DE60202261D1 - Verfahren zur herstellung von mesylaten von piperazinderivaten - Google Patents
Verfahren zur herstellung von mesylaten von piperazinderivatenInfo
- Publication number
- DE60202261D1 DE60202261D1 DE60202261T DE60202261T DE60202261D1 DE 60202261 D1 DE60202261 D1 DE 60202261D1 DE 60202261 T DE60202261 T DE 60202261T DE 60202261 T DE60202261 T DE 60202261T DE 60202261 D1 DE60202261 D1 DE 60202261D1
- Authority
- DE
- Germany
- Prior art keywords
- mesylates
- production
- piperazine derivatives
- piperazine
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical class C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 title 1
- 229940066771 systemic antihistamines piperazine derivative Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/52—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings condensed with carbocyclic rings or ring systems
- C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
- C07D263/58—Benzoxazoles; Hydrogenated benzoxazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP01200534 | 2001-02-16 | ||
| EP01200534 | 2001-02-16 | ||
| PCT/EP2002/001666 WO2002066449A2 (en) | 2001-02-16 | 2002-02-14 | Process for the preparation of mesylates of piperazine derivatives |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60202261D1 true DE60202261D1 (de) | 2005-01-20 |
| DE60202261T2 DE60202261T2 (de) | 2005-05-19 |
Family
ID=8179894
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60202261T Expired - Lifetime DE60202261T2 (de) | 2001-02-16 | 2002-02-14 | Verfahren zur herstellung von mesylaten von piperazinderivaten |
Country Status (35)
| Country | Link |
|---|---|
| US (1) | US7030241B2 (de) |
| EP (1) | EP1362040B1 (de) |
| JP (1) | JP4328528B2 (de) |
| KR (2) | KR100859106B1 (de) |
| CN (1) | CN1176079C (de) |
| AR (1) | AR034206A1 (de) |
| AT (1) | ATE284875T1 (de) |
| AU (1) | AU2002250962B2 (de) |
| BG (1) | BG66101B1 (de) |
| BR (1) | BR0205683A (de) |
| CA (1) | CA2422703C (de) |
| CZ (1) | CZ301780B6 (de) |
| DE (1) | DE60202261T2 (de) |
| DK (1) | DK1362040T3 (de) |
| DZ (1) | DZ3489A1 (de) |
| ES (1) | ES2230481T3 (de) |
| HK (1) | HK1059934A1 (de) |
| HR (1) | HRP20030610B1 (de) |
| HU (1) | HUP0400772A3 (de) |
| IL (1) | IL153509A (de) |
| IS (1) | IS2417B (de) |
| ME (1) | MEP37508A (de) |
| MX (1) | MXPA03002359A (de) |
| MY (1) | MY130687A (de) |
| NO (1) | NO324460B1 (de) |
| NZ (1) | NZ524632A (de) |
| PL (1) | PL208363B1 (de) |
| PT (1) | PT1362040E (de) |
| RS (1) | RS51126B (de) |
| RU (1) | RU2272036C2 (de) |
| SI (1) | SI1362040T1 (de) |
| SK (1) | SK286143B6 (de) |
| UA (1) | UA75390C2 (de) |
| WO (1) | WO2002066449A2 (de) |
| ZA (1) | ZA200301590B (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7435738B2 (en) | 2003-08-18 | 2008-10-14 | Solvay Pharmaceuticals, Inc. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
| AR045362A1 (es) * | 2003-08-18 | 2005-10-26 | Solvay Pharm Bv | Forma cristalina estable de mesilato de bifeprunox (monometansulfonato de 7-[4-([1,1- bifenil] -3- ilmetil) -1- piperazinil] - 2-(3h) -benzoxazolona |
| US7405216B2 (en) * | 2004-08-18 | 2008-07-29 | Solvay Pharmaceuticals, B.V. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
| US7423040B2 (en) * | 2005-02-18 | 2008-09-09 | Irene Eijgendaal | Stable crystalline form of bifeprunox mesylate, dosage forms thereof and methods for using same |
| US7964604B2 (en) * | 2005-02-18 | 2011-06-21 | Solvay Pharmaceuticals B.V. | Bifeprunox mesylate maintenance dose compositions and methods for using the same |
| US20070275977A1 (en) * | 2006-05-02 | 2007-11-29 | Van Aar Marcel P | N-oxides of pyridylmethyl -piperazine and -piperidine derivatives |
| US7786126B2 (en) * | 2006-06-16 | 2010-08-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising SLV308 and a dopamine agonist |
| US8106056B2 (en) * | 2006-06-16 | 2012-01-31 | Solvay Pharmaceuticals B.V. | Combination preparations comprising bifeprunox and a dopamine agonist |
| BRPI0715445A2 (pt) | 2006-08-31 | 2014-05-13 | Solvay Pharm Bv | Uso de um composto de bifeprunox, e, kit de titulação |
| US20090068290A1 (en) * | 2006-08-31 | 2009-03-12 | Michel Bourin | Bifeprunox doses for treating schizophrenia |
| US20080132520A1 (en) * | 2006-08-31 | 2008-06-05 | Winsemius Antje A | Compositions, kits and methods for administering a titration schedule comprising bifeprunox compounds |
| WO2009100258A1 (en) | 2008-02-05 | 2009-08-13 | Hollis-Eden Pharmaceuticals, Inc. | Pharmaceutical solid state forms |
| WO2011023796A1 (en) | 2009-08-31 | 2011-03-03 | Abbott Healthcare Products B.V. | Bifeprunox for treating addiction |
| UY32935A (es) | 2009-10-12 | 2011-05-31 | Abbott Healthcare Products Bv | Polimorfos de pardoprunox |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE81975T1 (de) | 1984-12-21 | 1992-11-15 | Duphar Int Res | Arzneimittel mit psychotroper wirkung. |
| EP0185429A1 (de) | 1984-12-21 | 1986-06-25 | Duphar International Research B.V | Bizyklische Piperazine |
| JPH0344383A (ja) * | 1989-07-12 | 1991-02-26 | Ihara Chem Ind Co Ltd | ５―トリフルオロメチル―２―ハロメチルベンゾチアゾール類の製造法 |
| JP3044383B2 (ja) * | 1990-05-22 | 2000-05-22 | コニカ株式会社 | 含窒素６員環化合物の製造方法 |
| PT889889E (pt) * | 1996-03-29 | 2007-01-31 | Duphar Int Res | Composto de piperazina e piperidina |
| SE9702799D0 (sv) * | 1997-07-25 | 1997-07-25 | Astra Ab | New compounds |
| UA71590C2 (en) * | 1998-11-13 | 2004-12-15 | Duphar Int Res | Piperazine and piperidine derivatives |
| US7435738B2 (en) | 2003-08-18 | 2008-10-14 | Solvay Pharmaceuticals, Inc. | Stable crystalline form of bifeprunox mesylate (7-[4-([1,1′-biphenyl]-3-ylmethyl)-1-piperazinyl]-2(3H)-benzoxazolone monomethanesulfonate) |
-
2002
- 2002-02-12 AR ARP020100460A patent/AR034206A1/es active IP Right Grant
- 2002-02-14 DE DE60202261T patent/DE60202261T2/de not_active Expired - Lifetime
- 2002-02-14 BR BR0205683-6A patent/BR0205683A/pt not_active Application Discontinuation
- 2002-02-14 ME MEP-375/08A patent/MEP37508A/xx unknown
- 2002-02-14 UA UA2003098528A patent/UA75390C2/uk unknown
- 2002-02-14 CZ CZ20030697A patent/CZ301780B6/cs not_active IP Right Cessation
- 2002-02-14 SI SI200230061T patent/SI1362040T1/xx unknown
- 2002-02-14 PT PT02719858T patent/PT1362040E/pt unknown
- 2002-02-14 NZ NZ524632A patent/NZ524632A/en not_active IP Right Cessation
- 2002-02-14 RU RU2003105902/04A patent/RU2272036C2/ru not_active IP Right Cessation
- 2002-02-14 HU HU0400772A patent/HUP0400772A3/hu unknown
- 2002-02-14 CN CNB028016858A patent/CN1176079C/zh not_active Expired - Fee Related
- 2002-02-14 DZ DZ023489A patent/DZ3489A1/fr active
- 2002-02-14 JP JP2002565965A patent/JP4328528B2/ja not_active Expired - Fee Related
- 2002-02-14 MX MXPA03002359A patent/MXPA03002359A/es active IP Right Grant
- 2002-02-14 MY MYPI20020505A patent/MY130687A/en unknown
- 2002-02-14 EP EP02719858A patent/EP1362040B1/de not_active Expired - Lifetime
- 2002-02-14 WO PCT/EP2002/001666 patent/WO2002066449A2/en active IP Right Grant
- 2002-02-14 CA CA2422703A patent/CA2422703C/en not_active Expired - Fee Related
- 2002-02-14 IL IL153509A patent/IL153509A/en not_active IP Right Cessation
- 2002-02-14 PL PL369330A patent/PL208363B1/pl unknown
- 2002-02-14 ES ES02719858T patent/ES2230481T3/es not_active Expired - Lifetime
- 2002-02-14 US US10/468,098 patent/US7030241B2/en not_active Expired - Fee Related
- 2002-02-14 DK DK02719858T patent/DK1362040T3/da active
- 2002-02-14 AU AU2002250962A patent/AU2002250962B2/en not_active Ceased
- 2002-02-14 KR KR1020037000026A patent/KR100859106B1/ko not_active IP Right Cessation
- 2002-02-14 KR KR1020087015071A patent/KR101000733B1/ko not_active IP Right Cessation
- 2002-02-14 AT AT02719858T patent/ATE284875T1/de active
- 2002-02-14 RS YUP-644/03A patent/RS51126B/sr unknown
- 2002-02-14 SK SK309-2003A patent/SK286143B6/sk not_active IP Right Cessation
-
2003
- 2003-02-26 ZA ZA200301590A patent/ZA200301590B/en unknown
- 2003-04-15 NO NO20031754A patent/NO324460B1/no not_active IP Right Cessation
- 2003-07-17 IS IS6876A patent/IS2417B/is unknown
- 2003-07-28 HR HR20030610A patent/HRP20030610B1/xx not_active IP Right Cessation
- 2003-08-13 BG BG108090A patent/BG66101B1/bg unknown
-
2004
- 2004-04-22 HK HK04102835A patent/HK1059934A1/xx not_active IP Right Cessation
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |