TW201634112A - Filter, coelomic fluid processing system, and coelomic fluid processing method - Google Patents

Abstract

This filter for filtering ascitic fluids suppresses deterioration in filtering capacity of the filter while reducing clogging of a hollow fiber membrane by using an external pressure method. A filter 21 is provided with a cylindrical container 40 having a hollow fiber membrane bundle 42 therein, and allows an ascitic fluid to pass through the hollow fiber membranes 41 of the hollow fiber membrane bundle 42 from the outside of the hollow fiber membranes 41 to the inside thereof, to remove a specific substance in the ascitic fluid. The hollow fiber membranes 41 are arranged so as to be distributed such that the filling ratio of the hollow fiber membrane bundle 42 is 20-41%.

Description

Filter, body cavity fluid treatment system and body cavity fluid treatment method

The present invention relates to a filter for ascites, pleural effusion, pericardial exudate, and the like, and a body cavity fluid treatment system and a body cavity fluid treatment method.

For example, as a treatment method for refractory ascites, there is a Cell-free and Concentrated Ascites Reinfusion Therapy method, and the ascites filtration concentrated re-injection method takes ascites from a patient and filters the ascites to remove The causative substance such as cancer cells or bacteria is secondarily concentrated, and the filtrate containing the useful substance of protein such as albumin is concentrated, and then the concentrate is reinjected into the body.

In the treatment method, an ascites treatment system is generally used. As a representative example, the ascites treatment system is provided with a liquid circuit in which an ascites bag, a filter, a concentrator, and a concentrated ascites bag are connected in series.

Furthermore, the filter of the ascites treatment system is provided with a hollow fiber membrane bundle as a filtration membrane inside the cylindrical container, and both ends of the hollow fiber membrane bundle are potted and processed in the cylindrical container by the potting material. Both end portions are formed with open end faces. In the past, the filter has been generally used for internal filtration in which ascites flows from the inside to the outside of the hollow fiber membrane, but in recent years, it has been proposed that, in the opposite manner, even ascites is derived from the hollow fiber membrane. The outside flows to the inside and is used for filtration and external pressure (see Patent Documents 1 and 2).

[Previous Technical Literature] [Patent Literature]

[Patent Document 1] Japanese Patent Laid-Open Publication No. 2009-297242

[Patent Document 2] Japanese Patent Laid-Open Publication No. 2011-172797

Ascites contains relatively large substances such as cancer cells, and has a very high viscosity. Even if a filter is used in a short time, it is likely to cause clogging in the hollow fiber membrane. Therefore, by using an external pressure method, the ascites is filtered from the outside of the hollow fiber membrane having a relatively large surface area to the inside, and the filtration of the hollow fiber membrane can be relaxed, and the life of the filter can be prolonged.

However, in the case of filtration by the above-described external pressure method, the hollow fiber membranes located on the central portion side (in the bundle) of the hollow fiber membrane bundle are densely packed with each other, and are disposed on the outer peripheral side (outside the bundle) of the hollow fiber membrane. Covering, therefore, if the viscosity is high as in ascites, the ascites does not reach the hollow fiber membrane at the center of the bundle, resulting in a decrease in filtration ability.

The present application has been made in view of the above, and it is an object of the present invention to suppress the clogging of a hollow fiber membrane by using an external pressure method in a filter for filtering a body cavity fluid such as ascites, thereby suppressing a decrease in the filtration ability of the filter.

The inventors of the present invention have found that the filtration ability is improved by dispersing a hollow fiber membrane of a hollow fiber membrane bundle in a cylindrical container of a filter in order to solve the above problems, and the present invention has been completed.

That is, the aspect of the invention includes the following.

(1) A filter having a cylindrical container having a hollow fiber membrane bundle therein, wherein the body cavity is passed from the outer side to the inner side of the hollow fiber membrane of the hollow fiber membrane bundle in the cylindrical container to remove the body cavity In the hollow fiber membrane, the hollow fiber membrane is dispersed in such a manner that the filling ratio of the hollow fiber membrane bundle is 20% or more and 41% or less in the internal cross section of the cylindrical container.

(2) The filter according to (1), wherein the largest hollow fiber membrane of the above hollow fiber membrane bundle The distance between the two is 300 μm or more.

(3) The filter according to (1) or (2), wherein the average hollow fiber membrane distance in the hollow fiber membrane bundle is 150 μm or more.

(4) The filter according to any one of (1) to (3), wherein both ends of the hollow fiber membrane bundle are potted and sealed at both ends of the cylindrical container by a potting material, The opening end faces of the hollow fiber membrane bundles are formed at both end portions of the cylindrical container, and the distance between the end faces of the hollow fiber membrane bundles is 50 mm or more and 300 mm or less.

(5) (1) to (4) according to any one of the filter, wherein the effective membrane area of the hollow fiber membrane bundle is 0.7m ² or more and 3.0m ² or less.

(6) The filter according to any one of (1) to (5) wherein the hollow fiber membrane has an inner diameter of 50 μm or more and 500 μm or less.

(7) The filter according to any one of (1) to (6) wherein the hollow fiber membrane has a curled shape.

(8) A body cavity liquid treatment system comprising at least the filter according to any one of (1) to (7), and a concentrator for concentrating the filtrate filtered by the filter, and at least the filtration The body cavity fluid is treated by external pressure in the device.

(9) A method for treating a body cavity liquid, which is the filter of any one of (1) to (7), comprising the steps of: treating the body cavity fluid by external pressure in the filter; and borrowing The filtrate filtered by the above filter was concentrated.

According to the present invention, in the filter for filtering the body cavity liquid, the external filter can be used to alleviate the blockage of the hollow fiber membrane while suppressing the decrease in the filter capacity of the filter.

1‧‧‧ ascites treatment system

10‧‧‧ Ascites treatment circuit

20‧‧‧ Ascites bag

21‧‧‧Filter

22‧‧‧ concentrator

23‧‧‧ Concentrated ascites bag

24‧‧‧1st flow path

25‧‧‧2nd flow path

26‧‧‧3rd flow path

30‧‧‧ tube pump

40‧‧‧Cylindrical container

40a‧‧‧Container body

40b‧‧‧ collecting tube

41‧‧‧ hollow fiber membrane

42‧‧‧Hollow fiber bundle

43‧‧‧埠

44‧‧‧埠

45‧‧‧埠

46‧‧‧埠

50‧‧‧ tube pump

60‧‧‧ cylindrical container

61‧‧‧ hollow fiber membrane

62‧‧‧Hollow fiber bundle

63‧‧‧埠

64‧‧‧埠

65‧‧‧埠

66‧‧‧埠

70‧‧‧ potting materials

71‧‧‧Open end face

A‧‧‧ pump

B‧‧‧ pump

C‧‧‧ pressure gauge

D1~D4‧‧‧Distance

d‧‧‧Inner diameter

K‧‧‧Inner diameter

L‧‧‧ distance

S‧‧‧Cross section area of the body part of the container

S‧‧‧1 cross-sectional area of hollow fiber membrane

Fig. 1 is an explanatory view showing an outline of a configuration of an ascites treatment system.

Figure 2 is an explanatory view of a longitudinal section of the filter.

Fig. 3 is an explanatory view showing a cross section of a cylindrical container.

Fig. 4 is an explanatory view showing the distance between hollow fiber membranes.

Fig. 5 is an explanatory view showing the diameter of the hollow fiber membrane.

Fig. 6 is an explanatory view for explaining a shape of a curl of a hollow fiber membrane.

Fig. 7 is an explanatory view showing an ascites treatment system of the embodiment.

Hereinafter, preferred embodiments of the present invention will be described with reference to the drawings. In addition, the positional relationship such as the upper and lower sides of the drawing is set as the positional relationship based on the drawing unless otherwise specified. The dimensional ratio of the drawings is not limited to the ratios shown. Further, the following embodiments are intended to illustrate the invention, and are not intended to limit the invention to the embodiments. Further, the present invention can be variously modified without departing from the spirit thereof.

Fig. 1 is an explanatory view showing the outline of the configuration of the ascites processing system 1 as the body cavity liquid processing system including the filter 21 of the present embodiment.

As shown in Fig. 1, the ascites treatment system 1 includes, for example, an ascites treatment circuit 10 as a liquid circuit. The ascites treatment circuit 10 includes an ascites bag 20 as a body cavity fluid reservoir, a filter 21, a concentrator 22, a concentrated ascites bag 23 as a concentrate reservoir, a first channel 24 connecting the ascites bag 20 and the filter 21, The second flow path 25 connecting the filter 21 and the concentrator 22, and the third flow path 26 connecting the concentrator 22 and the concentrated ascites bag 23 are provided.

The ascites bag 20 is, for example, a container containing a soft resin such as polyvinyl chloride, and can store ascites as a body cavity fluid taken from a patient.

The first flow path 24 is, for example, a flexible tube such as polyvinyl chloride, and is connected to the side surface 45 of the filter 21 from the outlet of the ascites bag 20 at the outlet. In the first flow path 24, for example, a tube pump 30 is provided, and the ascites of the ascites bag 20 can be transported to the filter 21. Further, the tube pump 30 may be omitted, and the ascites of the ascites bag 20 may be dropped by gravity to be supplied to the filter 21.

The filter 21 includes a cylindrical container 40, and a hollow fiber membrane bundle (bundle of hollow fiber membranes 41) 42 is disposed inside the cylindrical container 40 along the longitudinal direction thereof. Hollow fiber membrane 41 can A specific causative substance such as cancer cells and bacteria is removed from the ascites, and a component containing a useful substance such as albumin other than the above is passed. In the upper portion and the lower portion of the cylindrical container 40, the crucibles 43, 44 which communicate with the inner side (space) of the hollow fiber membrane 41 are provided, and the outer side (space) of the hollow fiber membrane 41 is provided on the side surface portion of the cylindrical container 40. The two 埠45, 46. The crotch portion 45 of the side portion of the filter 21 communicates with the ascites bag 20. The crucible 46 of the side surface portion of the filter 21 communicates with a liquid discharge portion (not shown) that does not discharge the components of the hollow fiber membrane 41. The crucible 43 at the upper portion of the filter 21 communicates with the concentrator 22 described below, and the crucible 44 at the lower portion of the filter 21 is closed, for example. The details of the contents of the cylindrical container 40 of the filter 21 are described below.

The second flow path 25 is, for example, a flexible tube such as polyvinyl chloride, and is connected to the crucible 63 of the concentrator 22 from the crucible 43 at the upper portion of the filter 21. In the second flow path 25, for example, a tube pump 50 is provided, and the filtrate filtered by the filter 21 can be sent to the concentrator 22.

Similarly to the filter 21 described above, the concentrator 22 has a cylindrical container 60 in which a hollow fiber membrane bundle (bundle of hollow fiber membranes 61) 62 as a concentrated membrane is disposed along the longitudinal direction of the tubular container 60. The hollow fiber membrane 61 allows water in the filtrate to pass through to remove moisture, and concentrates the filtrate. In the upper portion and the lower portion of the cylindrical container 60, the crucibles 63 and 64 which communicate with the inner space of the hollow fiber membrane 61 are provided, and the side surface of the cylindrical container 60 is provided with two communicating with the outer space of the hollow fiber membrane 61.埠 65, 66. The weir 63 of the upper portion of the concentrator 22 communicates with the weir 43 of the filter 21, and the weir 64 of the lower portion of the concentrator 22 communicates with the concentrated ascites bag 23. One of the side faces 65 of the concentrator 22 communicates with a drain portion that discharges moisture discharged from the filtrate, and the crucible 66 is closed. Further, the concentrator 22 is an internal pressure method, but may be an external pressure method.

The third flow path 26 is, for example, a flexible tube such as polyvinyl chloride, and is connected to the concentrated ascites bag 23 from the lower portion 64 of the lower portion of the concentrator 22.

The concentrated ascites bag 23 is, for example, a container containing a soft resin such as polyvinyl chloride, and can store a concentrated liquid containing a useful substance concentrated by the concentrator 22.

Next, the internal configuration of the cylindrical container 40 of the filter 21 will be described. FIG. 2 is an explanatory view showing a longitudinal section of the outline of the configuration of the filter 21.

The filter 21 has the cylindrical container 40 as described above, and the hollow fiber membrane bundle 42 is disposed inside the cylindrical container 40 along the longitudinal direction thereof. The cylindrical container 40 is constituted by a cylindrical container body portion 40a and a header 40b that closes both ends of the container body portion 40a. The crucibles 43, 44 are formed in the header 40b, and the crucibles 45, 46 are formed in the container body portion 40a.

Both ends of the hollow fiber membrane bundle 42 are potted at both ends of the cylindrical container 40 by a potting material 70 of a curable resin. Thereby, both end portions of the hollow fiber membrane bundle 42 are fixed to the cylindrical container 40, and the opening end faces 71 of the inner side openings of the hollow fiber membranes 41 of the hollow fiber membrane bundle 42 are formed at both end portions of the cylindrical container 40. The outer space of the hollow fiber membrane 41 inside the cylindrical container 40 communicates with the crucible 45 of the side surface portion of the cylindrical container 40. The inner space of the hollow fiber membrane 41 communicates with the opening end surface 71 and communicates with the crucible 43. With this configuration, the ascites flows into the space outside the hollow fiber membrane 41 from the crucible 45, and flows into the inner space of the hollow fiber membrane 41 via the hollow fiber membrane 41, and the causative substance can be removed by filtration from the ascites. The filtrate flowing into the inner space of the hollow fiber membrane 41 can be discharged from the crucible 43 through the opening end face 71.

In the hollow fiber membrane 41, the filling ratio J of the hollow fiber membrane bundle 42 in the internal cross section of the cylindrical container 40 is 20% or more and 41% or less, preferably 22% or more and 41% or less, and further preferably 25 % or more and 41% or less are dispersed and arranged. Also, 21%, 23%, 24%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%, 34%, 35%, 36%, 37%, 38%, 39%, 40%. The filling rate J of the hollow fiber membrane bundle 42 is such that the cross-sectional area of the inside of the container body portion 40a is S as shown in Fig. 3 (when the inner diameter of the container body portion 40a is set to K), S = (K/2) ² × π), the cross-sectional area of one hollow fiber membrane 41 is s (when the outer diameter of one hollow fiber is R), s = (R/2) ² × π When the total number of the hollow fiber membrane bundles 42 is N, it is represented by the following formula (1).

The filling rate of the hollow fiber membrane bundle 42 is J=s×N/S×100 (%). (Expression 1)

Further, when the cross-sectional area S of the container main portion 40a changes in the longitudinal direction of the container main portion 40a, the area of the smallest portion is set.

The hollow fiber membranes 41 are arranged so as not to be densely dispersed. Here, the term "dispersed and disposed" refers to a state in which the hollow fiber membranes are disposed so as not to be in close contact with each other, and for example, a method in which a hollow fiber membrane is disposed substantially uniformly in a fixed range by blowing air or the like is performed. State. Specifically, in the hollow fiber membrane bundle 42, the distance from the nearest four hollow fiber membranes is set to D1, D2, D3, and D4 with respect to any of the hollow fiber membranes 41 (shown in FIG. 4). In the present invention, the maximum value at which the maximum hollow fiber membrane distance is 300 μm or more is dispersed. In the same manner, in the present invention, the average hollow fiber membrane distance is 150 μm or more, and the hollow fiber membrane is made to have an average hollow fiber membrane distance of 150 μm or more. 41 scattered. Further, the "maximum hollow fiber membrane distance" and "average hollow fiber membrane distance" described in the present invention are expressed at least for a circle having a radius of 5 mm centering on the center point of the internal cross section of the container. The hollow fiber membrane in the area is established. When the radius of the internal cross section of the container is 5 mm or less, it is established for all hollow fiber membranes. Further, the above-mentioned D1, D2, D3, and D4 (shown in FIG. 4) can be measured on the opening end face 71 of the potting material when the cross-sectional area of the container body portion 40a is not changed in the longitudinal direction. . On the other hand, when the cross-sectional area of the container main body portion 40a changes in the longitudinal direction, D1, D2, D3, and D4 whose cross-sectional areas are the smallest are used. That is, based on the values of D1, D2, D3, and D4 measured on the opening end face 71 of the potting material and the cross-sectional area thereof, D1, D2, D3, and D4 having the smallest cross-sectional area are obtained by the ratio calculation. . Specifically, the ratio of the cross-sectional area of the opening end face 71 of the potting material to the cross-sectional area of the smallest portion is determined, and the D1, D2, D3, and D4 of the opening end face 71 of the potting material are multiplied by the above ratio to define the mode. Group D1, D2, D3, D4.

Further, the distance L between the two end faces 71 of the hollow fiber membrane bundle 42 shown in Fig. 2 is set to 50 mm or more and 300 mm or less, preferably 100 mm or more and 280 mm or less, more preferably 150 mm or more and 240 mm or less, and further Good is 200mm or more and 240mm or less. In addition, when the distance L is less than 50 mm, when the film area is designed to be equal, the number N of the hollow fiber membranes 41 becomes large, and the ascites does not reach the bundle, which is not preferable. . When the distance L is larger than 300 mm, the flow path as a whole of the module is narrowed. Therefore, when the clogging of the ascites entering the sputum 45 from the sputum 45 is caused, the pressure is liable to rise, which is not preferable.

The effective membrane area of the hollow fiber membrane bundle 42 (the inner circumference of the hollow fiber membrane 41 (the inner diameter d of the hollow fiber membrane 41 (shown in Fig. 5) × π) × the distance between the end faces of the openings L × the number of hollow fiber membranes N) is set to ² and less than 3.0m 0.7m ^2, preferably 1.0m ² or more and 2.5m ^2. Further, when the effective membrane area of the hollow fiber membrane bundle 42 is less than 0.7 m ² , the filtration ability as a whole filter is lowered, which is not preferable. If the effective membrane area of the hollow fiber membrane bundle 42 is more than 3.0 m ² , the loss becomes large when a small amount of ascites is treated, which is not preferable.

The inner diameter d of the hollow fiber membrane 41 is set to 50 μm or more and 500 μm or less, preferably 100 μm or more and 450 μm or less. In addition, when the inner diameter d is less than 50 μm, it is liable to be blocked when depositing proteins or the like inside the hollow fiber membrane, which is not preferable. Further, when the inner diameter d is more than 500 μm, the yield at the time of producing the hollow fiber is remarkably lowered, which is not preferable.

In addition, the number N of the hollow fiber membranes 41 is, for example, 2,000 or more and 10,000 or less, preferably 3,000 or more and 9,000 or less. Further, the diameter of the pores of the hollow fiber membrane 41 is 0.010 μm or more and 10 μm or less, preferably 0.05 μm or more and 5 μm or less. The outer diameter of the hollow fiber membrane 41 is 200 μm or more and 600 μm or less, preferably 300 μm or more and 500 μm or less. In addition, when the number N of the hollow fiber membranes 41 is less than 2,000, the filtration ability as a whole module is lowered, which is not preferable. If the number of the strips N is more than 10,000, the filling rate is increased and the clogging is easy, which is not preferable. Further, when the diameter of the pores of the hollow fiber membrane 41 is less than 0.010 μm, it becomes easy to block, which is not preferable. If the diameter of the hole of the hollow fiber membrane 41 When it is more than 10 μm, it becomes almost impossible to filter cancer cells, bacteria, etc., which is not preferable.

Next, the ascites treatment by the ascites treatment system 1 will be described.

First, the ascites bag 20 containing the ascites taken from the patient is connected to the first flow path 24. Next, the drive tube pumps 30 and 50 and the ascites water of the ascites bag 20 are supplied from the crucible 45 of the filter 21 to the outer space of the hollow fiber membrane 41 of the cylindrical container 40 through the first flow path 24. The ascites flows into the inner space from the space outside the hollow fiber membrane 41 through the pores of the hollow fiber membrane 41. At this time, specific causative substances such as cancer cells or bacteria are removed and filtered. The filtrate passing through the hollow fiber membrane 41 flows out from the crucible 43 to the second flow path 25, and flows from the crucible 63 of the concentrator 22 to the inner space of the hollow fiber membrane 61 through the second flow path 25. In the concentrator 22, the filtrate passes through the inner space of the hollow fiber membrane 61, and the moisture in the filtrate passes through the hollow fiber membrane 61 of the concentration membrane and is discharged to the outer space of the hollow fiber membrane 61, and the filtrate is concentrated. The concentrated liquid containing a useful substance such as albumin concentrated by the concentrator 22 is discharged from the crucible 64 to the third flow path 26, and is transported through the third flow path 26 and stored in the concentrated ascites bag 23. Thus, when all of the ascites in the ascites bag 20 is concentrated by filtration, the ascites treatment ends. Then, the concentrate of the concentrated ascites bag 23 is reinjected into the patient. Further, cancer cells or bacteria existing in the space on the outer side of the hollow fiber membrane 41 may be washed. For example, by closing the crucible 43 and the crucible 45 and transporting a cleaning liquid such as physiological saline from the crucible 44, the cleaning liquid is discharged from the crucible 46, whereby cleaning can be achieved.

According to the present embodiment, the hollow fiber membranes 41 of the filter liquid 21 are disposed so as to be dispersed so as to have a filling ratio J of the hollow fiber membrane bundles 42 in the internal cross section of the cylindrical container 40 of 20% or more and 41% or less. The ascites to the outer space of the hollow fiber membrane 41 reaches the hollow fiber membrane 41 on the central portion side of the hollow fiber membrane bundle 42, and the ascites can be efficiently filtered by the hollow fiber membrane bundle 42 as a whole. As a result, in the filter 21 for filtering the ascites, the clogging of the hollow fiber membrane 41 can be alleviated by the external pressure method, and the filtration ability of the filter 21 can be suppressed.

In the above embodiment, the hollow fiber membrane 41 of the filtration membrane 21 may have a curled shape. That is, the hollow fiber membrane 41 can also be bent into a wave shape as shown in FIG. Curl amplitude Preferably, it is 0.2 mm or more and 1.2 mm or less, and the wavelength is preferably 3.0 mm or more and 16 mm or less. In this case, it becomes easy to form a gap between the hollow fiber membranes 41, and the ascites easily penetrates into the center portion side of the hollow fiber membrane bundle 42. Further, when the amplitude and the wavelength of the curl are irregular in the filter 22, the ascites easily penetrates into the center portion side of the hollow fiber membrane bundle 42, which is not preferable.

The preferred embodiments of the present invention have been described above with reference to the accompanying drawings, but the invention is not limited thereto. It is to be understood that various modifications and changes can be made without departing from the scope of the invention.

For example, the configuration of the cylindrical container 40 of the above embodiment is not limited thereto, and may have other constituents. Further, the configuration of the ascites treatment system 1 or the ascites treatment circuit 10 is not limited thereto, and the present invention can be applied even if it has other constituents. Further, the present invention can also be applied to a pleural effusion treatment system that treats body fluid other than ascites, such as pleural fluid. Furthermore, the pleural effusion treatment system may have the same configuration as the above-described ascites treatment system, or may have a different configuration.

[Examples]

In the following examples, the experimental results obtained by verifying the relaxation of the clogging of the filter of the present invention and the maintenance of the filtration ability are shown.

<production of filter>

The granules of high-density polyethylene (trade name: Suntec HDJ240, Asahi Kasei Chemicals Co., Ltd.) were heated at 147 ° C and extruded by a pump, and nitrogen gas was flowed at a flow rate of 22 mL/min to be cooled. A hollow raw yarn is obtained. Then, the film was taken up by stretching at a temperature of 70 ° C to 120 ° C and a roll speed of 5 to 30 m / min, and cut into 330 mm, thereby obtaining a semi-finished product of a hollow fiber bundle having a microporous shape. Further, the hollow fiber membrane bundle blank was immersed in an EVAL (vinyl alcohol copolymer) coating liquid (trade name: Soaresin Japan Synthetic Chemical Co., Ltd.) dissolved in a 58% aqueous solution of 1-propanol for 1 hour. It was dried at 60 ° C, whereby a bundle of hollow fiber membranes was obtained. The hollow fiber membrane has an inner diameter of 280 μm and a membrane thickness of 50. Μm, the outer diameter is 380 μm, and the diameter of the pores is 0.2 μm. The obtained hollow fiber membrane bundle was packed in a cylindrical container made of polycarbonate (having an inner diameter of the container body of 50.5 mm), and the both ends were potted by a polyurethane resin, and then 25 kGy was used. The dose is subjected to gamma sterilization, whereby a filter is obtained.

<time required until blocking>

The bovine plasma 3L which adjusted the albumin concentration to 3 g/dL was set as pseudo-ascites. 3 L of pseudo-abdominal water was placed in the ascites bag, and was connected in the order of a filter, a concentrator, and a concentrated ascites bag, and connected by an ascites treatment circuit in an external pressure filtration mode ( FIG. 7 ). In the pump A, the flow rate was set to be 50 mL per minute, and the pump B was set to have a flow rate of 5 mL per minute, and the filtration concentration treatment was performed. In the filtration concentration treatment, the pressure of the pressure gauge C reached 500 mmHg, and it was judged as "blocked", and the time from the start of the treatment to the blockage was determined as follows.

The time until blocking is more than 20 minutes: ○

The time until the blockage is less than 20 minutes: ×

<Measurement of the distance between the maximum hollow fiber membranes and the average distance between hollow fiber membranes>

The encapsulation surface was visually observed by an optical microscope (manufactured by IX70 Olympus Co., Ltd.), and the image was taken by a field of view of 10 mm × 10 mm to measure the maximum hollow fiber membrane between any five hollow fiber membranes. Distance and average distance between hollow fiber membranes.

(Example 1)

A filter was produced using a hollow fiber membrane bundle of 7,200 strips of hollow fibers having no crimp. The distance L between the end faces of the openings was 240 mm, the filling ratio J was 41%, and the film area was 1.5 m ² . Further, the maximum distance between the hollow fiber membranes was 340 μm, and the average distance between the hollow fiber membranes was 120 μm.

(Example 2)

A filter was produced using a hollow fiber membrane bundle of 3,600 hollow fibers having no crimp. The distance L between the end faces of the openings was 240 mm, the filling ratio J was 20%, and the film area was 0.7 m ² . Further, the distance between the largest hollow fiber membranes was 520 μm, and the distance between the average hollow fiber membranes was 210 μm.

(Example 3)

A filter was produced using a hollow fiber membrane bundle of 7,200 strips of hollow fibers having no crimp. The distance L between the end faces of the openings was 200 mm, the filling ratio J was 41%, and the film area was 1.3 m ² . Further, the maximum distance between the hollow fiber membranes was 330 μm, and the average distance between the hollow fiber membranes was 110 μm.

(Example 4)

A filter was produced using a hollow fiber membrane bundle having 7,200 hollow fibers having a thickness of 0.7 mm and a wavelength of 9.0 mm. The distance L between the end faces of the openings was 240 mm, the filling ratio J was 41%, and the film area was 1.5 m ² . Further, the maximum distance between the hollow fiber membranes was 350 μm, and the average distance between the hollow fiber membranes was 140 μm.

(Comparative Example 1)

A filter was prepared using a hollow fiber membrane bundle of 11,000 strips of hollow fibers having no crimp. The distance between the end faces of the openings was 250 mm, the filling ratio was 65%, and the film area was 2.3 m ² . Further, the distance between the largest hollow fiber membranes was 190 μm, and the average distance between the hollow fiber membranes was 90 μm.

(Comparative Example 2)

A filter was produced using a hollow fiber membrane bundle of 2,300 strips of hollow fibers having no crimp. The distance L between the end faces of the openings was 250 mm, the filling ratio J was 13%, and the film area was 0.5 m ² . Further, the distance between the largest hollow fiber membranes was 610 μm, and the average distance between the hollow fiber membranes was 280 μm.

[Industrial availability]

In the filter for filtering a body cavity liquid, it is useful to suppress the clogging of the hollow fiber membrane by using an external pressure method while suppressing a decrease in the filtration ability of the filter.

40‧‧‧Cylindrical container

40a‧‧‧Container body

41‧‧‧ hollow fiber membrane

42‧‧‧Hollow fiber bundle

S‧‧‧Cross section area of the body part of the container

S‧‧‧1 cross-sectional area of hollow fiber membrane

Claims (9)

A filter having a cylindrical container having a hollow fiber membrane bundle therein, wherein in the cylindrical container, body cavity fluid is passed from the outer side of the hollow fiber membrane of the hollow fiber membrane bundle to the inner side to remove the body cavity fluid In the hollow fiber membrane, the hollow fiber membrane is dispersed so as to have a filling ratio of the hollow fiber membrane bundle of 20% or more and 41% or less in the internal cross section of the cylindrical container. The filter according to claim 1, wherein a distance between the largest hollow fiber membranes in the hollow fiber membrane bundle is 300 μm or more. The filter according to claim 1 or 2, wherein the average hollow fiber membrane distance in the hollow fiber membrane bundle is 150 μm or more. The filter according to any one of claims 1 to 3, wherein both ends of the hollow fiber membrane bundle are potted and sealed at both ends of the cylindrical container by a potting material, and the cylindrical container is The end faces of the hollow fiber membrane bundles are formed at both end portions, and the distance between the end faces of the hollow fiber membrane bundles is 50 mm or more and 300 mm or less. The requested item filter according to any one of 1 to 4, wherein the effective membrane area of the hollow fiber membrane bundle is 0.7m ² or more and 3.0m ² or less. The filter according to any one of claims 1 to 5, wherein the hollow fiber membrane has an inner diameter of 50 μm or more and 500 μm or less. The filter according to any one of claims 1 to 6, wherein the hollow fiber membrane has a curled shape. A body cavity liquid treatment system, comprising at least the filter according to any one of claims 1 to 7, and a concentrator for concentrating the filtrate filtered by the filter, and at least in the filter The body cavity fluid is treated in a pressurized manner. A method for treating a body cavity, which is the same as the filter of any one of claims 1 to 7, comprising the steps of: treating the body cavity fluid by external pressure in the filter; and using the filter The filtered filtrate was concentrated.