ATE373664T1 - Verfahren zur herstellung von olanzapin und ein zwischenprodukt dafür - Google Patents
Verfahren zur herstellung von olanzapin und ein zwischenprodukt dafürInfo
- Publication number
- ATE373664T1 ATE373664T1 AT03732782T AT03732782T ATE373664T1 AT E373664 T1 ATE373664 T1 AT E373664T1 AT 03732782 T AT03732782 T AT 03732782T AT 03732782 T AT03732782 T AT 03732782T AT E373664 T1 ATE373664 T1 AT E373664T1
- Authority
- AT
- Austria
- Prior art keywords
- olanzapine
- producing olanzapine
- preparation
- producing
- benzodiazepine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL354642A PL199016B1 (pl) | 2002-06-20 | 2002-06-20 | Sposób wytwarzania olanzapiny |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE373664T1 true ATE373664T1 (de) | 2007-10-15 |
Family
ID=29997625
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06100356T ATE371660T1 (de) | 2002-06-20 | 2003-06-10 | Verfahren zur herstellung von olanzapine und ein zwischenprodukt dafür |
AT03732782T ATE373664T1 (de) | 2002-06-20 | 2003-06-10 | Verfahren zur herstellung von olanzapin und ein zwischenprodukt dafür |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT06100356T ATE371660T1 (de) | 2002-06-20 | 2003-06-10 | Verfahren zur herstellung von olanzapine und ein zwischenprodukt dafür |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP1513845B2 (de) |
CN (1) | CN100338069C (de) |
AT (2) | ATE371660T1 (de) |
AU (1) | AU2003240167A1 (de) |
BR (1) | BR0305100A (de) |
DE (2) | DE60316439T3 (de) |
ES (2) | ES2289730T3 (de) |
HR (1) | HRP20041075B1 (de) |
MX (1) | MXPA04012200A (de) |
NO (1) | NO328873B1 (de) |
PL (1) | PL199016B1 (de) |
PT (2) | PT1669359E (de) |
RU (1) | RU2005101324A (de) |
SI (2) | SI1513845T2 (de) |
TN (1) | TNSN04226A1 (de) |
UA (1) | UA76616C2 (de) |
WO (1) | WO2004000847A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1575962A1 (de) | 2002-12-24 | 2005-09-21 | Teva Pharmaceutical Industries Limited | Neue kristallformen von olanzapin, verfahren zu deren herstellung und verfahren zur herstellung bekannter kristallformen von olanzapin |
WO2005070939A1 (en) * | 2004-01-27 | 2005-08-04 | Synthon B.V. | Synthesis of olanzapine and intermediates thereof |
AR047459A1 (es) | 2004-01-27 | 2006-01-18 | Synthon Bv | Sales estables de 2-metil-4-(4-metil-1-piperazinil)-10h-tieno[2,3-b][1,5]benzodiazepina (olanzapina) |
AR048272A1 (es) * | 2004-03-18 | 2006-04-12 | Lek Pharmaceuticals | Sintesis de 2 metil - 4- (4- metil -1- piperazinil) - 10 h- tieno ( 2,3-b) (1,5) benzodiazepina y sus sales, metodos para su preparacion, composiciones farmaceuticas que la contienen y su uso en la fabricacion de medicamentos para el tratamiento de enfermedades mentales. |
ES2427048T3 (es) | 2004-07-14 | 2013-10-28 | Jubilant Life Sciences Limited | Un procedimiento para producir una forma pura de 2-metil-4-(4-metil-1-piperazinil)-10H-tieno[2,3-B][1,5]benzodiazepina |
PL198589B1 (pl) | 2004-11-22 | 2008-06-30 | Adamed Sp Z Oo | Sposób wytwarzania N-demetyloolanzapiny |
CN100383144C (zh) * | 2006-09-11 | 2008-04-23 | 杭州盛美医药科技开发有限公司 | 一种奥氮平的中间体及其制备与应用 |
EP2292624A1 (de) | 2009-07-20 | 2011-03-09 | LEK Pharmaceuticals d.d. | Olanzapinreinigungsverfahren |
CN102234285B (zh) * | 2010-04-19 | 2013-06-12 | 江苏豪森药业股份有限公司 | 奥氮平的制备方法 |
CN102924470B (zh) * | 2011-08-31 | 2014-12-03 | 江苏豪森药业股份有限公司 | 新颖的奥氮平的制备方法 |
CN102942573B (zh) * | 2011-10-09 | 2015-03-25 | 连云港恒运医药科技有限公司 | 奥氮平的制备方法 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL7306069A (de) † | 1973-05-02 | 1974-11-05 | ||
SU629879A3 (ru) * | 1974-11-26 | 1978-10-25 | Лилли Индастриз Лимитед, (Фирма) | Способ получени тиено(1,5) бензодиазепинов или их солей |
US4115568A (en) † | 1974-11-26 | 1978-09-19 | Lilly Industries Limited | Thieno[3,2-b]-[1,5]benzodiazepines |
US5239071A (en) † | 1989-11-21 | 1993-08-24 | The B. F. Goodrich Company | Process for methylating a hindered nitrogen atom in an inert non-aqueous solvent |
GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
DK55192D0 (da) † | 1992-04-28 | 1992-04-28 | Lundbeck & Co As H | 1-piperazino-1,2-dihydroindenderivater |
ES2237188T3 (es) | 1998-11-23 | 2005-07-16 | Sepracor Inc. | Composiciones de desmetilolanzapina y metodos. |
-
2002
- 2002-06-20 PL PL354642A patent/PL199016B1/pl unknown
-
2003
- 2003-06-10 EP EP03732782A patent/EP1513845B2/de not_active Expired - Lifetime
- 2003-06-10 ES ES06100356T patent/ES2289730T3/es not_active Expired - Lifetime
- 2003-06-10 DE DE60316439T patent/DE60316439T3/de not_active Expired - Lifetime
- 2003-06-10 RU RU2005101324/04A patent/RU2005101324A/ru not_active Application Discontinuation
- 2003-06-10 CN CNB038141655A patent/CN100338069C/zh not_active Ceased
- 2003-06-10 SI SI200330991T patent/SI1513845T2/sl unknown
- 2003-06-10 PT PT06100356T patent/PT1669359E/pt unknown
- 2003-06-10 MX MXPA04012200A patent/MXPA04012200A/es not_active Application Discontinuation
- 2003-06-10 AU AU2003240167A patent/AU2003240167A1/en not_active Abandoned
- 2003-06-10 DE DE60316047T patent/DE60316047T2/de not_active Expired - Fee Related
- 2003-06-10 SI SI200330985T patent/SI1669359T1/sl unknown
- 2003-06-10 EP EP06100356A patent/EP1669359B1/de not_active Expired - Lifetime
- 2003-06-10 WO PCT/IB2003/002181 patent/WO2004000847A1/en active IP Right Grant
- 2003-06-10 AT AT06100356T patent/ATE371660T1/de not_active IP Right Cessation
- 2003-06-10 AT AT03732782T patent/ATE373664T1/de not_active IP Right Cessation
- 2003-06-10 BR BR0305100-5A patent/BR0305100A/pt not_active IP Right Cessation
- 2003-06-10 PT PT03732782T patent/PT1513845E/pt unknown
- 2003-06-10 ES ES03732782T patent/ES2291644T5/es not_active Expired - Lifetime
- 2003-10-06 UA UA20041109317A patent/UA76616C2/uk unknown
-
2004
- 2004-02-13 NO NO20040658A patent/NO328873B1/no not_active IP Right Cessation
- 2004-11-17 TN TNP2004000226A patent/TNSN04226A1/en unknown
- 2004-11-17 HR HR20041075A patent/HRP20041075B1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
EP1513845A1 (de) | 2005-03-16 |
EP1513845B2 (de) | 2010-11-03 |
CN100338069C (zh) | 2007-09-19 |
PL354642A1 (en) | 2003-12-29 |
UA76616C2 (en) | 2006-08-15 |
HRP20041075A2 (en) | 2005-02-28 |
EP1669359A1 (de) | 2006-06-14 |
DE60316047T2 (de) | 2008-05-21 |
PT1669359E (pt) | 2007-10-16 |
ES2291644T3 (es) | 2008-03-01 |
ES2289730T3 (es) | 2008-02-01 |
SI1513845T2 (sl) | 2011-01-31 |
TNSN04226A1 (en) | 2007-03-12 |
DE60316047D1 (de) | 2007-10-11 |
SI1669359T1 (sl) | 2007-12-31 |
ATE371660T1 (de) | 2007-09-15 |
DE60316439T3 (de) | 2011-05-05 |
DE60316439T2 (de) | 2008-07-31 |
EP1513845B1 (de) | 2007-09-19 |
WO2004000847A1 (en) | 2003-12-31 |
HRP20041075B1 (en) | 2008-05-31 |
PL199016B1 (pl) | 2008-08-29 |
ES2291644T5 (es) | 2011-02-15 |
EP1669359B1 (de) | 2007-08-29 |
BR0305100A (pt) | 2004-09-28 |
NO328873B1 (no) | 2010-06-07 |
PT1513845E (pt) | 2007-11-21 |
DE60316439D1 (de) | 2007-10-31 |
RU2005101324A (ru) | 2005-08-10 |
CN1662543A (zh) | 2005-08-31 |
NO20040658L (no) | 2004-02-13 |
AU2003240167A1 (en) | 2004-01-06 |
SI1513845T1 (sl) | 2007-12-31 |
MXPA04012200A (es) | 2005-08-26 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |