BR112022016490A2 - METHODS FOR EX VIVO ENRICHMENT AND EXPANSION OF TUMOR T-REACTIVE CELLS AND RELATED COMPOSITIONS THEREOF - Google Patents

METHODS FOR EX VIVO ENRICHMENT AND EXPANSION OF TUMOR T-REACTIVE CELLS AND RELATED COMPOSITIONS THEREOF

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Publication number
BR112022016490A2
BR112022016490A2 BR112022016490A BR112022016490A BR112022016490A2 BR 112022016490 A2 BR112022016490 A2 BR 112022016490A2 BR 112022016490 A BR112022016490 A BR 112022016490A BR 112022016490 A BR112022016490 A BR 112022016490A BR 112022016490 A2 BR112022016490 A2 BR 112022016490A2
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methods
expansion
tumor
cells
related compositions
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BR112022016490A
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Portuguese (pt)
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J Langer Timothy
James Miles Brodie
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Myst Therapeutics Llc
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Abstract

MÉTODOS PARA ENRIQUECIMENTO EX VIVO E EXPANSÃO DE CÉLULAS T REATIVAS A TUMOR E COMPOSIÇÕES RELACIONADAS DAS MESMAS. A presente invenção refere-se a métodos para fabricação de células T reativas tumorais que incluem enriquecimento ex vivo e expansão de células que secretam ligante 13 de quimiocina (motivo CXC) (CXCL13); superfície positiva de células para o receptor de quimiocina C-X-C tipo 5 (CXCR5); e/ou um ou mais de CD39, PD-1 e TIGIT. Também são fornecidas populações de células T produzidas por métodos descritos neste documento e composições farmacêuticas das mesmas.METHODS FOR EX VIVO ENRICHMENT AND EXPANSION OF TUMOR-REACTIVE T CELLS AND RELATED COMPOSITIONS THEREOF. The present invention relates to methods for manufacturing tumor reactive T cells that include ex vivo enrichment and expansion of cells that secrete chemokine ligand 13 (CXC motif) (CXCL13); positive cell surface for C-X-C chemokine receptor type 5 (CXCR5); and/or one or more of CD39, PD-1 and TIGIT. Also provided are populations of T cells produced by methods described herein and pharmaceutical compositions thereof.

BR112022016490A 2020-02-27 2021-03-01 METHODS FOR EX VIVO ENRICHMENT AND EXPANSION OF TUMOR T-REACTIVE CELLS AND RELATED COMPOSITIONS THEREOF BR112022016490A2 (en)

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Application Number Priority Date Filing Date Title
US202062982704P 2020-02-27 2020-02-27
PCT/US2021/020320 WO2021174208A1 (en) 2020-02-27 2021-03-01 Methods for ex vivo enrichment and expansion of tumor reactive t cells and related compositions thereof

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BR112022016490A2 true BR112022016490A2 (en) 2022-10-11

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EP (1) EP4110799A1 (en)
JP (1) JP2023516636A (en)
KR (1) KR20220158727A (en)
CN (1) CN115427438A (en)
AU (1) AU2021226903A1 (en)
BR (1) BR112022016490A2 (en)
CA (1) CA3172902A1 (en)
IL (2) IL295934A (en)
MX (1) MX2022010517A (en)
WO (1) WO2021174208A1 (en)

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WO2023220128A1 (en) * 2022-05-10 2023-11-16 H. Lee Moffitt Cancer Center And Research Institute, Inc. Targeting myeloid-derived suppressor cells (mdscs) in bladder cancer to enhance efficacy of adoptive cell therapy (act)
WO2023229979A1 (en) * 2022-05-22 2023-11-30 Skdw Holdings, Llc Methods of isolating and enhancing populations of tumor-reactive lymphocytes

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