AP604A - Substituted indoloquinoxalines and their use as HIV integrase inhibiting compositions. - Google Patents

Substituted indoloquinoxalines and their use as HIV integrase inhibiting compositions. Download PDF

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Publication number
AP604A
AP604A APAP/P/1995/000751A AP9500751A AP604A AP 604 A AP604 A AP 604A AP 9500751 A AP9500751 A AP 9500751A AP 604 A AP604 A AP 604A
Authority
AP
ARIPO
Prior art keywords
group
iodine
lower alkyl
formula
hiv integrase
Prior art date
Application number
APAP/P/1995/000751A
Other languages
English (en)
Other versions
AP9500751A0 (en
Inventor
Jan Olof Einar Bergman
Original Assignee
Leif J I Lundblad
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Leif J I Lundblad filed Critical Leif J I Lundblad
Publication of AP9500751A0 publication Critical patent/AP9500751A0/xx
Application granted granted Critical
Publication of AP604A publication Critical patent/AP604A/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
APAP/P/1995/000751A 1994-06-23 1995-06-21 Substituted indoloquinoxalines and their use as HIV integrase inhibiting compositions. AP604A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9402241A SE504289C2 (sv) 1994-06-23 1994-06-23 Användning av vissa indolo-2,3b-kinoxaliner för framställning av ett läkemedel för inhibering av enzymet HIV-integras

Publications (2)

Publication Number Publication Date
AP9500751A0 AP9500751A0 (en) 1995-07-31
AP604A true AP604A (en) 1997-07-21

Family

ID=20394513

Family Applications (1)

Application Number Title Priority Date Filing Date
APAP/P/1995/000751A AP604A (en) 1994-06-23 1995-06-21 Substituted indoloquinoxalines and their use as HIV integrase inhibiting compositions.

Country Status (9)

Country Link
US (1) US5866575A (es)
EP (1) EP0760662B1 (es)
AP (1) AP604A (es)
AU (1) AU2812195A (es)
DE (1) DE69523450T2 (es)
ES (1) ES2166400T3 (es)
IL (1) IL114201A (es)
SE (1) SE504289C2 (es)
WO (1) WO1996000067A1 (es)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE504289C2 (sv) * 1994-06-23 1996-12-23 Leif J I Lundblad Användning av vissa indolo-2,3b-kinoxaliner för framställning av ett läkemedel för inhibering av enzymet HIV-integras
SE504862C2 (sv) * 1994-12-27 1997-05-20 Leif J I Lundblad Användning av vissa indolo-§2,3b¤-kinoxaliner för framställning av ett läkemedel för skydd av DNA i initieringsfasen och/eller promotionsfasen av karcinogenes och för förhindrande av oxidativ stress i patienter med sjukdomar relaterade till fria radikaler
US6465466B1 (en) 1995-12-22 2002-10-15 Leif J. I. Lundblad Uses of indolo-2 [2,3b] -quinoxalines
SE9704723D0 (sv) * 1997-12-17 1997-12-17 Leif J I Lundblad Ligands
SE516133C2 (sv) * 1999-02-25 2001-11-19 Lundblad Leif J I Användning av vissa substituerade indolokinoxaliner för framställning av ett medel för skydd av vävnader, organ och celler vid transplantation
JP2023529877A (ja) * 2020-06-10 2023-07-12 シクソン エービー 結晶形のラベキシモドの調製方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238459A1 (en) * 1986-01-21 1987-09-23 Lundblad, Leif Substituted indoloquinoxalines

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE504289C2 (sv) * 1994-06-23 1996-12-23 Leif J I Lundblad Användning av vissa indolo-2,3b-kinoxaliner för framställning av ett läkemedel för inhibering av enzymet HIV-integras
SE504862C2 (sv) * 1994-12-27 1997-05-20 Leif J I Lundblad Användning av vissa indolo-§2,3b¤-kinoxaliner för framställning av ett läkemedel för skydd av DNA i initieringsfasen och/eller promotionsfasen av karcinogenes och för förhindrande av oxidativ stress i patienter med sjukdomar relaterade till fria radikaler

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0238459A1 (en) * 1986-01-21 1987-09-23 Lundblad, Leif Substituted indoloquinoxalines

Also Published As

Publication number Publication date
AP9500751A0 (en) 1995-07-31
AU2812195A (en) 1996-01-19
IL114201A0 (en) 1995-10-31
US5866575A (en) 1999-02-02
IL114201A (en) 2000-11-21
EP0760662B1 (en) 2001-10-24
SE504289C2 (sv) 1996-12-23
SE9402241D0 (sv) 1994-06-23
EP0760662A1 (en) 1997-03-12
WO1996000067A1 (en) 1996-01-04
DE69523450D1 (en) 2001-11-29
ES2166400T3 (es) 2002-04-16
SE9402241L (sv) 1995-12-24
DE69523450T2 (de) 2002-05-16

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