SG11201604979WA - Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists - Google Patents
Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonistsInfo
- Publication number
- SG11201604979WA SG11201604979WA SG11201604979WA SG11201604979WA SG11201604979WA SG 11201604979W A SG11201604979W A SG 11201604979WA SG 11201604979W A SG11201604979W A SG 11201604979WA SG 11201604979W A SG11201604979W A SG 11201604979WA SG 11201604979W A SG11201604979W A SG 11201604979WA
- Authority
- SG
- Singapore
- Prior art keywords
- binding
- combination therapy
- agonists
- antagonists
- axis
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
- A61K2039/507—Comprising a combination of two or more separate antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/55—Medicinal preparations containing antigens or antibodies characterised by the host/recipient, e.g. newborn with maternal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361917264P | 2013-12-17 | 2013-12-17 | |
US201462080991P | 2014-11-17 | 2014-11-17 | |
PCT/US2014/070998 WO2015095423A2 (en) | 2013-12-17 | 2014-12-17 | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201604979WA true SG11201604979WA (en) | 2016-07-28 |
Family
ID=52293264
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201604979WA SG11201604979WA (en) | 2013-12-17 | 2014-12-17 | Combination therapy comprising ox40 binding agonists and pd-1 axis binding antagonists |
Country Status (12)
Country | Link |
---|---|
US (2) | US20150190506A1 (en) |
EP (2) | EP3083687A2 (en) |
JP (1) | JP2017501167A (en) |
KR (1) | KR20160099092A (en) |
CN (1) | CN106102774A (en) |
AU (1) | AU2014364606A1 (en) |
BR (1) | BR112016013963A2 (en) |
CA (1) | CA2934028A1 (en) |
IL (1) | IL246251A0 (en) |
MX (1) | MX2016007965A (en) |
SG (1) | SG11201604979WA (en) |
WO (1) | WO2015095423A2 (en) |
Families Citing this family (164)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN114835812A (en) | 2008-12-09 | 2022-08-02 | 霍夫曼-拉罗奇有限公司 | anti-PD-L1 antibodies and their use for enhancing T cell function |
WO2013181452A1 (en) | 2012-05-31 | 2013-12-05 | Genentech, Inc. | Methods of treating cancer using pd-l1 axis binding antagonists and vegf antagonists |
US9605084B2 (en) | 2013-03-15 | 2017-03-28 | Xencor, Inc. | Heterodimeric proteins |
US11053316B2 (en) | 2013-01-14 | 2021-07-06 | Xencor, Inc. | Optimized antibody variable regions |
AU2014205086B2 (en) | 2013-01-14 | 2019-04-18 | Xencor, Inc. | Novel heterodimeric proteins |
US10968276B2 (en) | 2013-03-12 | 2021-04-06 | Xencor, Inc. | Optimized anti-CD3 variable regions |
US10858417B2 (en) | 2013-03-15 | 2020-12-08 | Xencor, Inc. | Heterodimeric proteins |
SG10201708048XA (en) | 2013-03-18 | 2017-10-30 | Biocerox Prod Bv | Humanized anti-cd134 (ox40) antibodies and uses thereof |
EP3049442A4 (en) | 2013-09-26 | 2017-06-28 | Costim Pharmaceuticals Inc. | Methods for treating hematologic cancers |
JOP20200094A1 (en) | 2014-01-24 | 2017-06-16 | Dana Farber Cancer Inst Inc | Antibody molecules to pd-1 and uses thereof |
US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
JOP20200096A1 (en) | 2014-01-31 | 2017-06-16 | Children’S Medical Center Corp | Antibody molecules to tim-3 and uses thereof |
KR102363008B1 (en) | 2014-02-10 | 2022-02-16 | 메르크 파텐트 게엠베하 | TARGETED TGFβ INHIBITION |
MX2016011993A (en) | 2014-03-14 | 2016-12-09 | Novartis Ag | Antibody molecules to lag-3 and uses thereof. |
US9822186B2 (en) | 2014-03-28 | 2017-11-21 | Xencor, Inc. | Bispecific antibodies that bind to CD38 and CD3 |
CA2943834A1 (en) | 2014-03-31 | 2015-10-08 | Genentech, Inc. | Combination therapy comprising anti-angiogenesis agents and ox40 binding agonists |
US11186640B2 (en) * | 2014-07-31 | 2021-11-30 | The University Of Western Australia | Method for the identification of immunotherapy-drug combinations using a network approach |
EP3925622A1 (en) | 2014-09-13 | 2021-12-22 | Novartis AG | Combination therapies |
CN107106687A (en) * | 2014-10-03 | 2017-08-29 | 诺华股份有限公司 | Combined therapy |
EP4245376A3 (en) | 2014-10-14 | 2023-12-13 | Novartis AG | Antibody molecules to pd-l1 and uses thereof |
AU2015343337A1 (en) | 2014-11-03 | 2017-06-15 | Genentech, Inc. | Assays for detecting T cell immune subsets and methods of use thereof |
SG11201703521UA (en) | 2014-11-03 | 2017-05-30 | Genentech Inc | Methods and biomarkers for predicting efficacy and evaluation of an ox40 agonist treatment |
US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
MA55043A (en) | 2014-11-26 | 2021-12-29 | Xencor Inc | HETERODIMERIC ANTIGEN-BINDING ANTIGEN CD3 AND CD20 ANTIGEN |
MA41019A (en) | 2014-11-26 | 2021-05-05 | Xencor Inc | HETERODIMERIC ANTIBODIES BINDING TO CD3 AND CD38 ANTIGENS |
TWI595006B (en) | 2014-12-09 | 2017-08-11 | 禮納特神經系統科學公司 | Anti-pd-1 antibodies and methods of use thereof |
BR112017017884A2 (en) | 2015-02-24 | 2018-04-10 | Univ California | binding triggered transcriptional switches and methods of using them |
SG10201810615VA (en) | 2015-02-26 | 2019-01-30 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
GB201506411D0 (en) | 2015-04-15 | 2015-05-27 | Bergenbio As | Humanized anti-axl antibodies |
TWI820377B (en) | 2015-05-07 | 2023-11-01 | 美商艾吉納斯公司 | Anti-ox40 antibodies and methods of use thereof |
BR112017024770A2 (en) * | 2015-05-21 | 2018-07-31 | Alligator Bioscience Ab | innovative polypeptides |
US20160347848A1 (en) * | 2015-05-28 | 2016-12-01 | Medimmune Limited | Therapeutic combinations and methods for treating neoplasia |
US20180237534A1 (en) | 2015-05-29 | 2018-08-23 | Bristol-Myers Squibb Company | Antibodies against ox40 and uses thereof |
EP3303397A1 (en) * | 2015-06-08 | 2018-04-11 | H. Hoffnabb-La Roche Ag | Methods of treating cancer using anti-ox40 antibodies and pd-1 axis binding antagonists |
IL256245B (en) | 2015-06-16 | 2022-09-01 | Merck Patent Gmbh | Pd-l1 antagonist combination treatments |
SG10201913303XA (en) | 2015-07-13 | 2020-03-30 | Cytomx Therapeutics Inc | Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof |
KR20180036974A (en) | 2015-07-16 | 2018-04-10 | 바이오엑셀 테라퓨틱스 인코포레이티드 | A novel approach to the treatment of cancer using immunomodulation |
WO2017024032A2 (en) | 2015-08-03 | 2017-02-09 | Enb Therapeutics, Llc | Compositions and methods for treating cancers associated with etbr activation |
BR112018002436A2 (en) * | 2015-08-04 | 2018-09-18 | Glaxosmithkline Ip Dev Ltd | combination treatment of methods uses of these |
US20180222989A1 (en) * | 2015-08-04 | 2018-08-09 | Glaxosmithkline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
TW201716084A (en) * | 2015-08-06 | 2017-05-16 | 葛蘭素史克智慧財產發展有限公司 | Combinations and uses and treatments thereof |
PE20181322A1 (en) | 2015-09-01 | 2018-08-14 | Agenus Inc | ANTI-PD1 ANTIBODY AND ITS METHODS OF USE |
WO2017046746A1 (en) | 2015-09-15 | 2017-03-23 | Acerta Pharma B.V. | Therapeutic combinations of a btk inhibitor and a gitr binding molecule, a 4-1bb agonist, or an ox40 agonist |
US10894044B2 (en) | 2015-09-16 | 2021-01-19 | Board Of Regents, The University Of Texas System | Combination of topoisomerase-I inhibitors with immunotherapy in the treatment of cancer |
UA126549C2 (en) | 2015-10-01 | 2022-11-02 | Хіт Байолоджикс, Інк. | Compositions and methods for adjoining type i and type ii extracellular domains as heterologous chimeric proteins |
EP3356403A2 (en) | 2015-10-02 | 2018-08-08 | H. Hoffnabb-La Roche Ag | Bispecific antibodies specific for a costimulatory tnf receptor |
HUE055407T2 (en) | 2015-10-02 | 2021-11-29 | Hoffmann La Roche | Bispecific antibodies specific for pd1 and tim3 |
KR20180084772A (en) * | 2015-10-08 | 2018-07-25 | 마크로제닉스, 인크. | Combination Therapy for Cancer Treatment |
TWI805542B (en) * | 2015-10-23 | 2023-06-21 | 日商坎巴斯有限公司 | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
US10149887B2 (en) * | 2015-10-23 | 2018-12-11 | Canbas Co., Ltd. | Peptides and peptidomimetics in combination with t cell activating and/or checkpoint inhibiting agents for cancer treatment |
WO2017093942A1 (en) * | 2015-12-01 | 2017-06-08 | Glaxosmithkline Intellectual Property Development Limited | Combination treatments and uses and methods thereof |
MA43389A (en) * | 2015-12-02 | 2021-05-12 | Agenus Inc | ANTI-OX40 ANTIBODIES AND PROCESSES FOR USE |
MA44312A (en) | 2015-12-02 | 2018-10-10 | Agenus Inc | ANTIBODIES AND THEIR METHODS OF USE |
CA3006963A1 (en) * | 2015-12-03 | 2017-06-08 | Ludwig Institute For Cancer Research Ltd. | Anti-ox40 antibodies and methods of use thereof |
EP3387013B1 (en) | 2015-12-07 | 2022-06-08 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and psma |
US10596257B2 (en) | 2016-01-08 | 2020-03-24 | Hoffmann-La Roche Inc. | Methods of treating CEA-positive cancers using PD-1 axis binding antagonists and anti-CEA/anti-CD3 bispecific antibodies |
BR112018013677A2 (en) | 2016-01-11 | 2019-01-22 | Inhibrx Inc | multivalent and multispecific 41bb binding fusion proteins |
WO2017123673A2 (en) * | 2016-01-11 | 2017-07-20 | Inhibrx Lp | Multivalent and multispecific ox40-binding fusion proteins |
US20190031765A1 (en) | 2016-01-25 | 2019-01-31 | Pfizer Inc. | Combination of an ox40 agonist and a 4-1bb agonist monoclonal antibody for treating cancer |
AU2017225854B2 (en) | 2016-02-29 | 2020-11-19 | Foundation Medicine, Inc. | Therapeutic and diagnostic methods for cancer |
CA3015913A1 (en) | 2016-02-29 | 2017-09-08 | Foundation Medicine, Inc. | Methods of treating cancer |
US10730950B2 (en) * | 2016-03-08 | 2020-08-04 | Janssen Biotech, Inc. | GITR antibodies, methods, and uses |
DE102016105069A1 (en) | 2016-03-18 | 2017-09-21 | Eberhard Karls Universität Tübingen Medizinische Fakultät | Antiviral immunotherapy by membrane receptor ligation |
AU2017261354A1 (en) * | 2016-05-06 | 2018-11-29 | Exicure Operating Company | Spherical Nucleic Acid TLR9 agonists |
AR108377A1 (en) | 2016-05-06 | 2018-08-15 | Medimmune Llc | BISPECIFIC UNION PROTEINS AND ITS USES |
EP3243832A1 (en) * | 2016-05-13 | 2017-11-15 | F. Hoffmann-La Roche AG | Antigen binding molecules comprising a tnf family ligand trimer and pd1 binding moiety |
CN109476718B (en) | 2016-05-18 | 2023-07-04 | 莫得纳特斯公司 | Combination of MRNA encoding immunomodulatory polypeptides and uses thereof |
JP7246930B2 (en) | 2016-05-18 | 2023-03-28 | モデルナティエックス インコーポレイテッド | Polynucleotides encoding interleukin-12 (IL12) and uses thereof |
CA3024509A1 (en) | 2016-05-18 | 2017-11-23 | Modernatx, Inc. | Mrna combination therapy for the treatment of cancer |
KR102523402B1 (en) | 2016-06-14 | 2023-04-19 | 젠코어 인코포레이티드 | Bispecific Checkpoint Inhibitor Antibodies |
JP7021127B2 (en) | 2016-06-28 | 2022-02-16 | ゼンコア インコーポレイテッド | Heterodimer antibody that binds to somatostatin receptor 2 |
JP7011764B2 (en) | 2016-07-07 | 2022-01-27 | ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー | Antibody adjuvant complex |
WO2018027204A1 (en) | 2016-08-05 | 2018-02-08 | Genentech, Inc. | Multivalent and multiepitopic anitibodies having agonistic activity and methods of use |
US20190175755A1 (en) * | 2016-08-23 | 2019-06-13 | The Johns Hopkins University | Immunoswitch nanoparticles for reprogrammed t cell responses |
US10793632B2 (en) | 2016-08-30 | 2020-10-06 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
WO2018045110A1 (en) * | 2016-08-30 | 2018-03-08 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
CA3038020A1 (en) | 2016-09-23 | 2018-03-29 | Merus N.V. | Bispecific binding molecules that bind cd137 |
JP2019534251A (en) * | 2016-09-29 | 2019-11-28 | ジェネンテック, インコーポレイテッド | Combination therapy using MEK inhibitor, PD-1 axis inhibitor, and taxane |
CA3038712A1 (en) | 2016-10-06 | 2018-04-12 | Genentech, Inc. | Therapeutic and diagnostic methods for cancer |
JP2019530704A (en) | 2016-10-06 | 2019-10-24 | ファイザー・インコーポレイテッド | Avelumab dosing regimen for the treatment of cancer |
EA037973B1 (en) * | 2016-10-12 | 2021-06-18 | Янссен Байотек, Инк. | Gitr antibodies, methods and uses |
TWI788307B (en) | 2016-10-31 | 2023-01-01 | 美商艾歐凡斯生物治療公司 | Engineered artificial antigen presenting cells for tumor infiltrating lymphocyte expansion |
US10342785B2 (en) | 2016-11-04 | 2019-07-09 | Askat Inc. | Use of EP4 receptor antagonists for the treatment of NASH-associated liver cancer |
CA3041340A1 (en) | 2016-11-09 | 2018-05-17 | Agenus Inc. | Anti-ox40 antibodies, anti-gitr antibodies, and methods of use thereof |
MA47236A (en) | 2017-01-06 | 2019-11-13 | Iovance Biotherapeutics Inc | TUMOR INFILTRATION LYMPHOCYTE (TIL) EXPANSION WITH TUMOR NECROSIS FACTOR (TNFRSF) SUPERFAMILY RECEPTOR AGONISTS AND THERAPEUTIC COMBINATIONS OF TIL AND TNFRSF AGONISTS |
US11192933B2 (en) | 2017-02-27 | 2021-12-07 | Shattuck Labs, Inc. | VSIG8-based chimeric proteins |
MX2019009812A (en) | 2017-02-27 | 2019-10-14 | Shattuck Labs Inc | Tigit- and light-based chimeric proteins. |
MX2019010173A (en) | 2017-02-27 | 2019-11-21 | Shattuck Labs Inc | Csf1r-based chimeric proteins. |
CN108623686A (en) | 2017-03-25 | 2018-10-09 | 信达生物制药(苏州)有限公司 | Anti- OX40 antibody and application thereof |
US11884738B2 (en) * | 2017-03-31 | 2024-01-30 | The University Of North Carolina At Chapel Hill | Methods and compositions for activation of T cells using nanoparticles conjugated with multiple ligands for binding receptors on T cells |
HUE059885T2 (en) | 2017-04-03 | 2023-01-28 | Hoffmann La Roche | Immunoconjugates of an anti-pd-1 antibody with a mutant il-2 or with il-15 |
TWI690538B (en) | 2017-04-05 | 2020-04-11 | 瑞士商赫孚孟拉羅股份公司 | Bispecific antibodies specifically binding to pd1 and lag3 |
CN110621787A (en) * | 2017-04-14 | 2019-12-27 | 豪夫迈·罗氏有限公司 | Methods for diagnosis and treatment of cancer |
CN110582303A (en) | 2017-04-20 | 2019-12-17 | Adc治疗有限公司 | Combination therapy with anti-CD 25 antibody-drug conjugates |
JP7408396B2 (en) | 2017-04-20 | 2024-01-05 | アーデーセー セラピューティクス ソシエテ アノニム | combination therapy |
US11819517B2 (en) | 2017-06-05 | 2023-11-21 | Iovance Biotherapeutics, Inc. | Methods of using tumor infiltrating lymphocytes in double-refractory melanoma |
BR112019026564A2 (en) | 2017-06-14 | 2020-06-30 | Adc Therapeutics Sa | dosing regimens for administration of an anti-cd19 adc |
JP2020527351A (en) | 2017-07-21 | 2020-09-10 | ジェネンテック, インコーポレイテッド | Cancer treatment and diagnosis |
US10981992B2 (en) | 2017-11-08 | 2021-04-20 | Xencor, Inc. | Bispecific immunomodulatory antibodies that bind costimulatory and checkpoint receptors |
CA3082383A1 (en) | 2017-11-08 | 2019-05-16 | Xencor, Inc. | Bispecific and monospecific antibodies using novel anti-pd-1 sequences |
EP3710576A1 (en) | 2017-11-17 | 2020-09-23 | Iovance Biotherapeutics, Inc. | Til expansion from fine needle aspirates and small biopsies |
JP2021506291A (en) | 2017-12-19 | 2021-02-22 | ゼンコア インコーポレイテッド | Modified IL-2 FC fusion protein |
WO2019129137A1 (en) | 2017-12-27 | 2019-07-04 | 信达生物制药(苏州)有限公司 | Anti-lag-3 antibody and uses thereof |
CN109970856B (en) | 2017-12-27 | 2022-08-23 | 信达生物制药(苏州)有限公司 | anti-LAG-3 antibodies and uses thereof |
CN108218990B (en) * | 2017-12-29 | 2021-03-02 | 南京优迈生物科技有限公司 | Isolated antibodies or antigen binding fragments thereof and their use in tumor therapy |
WO2019136459A1 (en) | 2018-01-08 | 2019-07-11 | Iovance Biotherapeutics, Inc. | Processes for generating til products enriched for tumor antigen-specific t-cells |
CN117866899A (en) | 2018-01-08 | 2024-04-12 | 艾欧凡斯生物治疗公司 | Method for producing a TIL product enriched in tumor antigen specific T cells |
US11713446B2 (en) | 2018-01-08 | 2023-08-01 | Iovance Biotherapeutics, Inc. | Processes for generating TIL products enriched for tumor antigen-specific T-cells |
KR20200119246A (en) | 2018-01-12 | 2020-10-19 | 이엔비 테라퓨틱스, 인크. | Deuterated compounds, compositions, and methods for treating cancer associated with ETBR activation |
CN111393529B (en) * | 2018-01-29 | 2022-02-22 | 康源博创生物科技(北京)有限公司 | anti-OX 40 antibodies that non-competitively bind to OX40L |
WO2019157124A1 (en) * | 2018-02-08 | 2019-08-15 | Bristol-Myers Squibb Company | Combination of a tetanus toxoid, anti-ox40 antibody and/or anti-pd-1 antibody to treat tumors |
JP2021512962A (en) | 2018-02-13 | 2021-05-20 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Expansion culture of tumor-infiltrating lymphocytes (TIL) with adenosine A2A receptor antagonist and therapeutic combination of TIL and adenosine A2A receptor antagonist |
CA3096052A1 (en) | 2018-04-04 | 2019-10-10 | Xencor, Inc. | Heterodimeric antibodies that bind fibroblast activation protein |
CN112437777A (en) | 2018-04-18 | 2021-03-02 | Xencor股份有限公司 | TIM-3 targeting heterodimeric fusion proteins comprising an IL-15/IL-15RA Fc fusion protein and a TIM-3 antigen binding domain |
US11524991B2 (en) | 2018-04-18 | 2022-12-13 | Xencor, Inc. | PD-1 targeted heterodimeric fusion proteins containing IL-15/IL-15Ra Fc-fusion proteins and PD-1 antigen binding domains and uses thereof |
CA3098303A1 (en) | 2018-04-27 | 2019-10-31 | Iovance Biotherapeutics, Inc. | Closed process for expansion and gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
JP2021524449A (en) | 2018-05-23 | 2021-09-13 | アーデーセー セラピューティクス ソシエテ アノニム | Molecular adjuvant |
US11447556B2 (en) | 2018-08-13 | 2022-09-20 | Inhibex, Inc. | OX40-binding polypeptides and uses thereof |
US10780121B2 (en) | 2018-08-29 | 2020-09-22 | Shattuck Labs, Inc. | FLT3L-based chimeric proteins |
TW202031273A (en) | 2018-08-31 | 2020-09-01 | 美商艾歐凡斯生物治療公司 | Treatment of nsclc patients refractory for anti-pd-1 antibody |
KR20210064269A (en) | 2018-09-20 | 2021-06-02 | 이오반스 바이오테라퓨틱스, 인크. | Expansion of TILs from cryopreserved tumor samples |
CN113195523A (en) | 2018-10-03 | 2021-07-30 | Xencor股份有限公司 | IL-12 heterodimer Fc fusion proteins |
WO2020096927A1 (en) | 2018-11-05 | 2020-05-14 | Iovance Biotherapeutics, Inc. | Expansion of tils utilizing akt pathway inhibitors |
BR112021008549A2 (en) | 2018-11-05 | 2022-01-04 | Iovance Biotherapeutics Inc | Method of treating non-small cell lung cancer with a population of tumor-infiltrating lymphocytes |
CN113272420A (en) | 2018-11-05 | 2021-08-17 | 艾欧凡斯生物治疗公司 | Improved selection of tumor-reactive T cells |
JOP20210094A1 (en) | 2018-11-05 | 2023-01-30 | Iovance Biotherapeutics Inc | Processes for production of tumor infiltrating lymphocytes and uses of the same in immunotherapy |
WO2020131547A1 (en) | 2018-12-19 | 2020-06-25 | Iovance Biotherapeutics, Inc. | Methods of expanding tumor infiltrating lymphocytes using engineered cytokine receptor pairs and uses thereof |
US20220370606A1 (en) | 2018-12-21 | 2022-11-24 | Pfizer Inc. | Combination Treatments Of Cancer Comprising A TLR Agonist |
CN114173875A (en) | 2019-03-01 | 2022-03-11 | Xencor股份有限公司 | Heterodimeric antibodies that bind ENPP3 and CD3 |
KR20220004634A (en) | 2019-03-15 | 2022-01-11 | 볼트 바이오테라퓨틱스 인코퍼레이티드 | Immunoconjugates targeting HER2 |
MX2021011608A (en) | 2019-03-29 | 2021-12-10 | Myst Therapeutics Llc | Ex vivo methods for producing a t cell therapeutic and related compositions and methods. |
US20220249559A1 (en) | 2019-05-13 | 2022-08-11 | Iovance Biotherapeutics, Inc. | Methods and compositions for selecting tumor infiltrating lymphocytes and uses of the same in immunotherapy |
CA3141452A1 (en) | 2019-05-24 | 2020-12-03 | Pfizer Inc. | Combination therapies using cdk inhibitors |
AU2020281535A1 (en) | 2019-05-24 | 2022-01-27 | Merck Patent Gmbh | Combination therapies using CDK inhibitors |
WO2021029368A1 (en) | 2019-08-09 | 2021-02-18 | 国立研究開発法人理化学研究所 | Combined use of artificial adjuvant vector cells and an immunostimulant |
EP4048295A1 (en) | 2019-10-25 | 2022-08-31 | Iovance Biotherapeutics, Inc. | Gene editing of tumor infiltrating lymphocytes and uses of same in immunotherapy |
JP2023503396A (en) * | 2019-11-21 | 2023-01-30 | ベイジーン リミテッド | Methods of treating cancer using anti-OX40 antibodies in combination with anti-PD1 antibodies or anti-PDL1 antibodies |
JP2023504042A (en) | 2019-11-27 | 2023-02-01 | ミスト セラピューティクス リミテッド ライアビリティ カンパニー | Methods of generating tumor-reactive T-cell compositions using modulators |
GB201917254D0 (en) | 2019-11-27 | 2020-01-08 | Adc Therapeutics Sa | Combination therapy |
WO2021118990A1 (en) | 2019-12-11 | 2021-06-17 | Iovance Biotherapeutics, Inc. | Processes for the production of tumor infiltrating lymphocytes (tils) and methods of using the same |
BR112022016490A2 (en) | 2020-02-27 | 2022-10-11 | Myst Therapeutics Llc | METHODS FOR EX VIVO ENRICHMENT AND EXPANSION OF TUMOR T-REACTIVE CELLS AND RELATED COMPOSITIONS THEREOF |
JP2023523855A (en) | 2020-05-04 | 2023-06-07 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Method for producing tumor-infiltrating lymphocytes and their use in immunotherapy |
JP2023524108A (en) | 2020-05-04 | 2023-06-08 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Selection of improved tumor-reactive T cells |
US11919956B2 (en) | 2020-05-14 | 2024-03-05 | Xencor, Inc. | Heterodimeric antibodies that bind prostate specific membrane antigen (PSMA) and CD3 |
IL300666A (en) | 2020-08-19 | 2023-04-01 | Xencor Inc | Anti-cd28 compositions |
JP2023546359A (en) | 2020-10-06 | 2023-11-02 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Treatment of NSCLC patients with tumor-infiltrating lymphocyte therapy |
WO2022076606A1 (en) | 2020-10-06 | 2022-04-14 | Iovance Biotherapeutics, Inc. | Treatment of nsclc patients with tumor infiltrating lymphocyte therapies |
WO2022087361A1 (en) * | 2020-10-22 | 2022-04-28 | The Regents Of The University Of California | Monoamine oxidase blockade therapy for treating cancer through regulating antitumor t cell immunity |
WO2022100659A1 (en) * | 2020-11-12 | 2022-05-19 | Curon Biopharmaceutical (Shanghai) Co., Limited | Combination therapy and methods utilizing the same |
WO2022118197A1 (en) | 2020-12-02 | 2022-06-09 | Pfizer Inc. | Time to resolution of axitinib-related adverse events |
JP2024501452A (en) | 2020-12-11 | 2024-01-12 | アイオバンス バイオセラピューティクス,インコーポレイテッド | Treatment of cancer patients with tumor-infiltrating lymphocyte therapy in combination with BRAF inhibitors and/or MEK inhibitors |
WO2022130206A1 (en) | 2020-12-16 | 2022-06-23 | Pfizer Inc. | TGFβr1 INHIBITOR COMBINATION THERAPIES |
EP4262827A1 (en) | 2020-12-17 | 2023-10-25 | Iovance Biotherapeutics, Inc. | Treatment of cancers with tumor infiltrating lymphocytes |
AU2021401302A1 (en) | 2020-12-17 | 2023-07-06 | Iovance Biotherapeutics, Inc. | Treatment with tumor infiltrating lymphocyte therapies in combination with ctla-4 and pd-1 inhibitors |
JP2024500847A (en) | 2020-12-18 | 2024-01-10 | センチュリー セラピューティクス,インコーポレイテッド | Chimeric antigen receptor systems with compatible receptor specificities |
GB202102396D0 (en) | 2021-02-19 | 2021-04-07 | Adc Therapeutics Sa | Molecular adjuvant |
EP4305067A1 (en) | 2021-03-09 | 2024-01-17 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and cldn6 |
WO2022192586A1 (en) | 2021-03-10 | 2022-09-15 | Xencor, Inc. | Heterodimeric antibodies that bind cd3 and gpc3 |
KR20240037185A (en) | 2021-04-19 | 2024-03-21 | 이오반스 바이오테라퓨틱스, 인크. | Chimeric costimulatory receptors, chemokine receptors, and their uses in cellular immunotherapy |
TW202327631A (en) | 2021-07-28 | 2023-07-16 | 美商艾歐凡斯生物治療公司 | Treatment of cancer patients with tumor infiltrating lymphocyte therapies in combination with kras inhibitors |
AR127482A1 (en) | 2021-10-27 | 2024-01-31 | Iovance Biotherapeutics Inc | SYSTEMS AND METHODS TO COORDINATE THE MANUFACTURE OF CELLS FOR PATIENT-SPECIFIC IMMUNOTHERAPY |
WO2023086803A1 (en) | 2021-11-10 | 2023-05-19 | Iovance Biotherapeutics, Inc. | Methods of expansion treatment utilizing cd8 tumor infiltrating lymphocytes |
WO2023147486A1 (en) | 2022-01-28 | 2023-08-03 | Iovance Biotherapeutics, Inc. | Tumor infiltrating lymphocytes engineered to express payloads |
WO2024030758A1 (en) | 2022-08-01 | 2024-02-08 | Iovance Biotherapeutics, Inc. | Chimeric costimulatory receptors, chemokine receptors, and the use of same in cellular immunotherapies |
Family Cites Families (181)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH119431A (en) | 1926-04-21 | 1927-03-16 | Beck Sigmund | Painter's brush. |
US4018653A (en) | 1971-10-29 | 1977-04-19 | U.S. Packaging Corporation | Instrument for the detection of Neisseria gonorrhoeae without culture |
CU22545A1 (en) | 1994-11-18 | 1999-03-31 | Centro Inmunologia Molecular | OBTAINING A CHEMICAL AND HUMANIZED ANTIBODY AGAINST THE RECEPTOR OF THE EPIDERMAL GROWTH FACTOR FOR DIAGNOSTIC AND THERAPEUTIC USE |
US4016043A (en) | 1975-09-04 | 1977-04-05 | Akzona Incorporated | Enzymatic immunological method for the determination of antigens and antibodies |
USRE30985E (en) | 1978-01-01 | 1982-06-29 | Serum-free cell culture media | |
FR2413974A1 (en) | 1978-01-06 | 1979-08-03 | David Bernard | DRYER FOR SCREEN-PRINTED SHEETS |
US4275149A (en) | 1978-11-24 | 1981-06-23 | Syva Company | Macromolecular environment control in specific receptor assays |
US4318980A (en) | 1978-04-10 | 1982-03-09 | Miles Laboratories, Inc. | Heterogenous specific binding assay employing a cycling reactant as label |
US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
US4424279A (en) | 1982-08-12 | 1984-01-03 | Quidel | Rapid plunger immunoassay method and apparatus |
US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
US4560655A (en) | 1982-12-16 | 1985-12-24 | Immunex Corporation | Serum-free cell culture medium and process for making same |
US4657866A (en) | 1982-12-21 | 1987-04-14 | Sudhir Kumar | Serum-free, synthetic, completely chemically defined tissue culture media |
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
DD266710A3 (en) | 1983-06-06 | 1989-04-12 | Ve Forschungszentrum Biotechnologie | Process for the biotechnical production of alkaline phosphatase |
US4767704A (en) | 1983-10-07 | 1988-08-30 | Columbia University In The City Of New York | Protein-free culture medium |
US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4737456A (en) | 1985-05-09 | 1988-04-12 | Syntex (U.S.A.) Inc. | Reducing interference in ligand-receptor binding assays |
GB8516415D0 (en) | 1985-06-28 | 1985-07-31 | Celltech Ltd | Culture of animal cells |
US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
US6548640B1 (en) | 1986-03-27 | 2003-04-15 | Btg International Limited | Altered antibodies |
US4927762A (en) | 1986-04-01 | 1990-05-22 | Cell Enterprises, Inc. | Cell culture medium with antioxidant |
GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
EP0307434B2 (en) | 1987-03-18 | 1998-07-29 | Scotgen Biopharmaceuticals, Inc. | Altered antibodies |
AU632065B2 (en) | 1988-09-23 | 1992-12-17 | Novartis Vaccines And Diagnostics, Inc. | Cell culture medium for enhanced cell growth, culture longevity and product expression |
GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
ES2052027T5 (en) | 1988-11-11 | 2005-04-16 | Medical Research Council | IMMUNOGLOBULINE VARIABLE DOMAIN SEQUENCE CLONING. |
FR2646437B1 (en) | 1989-04-28 | 1991-08-30 | Transgene Sa | NOVEL DNA SEQUENCES, THEIR APPLICATION AS A SEQUENCE ENCODING A SIGNAL PEPTIDE FOR THE SECRETION OF MATURE PROTEINS BY RECOMBINANT YEASTS, EXPRESSION CASSETTES, PROCESSED YEASTS AND PROCESS FOR PREPARING THE SAME |
EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
DE3920358A1 (en) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | BISPECIFIC AND OLIGO-SPECIFIC, MONO- AND OLIGOVALENT ANTI-BODY CONSTRUCTS, THEIR PRODUCTION AND USE |
ES2096590T3 (en) | 1989-06-29 | 1997-03-16 | Medarex Inc | BI-SPECIFIC REAGENTS FOR AIDS THERAPY. |
DE69025946T2 (en) | 1989-09-08 | 1996-10-17 | Univ Johns Hopkins | MODIFICATIONS OF THE STRUCTURE OF THE EGF RECEPTOR GENE IN HUMAN GLIOMA |
US5959177A (en) | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
US6150584A (en) | 1990-01-12 | 2000-11-21 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US6075181A (en) | 1990-01-12 | 2000-06-13 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
SG48759A1 (en) | 1990-01-12 | 2002-07-23 | Abgenix Inc | Generation of xenogenic antibodies |
EP0547065B1 (en) | 1990-06-29 | 2001-08-29 | Large Scale Biology Corporation | Melanin production by transformed microorganisms |
US5770429A (en) | 1990-08-29 | 1998-06-23 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
ES2108048T3 (en) | 1990-08-29 | 1997-12-16 | Genpharm Int | PRODUCTION AND USE OF LOWER TRANSGENIC ANIMALS CAPABLE OF PRODUCING HETEROLOGICAL ANTIBODIES. |
US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
US5122469A (en) | 1990-10-03 | 1992-06-16 | Genentech, Inc. | Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins |
ES2113940T3 (en) | 1990-12-03 | 1998-05-16 | Genentech Inc | ENRICHMENT METHOD FOR PROTEIN VARIANTS WITH ALTERED UNION PROPERTIES. |
US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
WO1992020373A1 (en) | 1991-05-14 | 1992-11-26 | Repligen Corporation | Heteroconjugate antibodies for treatment of hiv infection |
JP4124480B2 (en) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | Immunoglobulin variants |
GB9114948D0 (en) | 1991-07-11 | 1991-08-28 | Pfizer Ltd | Process for preparing sertraline intermediates |
JP3951062B2 (en) | 1991-09-19 | 2007-08-01 | ジェネンテック・インコーポレーテッド | Expression of antibody fragments with cysteine present at least as a free thiol in E. coli for the production of bifunctional F (ab ') 2 antibodies |
US5587458A (en) | 1991-10-07 | 1996-12-24 | Aronex Pharmaceuticals, Inc. | Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof |
WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
WO1993016185A2 (en) | 1992-02-06 | 1993-08-19 | Creative Biomolecules, Inc. | Biosynthetic binding protein for cancer marker |
EP0656064B1 (en) | 1992-08-17 | 1997-03-05 | Genentech, Inc. | Bispecific immunoadhesins |
CA2146559A1 (en) | 1992-10-23 | 1994-05-11 | Melanie K. Spriggs | Methods of preparing soluble, oligomeric proteins |
RO118524B1 (en) | 1992-11-13 | 2003-06-30 | Idec Pharmaceuticals Corp San | Method for treating a disorder related to cells b |
AU691811B2 (en) | 1993-06-16 | 1998-05-28 | Celltech Therapeutics Limited | Antibodies |
GB9314893D0 (en) | 1993-07-19 | 1993-09-01 | Zeneca Ltd | Quinazoline derivatives |
DE69428764T2 (en) | 1993-12-24 | 2002-06-20 | Merck Patent Gmbh | immunoconjugates |
IL112248A0 (en) | 1994-01-25 | 1995-03-30 | Warner Lambert Co | Tricyclic heteroaromatic compounds and pharmaceutical compositions containing them |
US5679683A (en) | 1994-01-25 | 1997-10-21 | Warner-Lambert Company | Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family |
IL112249A (en) | 1994-01-25 | 2001-11-25 | Warner Lambert Co | Pharmaceutical compositions containing di and tricyclic pyrimidine derivatives for inhibiting tyrosine kinases of the epidermal growth factor receptor family and some new such compounds |
EP0772609B1 (en) | 1994-07-21 | 1999-02-24 | Akzo Nobel N.V. | Cyclic ketone peroxide formulations |
US5804396A (en) | 1994-10-12 | 1998-09-08 | Sugen, Inc. | Assay for agents active in proliferative disorders |
US5789199A (en) | 1994-11-03 | 1998-08-04 | Genentech, Inc. | Process for bacterial production of polypeptides |
US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
CA2216796C (en) | 1995-03-30 | 2003-09-02 | Pfizer Inc. | Quinazoline derivatives |
US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
GB9508537D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9508565D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quiazoline derivative |
CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
GB9508538D0 (en) | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
AU2466895A (en) | 1995-04-28 | 1996-11-18 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
US5747498A (en) | 1996-05-28 | 1998-05-05 | Pfizer Inc. | Alkynyl and azido-substituted 4-anilinoquinazolines |
AU6267896A (en) | 1995-06-07 | 1996-12-30 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth oftumors |
KR100437582B1 (en) | 1995-07-06 | 2004-12-17 | 노파르티스 아게 | Pyrrolopyrimidines and Processes for the Preparation Thereof |
US6267958B1 (en) | 1995-07-27 | 2001-07-31 | Genentech, Inc. | Protein formulation |
US5760041A (en) | 1996-02-05 | 1998-06-02 | American Cyanamid Company | 4-aminoquinazoline EGFR Inhibitors |
GB9603095D0 (en) | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
GB9603256D0 (en) | 1996-02-16 | 1996-04-17 | Wellcome Found | Antibodies |
CA2249446C (en) | 1996-04-12 | 2008-06-17 | Warner-Lambert Company | Irreversible inhibitors of tyrosine kinases |
WO1998002434A1 (en) | 1996-07-13 | 1998-01-22 | Glaxo Group Limited | Fused heterocyclic compounds as protein tyrosine kinase inhibitors |
ATE254502T1 (en) | 1996-08-30 | 2003-12-15 | Upfront Chromatography As | ISOLATION OF IMMUNOGLOBULINS |
ID18494A (en) | 1996-10-02 | 1998-04-16 | Novartis Ag | PIRAZOLA DISTRIBUTION IN THE SEQUENCE AND THE PROCESS OF MAKING IT |
EP2305027B1 (en) | 1996-12-03 | 2014-07-02 | Amgen Fremont Inc. | Transgenic mammals having human Ig loci including plural VH and Vkappa regions and antibodies produced therefrom |
US20080318254A9 (en) | 1997-03-10 | 2008-12-25 | The Regents Of The University Of California | PSCA antibodies and hybridomas producing them |
US6002008A (en) | 1997-04-03 | 1999-12-14 | American Cyanamid Company | Substituted 3-cyano quinolines |
UA73073C2 (en) | 1997-04-03 | 2005-06-15 | Уайт Холдінгз Корпорейшн | Substituted 3-cyan chinolines |
US20020173629A1 (en) | 1997-05-05 | 2002-11-21 | Aya Jakobovits | Human monoclonal antibodies to epidermal growth factor receptor |
US6235883B1 (en) | 1997-05-05 | 2001-05-22 | Abgenix, Inc. | Human monoclonal antibodies to epidermal growth factor receptor |
WO1998050038A1 (en) | 1997-05-06 | 1998-11-12 | American Cyanamid Company | Use of quinazoline compounds for the treatment of polycystic kidney disease |
US6171586B1 (en) | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
ES2244066T3 (en) | 1997-06-24 | 2005-12-01 | Genentech, Inc. | PROCEDURE AND COMPOSITIONS OF GALACTOSILATED GLICOPROTEINS. |
ZA986732B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
ZA986729B (en) | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitors of tyrosine kinases |
TW436485B (en) | 1997-08-01 | 2001-05-28 | American Cyanamid Co | Substituted quinazoline derivatives |
US6040498A (en) | 1998-08-11 | 2000-03-21 | North Caroline State University | Genetically engineered duckweed |
WO1999022764A1 (en) | 1997-10-31 | 1999-05-14 | Genentech, Inc. | Methods and compositions comprising glycoprotein glycoforms |
WO1999024037A1 (en) | 1997-11-06 | 1999-05-20 | American Cyanamid Company | Use of quinazoline derivatives as tyrosine kinase inhibitors for treating colonic polyps |
US6610833B1 (en) | 1997-11-24 | 2003-08-26 | The Institute For Human Genetics And Biochemistry | Monoclonal human natural antibodies |
EP1034298B1 (en) | 1997-12-05 | 2011-11-02 | The Scripps Research Institute | Humanization of murine antibody |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
EP1068241B1 (en) | 1998-04-02 | 2007-10-10 | Genentech, Inc. | Antibody variants and fragments thereof |
DK2180007T4 (en) | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosylation technique for antibodies to enhance antibody-dependent cell cytotoxicity |
PT1131304E (en) | 1998-11-19 | 2003-04-30 | Warner Lambert Co | N-4- (3-CHLORO-4-FLUORO-PHENYLAMINO) -7- (3-MORFOLIN-4-IL-PROPOXY) -QUINAZOLIN-6-IL | -ACRYLAMIDE AN IRREVERSIVAL INJECTOR OF TYROSOS KINASES |
US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
KR100940380B1 (en) | 1999-01-15 | 2010-02-02 | 제넨테크, 인크. | Polypeptide Variants with Altered Effector Function |
ATE402267T1 (en) | 1999-03-30 | 2008-08-15 | Japan Tobacco Inc | METHOD FOR PRODUCING MONOCLONAL ANTIBODIES |
DK2270147T4 (en) | 1999-04-09 | 2020-08-31 | Kyowa Kirin Co Ltd | METHOD OF MONITORING THE ACTIVITY OF IMMUNOLOGICAL FUNCTIONAL MOLECULE |
US7125978B1 (en) | 1999-10-04 | 2006-10-24 | Medicago Inc. | Promoter for regulating expression of foreign genes |
CA2385347C (en) | 1999-10-04 | 2009-12-15 | Medicago Inc. | Method for regulating transcription of foreign genes |
US7504256B1 (en) | 1999-10-19 | 2009-03-17 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing polypeptide |
AU784983B2 (en) | 1999-12-15 | 2006-08-17 | Genentech Inc. | Shotgun scanning, a combinatorial method for mapping functional protein epitopes |
US6946292B2 (en) | 2000-10-06 | 2005-09-20 | Kyowa Hakko Kogyo Co., Ltd. | Cells producing antibody compositions with increased antibody dependent cytotoxic activity |
CA2424602C (en) | 2000-10-06 | 2012-09-18 | Kyowa Hakko Kogyo Co., Ltd. | Antibody composition-producing cell |
US7064191B2 (en) | 2000-10-06 | 2006-06-20 | Kyowa Hakko Kogyo Co., Ltd. | Process for purifying antibody |
US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
CN1487996B (en) | 2000-11-30 | 2010-06-16 | 米德列斯公司 | Transgenic transchromosomal rodents for making human antibodies |
WO2002092017A2 (en) | 2001-05-16 | 2002-11-21 | Albert Einstein College Of Medicine Of Yeshiva University | Human antipneumococcal antibodies from non-human animals |
KR20040054669A (en) | 2001-08-03 | 2004-06-25 | 글리카트 바이오테크놀로지 아게 | Antibody glycosylation variants having increased antibody-dependent cellular cytotoxicity |
PT1425389E (en) | 2001-08-23 | 2012-02-07 | Genmab As | Human antibodies specific for interleukin 15 (il-15) |
CN100423777C (en) | 2001-10-25 | 2008-10-08 | 杰南技术公司 | Glycoprotein compositions |
US20040093621A1 (en) | 2001-12-25 | 2004-05-13 | Kyowa Hakko Kogyo Co., Ltd | Antibody composition which specifically binds to CD20 |
CA2481925A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Therapeutic agent for patients having human fc.gamma.riiia |
AU2003236017B2 (en) | 2002-04-09 | 2009-03-26 | Kyowa Kirin Co., Ltd. | Drug containing antibody composition |
WO2003085118A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing antibody composition |
US20040259150A1 (en) | 2002-04-09 | 2004-12-23 | Kyowa Hakko Kogyo Co., Ltd. | Method of enhancing of binding activity of antibody composition to Fcgamma receptor IIIa |
WO2003085102A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Cell with depression or deletion of the activity of protein participating in gdp-fucose transport |
CA2481657A1 (en) | 2002-04-09 | 2003-10-16 | Kyowa Hakko Kogyo Co., Ltd. | Cells of which genome is modified |
EP1513879B1 (en) | 2002-06-03 | 2018-08-22 | Genentech, Inc. | Synthetic antibody phage libraries |
EP1525223B1 (en) | 2002-06-13 | 2007-11-21 | Crucell Holland B.V. | Ox40 (=cd134) receptor agonists and therapeutic use |
US7361740B2 (en) | 2002-10-15 | 2008-04-22 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
US7217797B2 (en) | 2002-10-15 | 2007-05-15 | Pdl Biopharma, Inc. | Alteration of FcRn binding affinities or serum half-lives of antibodies by mutagenesis |
JP4351674B2 (en) | 2002-12-16 | 2009-10-28 | ジェネンテック・インコーポレーテッド | Immunoglobulin variants and their use and use |
EP1585767A2 (en) | 2003-01-16 | 2005-10-19 | Genentech, Inc. | Synthetic antibody phage libraries |
CN1761482A (en) | 2003-01-17 | 2006-04-19 | 纽约州立大学研究基金会 | The antigen relevant with cancer of pancreas, at its antibody and diagnosis and Therapeutic Method |
US20060104968A1 (en) | 2003-03-05 | 2006-05-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminogly ycanases |
US7871607B2 (en) | 2003-03-05 | 2011-01-18 | Halozyme, Inc. | Soluble glycosaminoglycanases and methods of preparing and using soluble glycosaminoglycanases |
CA2526398C (en) | 2003-05-21 | 2014-07-15 | Medarex, Inc. | Human monoclonal antibodies against bacillus anthracis protective antigen |
AU2004279742A1 (en) | 2003-10-08 | 2005-04-21 | Kyowa Hakko Kirin Co., Ltd. | Fused protein composition |
WO2005035778A1 (en) | 2003-10-09 | 2005-04-21 | Kyowa Hakko Kogyo Co., Ltd. | PROCESS FOR PRODUCING ANTIBODY COMPOSITION BY USING RNA INHIBITING THE FUNCTION OF α1,6-FUCOSYLTRANSFERASE |
RS57466B1 (en) | 2003-11-05 | 2018-09-28 | Roche Glycart Ag | Antigen binding molecules with increased fc receptor binding affinity and effector function |
JPWO2005053742A1 (en) | 2003-12-04 | 2007-06-28 | 協和醗酵工業株式会社 | Medicament containing antibody composition |
EP1740615B1 (en) | 2004-03-31 | 2014-11-05 | Genentech, Inc. | Humanized anti-tgf-beta antibodies |
US7785903B2 (en) | 2004-04-09 | 2010-08-31 | Genentech, Inc. | Variable domain library and uses |
BR122019012028B1 (en) | 2004-04-13 | 2023-09-26 | F. Hoffmann-La Roche Ag | ANTI-P-SELECTIN ANTIBODIES, NUCLEIC ACID MOLECULE, VECTOR, AND COMPOSITION |
TWI380996B (en) | 2004-09-17 | 2013-01-01 | Hoffmann La Roche | Anti-ox40l antibodies |
JO3000B1 (en) | 2004-10-20 | 2016-09-05 | Genentech Inc | Antibody Formulations. |
EP1814568A4 (en) | 2004-10-29 | 2009-08-12 | Univ Southern California | Combination cancer immunotherapy with co-stimulatory molecules |
CA2606809C (en) | 2005-05-06 | 2016-01-05 | Providence Health System | Trimeric ox40-immunoglobulin fusion protein and methods of use |
PL2439273T3 (en) | 2005-05-09 | 2019-08-30 | Ono Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics |
RS54271B1 (en) | 2005-07-01 | 2016-02-29 | E. R. Squibb & Sons, L.L.C. | Human monoclonal antibodies to programmed death ligand 1 (pd-l1) |
ES2577292T3 (en) | 2005-11-07 | 2016-07-14 | Genentech, Inc. | Binding polypeptides with diversified VH / VL hypervariable sequences and consensus |
US20070237764A1 (en) | 2005-12-02 | 2007-10-11 | Genentech, Inc. | Binding polypeptides with restricted diversity sequences |
CA2651567A1 (en) | 2006-05-09 | 2007-11-22 | Genentech, Inc. | Binding polypeptides with optimized scaffolds |
US20080226635A1 (en) | 2006-12-22 | 2008-09-18 | Hans Koll | Antibodies against insulin-like growth factor I receptor and uses thereof |
CN100592373C (en) | 2007-05-25 | 2010-02-24 | 群康科技(深圳)有限公司 | Liquid crystal panel drive device and its drive method |
SI2594590T1 (en) | 2007-12-14 | 2015-03-31 | Bristol-Myers Squibb Company | Method of producing binding molecules for the human OX40 receptor |
HUE034465T2 (en) | 2008-02-11 | 2018-02-28 | Cure Tech Ltd | Monoclonal antibodies for tumor treatment |
EP2262837A4 (en) | 2008-03-12 | 2011-04-06 | Merck Sharp & Dohme | Pd-1 binding proteins |
MX2011002252A (en) * | 2008-08-25 | 2011-06-24 | Amplimmune Inc | Compositions of pd-1 antagonists and methods of use. |
KR20110074850A (en) | 2008-08-25 | 2011-07-04 | 앰플리뮨, 인크. | Pd-1 antagonists and methods of use thereof |
CN114835812A (en) * | 2008-12-09 | 2022-08-02 | 霍夫曼-拉罗奇有限公司 | anti-PD-L1 antibodies and their use for enhancing T cell function |
US20130017199A1 (en) | 2009-11-24 | 2013-01-17 | AMPLIMMUNE ,Inc. a corporation | Simultaneous inhibition of pd-l1/pd-l2 |
LT3279215T (en) | 2009-11-24 | 2020-04-10 | Medimmune Limited | Targeted binding agents against b7-h1 |
PE20131403A1 (en) | 2010-08-23 | 2014-01-10 | Univ Texas | ANTI-OX40 ANTIBODIES AND METHODS OF USING THEM |
AU2012290121B2 (en) * | 2011-08-01 | 2015-11-26 | Genentech, Inc. | Methods of treating cancer using PD-1 axis binding antagonists and MEK inhibitors |
KR101685262B1 (en) | 2011-08-23 | 2016-12-21 | 보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템 | Anti-ox40 antibodies and methods of using the same |
GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
SG10201708048XA (en) | 2013-03-18 | 2017-10-30 | Biocerox Prod Bv | Humanized anti-cd134 (ox40) antibodies and uses thereof |
TW201619200A (en) * | 2014-10-10 | 2016-06-01 | 麥迪紐有限責任公司 | Humanized anti-OX40 antibodies and uses thereof |
EP4245376A3 (en) * | 2014-10-14 | 2023-12-13 | Novartis AG | Antibody molecules to pd-l1 and uses thereof |
WO2017025610A1 (en) * | 2015-08-12 | 2017-02-16 | Medimmune Limited | Gitrl fusion proteins and uses thereof |
-
2014
- 2014-12-17 SG SG11201604979WA patent/SG11201604979WA/en unknown
- 2014-12-17 JP JP2016540597A patent/JP2017501167A/en active Pending
- 2014-12-17 KR KR1020167018833A patent/KR20160099092A/en not_active Application Discontinuation
- 2014-12-17 AU AU2014364606A patent/AU2014364606A1/en not_active Abandoned
- 2014-12-17 CA CA2934028A patent/CA2934028A1/en not_active Abandoned
- 2014-12-17 BR BR112016013963A patent/BR112016013963A2/en not_active Application Discontinuation
- 2014-12-17 EP EP14824702.6A patent/EP3083687A2/en not_active Withdrawn
- 2014-12-17 WO PCT/US2014/070998 patent/WO2015095423A2/en active Application Filing
- 2014-12-17 US US14/574,365 patent/US20150190506A1/en not_active Abandoned
- 2014-12-17 CN CN201480073061.9A patent/CN106102774A/en active Pending
- 2014-12-17 MX MX2016007965A patent/MX2016007965A/en unknown
- 2014-12-17 EP EP18206645.6A patent/EP3527587A1/en not_active Withdrawn
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2016
- 2016-06-15 IL IL246251A patent/IL246251A0/en unknown
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2018
- 2018-02-01 US US15/886,454 patent/US20180303936A1/en not_active Abandoned
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JP2017501167A (en) | 2017-01-12 |
WO2015095423A3 (en) | 2015-08-13 |
EP3527587A1 (en) | 2019-08-21 |
CN106102774A (en) | 2016-11-09 |
BR112016013963A2 (en) | 2017-10-10 |
WO2015095423A2 (en) | 2015-06-25 |
AU2014364606A1 (en) | 2016-07-07 |
IL246251A0 (en) | 2016-07-31 |
US20150190506A1 (en) | 2015-07-09 |
MX2016007965A (en) | 2016-10-28 |
EP3083687A2 (en) | 2016-10-26 |
US20180303936A1 (en) | 2018-10-25 |
KR20160099092A (en) | 2016-08-19 |
CA2934028A1 (en) | 2015-06-25 |
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