CN106999855A - Filter, body cavity liquid treating system and body cavity liquid processing method - Google Patents
Filter, body cavity liquid treating system and body cavity liquid processing method Download PDFInfo
- Publication number
- CN106999855A CN106999855A CN201680004171.9A CN201680004171A CN106999855A CN 106999855 A CN106999855 A CN 106999855A CN 201680004171 A CN201680004171 A CN 201680004171A CN 106999855 A CN106999855 A CN 106999855A
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- filter
- fibre membrane
- hollow fiber
- ascites
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- 239000007788 liquid Substances 0.000 title claims description 19
- 238000003672 processing method Methods 0.000 title claims description 8
- 239000012528 membrane Substances 0.000 claims abstract description 175
- 239000000835 fiber Substances 0.000 claims abstract description 112
- 239000012510 hollow fiber Substances 0.000 claims abstract description 54
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 239000000463 material Substances 0.000 claims abstract description 15
- 238000011049 filling Methods 0.000 claims abstract description 14
- 239000012530 fluid Substances 0.000 claims description 30
- 238000012545 processing Methods 0.000 claims description 23
- 239000012141 concentrate Substances 0.000 claims description 8
- 206010003445 Ascites Diseases 0.000 abstract description 80
- 230000000903 blocking effect Effects 0.000 abstract description 13
- 230000007423 decrease Effects 0.000 abstract description 6
- 235000012489 doughnuts Nutrition 0.000 description 15
- 238000000034 method Methods 0.000 description 7
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 210000000578 peripheral nerve Anatomy 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 229920000915 polyvinyl chloride Polymers 0.000 description 5
- 239000004800 polyvinyl chloride Substances 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- 206010048612 Hydrothorax Diseases 0.000 description 4
- 231100000676 disease causative agent Toxicity 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 239000004425 Makrolon Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 238000001125 extrusion Methods 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000000116 mitigating effect Effects 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/031—Two or more types of hollow fibres within one bundle or within one potting or tube-sheet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- External Artificial Organs (AREA)
- Artificial Filaments (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
In the filter of filtering ascites, the blocking of hollow-fibre membrane is relaxed using external pressure mode, and suppress the decline of the filter capacity of filter.Filter (21), which has, internally includes the cylindrical containers (40) of hollow fiber membrane bundle (42), by making ascites from the inner side of the outer lateral hollow-fibre membrane (41) of the hollow-fibre membrane (41) of hollow fiber membrane bundle (42) by hollow-fibre membrane (41) so as to removing the specific material in ascites.Hollow-fibre membrane (41) is distributed in the way of the filling rate of hollow fiber membrane bundle (42) is more than 20% and less than 41% in the internal cross section of cylindrical container (40).
Description
Technical field
The present invention relates to the filter of ascites, hydrothorax, hydropericardium etc., body cavity liquid treating system and coelomic fluid processing side
Method.
Background technology
For example, as the treatment method of difficultly curing ascites disease, there are a kind of ascites filtering and concentrating intravenous injection again
(Cell-free and Concentrated Ascites Reinfusion Therapy)：Ascites is extracted from patient, filtering should
Ascites simultaneously removes the causative agents such as cancer cell, bacterium, then, including the utility of its protein comprising albumin etc.
Filtered fluid is concentrated, and then, the concentrate is re-injected into vivo.
In the treatment method, usually using ascites processing system, representational example, the ascites processing system bag are used as
Include the fluid loop for them being connected in series according to the order of ascites bag, filter, inspissator, concentration ascites bag.
However, the filter of ascites processing system is configured with the hollow-fibre membrane as filter membrane in the inside of cylindrical container
Beam, the both ends of hollow fiber membrane bundle are packaged processing at the both ends of cylindrical container using encapsulating material, and are formed with out
Mouth end face.In the past, the filter was generally so that ascites was from the inner side flow direction outside of hollow-fibre membrane so that the internal pressure filtered
Mode is used, however, in recent years, propose to have in opposite to that mode, i.e., make ascites interior from the outside flow direction of hollow-fibre membrane
The method that side uses so as to the external pressure mode filtered (with reference to patent document 1,2).
Prior art literature
Patent document
Patent document 1：Japanese Unexamined Patent Publication 2009-297242 publications
Patent document 2：Japanese Unexamined Patent Publication 2011-172797 publications
The content of the invention
Problems to be solved by the invention
Ascites contains the relatively large material such as cancer cell and viscosity is high, even if the short time uses filter, also easily
Blocking is produced in hollow-fibre membrane.Then, by using external pressure mode, make ascites relatively large from the surface area of hollow-fibre membrane
Outside flow direction inner side filtered, so as to relax the blocking of hollow-fibre membrane, extend the service life of filter.
However, in the case where being filtered using above-mentioned external pressure mode, being located at center due to hollow fiber membrane bundle
The hollow-fibre membrane of the position of portion side (in beam) immediately gathers together mutually, and is located at peripheral part side by hollow fiber membrane bundle
The hollow-fibre membrane covering of the position of (outside beam), therefore, if viscosity is higher as ascites, ascites does not reach doughnut
The hollow-fibre membrane of the central part of perineurium, as a result causes filter capacity to decline.
The application be in view of the problem points and make, it is intended that in the filter of the filtering coelomic fluid such as ascites
In, the blocking of hollow-fibre membrane is relaxed using external pressure mode, and suppress the decline of the filter capacity of filter.
The solution used to solve the problem
The present inventors for above-mentioned problem, obtained by the cylindrical container of filter by hollow fiber membrane bundle
The opinion that hollow-fibre membrane is distributed and improves filter capacity, so as to complete the present invention.
That is, the present invention includes following mode.
(1) a kind of filter, the filter has the cylindrical container for internally including hollow fiber membrane bundle, in the tubular
Make in container coelomic fluid from the outer lateral hollow-fibre membrane of the hollow-fibre membrane of the hollow fiber membrane bundle inner side pass through it is hollow
Tunica fibrosa so as to remove specific material in coelomic fluid, wherein, the hollow-fibre membrane is filled out with the hollow fiber membrane bundle
The mode that rate is more than 20% and less than 41% in the internal cross section of the cylindrical container is filled to be distributed.
(2) filter according to (1), wherein, distance between the maximum hollow-fibre membrane in the hollow fiber membrane bundle
For more than 300 μm.
(3) filter according to (1) or (2), wherein, the average doughnut in the hollow fiber membrane bundle is intermembranous
Distance is more than 150 μm.
(4) filter according to any one of (1)~(3), wherein, the both ends of the hollow fiber membrane bundle are utilized
Encapsulating material is packaged processing at the both ends of the cylindrical container, forms described hollow at the both ends of the cylindrical container
The open end of fiber-film bundle, the distance between two open ends of the hollow fiber membrane bundle for more than 50mm and 300mm with
Under.
(5) filter according to any one of (1)~(4), wherein, effective membrane area of the hollow fiber membrane bundle
For 0.7m2Above and 3.0m2Below.
(6) according to the filter any one of (1)~(5), wherein, the internal diameter of the hollow-fibre membrane for 50 μm with
Go up and less than 500 μm.
(7) filter according to any one of (1)~(6), wherein, the hollow-fibre membrane has curly form.
(8) a kind of body cavity liquid treating system, the body cavity liquid treating system is at least included any one of (1)~(7)
Filter and the inspissator by the filtered fluid concentration after filter filtering, utilize external pressure at least in the filter
Mode handles coelomic fluid.
(9) a kind of body cavity liquid processing method, the body cavity liquid processing method uses the filtering any one of (1)~(7)
Device, wherein, the body cavity liquid processing method is comprised the steps of：The step of coelomic fluid is handled using external pressure mode in the filter
Suddenly；And by through the filter filter after filtered fluid concentrate the step of.
The effect of invention
In accordance with the invention it is possible to which the stifled of hollow-fibre membrane is relaxed using external pressure mode in the filter of filtering coelomic fluid
Plug, and suppress the decline of the filter capacity of filter.
Brief description of the drawings
Fig. 1 is the explanation figure of the outline for the structure for representing ascites processing system.
Fig. 2 is the explanation figure in the vertical section of filter.
Fig. 3 is the explanation figure for the cross section for representing cylindrical container.
Fig. 4 is the explanation figure for representing the distance between hollow-fibre membrane.
Fig. 5 is the explanation figure for the diameter for representing hollow-fibre membrane.
Fig. 6 is the explanation figure for illustrating the curly form of hollow-fibre membrane.
Fig. 7 is the explanation figure for the ascites processing system for representing embodiment.
Embodiment
Hereinafter, with reference to the accompanying drawings of the present invention preferred embodiment.If in addition, do not make specified otherwise, then accompanying drawing
Up and down wait position relationship be based on position relationship shown in the drawings.The dimension scale of accompanying drawing is not limited to the ratio of diagram
Example.In addition, following embodiment is the illustration for illustrating the present invention, its purport is not that the present invention is only defined in into the reality
Apply mode.In addition, the present invention can carry out various modifications in the range of without departing from its spirit.
Fig. 1 is to be denoted as including at the ascites of the body cavity liquid treating system of the filter 21 involved by present embodiment
The explanation figure of the outline of the structure of reason system 1.
As shown in figure 1, ascites processing system 1 for example includes the ascites treatment loop 10 as fluid loop.At ascites
Reason loop 10 has as the ascites bag 20 of coelomic fluid reservoir, filter 21, inspissator 22, is used as the dense of concentrate reservoir
Contracting ascites bag 23, the 1st stream 24 of connection ascites bag 20 and filter 21, the 2nd stream for connecting filter 21 and inspissator 22
25 and connection inspissator 22 and concentration ascites bag 23 the 3rd stream 26.
Ascites bag 20 is, for example, the container formed by the resin of the soft property such as polyvinyl chloride, can house and be taken out as from patient
The ascites for the coelomic fluid got.
1st stream 24 is, for example, the pipe of the soft property of polyvinyl chloride etc., and filter 21 is connected to from the outlet of ascites bag 20
Side surface part described later port 45.For example provided with tube pump 30 on the 1st stream 24, the ascites of ascites bag 20 can be transported to
Filter 21.Furthermore it is also possible to be not provided with tube pump 30, and fallen using gravity and the ascites of ascites bag 20 is supplied to filter
21。
Filter 21 has cylindrical container 40, and doughnut is configured with along its length direction in the inside of cylindrical container 40
Perineurium (beam of hollow-fibre membrane 41) 42.Hollow-fibre membrane 41 can remove the predetermined cause of disease such as cancer cell, bacterium from ascites
Material, and pass through the composition of the utility of the protein comprising albumin etc. in addition to the predetermined causative agent.
The top of cylindrical container 40 is provided with the port 43 towards the inner side (space) of hollow-fibre membrane 41, is set in the bottom of cylindrical container 40
There is the port 44 towards the inner side (space) of hollow-fibre membrane 41, be provided with the side surface part of cylindrical container 40 and lead to hollow-fibre membrane
Two ports 45,46 in 41 outside (space).The port 45 of the side surface part of filter 21 leads to ascites bag 20.Filter 21
The port 46 of side surface part is connected with by the discharge opeing portion (not shown) not discharged by the composition of hollow-fibre membrane 41.Filter 21
The port 43 on top is connected with inspissator 22 described later, and the port 44 of the bottom of filter 21 is for example closed.Filter 21
The details of the content structure of cylindrical container 40 is illustrated later.
2nd stream 25 is, for example, the soft property pipe of polyvinyl chloride etc., and the port 43 on the top of inherent filtration device 21 is connected to dense
The port 63 of contracting device 22., can be defeated by the filtered fluid after being filtered using filter 21 for example provided with tube pump 50 on the 2nd stream 25
It is sent to inspissator 22.
Identical with above-mentioned filter 21, inspissator 22 has cylindrical container 60, is grown in the inside of cylindrical container 60 along it
Degree direction is configured with the hollow fiber membrane bundle (beam of hollow-fibre membrane 61) 62 as concentration film.Hollow-fibre membrane 61 can make
Moisture in filtrate is removed by and by moisture, so that filtered fluid be concentrated.It is provided with the top of cylindrical container 60 towards hollow
The port 63 of the inner space of tunica fibrosa 61, is provided with the bottom of cylindrical container 60 towards the inner space of hollow-fibre membrane 61
Port 64, is provided with towards two ports 65,66 of the outer space of hollow-fibre membrane 61 in the side surface part of cylindrical container 60.Concentration
The port 63 on the top of device 22 is connected with the port 43 of filter 21, port 64 and the concentration ascites bag 23 of the bottom of inspissator 22
Connection.The a port 65 of the side surface part of inspissator 22 is connected with the discharge opeing portion for discharging the moisture discharged from filtered fluid, end
Mouth 66 is closed.In addition, the inspissator 22 is the inspissator using internal pressure mode, it is also possible to being the concentration using external pressure mode
Device.
3rd stream 26 is, for example, the soft property pipe of polyvinyl chloride etc., is connected to from the port 64 of the bottom of inspissator 22 dense
Contracting ascites bag 23.
Concentration ascites bag 23 is, for example, the container formed by the resin of the soft property such as polyvinyl chloride, can house and utilize concentration
The concentrate included including utility after the concentration of device 22.
Then, the internal structure of the cylindrical container 40 of filter 21 is illustrated.Fig. 2 is the outline for the structure for representing filter 21
Vertical section explanation figure.
As described above, filter 21 has cylindrical container 40, configured in the inside of cylindrical container 40 along its length direction
There is hollow fiber membrane bundle 42.Cylindrical container 40 includes the two of the container body portion 40a and closed vessel main part 40a of cylindrical shape
The joint 40b of end opening.Port 43,44 is formed at joint 40b, and port 45,46 is formed at container body portion 40a.
The both ends of hollow fiber membrane bundle 42 utilize the encapsulating material 70 of curable resin at the both ends of cylindrical container 40
Encapsulation process is carried out.Thus, the both ends of hollow fiber membrane bundle 42 are fixed in cylindrical container 40, the two of cylindrical container 40
End forms the open end 71 of the interior side opening of each hollow-fibre membrane 41 of hollow fiber membrane bundle 42.The inside of cylindrical container 40
The outer space of hollow-fibre membrane 41 connected with the port 45 of the side surface part of cylindrical container 40.The inner side of hollow-fibre membrane 41 is empty
Between connected by open end 71 with port 43.Using the structure, ascites is set to flow into the outside of hollow-fibre membrane 41 from port 45
Space, and via the inner space of the inflow hollow-fibre membrane 41 of hollow-fibre membrane 41, so as to filter and remove from ascites
Causative agent.Being flowed into the filtered fluid of the inner space of hollow-fibre membrane 41 can be arranged by open end 71 from port 43
Go out.
Hollow-fibre membrane 41 using the filling rate J of hollow fiber membrane bundle 42 cylindrical container 40 internal cross section as 20% with
Upper and less than 41%, preferably more than 22% and less than 41%, more preferably more than 25% and less than 41% mode is scattered to match somebody with somebody
Put.In addition, filling rate J can be 21%, 23%, 24%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%,
34%th, 35%, 36%, 37%, 38%, 39%, 40%.As shown in figure 3, by the cross section of container body portion 40a inside
Area be set to S (in the case where container body portion 40a internal diameter is set into K, S=(K/2)2× π), by a hollow-fibre membrane
41 sectional area be set to s (in the case where the external diameter of a doughnut is set into R, s=(R/2)2× π), by doughnut
In the case that total radical of perineurium 42 is set to N, the filling rate J of hollow fiber membrane bundle 42 is represented by following formula (1).
The filling rate J=s of hollow fiber membrane bundle 42 × N/S × 100 (%) (formula 1)
In addition, for container body portion 40a sectional area S, in situation about changing along container body portion 40a length side
Under, it is set to the area of least part.
Hollow-fibre membrane 41 is distributed in the way of not gathering together immediately mutually.Here, during " being distributed " is
The state that hollow fiber film is configured in the way of not being close to each other, for example, can there are by blowing air etc., so that doughnut
The mode that film is substantially evenly configured in fixed scope handle after state.Specifically, in hollow fiber membrane bundle 42,
For arbitrary hollow-fibre membrane 41, it is set to D1, D2, D3, D4 (figure the distance between with four nearest hollow-fibre membranes
Shown in 4).By five hollow-fibre membranes are measured this apart from when maximum be defined as maximum hollow-fibre membrane distance,
In the present invention, hollow-fibre membrane 41 is disperseed by distance between maximum hollow-fibre membrane in the way of more than 300 μm.Similarly, inciting somebody to action
Value obtained from D1~D4 of any five hollow-fibre membranes is all average be defined as between average hollow-fibre membrane apart from when,
In invention, hollow-fibre membrane 41 is disperseed by distance between average hollow-fibre membrane in the way of more than 150 μm.In addition, in the present invention
Described " distance between maximum hollow-fibre membrane " and " distance between average hollow-fibre membrane ", at least to being present in in container
Radius centered on the central point of cross section is set up for the hollow-fibre membrane in the region shown in 5mm circle.In container
In the case that the radius of cross section is below 5mm, all hollow-fibre membranes are set up.In addition, container body portion 40a's
In the case that sectional area does not produce the component of change alongst, above-mentioned D1, D2, D3, D4 (shown in Fig. 4) can be in envelope
Measured on package material open end 71.On the other hand, situation about being varied along its length in container body portion 40a sectional area
Under, D1, D2, D3, D4 of minimum part are turned into using container body portion 40a sectional area.That is, according in package material
D1, D2, D3, D4 for being measured on material open end 71 value and container body portion 40a sectional area, proportion of utilization are calculated and tried to achieve
Sectional area turns into D1, D2, D3, D4 of minimum part.Specifically, try to achieve the sectional area of encapsulating material open end 71 with most
Ratio between the sectional area of fraction, will be multiplied by the ratio on D1, D2, D3, D4 in encapsulating material open end 71
Obtained from value be defined as D1, D2, D3, D4 in the component.
In addition, the distance between two open ends 71 of hollow fiber membrane bundle 42 shown in Fig. 2 L be set as more than 50mm and
Below 300mm, is preferably set to more than 100mm and below 280mm, is more preferably set as more than 150mm and below 240mm, enter
One step is preferably set to more than 200mm and below 240mm.If in addition, being less than 50mm apart from L, with the equal side of membrane area
In the case that formula is designed, the radical N of hollow-fibre membrane 41 becomes big, and ascites will not be reached in beam on the contrary, thus not preferred.If
It is more than 300mm apart from L, then the overall stream of component narrows, therefore, before the ascites entered from port 45 is gone out from port 43
When somewhere causing blocking, easily pressure is set to increase, thus it is not preferred.
Effective membrane area (inner circumferential (internal diameter d (Fig. 5 of hollow-fibre membrane 41 of hollow-fibre membrane 41 of hollow fiber membrane bundle 42
Shown in) × π) × openend distance between the surface L × hollow-fibre membrane quantity N) be set as 0.7m2Above and 3.0m2Hereinafter, it is excellent
Choosing is set as 1.0m2Above and 2.5m2Below.If in addition, effective membrane area of hollow fiber membrane bundle 42 is less than 0.7m2, then filter
The overall filter capacity of device declines, thus not preferred.If effective membrane area of hollow fiber membrane bundle 42 is more than 3.0m2, then at place
Loss becomes big thus not preferred when managing a small amount of ascites.
The internal diameter d of hollow-fibre membrane 41 is set as more than 50 μm and less than 500 μm, is preferably set to more than 100 μm and 450
Below μm.In addition, if internal diameter d is less than 50 μm, easily blocked when hollow-fibre membrane building up inside has protein etc., thus not
It is preferred that.In addition, if internal diameter d is more than 500 μm, yield rate when doughnut is manufactured is decreased obviously, thus not preferred.
In addition, the radical N of hollow-fibre membrane 41 is, for example, more than 2000 and less than 10000, preferably 3000 with
Go up and less than 9000.In addition, a diameter of more than 0.010 μm of the hole of hollow-fibre membrane 41 and less than 10 μm, preferably 0.05 μ
Less than more than m and 5 μm.The external diameter of hollow-fibre membrane 41 is more than 200 μm and less than 600 μm, preferably more than 300 μm and 500 μ
Below m.In addition, if the radical N of hollow-fibre membrane 41 is less than 2000, the overall filter capacity of component declines, thus unexcellent
Choosing.If radical N is more than 10000, filling rate increases and easily blocked, thus not preferred.If in addition, hollow-fibre membrane 41
The diameter in hole is less than 0.010 μm, then easily blocks, thus not preferred.If the diameter in the hole of hollow-fibre membrane 41 is more than 10 μm,
Cancer cell, bacterium etc. can not be almost filtered, thus it is not preferred.
Then, the ascites processing carried out using ascites processing system 1 is illustrated.
First, the ascites bag 20 for containing the ascites extracted from patient is connected with the 1st stream 24.Then, make tube pump 30,
50 drivings, the hollow of cylindrical container 40 is supplied to by the ascites of ascites bag 20 by the port 45 of the inherent filtration device 21 of the 1st stream 24
The outer space of tunica fibrosa 41.Ascites is empty by the hole inflow inner side of hollow-fibre membrane 41 from the outer space of hollow-fibre membrane 41
Between, now, remove and filter cancer cell, the predetermined causative agent such as bacterium.Held certainly by the filtered fluid after hollow-fibre membrane 41
Mouth 43 flows out to the 2nd stream 25, and empty from the inner side that the port 63 of inspissator 22 flows into hollow-fibre membrane 61 by the 2nd stream 25
Between.In inspissator 22, filtered fluid is by the inner space of hollow-fibre membrane 61, and the moisture in filtered fluid is by concentrating in film
Hollow fiber film 61 and the outer space for being discharged to hollow-fibre membrane 61, filtered fluid are concentrated.After being concentrated using inspissator 22
Concentrate including utility comprising albumin etc. is discharged to the 3rd stream 26 from port 64, defeated by the 3rd stream 26
Send and house concentration ascites bag 23.Thus, if whole ascites in ascites bag 20 are completed at ascites by filtering and concentrating
Reason.Then, the concentrate for concentrating ascites bag 23 is refilled in patient.It is present in hollow-fibre membrane in addition it is possible to clean
The cancer cell of 41 outer space, bacterium.For example, close port 43 and port 45, from cleanings such as the supply of port 44 physiological saline
Liquid, afterwards, is discharged from port 46, thus allows for cleaning.
According to present embodiment, the hollow-fibre membrane 41 of filtered fluid 21 is with the filling rate J of hollow fiber membrane bundle 42 in tubular
The internal cross section of container 40 is distributed for more than 20% and less than 41% mode, therefore, flows into hollow-fibre membrane 41
The ascites of outer space reaches the hollow-fibre membrane 41 by central part side of hollow fiber membrane bundle 42, and can utilize doughnut
Perineurium 42 is overall effectively to filter ascites.As a result, in the filter 21 of filtering ascites external pressure mode being used to relax
The blocking of hollow fiber film 41, also, suppress the decline of the filter capacity of filter 21.
In the above-described embodiment, the hollow-fibre membrane 41 of filter membrane 21 can have curly form.That is, as shown in fig. 6,
Hollow-fibre membrane 41 can be with wave sigmoid.The amplitude of curling is preferably more than 0.2mm~below 1.2mm, and wavelength is preferably
More than 3.0mm~below 16mm.In this case, easily producing gap between hollow-fibre membrane 41, and make ascites easily in
The central part side of hollow fiber perineurium 42 enters.In addition, if the amplitude and wavelength of curling are irregular in filter 22, ascites is held
Easily enter to the central part side of hollow fiber membrane bundle 42, thus preferably.
More than, with reference to the accompanying drawings of the present invention preferred embodiment, but the present invention is not limited to the example.It is right
It will be clear that in the range of the thought described in claims for those skilled in the art, alternatively it is conceivable to various
Modification or fixed case, it will be appreciated that be that these modifications or fixed case fall within protection scope of the present invention certainly.
For example, the structure of the cylindrical container 40 in above-mentioned embodiment is not limited to this, there can also be other knots
Structure.In addition, ascites processing system 1, the structure of ascites treatment loop 10 are not limited to this, the present invention can also be applied to have
The ascites processing system 1 of other structures, ascites treatment loop 10.In addition, the present invention can also be applied to beyond processing ascites
The hydrothorax processing system of other coelomic fluids, such as hydrothorax.In addition, the hydrothorax processing system can both have the ascites with more than
Processing system identical structure, it is possible to have different structures.
Embodiment
Below in an example, show that the mitigation of blocking in the filter to the present invention, the maintenance of filter capacity are entered
The experimental result that row checking is obtained.
＜ makes filter ＞
By the particle of high density polyethylene (HDPE) (trade name SUNTEC HDJ240 Asahi Chemical Industries chemistry (strain) company system) at 147 DEG C
At a temperature of heated, and using pump extrusion, for the material extruded, nitrogen is passed through with 22mL/min flow, carry out
Cooling, so as to obtain the precursor of hollow form.Then, using temperature be 70 DEG C~120 DEG C and rolling speed as 5m/min~30m/
It is wound after min condition extension, so that 330mm is cut off and is obtained with product in the middle of micro- porous hollow fiber membrane bundle.Then,
By product in the middle of the hollow fiber membrane bundle the 1- aqueous propanol solutions for being dissolved in 58% EVAL coating liquids (trade name Suo Anuo that days
This synthesis chemistry (strain) company system) in dipping one hour, afterwards, at a temperature of 60 DEG C dry, so as to obtain hollow-fibre membrane
Beam.The internal diameter of hollow-fibre membrane is 280 μm, and thickness is 50 μm, and external diameter is 380 μm, a diameter of 0.2 μm of hole.By what is obtained
Hollow fiber membrane bundle is loaded on the cylindrical container of makrolon system (internal diameter of container body portion is 50.5mm), and utilizes polyurethane
Resin is packaged processing to two ends, afterwards, γ sterilizings is carried out with 25kGy quantity of X-rays X, so as to obtain filter.
Time ＞s of the ＜ needed for untill blocking
The ox blood slurry that 3L albumin concentrations are adjusted to 3g/dL is used as simulation ascites.3L simulation ascites is loaded into ascites bag,
Be tod in the way of as external pressure filter type according to the order of filter, inspissator, concentration ascites bag using ascites treatment loop
They are connected (Fig. 7).Pump A is set as to 50mL per minute flow, pump B is set as to 5mL per minute flow, is carried out
Filtering and concentrating processing.In filtering and concentrating processing procedure, the pressure based on pressure gauge C reaches 500mmHg situation and sentenced
Break as " produce blocking ", and the time since processing untill blocking is judged in the following way.
Time untill blocking is more than 20 minutes：〇
Time untill blocking is less than 20 minutes：×
Between ＜ maximum hollow-fibre membranes between distance, average hollow-fibre membrane distance measurement ＞
Using light microscope (trade name IX70 Olympus (strain) company system) visual observations encapsulation process face, based on
The visual field turns into the image that 10mm × 10mm mode is photographed, and measures the maximum hollow-fibre membrane of any five hollow-fibre membranes
Between distance between distance and average hollow-fibre membrane.
(embodiment 1)
Using the doughnut radical without curling filter is made for the hollow fiber membrane bundle of 7200.Open end spacing
It is 240mm from L, filling rate J is 41%, and membrane area is 1.5m2.In addition, distance is 340 μm between maximum hollow-fibre membrane, it is average
Distance is 120 μm between hollow-fibre membrane.
(embodiment 2)
Using the doughnut radical without curling filter is made for the hollow fiber membrane bundle of 3600.Open end spacing
It is 240mm from L, filling rate J is 20%, and membrane area is 0.7m2.In addition, distance is 520 μm between maximum hollow-fibre membrane, it is average
Distance is 210 μm between hollow-fibre membrane.
(embodiment 3)
Using the doughnut radical without curling filter is made for the hollow fiber membrane bundle of 7200.Open end spacing
It is 200mm from L, filling rate J is 41%, and membrane area is 1.3m2.In addition, distance is 330 μm between maximum hollow-fibre membrane, it is average
Distance is 110 μm between hollow-fibre membrane.
(embodiment 4)
Using with the doughnut that the doughnut radical that amplitude is the curling that 0.7mm, wavelength are 9.0mm is 7200
Perineurium makes filter.Openend distance between the surface L is 240mm, and filling rate J is 41%, and membrane area is 1.5m2.In addition, most big-and-middle
The intermembranous distance of hollow fiber is 350 μm, and distance is 140 μm between average hollow-fibre membrane.
(comparative example 1)
Using the doughnut radical without curling filter is made for the hollow fiber membrane bundle of 11000.Between open end
Distance is 250mm, and filling rate is 65%, and membrane area is 2.3m2.In addition, distance is 190 μm between maximum hollow-fibre membrane, it is average
Distance is 90 μm between hollow-fibre membrane.
(comparative example 2)
Using the doughnut radical without curling filter is made for the hollow fiber membrane bundle of 2300.Open end spacing
It is 250mm from L, filling rate J is 13%, and membrane area is 0.5m2.In addition, distance is 610 μm between maximum hollow-fibre membrane, it is average
Distance is 280 μm between hollow-fibre membrane.
Table 1
Industrial applicability
The filter of the filtering coelomic fluid of the present invention is relaxing the blocking and suppression of hollow-fibre membrane using external pressure mode
It is useful during the decline of the filter capacity of filter processed.
Description of reference numerals
1st, ascites processing system；10th, ascites treatment loop；20th, ascites bag；21st, filter；22nd, inspissator；23rd, concentrate
Ascites bag；40th, cylindrical container；41st, hollow-fibre membrane；42nd, hollow fiber membrane bundle.
Claims (9)
1. a kind of filter, it has the cylindrical container for internally including hollow fiber membrane bundle, makes body in the cylindrical container
Chamber liquid passes through so as to remove coelomic fluid from the inner side of the outer lateral hollow-fibre membrane of the hollow-fibre membrane of the hollow fiber membrane bundle
In specific material, wherein,
The hollow-fibre membrane is in the internal cross section of the cylindrical container with the filling rate of the hollow fiber membrane bundle
More than 20% and less than 41% mode is distributed.
2. filter according to claim 1, wherein,
Distance is more than 300 μm between maximum hollow-fibre membrane in the hollow fiber membrane bundle.
3. filter according to claim 1 or 2, wherein,
Distance is more than 150 μm between average hollow-fibre membrane in the hollow fiber membrane bundle.
4. according to filter according to any one of claims 1 to 3, wherein,
The both ends of the hollow fiber membrane bundle are packaged processing using encapsulating material at the both ends of the cylindrical container,
The both ends of the cylindrical container form the open end of the hollow fiber membrane bundle,
The distance between two open ends of the hollow fiber membrane bundle are more than 50mm and below 300mm.
5. according to filter according to any one of claims 1 to 4, wherein,
Effective membrane area of the hollow fiber membrane bundle is 0.7m2Above and 3.0m2Below.
6. according to filter according to any one of claims 1 to 5, wherein,
The internal diameter of the hollow-fibre membrane is more than 50 μm and less than 500 μm.
7. according to filter according to any one of claims 1 to 6, wherein,
The hollow-fibre membrane has curly form.
8. a kind of body cavity liquid treating system, wherein,
The body cavity liquid treating system at least includes filter according to any one of claims 1 to 7 and will be through the filter
The inspissator of filtered fluid concentration after filtering, coelomic fluid is handled at least in the filter using external pressure mode.
9. a kind of body cavity liquid processing method, the filtering any one of body cavity liquid processing method usage right requirement 1~7
Device, wherein,
The body cavity liquid processing method is comprised the steps of：The step of coelomic fluid being handled in the filter using external pressure mode；
And by through the filter filter after filtered fluid concentrate the step of.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-001497 | 2015-01-07 | ||
| JP2015001497 | 2015-01-07 | ||
| PCT/JP2016/050277 WO2016111320A1 (en) | 2015-01-07 | 2016-01-06 | Filter, coelomic fluid processing system, and coelomic fluid processing method |
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| CN106999855A true CN106999855A (en) | 2017-08-01 |
| CN106999855B CN106999855B (en) | 2019-09-20 |
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| JP (1) | JP6480956B2 (en) |
| CN (1) | CN106999855B (en) |
| TW (1) | TWI584868B (en) |
| WO (1) | WO2016111320A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112703022A (en) * | 2018-08-18 | 2021-04-23 | 国立大学法人德岛大学 | Raw liquid processing apparatus, method for operating raw liquid processing apparatus, and method for cleaning instrument |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP6532913B2 (en) * | 2017-07-07 | 2019-06-19 | 旭化成メディカル株式会社 | Body cavity fluid treatment device |
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| US3616928A (en) * | 1969-10-02 | 1971-11-02 | Du Pont | Permeation separation device for separating fluids |
| CN1256158A (en) * | 1998-12-09 | 2000-06-14 | 株式会社Jms | Filter for transfusion |
| CN1781584A (en) * | 2000-02-17 | 2006-06-07 | 弗雷森纽斯医疗护理德国有限责任公司 | Filter device, preferably a hollow fibre dialyser, comprising curled hollow fibres |
| JP2011172797A (en) * | 2010-02-25 | 2011-09-08 | Keisuke Matsuzaki | Ascites treatment system and cleaning method thereof |
| EP2735326A1 (en) * | 2012-11-26 | 2014-05-28 | Gambro Lundia AB | Liver support system |
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| JP3528723B2 (en) * | 1998-12-09 | 2004-05-24 | 株式会社ジェイ・エム・エス | Infusion filter |
| JP6231733B2 (en) * | 2011-05-23 | 2017-11-15 | 旭化成メディカル株式会社 | Hollow fiber membrane medical device |
| TWI549744B (en) * | 2012-03-28 | 2016-09-21 | 東麗股份有限公司 | Hollow fiber membrane of polysulfone and hollow fiber membrane module for purification of blood product |
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2016
- 2016-01-06 CN CN201680004171.9A patent/CN106999855B/en active Active
- 2016-01-06 JP JP2016568741A patent/JP6480956B2/en active Active
- 2016-01-06 WO PCT/JP2016/050277 patent/WO2016111320A1/en active Application Filing
- 2016-01-07 TW TW105100411A patent/TWI584868B/en active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3616928A (en) * | 1969-10-02 | 1971-11-02 | Du Pont | Permeation separation device for separating fluids |
| CN1256158A (en) * | 1998-12-09 | 2000-06-14 | 株式会社Jms | Filter for transfusion |
| CN1781584A (en) * | 2000-02-17 | 2006-06-07 | 弗雷森纽斯医疗护理德国有限责任公司 | Filter device, preferably a hollow fibre dialyser, comprising curled hollow fibres |
| JP2011172797A (en) * | 2010-02-25 | 2011-09-08 | Keisuke Matsuzaki | Ascites treatment system and cleaning method thereof |
| EP2735326A1 (en) * | 2012-11-26 | 2014-05-28 | Gambro Lundia AB | Liver support system |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112703022A (en) * | 2018-08-18 | 2021-04-23 | 国立大学法人德岛大学 | Raw liquid processing apparatus, method for operating raw liquid processing apparatus, and method for cleaning instrument |
Also Published As
| Publication number | Publication date |
|---|---|
| TW201634112A (en) | 2016-10-01 |
| JPWO2016111320A1 (en) | 2017-08-31 |
| WO2016111320A1 (en) | 2016-07-14 |
| CN106999855B (en) | 2019-09-20 |
| JP6480956B2 (en) | 2019-03-13 |
| TWI584868B (en) | 2017-06-01 |
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