de hidrogeno.
CO4770883A1 (es) Procedimiento para preparar acido l-ascorbico
SE9604582D0 (sv) Novel compounds
GB2273495B (en) Process for the production of coarse-grained, anhydrous dicalcium phosphate anhydride
ES2187684T3 (es) Procedimiento para preparar productos intermedios para la sintesis de agentes antifungicos.
ES2089654T3 (es) Procedimiento para purificar amidas de acidos grasos.
DE69417895D1 (de) Direkter cholesterolassay
PT1104409E (pt) Processo para a preparacao do acido piperazico e a sua transformacao em aneis biciclicos n-acilados que contem ligacoes n,n uteis como intermediarios para a fabricacao de inibidores da caspase
ATE229475T1 (de) Herstellung von dicalciumphosphat oder monocalciumphosphat aus calciumphosphat
PT1001929E (pt) Processo para o fabrico de acidos 3-ciano-2,4-di-halogeno-5-fluorobenzoicos
ES2162351T3 (es) Metodos para la preparacion de derivados de benzofenona.
MY148387A (en) Improved detergent bar and process of manufacture
DE69814663D1 (de) Flüssigkeit für verdampfungsapparat