AP2228A - Tricyclic pyrazole derivatives as cannabinoid receptor modulators. - Google Patents

Tricyclic pyrazole derivatives as cannabinoid receptor modulators.

Info

Publication number
AP2228A
AP2228A AP2007003880A AP2007003880A AP2228A AP 2228 A AP2228 A AP 2228A AP 2007003880 A AP2007003880 A AP 2007003880A AP 2007003880 A AP2007003880 A AP 2007003880A AP 2228 A AP2228 A AP 2228A
Authority
AP
ARIPO
Prior art keywords
receptor modulators
cannabinoid receptor
pyrazole derivatives
tricyclic pyrazole
tricyclic
Prior art date
Application number
AP2007003880A
Other languages
English (en)
Other versions
AP2007003880A0 (en
Inventor
Braj Lohray
Vidya Bhushan Lohray
Brijesh Srivastava
Original Assignee
Cadila Healthcare Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cadila Healthcare Ltd filed Critical Cadila Healthcare Ltd
Publication of AP2007003880A0 publication Critical patent/AP2007003880A0/xx
Application granted granted Critical
Publication of AP2228A publication Critical patent/AP2228A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
AP2007003880A 2004-07-12 2005-07-08 Tricyclic pyrazole derivatives as cannabinoid receptor modulators. AP2228A (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN745MU2004 2004-07-12
PCT/IN2005/000237 WO2006025069A2 (en) 2004-07-12 2005-07-08 Tricyclic pyrazole derivatives as cannabinoid receptor modulators

Publications (2)

Publication Number Publication Date
AP2007003880A0 AP2007003880A0 (en) 2007-02-28
AP2228A true AP2228A (en) 2011-04-01

Family

ID=35636669

Family Applications (1)

Application Number Title Priority Date Filing Date
AP2007003880A AP2228A (en) 2004-07-12 2005-07-08 Tricyclic pyrazole derivatives as cannabinoid receptor modulators.

Country Status (20)

Country Link
US (2) US8030345B2 (pt)
EP (2) EP2343302A1 (pt)
JP (1) JP2008505965A (pt)
KR (1) KR20070041717A (pt)
CN (1) CN101014605A (pt)
AP (1) AP2228A (pt)
AU (1) AU2005278781B2 (pt)
BR (1) BRPI0513104A (pt)
CA (1) CA2586011C (pt)
EA (1) EA011307B1 (pt)
EC (1) ECSP077167A (pt)
GE (1) GEP20094682B (pt)
IL (1) IL180637A0 (pt)
MX (1) MX2007000491A (pt)
NO (1) NO20070299L (pt)
NZ (2) NZ580387A (pt)
TN (1) TNSN07006A1 (pt)
UA (1) UA88910C2 (pt)
WO (1) WO2006025069A2 (pt)
ZA (1) ZA200700162B (pt)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0513104A (pt) * 2004-07-12 2008-04-29 Cadila Healthcare Ltd composto, composição farmacêutica, método para o tratamento de doenças associadas com os receptores de canabinóide, medicamento para o tratamento/redução de doenças associadas com os receptores de canabinóides, uso do composto, processo para a preparação do composto e intermediário
SG178907A1 (en) 2009-08-28 2012-04-27 Arena Pharm Inc Cannabinoid receptor modulators
WO2012116279A1 (en) * 2011-02-25 2012-08-30 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
PH12013501726A1 (en) 2011-02-25 2014-01-13 Arena Pharm Inc Crystalline forms and processes for the preparation of condensed azacycles (cannabinoid receptor modulators)
US9597340B2 (en) 2011-02-25 2017-03-21 Arena Pharmaceuticals, Inc. Cannabinoid receptor modulators
WO2016174616A1 (en) * 2015-04-30 2016-11-03 Novartis Ag Fused tricyclic pyrazole derivatives useful for modulating farnesoid x receptors
CN108602775B (zh) 2016-01-14 2022-04-29 贝思以色列女会吏医学中心公司 肥大细胞调节剂及其用途
KR20200005614A (ko) 2017-05-08 2020-01-15 아레나 파마슈티칼스, 인크. 내장 통증의 치료를 위한 화합물 및 방법
EP3746438A1 (en) * 2018-01-29 2020-12-09 Cadila Healthcare Limited Heterocyclic compounds useful as antibacterial agents

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032629A1 (fr) * 1999-11-03 2001-05-10 Sanofi-Synthelabo Derives trycycliques d'acides 1-benzylpyrazole-3-carboxylique comme antagonistes des recepteurs de cannabinoides
WO2001032663A2 (fr) * 1999-11-03 2001-05-10 Sanofi-Synthelabo Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant

Family Cites Families (24)

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Publication number Priority date Publication date Assignee Title
US3260721A (en) * 1962-04-10 1966-07-12 American Cyanamid Co Heterocyclic derivatives of yohimbe alkaloids
DK7779A (da) * 1978-01-16 1979-07-17 Sandoz Ag Fremgangsmaade til fremstilling af pnenicilliner eller cephalosporiner
EP0122952B1 (en) 1983-04-22 1987-10-28 Mitsubishi Rayon Co., Ltd. Apparatus for measuring gas partial pressure in living body
FR2713225B1 (fr) 1993-12-02 1996-03-01 Sanofi Sa N-pipéridino-3-pyrazolecarboxamide substitué.
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
CA2106642C (en) * 1992-10-14 2005-08-16 Peter Bod Carbazolone derivatives and process for preparing the same
FR2714057B1 (fr) 1993-12-17 1996-03-08 Sanofi Elf Nouveaux dérivés du 3-pyrazolecarboxamide, procédé pour leur préparation et compositions pharmaceutiques les contenant.
US5547975A (en) * 1994-09-20 1996-08-20 Talley; John J. Benzopyranopyrazolyl derivatives for the treatment of inflammation
FR2741621B1 (fr) 1995-11-23 1998-02-13 Sanofi Sa Nouveaux derives de pyrazole, procede pour leur preparation et compositions pharmaceutiques en contenant
FR2742148B1 (fr) 1995-12-08 1999-10-22 Sanofi Sa Nouveaux derives du pyrazole-3-carboxamide, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2758723B1 (fr) 1997-01-28 1999-04-23 Sanofi Sa Utilisation des antagonistes des recepteurs aux cannabinoides centraux pour la preparation de medicaments
FR2761266B1 (fr) 1997-03-28 1999-07-02 Sanofi Sa Composition pharmaceutique formee par granulation humide pour l'administration orale d'un derive du n-piperidino-3- pyrazolecarboxamide, de ses sels et de leurs solvates
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
FR2804604B1 (fr) 2000-02-09 2005-05-27 Sanofi Synthelabo Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles pour faciliter l'arret de la consommation de tabac
FR2809621B1 (fr) 2000-05-12 2002-09-06 Sanofi Synthelabo Utilisation d'un antagoniste des recepteurs aux cannabinoides centraux pour la preparation de medicaments utiles comme antidiarrheiques
FR2816938B1 (fr) 2000-11-22 2003-01-03 Sanofi Synthelabo Derives de 3-aroylindole, leur procede de preparation et les compositions pharmaceutiques en contenant
AU2002331766A1 (en) 2001-08-31 2003-03-18 University Of Connecticut Novel pyrazole analogs acting on cannabinoid receptors
JP4313672B2 (ja) 2001-09-21 2009-08-12 ソルベイ・フアーマシユーチカルズ・ベー・ブイ 強力なｃｂ１−拮抗活性を有する４，５−ジヒドロ−１ｈ−ピラゾール誘導体
TWI231757B (en) 2001-09-21 2005-05-01 Solvay Pharm Bv 1H-Imidazole derivatives having CB1 agonistic, CB1 partial agonistic or CB1-antagonistic activity
AU2002333852B2 (en) 2001-09-21 2006-07-13 Solvay Pharmaceuticals B.V. Novel 4,5-dihydro-1H-pyrazole derivativeshaving CB1-antagonistic activity
US6509367B1 (en) 2001-09-22 2003-01-21 Virginia Commonwealth University Pyrazole cannabinoid agonist and antagonists
AU2003225580A1 (en) * 2002-02-19 2003-09-09 Pharmacia Corporation Tricyclic pyrazole derivatives for the treatment of inflammation
ITMI20041033A1 (it) * 2004-05-24 2004-08-24 Neuroscienze S C A R L Composti farmaceutici
BRPI0513104A (pt) * 2004-07-12 2008-04-29 Cadila Healthcare Ltd composto, composição farmacêutica, método para o tratamento de doenças associadas com os receptores de canabinóide, medicamento para o tratamento/redução de doenças associadas com os receptores de canabinóides, uso do composto, processo para a preparação do composto e intermediário

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2001032629A1 (fr) * 1999-11-03 2001-05-10 Sanofi-Synthelabo Derives trycycliques d'acides 1-benzylpyrazole-3-carboxylique comme antagonistes des recepteurs de cannabinoides
WO2001032663A2 (fr) * 1999-11-03 2001-05-10 Sanofi-Synthelabo Derives tricycliques d'acide pyrazolecarboxylique, leur preparation, les compositions pharmaceutiques en contenant

Also Published As

Publication number Publication date
AU2005278781A1 (en) 2006-03-09
BRPI0513104A (pt) 2008-04-29
NO20070299L (no) 2007-03-26
WO2006025069A2 (en) 2006-03-09
EA011307B1 (ru) 2009-02-27
JP2008505965A (ja) 2008-02-28
WO2006025069A3 (en) 2006-04-27
ZA200700162B (en) 2009-09-30
UA88910C2 (ru) 2009-12-10
CA2586011A1 (en) 2006-03-09
EP1781668A2 (en) 2007-05-09
EP2343302A1 (en) 2011-07-13
NZ552670A (en) 2010-02-26
GEP20094682B (en) 2009-05-10
IL180637A0 (en) 2007-06-03
CA2586011C (en) 2011-07-19
US8030345B2 (en) 2011-10-04
NZ580387A (en) 2011-06-30
MX2007000491A (es) 2007-03-28
TNSN07006A1 (en) 2008-06-02
AU2005278781B2 (en) 2009-06-18
EA200700246A1 (ru) 2007-08-31
WO2006025069A8 (en) 2007-03-15
AP2007003880A0 (en) 2007-02-28
CN101014605A (zh) 2007-08-08
ECSP077167A (es) 2007-05-30
US20080051386A1 (en) 2008-02-28
US20100273791A1 (en) 2010-10-28
KR20070041717A (ko) 2007-04-19

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