SG10201810615VA - Pd-1 / pd-l1 inhibitors for the treatment of cancer - Google Patents
Pd-1 / pd-l1 inhibitors for the treatment of cancerInfo
- Publication number
- SG10201810615VA SG10201810615VA SG10201810615VA SG10201810615VA SG10201810615VA SG 10201810615V A SG10201810615V A SG 10201810615VA SG 10201810615V A SG10201810615V A SG 10201810615VA SG 10201810615V A SG10201810615V A SG 10201810615VA SG 10201810615V A SG10201810615V A SG 10201810615VA
- Authority
- SG
- Singapore
- Prior art keywords
- cancer
- inhibitors
- treatment
- subject
- ligand
- Prior art date
Links
- 206010028980 Neoplasm Diseases 0.000 title abstract 3
- 201000011510 cancer Diseases 0.000 title abstract 3
- 239000012269 PD-1/PD-L1 inhibitor Substances 0.000 title abstract 2
- 229940121653 pd-1/pd-l1 inhibitor Drugs 0.000 title abstract 2
- 102000008096 B7-H1 Antigen Human genes 0.000 abstract 1
- 108010074708 B7-H1 Antigen Proteins 0.000 abstract 1
- 102100040678 Programmed cell death protein 1 Human genes 0.000 abstract 1
- 101710089372 Programmed cell death protein 1 Proteins 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000003993 interaction Effects 0.000 abstract 1
- 239000003446 ligand Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Oncology (AREA)
- Engineering & Computer Science (AREA)
- Cell Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Biomedical Technology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
PD-1 / PD-L1 INHIBITORS FOR THE TREATMENT OF CANCER The invention relates to methods of treating cancer in a subject, comprising administering to the subject a therapeutically effective amount of an inhibitor of the interaction between the PD-1 receptor and its ligand PD-L1. ( No figure )
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562121025P | 2015-02-26 | 2015-02-26 | |
US201562133721P | 2015-03-16 | 2015-03-16 | |
US201562160291P | 2015-05-12 | 2015-05-12 | |
US201562215394P | 2015-09-08 | 2015-09-08 | |
US201562254424P | 2015-11-12 | 2015-11-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
SG10201810615VA true SG10201810615VA (en) | 2019-01-30 |
Family
ID=55588542
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201706918YA SG11201706918YA (en) | 2015-02-26 | 2016-02-23 | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
SG10201810615VA SG10201810615VA (en) | 2015-02-26 | 2016-02-23 | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201706918YA SG11201706918YA (en) | 2015-02-26 | 2016-02-23 | Pd-1 / pd-l1 inhibitors for the treatment of cancer |
Country Status (15)
Country | Link |
---|---|
US (2) | US10800846B2 (en) |
EP (2) | EP4279087A3 (en) |
JP (3) | JP6885869B2 (en) |
KR (1) | KR20170132171A (en) |
CN (2) | CN112263677A (en) |
AU (3) | AU2016222928B2 (en) |
BR (1) | BR112017018234A2 (en) |
CA (1) | CA2977767C (en) |
IL (2) | IL278423B2 (en) |
MX (2) | MX2017010773A (en) |
NZ (1) | NZ733854A (en) |
RU (1) | RU2714233C2 (en) |
SG (2) | SG11201706918YA (en) |
TW (2) | TWI748942B (en) |
WO (1) | WO2016137985A1 (en) |
Families Citing this family (27)
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US10441654B2 (en) | 2014-01-24 | 2019-10-15 | Children's Hospital Of Eastern Ontario Research Institute Inc. | SMC combination therapy for the treatment of cancer |
JP6885869B2 (en) | 2015-02-26 | 2021-06-16 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | PD-1 / PD-L1 Inhibitors for Treating Cancer |
MA42971A (en) | 2015-03-13 | 2018-08-15 | Cytomx Therapeutics Inc | ANTI-PDL1 ANTIBODIES, ACTIVABLE ANTI-PLD1 ANTIBODIES, AND METHODS OF USE THEREOF |
AU2016280003B2 (en) | 2015-06-16 | 2021-09-16 | Merck Patent Gmbh | PD-L1 antagonist combination treatments |
IL293385A (en) | 2015-08-11 | 2022-07-01 | Omniab Inc | Novel anti-pd-1 antibodies |
CN107949573B (en) | 2015-09-01 | 2022-05-03 | 艾吉纳斯公司 | anti-PD-1 antibodies and methods of use thereof |
JP6925337B2 (en) | 2015-12-07 | 2021-08-25 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Aqueous pharmaceutical preparation containing anti-PD-L1 antibody avelumab |
CA3025391A1 (en) * | 2016-05-26 | 2017-11-30 | Merck Patent Gmbh | Pd-1 / pd-l1 inhibitors for cancer treatment |
KR102543015B1 (en) | 2016-06-17 | 2023-06-13 | 더 트러스티스 오브 더 유니버시티 오브 펜실베니아 | Compounds, compositions and methods for the prevention and/or treatment of cancer |
TN2019000081A1 (en) * | 2016-09-14 | 2020-07-15 | Beijing hanmi pharm co ltd | Antibody specifically binding to pd-1 and functional fragment thereof |
BR112019006504A2 (en) * | 2016-10-06 | 2019-06-25 | Merck Patent Gmbh | Avelumab Dosage Regimen For Cancer Treatment |
WO2018098352A2 (en) | 2016-11-22 | 2018-05-31 | Jun Oishi | Targeting kras induced immune checkpoint expression |
KR20190125363A (en) | 2017-03-06 | 2019-11-06 | 메르크 파텐트 게엠베하 | Aqueous Anti-PD-L1 Antibody Formulations |
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EP3600410A1 (en) * | 2017-03-30 | 2020-02-05 | Merck Patent GmbH | Combination of an anti-pd-l1 antibody and a dna-pk inhibitor for the treatment of cancer |
BR112019025188A2 (en) | 2017-06-01 | 2020-06-23 | Cytomx Therapeutics, Inc. | ACTIVABLE ANTI-PDL1 ANTIBODIES AND METHODS OF USE OF THE SAME |
JP2020536887A (en) * | 2017-10-13 | 2020-12-17 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | Combination of PARP inhibitor and PD-1 binding antagonist |
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US20210169979A1 (en) * | 2019-12-05 | 2021-06-10 | The Board of Regents for the Oklahoma Agricultural and Mechanical Colleges | System and method for sonosensitized cancer immunotherapy with nanoparticles |
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