WO2004048385A3 - Procede de preparation de la forme cristalline 1 du clopidogrel hydrogene sulfate - Google Patents

Procede de preparation de la forme cristalline 1 du clopidogrel hydrogene sulfate Download PDF

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Publication number
WO2004048385A3
WO2004048385A3 PCT/PL2003/000130 PL0300130W WO2004048385A3 WO 2004048385 A3 WO2004048385 A3 WO 2004048385A3 PL 0300130 W PL0300130 W PL 0300130W WO 2004048385 A3 WO2004048385 A3 WO 2004048385A3
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WO
WIPO (PCT)
Prior art keywords
hydrogen sulfate
methyl
crystalline form
preparation
clopidogrel hydrogen
Prior art date
Application number
PCT/PL2003/000130
Other languages
English (en)
Other versions
WO2004048385A2 (fr
Inventor
Janina Piechaczek
Jadwiga Serafin
Wioleta Maruszak
Roman Balicki
Wieslaw Szelejewski
Marcin Cybulski
Grzegorz Maciejewski
Maria Wysoczynska
Magdalena Glice
Katarzyna Korczak
Original Assignee
Anpharm Przed Farmaceutyczne S
Janina Piechaczek
Jadwiga Serafin
Wioleta Maruszak
Roman Balicki
Wieslaw Szelejewski
Marcin Cybulski
Grzegorz Maciejewski
Maria Wysoczynska
Magdalena Glice
Katarzyna Korczak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Anpharm Przed Farmaceutyczne S, Janina Piechaczek, Jadwiga Serafin, Wioleta Maruszak, Roman Balicki, Wieslaw Szelejewski, Marcin Cybulski, Grzegorz Maciejewski, Maria Wysoczynska, Magdalena Glice, Katarzyna Korczak filed Critical Anpharm Przed Farmaceutyczne S
Priority to AU2003285841A priority Critical patent/AU2003285841A1/en
Publication of WO2004048385A2 publication Critical patent/WO2004048385A2/fr
Publication of WO2004048385A3 publication Critical patent/WO2004048385A3/fr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

L'invention concerne un procédé de préparation de la forme cristalline 1 du méthyl (S)-clopidogrel hydrogène sulfate par la précipitation du sel formé au cours de la réaction entre le méthyl (S)- (+) -α- (2-chlorophényl) -4, 5, 6, 7-tétrahydrothiéno[3,2-c]pyridine-5-acétate à base optiquement active et de l'acide sulfurique concentré, au moyen d'un solvant précipitant sélectionné dans le groupe constitué par des éthers aliphatiques et cycliques ainsi que le méthyl isobutyl cétone. Le méthyl (S) - (+) -α- (2-chlorophényl) -4,5,6,7- tétrahydrothiéno[3,2-c]pyridine-5-acétate hydrogène sulfate est utile dans le traitement et la prévention de la thrombose par son effet anticoagulant et inhibiteur d'agrégation plaquettaire.
PCT/PL2003/000130 2002-11-28 2003-11-26 Procede de preparation de la forme cristalline 1 du clopidogrel hydrogene sulfate WO2004048385A2 (fr)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003285841A AU2003285841A1 (en) 2002-11-28 2003-11-26 A process for the preparation of crystalline form 1 or clopidogrel hydrogen sulfate

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PL25442702 2002-11-28
PLP-357427 2002-11-28

Publications (2)

Publication Number Publication Date
WO2004048385A2 WO2004048385A2 (fr) 2004-06-10
WO2004048385A3 true WO2004048385A3 (fr) 2004-08-05

Family

ID=32389835

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/PL2003/000130 WO2004048385A2 (fr) 2002-11-28 2003-11-26 Procede de preparation de la forme cristalline 1 du clopidogrel hydrogene sulfate

Country Status (2)

Country Link
AU (1) AU2003285841A1 (fr)
WO (1) WO2004048385A2 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10337773A1 (de) * 2003-08-13 2005-03-24 Krka Tovarna Zdravil, D.D. Kristallisation von festen Formen von Clopidogrel-Additionssalzen
EA010198B1 (ru) * 2004-04-19 2008-06-30 Крка, Товарна Здравил, Д.Д., Ново Место Способы получения полиморфной формы i гидросульфата клопидогрела
RU2008146758A (ru) * 2006-04-27 2010-06-10 Инд-Свифт Лэборетриз Лимитед (In) Способ получения полиморфных форм клопидогрела гидросульфата
US20090247569A1 (en) * 2006-08-03 2009-10-01 Claude Singer Process for Preparing Clopidogrel Bisulphate
WO2008093357A2 (fr) * 2007-01-29 2008-08-07 Ipca Laboratories Limited Procédé de préparation d'une forme 1 cristalline d'un sulfate d'hydrogène de clopidogrel
PL382055A1 (pl) * 2007-03-23 2008-09-29 Koźluk Tomasz Nobilus Ent Sposób wytwarzania formy krystalicznej 1 wodorosiarczanu klopidogrelu
EP2107061A1 (fr) 2008-04-02 2009-10-07 Krka Tovarna Zdravil, D.D., Novo Mesto Procédé de préparation de clopidogrel enrichi optiquement
WO2011042804A2 (fr) 2009-10-08 2011-04-14 Jubliant Life Sciences Limited Procédé perfectionné pour la préparation de la forme i d'hydrogénosulfate de clopidogrel
WO2011051976A2 (fr) 2009-10-30 2011-05-05 Matrix Laboratories Ltd Procédé amélioré de préparation de la forme i du bisulfate de clopidogrel
CN102875568B (zh) * 2012-09-06 2015-12-09 苏州晶云药物科技有限公司 制备(+)-(s)-氯吡格雷硫酸氢盐纯晶型i的方法
KR102220480B1 (ko) 2019-02-13 2021-02-25 한국바이오켐제약 주식회사 클로피도그렐황산염의 제조방법 및 이를 포함하는 약학제제

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281459A1 (fr) * 1987-02-17 1988-09-07 Sanofi Enantiomère dextrogyre de l'alpha-(tétrahydro-4,5,6,7 thiéno (3,2-c)pyridyl-5) (chloro-2 phényl)-acétate de méthyle, son procédé de préparation et les compositions pharmaceutiques le renfermant
WO1999065915A1 (fr) * 1998-06-15 1999-12-23 Sanofi-Synthelabo Forme polymorphe de l'hydrogenosulfate de clopidogrel
WO2003051362A2 (fr) * 2001-12-18 2003-06-26 Teva Pharmaceutical Industries Ltd. Polymorphes d'hydrogenosulfate de clopidogrel

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0281459A1 (fr) * 1987-02-17 1988-09-07 Sanofi Enantiomère dextrogyre de l'alpha-(tétrahydro-4,5,6,7 thiéno (3,2-c)pyridyl-5) (chloro-2 phényl)-acétate de méthyle, son procédé de préparation et les compositions pharmaceutiques le renfermant
WO1999065915A1 (fr) * 1998-06-15 1999-12-23 Sanofi-Synthelabo Forme polymorphe de l'hydrogenosulfate de clopidogrel
US6429210B1 (en) * 1998-06-15 2002-08-06 Sanofi-Synthelabo Polymorphic clopidogrel hydrogenesulphate form
WO2003051362A2 (fr) * 2001-12-18 2003-06-26 Teva Pharmaceutical Industries Ltd. Polymorphes d'hydrogenosulfate de clopidogrel

Also Published As

Publication number Publication date
WO2004048385A2 (fr) 2004-06-10
AU2003285841A1 (en) 2004-06-18
AU2003285841A8 (en) 2004-06-18

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