CN106999855B - Filter, body cavity liquid treating system and body cavity liquid processing method - Google Patents
Filter, body cavity liquid treating system and body cavity liquid processing method Download PDFInfo
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- CN106999855B CN106999855B CN201680004171.9A CN201680004171A CN106999855B CN 106999855 B CN106999855 B CN 106999855B CN 201680004171 A CN201680004171 A CN 201680004171A CN 106999855 B CN106999855 B CN 106999855B
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- 239000007788 liquid Substances 0.000 title claims description 19
- 238000003672 processing method Methods 0.000 title claims description 8
- 239000012528 membrane Substances 0.000 claims abstract description 192
- 239000000835 fiber Substances 0.000 claims abstract description 127
- 239000012510 hollow fiber Substances 0.000 claims abstract description 51
- 238000001914 filtration Methods 0.000 claims abstract description 16
- 238000011049 filling Methods 0.000 claims abstract description 14
- 239000000126 substance Substances 0.000 claims abstract description 6
- 239000012530 fluid Substances 0.000 claims description 30
- 238000012545 processing Methods 0.000 claims description 21
- 239000000463 material Substances 0.000 claims description 10
- 206010003445 Ascites Diseases 0.000 abstract description 80
- 230000000903 blocking effect Effects 0.000 abstract description 16
- 230000007423 decrease Effects 0.000 abstract description 6
- 235000012489 doughnuts Nutrition 0.000 description 14
- 238000010586 diagram Methods 0.000 description 10
- 238000000034 method Methods 0.000 description 8
- 206010028980 Neoplasm Diseases 0.000 description 6
- 201000011510 cancer Diseases 0.000 description 6
- 210000000578 peripheral nerve Anatomy 0.000 description 6
- 241000894006 Bacteria Species 0.000 description 5
- 229920000915 polyvinyl chloride Polymers 0.000 description 5
- 239000004800 polyvinyl chloride Substances 0.000 description 5
- 102000009027 Albumins Human genes 0.000 description 4
- 108010088751 Albumins Proteins 0.000 description 4
- 206010048612 Hydrothorax Diseases 0.000 description 4
- 239000012141 concentrate Substances 0.000 description 4
- 231100000676 disease causative agent Toxicity 0.000 description 4
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108090000623 proteins and genes Proteins 0.000 description 3
- 229920005989 resin Polymers 0.000 description 3
- 239000011347 resin Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 238000004140 cleaning Methods 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 2
- 238000005538 encapsulation Methods 0.000 description 2
- 229920001903 high density polyethylene Polymers 0.000 description 2
- 239000004700 high-density polyethylene Substances 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 230000000116 mitigating effect Effects 0.000 description 2
- 238000004088 simulation Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 230000000007 visual effect Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 238000007664 blowing Methods 0.000 description 1
- 239000006227 byproduct Substances 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000000706 filtrate Substances 0.000 description 1
- 230000005484 gravity Effects 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 230000001788 irregular Effects 0.000 description 1
- 238000012423 maintenance Methods 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000000399 optical microscopy Methods 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004417 polycarbonate Substances 0.000 description 1
- 229920000515 polycarbonate Polymers 0.000 description 1
- 229920005749 polyurethane resin Polymers 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 238000005096 rolling process Methods 0.000 description 1
- 239000002002 slurry Substances 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 230000001629 suppression Effects 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
Classifications
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
- B01D63/031—Two or more types of hollow fibres within one bundle or within one potting or tube-sheet
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
- B01D63/02—Hollow fibre modules
Landscapes
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Chemical & Material Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- External Artificial Organs (AREA)
- Artificial Filaments (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
Abstract
In the filter of filtering ascites, the blocking of hollow-fibre membrane is mitigated using external pressure mode, and inhibit the decline of the filter capacity of filter.It includes the cylindrical container (40) of hollow fiber membrane bundle (42) that filter (21), which has in inside, by making ascites pass through hollow-fibre membrane (41) from the inside of the outer lateral hollow-fibre membrane (41) of the hollow-fibre membrane (41) of hollow fiber membrane bundle (42) to remove the specific substance in ascites.Hollow-fibre membrane (41) is to be distributed in the internal cross section of cylindrical container (40) in a manner of 20% or more and 41% below by the filling rate of hollow fiber membrane bundle (42).
Description
Technical field
The present invention relates to the filter of ascites, hydrothorax, hydropericardium etc., body cavity liquid treating system and coelomic fluid processing sides
Method.
Background technique
For example, the treatment method as difficultly curing ascites disease, there are a kind of ascites filtering and concentrating intravenous injections again
(Cell-free and Concentrated Ascites Reinfusion Therapy): ascites is extracted from patient, filtering should
Ascites simultaneously removes the causative agents such as cancer cell, bacterium, then, by it includes including the utility of the protein of albumin etc.
Filtered fluid concentration, then, which is re-injected into vivo.
In the treatment method, usually using ascites processing system, as representative example, the ascites processing system packet
It includes and the fluid loop of getting up is connected in series in they according to the sequence of ascites bag, filter, inspissator, concentration ascites bag.
However, the filter of ascites processing system is in the inside of cylindrical container configured with the hollow-fibre membrane as filter membrane
The both ends of beam, hollow fiber membrane bundle are packaged processing using encapsulating material at the both ends of cylindrical container, and are formed with out
Mouth end face.In the past, the filter was usually so that internal pressure of the ascites from the inside of hollow-fibre membrane flow direction outside to be filtered
Mode come using, however, in recent years, propose to have in opposite to that mode, i.e., make in ascites flows to from the outside of hollow-fibre membrane
Side to the external pressure mode that is filtered come using method (referring to patent document 1,2).
Existing technical literature
Patent document
Patent document 1: Japanese Unexamined Patent Publication 2009-297242 bulletin
Patent document 2: Japanese Unexamined Patent Publication 2011-172797 bulletin
Summary of the invention
Problems to be solved by the invention
Ascites contains the relatively large substance such as cancer cell and viscosity is high, even if the short time uses filter, is also easy
Blocking is generated in hollow-fibre membrane.Then, by using external pressure mode, keep ascites relatively large from the surface area of hollow-fibre membrane
Outside flow direction inside be filtered, so as to mitigate the blocking of hollow-fibre membrane, extend the service life of filter.
However, being located at center due to hollow fiber membrane bundle in the case where being filtered in the way of above-mentioned external pressure
The hollow-fibre membrane of the position of portion side (in beam) immediately gathers together mutually, and is located at peripheral part side by hollow fiber membrane bundle
The hollow-fibre membrane of the position of (outside beam) covers, and therefore, if viscosity is higher as ascites, ascites does not reach doughnut
The hollow-fibre membrane of the central part of perineurium, as a result causes filter capacity to decline.
The application is to be made into view of the problem, it is intended that in the filter of the coelomic fluids such as filtering ascites
In, the blocking of hollow-fibre membrane is mitigated using external pressure mode, and inhibit the decline of the filter capacity of filter.
The solution to the problem
The present inventors for the above subject, obtained by the cylindrical container of filter by hollow fiber membrane bundle
Hollow-fibre membrane is distributed and makes the opinion of filter capacity raising, so as to complete the present invention.
That is, the present invention includes mode below.
(1) a kind of filter, it includes the cylindrical container of hollow fiber membrane bundle which, which has in inside, in the tubular
Pass through coelomic fluid from the inside of the outer lateral hollow-fibre membrane of the hollow-fibre membrane of the hollow fiber membrane bundle hollow
Tunica fibrosa is to remove the specific substance in coelomic fluid, wherein the hollow-fibre membrane is filled out with the hollow fiber membrane bundle
It fills rate and is distributed in the internal cross section of the cylindrical container for 20% or more and 41% mode below.
(2) filter according to (1), wherein distance between the maximum hollow-fibre membrane in the hollow fiber membrane bundle
It is 300 μm or more.
(3) filter according to (1) or (2), wherein between the average hollow-fibre membrane in the hollow fiber membrane bundle
Distance is 150 μm or more.
(4) filter according to any one of (1)~(3), wherein the both ends of the hollow fiber membrane bundle utilize
Encapsulating material is packaged processing at the both ends of the cylindrical container, is formed at the both ends of the cylindrical container described hollow
The open end of fiber-film bundle, the distance between two open ends of the hollow fiber membrane bundle be 50mm or more and 300mm with
Under.
(5) filter according to any one of (1)~(4), wherein effective membrane area of the hollow fiber membrane bundle
For 0.7m2Above and 3.0m2Below.
(6) filter according to any one of (1)~(5), wherein the internal diameter of the hollow-fibre membrane be 50 μm with
It is upper and 500 μm or less.
(7) filter according to any one of (1)~(6), wherein the hollow-fibre membrane has curly form.
(8) a kind of body cavity liquid treating system, the body cavity liquid treating system include at least described in any one of (1)~(7)
Filter and the inspissator that will be concentrated through the filtered filtered fluid of the filter, utilize external pressure at least in the filter
Mode handles coelomic fluid.
(9) a kind of body cavity liquid processing method, the body cavity liquid processing method use filtering described in any one of (1)~(7)
Device, wherein the body cavity liquid processing method comprises the steps of: the step for handling coelomic fluid in the way of external pressure in the filter
Suddenly；And the step of being concentrated through the filtered filtered fluid of the filter.
The effect of invention
In accordance with the invention it is possible to which the stifled of hollow-fibre membrane is mitigated using external pressure mode in the filter of filtering coelomic fluid
Plug, and inhibit the decline of the filter capacity of filter.
Detailed description of the invention
Fig. 1 is the explanatory diagram for indicating the outline of structure of ascites processing system.
Fig. 2 is the explanatory diagram in the vertical section of filter.
Fig. 3 is the explanatory diagram for indicating the cross section of cylindrical container.
Fig. 4 is the explanatory diagram for indicating the distance between hollow-fibre membrane.
Fig. 5 is the explanatory diagram for indicating the diameter of hollow-fibre membrane.
Fig. 6 is the explanatory diagram for illustrating the curly form of hollow-fibre membrane.
Fig. 7 is the explanatory diagram for indicating the ascites processing system of embodiment.
Specific embodiment
Hereinafter, being described with reference to the preferred embodiments of the present invention.If in addition, do not make specified otherwise, attached drawing
Positional relationship positional relationship based on the figure equal up and down.The dimension scale of attached drawing is not limited to the ratio of diagram
Example.In addition, the following embodiments and the accompanying drawings is for illustrating that illustration of the invention, purport are not that the present invention is only defined in the reality
Apply mode.In addition, the present invention is able to carry out various modifications in the range of without departing from its spirit.
Fig. 1 be indicate as include filter 21 involved in present embodiment the ascites of body cavity liquid treating system at
The explanatory diagram of the outline of the structure of reason system 1.
As shown in Figure 1, ascites processing system 1 is for example including the ascites treatment loop 10 having as fluid loop.At ascites
Manage circuit 10 have as the ascites bag 20 of coelomic fluid reservoir, filter 21, inspissator 22, as the dense of concentrate reservoir
Contracting ascites bag 23, the 1st flow path 24 for connecting ascites bag 20 and filter 21, the 2nd flow path for connecting filter 21 and inspissator 22
25 and connection inspissator 22 and be concentrated ascites bag 23 the 3rd flow path 26.
Ascites bag 20 is, for example, the container formed by the resin of the soft property such as polyvinyl chloride, can accommodate and take out as from patient
The ascites for the coelomic fluid got.
1st flow path 24 is, for example, the pipe of the soft property of polyvinyl chloride etc., is connected to filter 21 from the outlet of ascites bag 20
Aftermentioned side surface part port 45.The ascites of ascites bag 20 can be for example transported to equipped with tube pump 30 on the 1st flow path 24
Filter 21.Furthermore it is also possible to be not provided with tube pump 30, and is fallen using gravity and the ascites of ascites bag 20 is supplied to filter
21。
Filter 21 has cylindrical container 40, is configured with doughnut along its length direction in the inside of cylindrical container 40
Perineurium (beam of hollow-fibre membrane 41) 42.Hollow-fibre membrane 41 can remove the scheduled cause of disease such as cancer cell, bacterium from ascites
Substance, and pass through the ingredient of the utility of the protein comprising albumin etc. in addition to the scheduled causative agent.?
The top of cylindrical container 40 is equipped with the port 43 towards the inside (space) of hollow-fibre membrane 41, sets in the lower part of cylindrical container 40
There is the port 44 towards the inside (space) of hollow-fibre membrane 41, is equipped in the side surface part of cylindrical container 40 and leads to hollow-fibre membrane
Two ports 45,46 in 41 outside (space).The port 45 of the side surface part of filter 21 leads to ascites bag 20.Filter 21
The port 46 of side surface part with will be connected to by the drain portion (not shown) that the ingredient of hollow-fibre membrane 41 is discharged.Filter 21
The port 43 on top is connected to aftermentioned inspissator 22, and the port 44 of the lower part of filter 21 is for example closed.Filter 21
The details of the content structure of cylindrical container 40 is illustrated later.
2nd flow path 25 is, for example, the soft property pipe of polyvinyl chloride etc., and the port 43 on the top of inherent filtration device 21 is connected to dense
The port 63 of contracting device 22.For example the filtered filtered fluid of filter 21 can will be utilized defeated equipped with tube pump 50 on the 2nd flow path 25
It is sent to inspissator 22.
Identical as above-mentioned filter 21, inspissator 22 has cylindrical container 60, in the inside of cylindrical container 60 along its length
Direction is spent to be configured with as the hollow fiber membrane bundle (beam of hollow-fibre membrane 61) 62 that film is concentrated.Hollow-fibre membrane 61 can make
Moisture in filtrate passes through and removes moisture, so that filtered fluid is concentrated.It is equipped on the top of cylindrical container 60 towards hollow
The port 63 of the inner space of tunica fibrosa 61 is equipped in the lower part of cylindrical container 60 towards the inner space of hollow-fibre membrane 61
Port 64 is equipped in the side surface part of cylindrical container 60 towards two ports 65,66 of the outer space of hollow-fibre membrane 61.Concentration
The port 63 on the top of device 22 is connected to the port 43 of filter 21, the port 64 of the lower part of inspissator 22 and concentration ascites bag 23
Connection.The a port 65 of the side surface part of inspissator 22 is connected to the drain portion that the moisture being discharged from filtered fluid is discharged, end
Mouth 66 is closed.In addition, the inspissator 22 is the inspissator using internal pressure mode, it is also possible to be the concentration using external pressure mode
Device.
3rd flow path 26 is, for example, the soft property pipe of polyvinyl chloride etc., is connected to from the port 64 of the lower part of inspissator 22 dense
Contracting ascites bag 23.
Concentration ascites bag 23 is, for example, the container formed by the resin of the soft property such as polyvinyl chloride, can accommodate and utilize concentration
Include the concentrate including utility after the concentration of device 22.
Then, illustrate the internal structure of the cylindrical container 40 of filter 21.Fig. 2 is the outline for indicating the structure of filter 21
Vertical section explanatory diagram.
As described above, filter 21 has cylindrical container 40, configured in the inside of cylindrical container 40 along its length direction
There is hollow fiber membrane bundle 42.Cylindrical container 40 includes the two of cylindric container body portion 40a and closed container main part 40a
The connector 40b of end opening.Port 43,44 is formed in connector 40b, and port 45,46 is formed in container body portion 40a.
The both ends of hollow fiber membrane bundle 42 utilize the encapsulating material 70 of curable resin at the both ends of cylindrical container 40
Encapsulation process is carried out.The both ends of hollow fiber membrane bundle 42 are fixed in cylindrical container 40 as a result, the two of cylindrical container 40
End forms the open end 71 of the inside opening of each hollow-fibre membrane 41 of hollow fiber membrane bundle 42.The inside of cylindrical container 40
The outer space of hollow-fibre membrane 41 be connected to the port 45 of the side surface part of cylindrical container 40.The inside of hollow-fibre membrane 41 is empty
Between be connected to port 43 by open end 71.Using the structure, ascites is made to flow into the outside of hollow-fibre membrane 41 from port 45
Space, and via the inner space of the inflow hollow-fibre membrane 41 of hollow-fibre membrane 41, so as to filter and remove from ascites
Causative agent.The filtered fluid for being flowed into the inner space of hollow-fibre membrane 41 can be arranged by open end 71 from port 43
Out.
Hollow-fibre membrane 41 with the filling rate J of hollow fiber membrane bundle 42 cylindrical container 40 internal cross section be 20% with
It is upper and 41% or less, preferably 22% or more and 41% or less, more preferably 25% or more and 41% mode below disperses to match
It sets.In addition, filling rate J can be 21%, 23%, 24%, 26%, 27%, 28%, 29%, 30%, 31%, 32%, 33%,
34%, 35%, 36%, 37%, 38%, 39%, 40%.As shown in figure 3, by the cross section of the inside of container body portion 40a
Area be set as S (in the case where the internal diameter of container body portion 40a is set as K, S=(K/2)2× π), by a hollow-fibre membrane
41 sectional area be set as s (in the case where the outer diameter of a doughnut is set as R, s=(R/2)2× π), by doughnut
In the case that total radical of perineurium 42 is set as N, the filling rate J of hollow fiber membrane bundle 42 is indicated by formula below (1).
Filling rate J=s × N/S × 100 (%) (formula 1) of hollow fiber membrane bundle 42
In addition, for the sectional area S of container body portion 40a, the case where changing along the length side of container body portion 40a
Under, it is set as the area of least part.
Hollow-fibre membrane 41 is distributed in a manner of not gathering together immediately mutually.Here, during " being distributed " be
The state that empty fiber membrane is configured in a manner of not being close to each other, for example, can there are by blowing air etc., so that doughnut
The mode that film substantially evenly configures in fixed range treated state.Specifically, in hollow fiber membrane bundle 42,
For arbitrary hollow-fibre membrane 41, it is set as D1, D2, D3, D4 (figure with nearest the distance between four hollow-fibre membranes
Shown in 4).By between five hollow-fibre membranes measure this apart from when maximum value be defined as maximum hollow-fibre membrane distance,
In the present invention, hollow-fibre membrane 41 disperses in such a way that distance between maximum hollow-fibre membrane is 300 μm or more.Similarly, it is inciting somebody to action
Value obtained from D1~D4 of any five hollow-fibre membranes is all average be defined as between average hollow-fibre membrane apart from when,
In invention, hollow-fibre membrane 41 disperses in such a way that distance between average hollow-fibre membrane is 150 μm or more.In addition, in the present invention
" distance between maximum hollow-fibre membrane " and " distance between average hollow-fibre membrane ", at least to being present in container
Radius centered on the central point of cross section is that the hollow-fibre membrane in region shown in the circle of 5mm is set up.In container
The radius of cross section is to set up in 5mm situation below to all hollow-fibre membranes.In addition, container body portion 40a's
In the case that sectional area does not generate the component of variation alongst, above-mentioned D1, D2, D3, D4 (shown in Fig. 4) can sealed
It is measured on package material open end 71.On the other hand, the case where the sectional area of container body portion 40a varies along its length
Under, become D1, D2, D3, D4 of the smallest part using the sectional area of container body portion 40a.That is, according in package material
The value of D1, D2, D3, D4 for measuring on material open end 71 and the sectional area of container body portion 40a, proportion of utilization calculating acquire
Sectional area becomes D1, D2, D3, D4 of the smallest part.Specifically, acquire the sectional area of encapsulating material open end 71 with most
Ratio between the sectional area of fraction, by D1, D2, D3, D4 in encapsulating material open end 71 multiplied by the ratio
Obtained from value be defined as D1, D2, D3, D4 in the component.
In addition, the distance between two open ends 71 of hollow fiber membrane bundle 42 shown in Fig. 2 L be set as 50mm or more and
300mm hereinafter, be preferably set to 100mm or more and 280mm hereinafter, more preferably be set as 150mm or more and 240mm hereinafter, into
One step is preferably set to 200mm or more and 240mm or less.In addition, if distance L is less than 50mm, in the side equal with membrane area
In the case that formula is designed, the radical N of hollow-fibre membrane 41 becomes larger, and ascites will not reach in beam instead, thus not preferred.If
Distance L is greater than 300mm, then the flow path of component entirety narrows, therefore, before the ascites entered from port 45 is gone out from port 43
When somewhere causing blocking, it is easy increase pressure, it is thus not preferred.
Effective membrane area (inner circumferential (internal diameter d (Fig. 5 of hollow-fibre membrane 41 of hollow-fibre membrane 41 of hollow fiber membrane bundle 42
Shown in) × π) × open end distance between the surface L × hollow-fibre membrane quantity N) it is set as 0.7m2Above and 3.0m2Hereinafter, excellent
Choosing is set as 1.0m2Above and 2.5m2Below.In addition, if effective membrane area of hollow fiber membrane bundle 42 is less than 0.7m2, then filter
The filter capacity of device entirety declines, thus not preferred.If effective membrane area of hollow fiber membrane bundle 42 is greater than 3.0m2, then locating
Loss becomes larger when managing a small amount of ascites, thus not preferred.
The internal diameter d of hollow-fibre membrane 41 is set as 50 μm or more and 500 μm hereinafter, being preferably set to 100 μm or more and 450
μm or less.In addition, if internal diameter d less than 50 μm, when hollow-fibre membrane building up inside has protein etc. be easy blocking, because without
It is preferred that.In addition, yield rate when doughnut manufactures is decreased obviously, thus not preferred if internal diameter d is greater than 500 μm.
In addition, the radical N of hollow-fibre membrane 41 be, for example, 2000 or more and 10000 hereinafter, preferably 3000 with
It is upper and 9000 or less.In addition, the diameter in the hole of hollow-fibre membrane 41 is 0.010 μm or more and 10 μm hereinafter, preferably 0.05 μ
M or more and 5 μm or less.The outer diameter of hollow-fibre membrane 41 is 200 μm or more and 600 μm hereinafter, preferably 300 μm or more and 500 μ
M or less.In addition, the filter capacity of component entirety declines, because without excellent if the radical N of hollow-fibre membrane 41 is less than 2000
Choosing.If radical N is more than 10000, filling rate increases and is easy blocking, thus not preferred.In addition, if hollow-fibre membrane 41
The diameter in hole is then easy blocking less than 0.010 μm, thus not preferred.If the diameter in the hole of hollow-fibre membrane 41 is greater than 10 μm,
Cancer cell, bacterium etc. can not be almost filtered, it is thus not preferred.
Then, illustrate to handle using the ascites that ascites processing system 1 carries out.
Firstly, the ascites bag 20 for containing the ascites extracted from patient is connect with the 1st flow path 24.Then, make tube pump 30,
The ascites of ascites bag 20 is supplied to the hollow of cylindrical container 40 by the port 45 of 24 inherent filtration device 21 of the 1st flow path by 50 drivings
The outer space of tunica fibrosa 41.Ascites flows into inside sky by the hole of hollow-fibre membrane 41 from the outer space of hollow-fibre membrane 41
Between, at this point, removing and filtering the scheduled causative agent such as cancer cell, bacterium.It is held certainly by the filtered fluid after hollow-fibre membrane 41
Mouth 43 flows out to the 2nd flow path 25, and empty from the inside that the port of inspissator 22 63 flows into hollow-fibre membrane 61 by the 2nd flow path 25
Between.In inspissator 22, filtered fluid passes through the inner space of hollow-fibre membrane 61, and the moisture in filtered fluid passes through in concentration film
Empty fiber membrane 61 and the outer space for being discharged to hollow-fibre membrane 61, filtered fluid are concentrated.After being concentrated using inspissator 22
Concentrate including utility comprising albumin etc. is discharged to the 3rd flow path 26 from port 64, defeated by the 3rd flow path 26
It send and accommodates concentration ascites bag 23.If whole ascites as a result, in ascites bag 20 are completed at ascites by filtering and concentrating
Reason.Then, the concentrate that ascites bag 23 is concentrated is refilled in patient.It is present in hollow-fibre membrane in addition it is possible to clean
The cancer cell of 41 outer space, bacterium.For example, close port 43 and port 45, supply the cleaning such as physiological saline from port 44
Liquid is discharged from port 46 later, thus allows for cleaning.
According to the present embodiment, the hollow-fibre membrane 41 of filtered fluid 21 is with the filling rate J of hollow fiber membrane bundle 42 in tubular
The internal cross section of container 40 is that 20% or more and 41% mode below is distributed, and therefore, flows into hollow-fibre membrane 41
The ascites of outer space reaches the hollow-fibre membrane 41 by central part side of hollow fiber membrane bundle 42, and can utilize doughnut
Perineurium 42 is whole effectively to filter ascites.As a result, being able to use in the filter 21 of filtering ascites during external pressure mode mitigates
The blocking of empty fiber membrane 41, also, inhibit the decline of the filter capacity of filter 21.
In the above-described embodiment, the hollow-fibre membrane 41 of filter membrane 21 can have curly form.That is, as shown in fig. 6,
Hollow-fibre membrane 41 can be with wave sigmoid.The amplitude of curling is preferably 0.2mm or more~1.2mm hereinafter, wavelength is preferably
3.0mm or more~16mm or less.In this case, being easy to generate gap between hollow-fibre membrane 41, and it is easy ascites in
The central part side of hollow fiber perineurium 42 enters.In addition, ascites is held if the amplitude and wavelength of curling are irregular in filter 22
Easily enter to the central part side of hollow fiber membrane bundle 42, thus preferably.
More than, with reference to the accompanying drawings of the preferred embodiments of the present invention, but the present invention is not limited to the examples.It is right
In the range of thought for those skilled in the art it will be clear that described in claims, alternatively it is conceivable to various
Modification or fixed case, it will be appreciated that also belong to protection scope of the present invention certainly for these modifications or fixed case.
For example, it's not limited to that for the structure of the cylindrical container 40 in above embodiment, there can also be other knots
Structure.In addition, it's not limited to that for the structure of ascites processing system 1, ascites treatment loop 10, the present invention can also be applied to have
The ascites processing system 1 of other structures, ascites treatment loop 10.In addition, the present invention can also be applied to other than processing ascites
The hydrothorax processing system of other coelomic fluids, such as hydrothorax.In addition, the hydrothorax processing system both can have and above ascites
The identical structure of processing system, it is possible to have different structures.
Embodiment
Below in an example, show the mitigation to the blocking in filter of the invention, the maintenance of filter capacity into
The experimental result that row verifying obtains.
< makes filter >
By the particle of high density polyethylene (HDPE) (trade name SUNTEC HDJ240 Asahi Chemical Industry chemistry (strain) corporation) at 147 DEG C
At a temperature of heated, and using pump squeeze out, for the material extruded, nitrogen is passed through with the flow of 22mL/min, carry out
It is cooling, to obtain the precursor of hollow form.It then, is being 70 DEG C~120 DEG C with temperature and rolling speed is 5m/min~30m/
The condition of min is wound after extending, and with 330mm cutting, obtaining has product among micro- porous hollow fiber membrane bundle.Then,
By product among the hollow fiber membrane bundle the 1- aqueous propanol solution for being dissolved in 58% EVAL coating liquid (trade name Suo Anuo that day
This synthesis chemistry (strain) corporation) middle dipping one hour, later, in 60 DEG C of at a temperature of drying, to obtain hollow-fibre membrane
Beam.The internal diameter of hollow-fibre membrane is 280 μm, and film thickness is 50 μm, and outer diameter is 380 μm, and the diameter in hole is 0.2 μm.It will be obtained
Hollow fiber membrane bundle is loaded on the cylindrical container of polycarbonate system (internal diameter of container body portion is 50.5mm), and utilizes polyurethane
Resin is packaged processing to both ends, later, γ sterilizing is carried out with the quantity of X-rays X of 25kGy, to obtain filter.
Time > needed for until < to blocking
3L albumin concentration is adjusted to the ox blood slurry of 3g/dL as simulation ascites.3L simulation ascites is packed into ascites bag,
It is incited somebody to action according to the sequence of filter, inspissator, concentration ascites bag using ascites treatment loop in a manner of becoming external pressure filter type
They connect (Fig. 7).Pump A is set as to the flow of 50mL per minute, pump B is set as to the flow of 5mL per minute, is carried out
Filtering and concentrating processing.In filtering and concentrating treatment process, the case where pressure based on pressure gauge C reaches 500mmHg and sentence
Break as " generate blocking ", and the time since processing until blocking is determined in the following way.
Time until blocking is 20 minutes or more: 〇
Time until blocking was less than 20 minutes: ×
The measurement > of distance between distance between < maximum hollow-fibre membrane, average hollow-fibre membrane
Using optical microscopy (trade name IX70 Olympus (strain) corporation) visual observations encapsulation process face, based on
The image that the visual field takes as the mode of 10mm × 10mm, measures the maximum hollow-fibre membrane of any five hollow-fibre membranes
Between distance between distance and average hollow-fibre membrane.
(embodiment 1)
The hollow fiber membrane bundle that doughnut radical using no curling is 7200 makes filter.Open end spacing
It is 240mm from L, filling rate J is 41%, membrane area 1.5m2.In addition, distance is 340 μm between maximum hollow-fibre membrane, it is average
Distance is 120 μm between hollow-fibre membrane.
(embodiment 2)
The hollow fiber membrane bundle that doughnut radical using no curling is 3600 makes filter.Open end spacing
It is 240mm from L, filling rate J is 20%, membrane area 0.7m2.In addition, distance is 520 μm between maximum hollow-fibre membrane, it is average
Distance is 210 μm between hollow-fibre membrane.
(embodiment 3)
The hollow fiber membrane bundle that doughnut radical using no curling is 7200 makes filter.Open end spacing
It is 200mm from L, filling rate J is 41%, membrane area 1.3m2.In addition, distance is 330 μm between maximum hollow-fibre membrane, it is average
Distance is 110 μm between hollow-fibre membrane.
(embodiment 4)
The doughnut for the use of the doughnut radical with the curling that amplitude is 0.7mm, wavelength is 9.0mm being 7200
Perineurium makes filter.Open end distance between the surface L is 240mm, and filling rate J is 41%, membrane area 1.5m2.In addition, most big-and-middle
Distance is 350 μm between empty fiber membrane, and distance is 140 μm between average hollow-fibre membrane.
(comparative example 1)
The hollow fiber membrane bundle that doughnut radical using no curling is 11000 makes filter.Between open end
Distance is 250mm, filling rate 65%, membrane area 2.3m2.In addition, distance is 190 μm between maximum hollow-fibre membrane, it is average
Distance is 90 μm between hollow-fibre membrane.
(comparative example 2)
The hollow fiber membrane bundle that doughnut radical using no curling is 2300 makes filter.Open end spacing
It is 250mm from L, filling rate J is 13%, membrane area 0.5m2.In addition, distance is 610 μm between maximum hollow-fibre membrane, it is average
Distance is 280 μm between hollow-fibre membrane.
Table 1
Industrial availability
The filter of filtering coelomic fluid of the invention is in blocking and the suppression for mitigating hollow-fibre membrane using external pressure mode
It is useful when the decline of the filter capacity of filter processed.
Description of symbols
1, ascites processing system；10, ascites treatment loop；20, ascites bag；21, filter；22, inspissator；23, it is concentrated
Ascites bag；40, cylindrical container；41, hollow-fibre membrane；42, hollow fiber membrane bundle.
Claims (19)
1. a kind of filter, having in inside includes the cylindrical container of hollow fiber membrane bundle, make body in the cylindrical container
The inside of chamber liquid from the outer lateral hollow-fibre membrane of the hollow-fibre membrane of the hollow fiber membrane bundle passes through to remove coelomic fluid
In specific substance, wherein
The hollow-fibre membrane is in the internal cross section of the cylindrical container with the filling rate of the hollow fiber membrane bundle
20% or more and 41% mode below is distributed,
Distance is 150 μm or more between average hollow-fibre membrane in the hollow fiber membrane bundle.
2. filter according to claim 1, wherein
Distance is 300 μm or more between maximum hollow-fibre membrane in the hollow fiber membrane bundle.
3. filter according to claim 1 or 2, wherein
The both ends of the hollow fiber membrane bundle are packaged processing at the both ends of the cylindrical container using encapsulating material,
The both ends of the cylindrical container form the open end of the hollow fiber membrane bundle,
The distance between two open ends of the hollow fiber membrane bundle are 50mm or more and 300mm or less.
4. filter according to claim 1 or 2, wherein
Effective membrane area of the hollow fiber membrane bundle is 0.7m2Above and 3.0m2Below.
5. filter according to claim 3, wherein
Effective membrane area of the hollow fiber membrane bundle is 0.7m2Above and 3.0m2Below.
6. filter according to claim 1 or 2, wherein
The internal diameter of the hollow-fibre membrane is 50 μm or more and 500 μm or less.
7. filter according to claim 3, wherein
The internal diameter of the hollow-fibre membrane is 50 μm or more and 500 μm or less.
8. filter according to claim 4, wherein
The internal diameter of the hollow-fibre membrane is 50 μm or more and 500 μm or less.
9. filter according to claim 5, wherein
The internal diameter of the hollow-fibre membrane is 50 μm or more and 500 μm or less.
10. filter according to claim 1 or 2, wherein
The hollow-fibre membrane has curly form.
11. filter according to claim 3, wherein
The hollow-fibre membrane has curly form.
12. filter according to claim 4, wherein
The hollow-fibre membrane has curly form.
13. filter according to claim 5, wherein
The hollow-fibre membrane has curly form.
14. filter according to claim 6, wherein
The hollow-fibre membrane has curly form.
15. filter according to claim 7, wherein
The hollow-fibre membrane has curly form.
16. filter according to claim 8, wherein
The hollow-fibre membrane has curly form.
17. filter according to claim 9, wherein
The hollow-fibre membrane has curly form.
18. a kind of body cavity liquid treating system, wherein
The body cavity liquid treating system includes at least filter described in any one of claim 1~17 and will be through the filtering
The inspissator of the filtered filtered fluid concentration of device, at least handles coelomic fluid in the filter in the way of external pressure.
19. a kind of body cavity liquid processing method, the body cavity liquid processing method right to use benefit require any one of 1~17 described in filtering
Device, wherein
The body cavity liquid processing method comprises the steps of: the step of handling coelomic fluid in the way of external pressure in the filter；
And the step of being concentrated through the filtered filtered fluid of the filter.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2015-001497 | 2015-01-07 | ||
| JP2015001497 | 2015-01-07 | ||
| PCT/JP2016/050277 WO2016111320A1 (en) | 2015-01-07 | 2016-01-06 | Filter, coelomic fluid processing system, and coelomic fluid processing method |
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| Publication Number | Publication Date |
|---|---|
| CN106999855A CN106999855A (en) | 2017-08-01 |
| CN106999855B true CN106999855B (en) | 2019-09-20 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201680004171.9A Active CN106999855B (en) | 2015-01-07 | 2016-01-06 | Filter, body cavity liquid treating system and body cavity liquid processing method |
Country Status (4)
| Country | Link |
|---|---|
| JP (1) | JP6480956B2 (en) |
| CN (1) | CN106999855B (en) |
| TW (1) | TWI584868B (en) |
| WO (1) | WO2016111320A1 (en) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6532913B2 (en) * | 2017-07-07 | 2019-06-19 | 旭化成メディカル株式会社 | Body cavity fluid treatment device |
| CN112703022A (en) * | 2018-08-18 | 2021-04-23 | 国立大学法人德岛大学 | Raw liquid processing apparatus, method for operating raw liquid processing apparatus, and method for cleaning instrument |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3616928A (en) * | 1969-10-02 | 1971-11-02 | Du Pont | Permeation separation device for separating fluids |
| CN1256158A (en) * | 1998-12-09 | 2000-06-14 | 株式会社Jms | Filter for transfusion |
| CN1781584A (en) * | 2000-02-17 | 2006-06-07 | 弗雷森纽斯医疗护理德国有限责任公司 | Filter device, preferably a hollow fibre dialyser, comprising curled hollow fibres |
| JP2011172797A (en) * | 2010-02-25 | 2011-09-08 | Keisuke Matsuzaki | Ascites treatment system and cleaning method thereof |
| EP2735326A1 (en) * | 2012-11-26 | 2014-05-28 | Gambro Lundia AB | Liver support system |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3528723B2 (en) * | 1998-12-09 | 2004-05-24 | 株式会社ジェイ・エム・エス | Infusion filter |
| JP6231733B2 (en) * | 2011-05-23 | 2017-11-15 | 旭化成メディカル株式会社 | Hollow fiber membrane medical device |
| TWI549744B (en) * | 2012-03-28 | 2016-09-21 | 東麗股份有限公司 | Hollow fiber membrane of polysulfone and hollow fiber membrane module for purification of blood product |
-
2016
- 2016-01-06 CN CN201680004171.9A patent/CN106999855B/en active Active
- 2016-01-06 JP JP2016568741A patent/JP6480956B2/en active Active
- 2016-01-06 WO PCT/JP2016/050277 patent/WO2016111320A1/en active Application Filing
- 2016-01-07 TW TW105100411A patent/TWI584868B/en active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3616928A (en) * | 1969-10-02 | 1971-11-02 | Du Pont | Permeation separation device for separating fluids |
| CN1256158A (en) * | 1998-12-09 | 2000-06-14 | 株式会社Jms | Filter for transfusion |
| CN1781584A (en) * | 2000-02-17 | 2006-06-07 | 弗雷森纽斯医疗护理德国有限责任公司 | Filter device, preferably a hollow fibre dialyser, comprising curled hollow fibres |
| JP2011172797A (en) * | 2010-02-25 | 2011-09-08 | Keisuke Matsuzaki | Ascites treatment system and cleaning method thereof |
| EP2735326A1 (en) * | 2012-11-26 | 2014-05-28 | Gambro Lundia AB | Liver support system |
Also Published As
| Publication number | Publication date |
|---|---|
| CN106999855A (en) | 2017-08-01 |
| TW201634112A (en) | 2016-10-01 |
| JPWO2016111320A1 (en) | 2017-08-31 |
| WO2016111320A1 (en) | 2016-07-14 |
| JP6480956B2 (en) | 2019-03-13 |
| TWI584868B (en) | 2017-06-01 |
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