NO139127B - ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PHENYLALYLAMINES - Google Patents

ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PHENYLALYLAMINES Download PDF

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Publication number
NO139127B
NO139127B NO773495A NO773495A NO139127B NO 139127 B NO139127 B NO 139127B NO 773495 A NO773495 A NO 773495A NO 773495 A NO773495 A NO 773495A NO 139127 B NO139127 B NO 139127B
Authority
NO
Norway
Prior art keywords
funnel
filter
coffee
filter body
phenylalylamines
Prior art date
Application number
NO773495A
Other languages
Norwegian (no)
Other versions
NO139127C (en
NO773495L (en
Inventor
Winston Stanley Marshall
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US752800A external-priority patent/US3649679A/en
Priority claimed from US828756A external-priority patent/US3600437A/en
Publication of NO773495L publication Critical patent/NO773495L/en
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of NO139127B publication Critical patent/NO139127B/en
Publication of NO139127C publication Critical patent/NO139127C/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D257/00Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04Five-membered rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00Ethers; Compounds having groups, groups or groups
    • C07C43/02Ethers
    • C07C43/257Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/295Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Description

Filterinnsats til kaffekolher. Filter insert for coffee grounds.

Oppfinnelsen angår en filterinnsats til kaffekolber, bestående av et filterlegeme fremstillet av kunststoff bestemt til å an-bringes i bunnen av kaffekolbens filter - trakt over traktrørets munning, og som på sin underside er utformet med kanaler av slike dimensjoner, at væske fritt kan strømme gjennom, mens den malte kaffe tilbakeholdes i trakten. The invention relates to a filter insert for coffee flasks, consisting of a filter body made of plastic designed to be placed at the bottom of the coffee flask's filter - funnel above the mouth of the funnel tube, and which on its underside is designed with channels of such dimensions that liquid can freely flow through , while the ground coffee is retained in the funnel.

De hittil kjente filterinnsatser av den omhandlede utformning som kan bestå av kunststoff eller kjeramisk materiale, har form av hovedsaklig soppformet hvel-vede legemer, slik at filterlegemet ikke kan tilbakeholde væske på sin overside, når væsken strømmer fra filtertrakten ned i kolben. The previously known filter inserts of the design in question, which can consist of plastic or ceramic material, have the shape of mainly mushroom-shaped vaulted bodies, so that the filter body cannot retain liquid on its upper side, when the liquid flows from the filter funnel down into the flask.

Som bekjent har det ved fremstilling av kaffe på kaffekolbe hittil vært nødven-dig å anvende temmelig grovmalte kaffe-bønner, idet filterinnsatsen på grunn av de i praksis alltid forekommende formmessige uregelmessigheter i bunnen av den vanlig-vis av glass bestående filtertrakt, ikke kan komme i så tett anlegg overalt langs sin omkrets mot traktens bunn, at finmalte kaffebønner med sikkerhet kan tilbakeholdes i trakten. Det som er avgjørende for hvor finmalte kaffebønner man kan bruke, er således ikke bare de nevnte ka-nalers dimensjoner, men også hvor tett filterinnsatsen kan bringes til å slutte seg til filtertraktens bunn. As you know, when making coffee in a coffee flask, it has so far been necessary to use rather coarsely ground coffee beans, as the filter insert, due to the practically always-occurring shape irregularities at the bottom of the filter funnel, usually made of glass, cannot fit in such a dense arrangement everywhere along its circumference towards the bottom of the funnel, that finely ground coffee beans can be safely retained in the funnel. What is decisive for how finely ground coffee beans can be used is thus not only the dimensions of the aforementioned channels, but also how closely the filter insert can be brought to join the bottom of the filter funnel.

Nå er det midlertid ønskelig å anvende kaffebønnene i så finmalt tilstand som mulig, idet det oppnås en både hurtigere og fullstendigere ekstraksjon av bønnene når disse er finmalt, enn når de er grov-malt. Oppfinnelsen har derfor til hensikt Currently, it is desirable to use the coffee beans in as finely ground a state as possible, as a faster and more complete extraction of the beans is achieved when these are finely ground than when they are coarsely ground. The invention therefore aims to

å skaffe en filterinnsats som muliggjør anvendelsen av ytterst finmalte kaffebøn-ner. to provide a filter insert which enables the use of extremely finely ground coffee beans.

Dette oppnås ifølge oppfinnelsen ved at filterlegemet har form av en hovedsaklig flat, tynn skive som har en mot skivens rand gradvis avtagende tykkelse og består av et i og for seg kjent kokefast, ved vannets kokepunkt elastisk deformerbart kunststoff, f. eks. polyetylen. Ved filterinnsatsen ifølge oppfinnelsen gis det således bevisst avkall på den hittil alminnelige soppform av filterlegemet og den derav betingede bedre tømming av filtertrakten for væske til fordel for et mere tettslut-tende anlegg av filterlegemet mot filtertraktens bunn. Når filterlegemet holdes trykket mot tounnnen av filtertrakten, f. eks. ved hjelp av en i filterlegemet fastgjort skruefjær, som strekker seg ned gjennom traktens rør og er fastgjort ved dettes nedre ende, vil det ved berøring med det i trakten værende kokende vann bløtgjøres så meget at det under innvirk-ning av fjæren med sin rand legger seg tett mot bunnen av trakten, uansett even-tuelle uregelmessigheter i denne, slik at kun dimensjonene av de i filterlegemets underside utformede kanaler er bestem-mende for den brukbare formalingsgrad av kaffebønnene. Det har i praksis vist seg at kanalene kan utformes med en dybde av bare 0,2 mm hvorved det blir mulig å anvende ytterst fint pulveriserte kaffebønner uten at derfor større eller mindre meng-der herav kan trenge gjennom filterinnsatsen. According to the invention, this is achieved by the filter body having the form of an essentially flat, thin disk which has a gradually decreasing thickness towards the edge of the disk and consists of a known in and of itself non-boiling plastic that is elastically deformable at the boiling point of water, e.g. polyethylene. With the filter insert according to the invention, the hitherto common mushroom shape of the filter body and the resulting better emptying of the filter funnel for liquid are thus deliberately renounced in favor of a more tightly fitting fit of the filter body against the bottom of the filter funnel. When the filter body is kept pressed against the bottom of the filter funnel, e.g. by means of a screw spring fixed in the filter body, which extends down through the funnel's tube and is fixed at its lower end, when it comes into contact with the boiling water in the funnel, it will be softened so much that under the influence of the spring, it lays with its edge close to the bottom of the funnel, regardless of any irregularities therein, so that only the dimensions of the channels formed on the underside of the filter body are decisive for the usable degree of grinding of the coffee beans. It has been shown in practice that the channels can be designed with a depth of just 0.2 mm, which makes it possible to use extremely finely powdered coffee beans without therefore larger or smaller amounts of this being able to penetrate the filter insert.

Flor at filterinnsatsen skal ha tilstrekkelig mekanisk styrke i forbindelse med en tilstrekkelig deformerbarhet, har ifølge oppfinnelsen den skive som danner filterlegemet en mot skivens rand gradvis avtagende tykkelse, slik at skiven har størst deformerbarhet ved randen, hvor den hovedsaklig ligger an mot filtertrakten, og hvor en deformerbarhet derfor er mest på-krevet, mens den i avstand fra randen har større tykkelse og stivhet. In order that the filter insert must have sufficient mechanical strength in connection with sufficient deformability, according to the invention the disk that forms the filter body has a gradually decreasing thickness towards the edge of the disk, so that the disk has the greatest deformability at the edge, where it mainly rests against the filter funnel, and where a deformability is therefore most required, while at a distance from the edge it has greater thickness and stiffness.

En utførelsesform for en filterinnsats ifølge oppfinnelsen er vist på tegningen, sett skrått nedenfra i perspektiv. An embodiment of a filter insert according to the invention is shown in the drawing, seen obliquely from below in perspective.

Den viste filterinnsats har form som et på oversiden plant, hovedsaklig sirku-lært, skivef ormet filterlegeme 1, f. eks. av polyetylen, som på sin underside er svakt kjeglestumpf ormet, slik at skiven er ve-sentlig tynnere ved randen enn i området omkring dens sentrum. F. eks. kan skiven i området omkring sitt sentrum ha en tykkelse på 3>—5 mm, mens tykkelsen ved randen kan være ca. 0,5—1 mm. The filter insert shown has the shape of a flat on the upper side, mainly circular, disk-shaped filter body 1, e.g. of polyethylene, which is slightly truncated on its underside, so that the disc is significantly thinner at the edge than in the area around its centre. For example the disc in the area around its center can have a thickness of 3>-5 mm, while the thickness at the edge can be approx. 0.5—1 mm.

Skiven er på sin underside utformet med et stort antall radiale kanaler 2 av kapillære dimensjoner, f. eks. med en maksimal dybde av 0,2 mm, som strekker seg fra skivens rand til et område omkring dens sentrum, som under filterinnsatsens bruk ikke er i berøring med filtertraktens bunn. Skiven 1 har et sentralt anbragt nedadrettet fremspring 3, ved hvis nedre ende det er utformet eller anbragt en gjengetapp 4, på hvilken er påskrudd noen vindinger av en skruefjær 5. Fjæren er bestemt til å strekke seg ned gjennom filtertraktens rør og fastgjøres ved rørets nedre ende med en krok 6 utformet på dens nedre ende, slik at skiven 1 dermed i hvert fall med sin rand, trykkes mot bunnen av filtertrakten. The disc is designed on its underside with a large number of radial channels 2 of capillary dimensions, e.g. with a maximum depth of 0.2 mm, which extends from the disc's edge to an area around its centre, which during use of the filter insert is not in contact with the bottom of the filter funnel. The disc 1 has a centrally placed downward projection 3, at the lower end of which a threaded pin 4 is formed or placed, on which a few turns of a helical spring 5 are screwed. The spring is intended to extend down through the tube of the filter funnel and is attached to the tube's lower end with a hook 6 formed on its lower end, so that the disc 1 is thus pressed, at least with its edge, against the bottom of the filter funnel.

På tegningen er kanalene 2 vist med hovedsaklig trekantet tverrsnittsform. Det kan dog også anvendes annen tverrsnittsform, f. eks. rektangulær eller trapes-formet. Fjæren 5 kan være forbundet med filterlegemet på annen måte enn vist, f. eks. ved at skiven ved sitt sentrum har et hull i hvilket den øvre ende av den tråd som danner fjæren er fastgjort. Eventu-elt kan fjæren erstattes med andre orga-ner for å skaffe et nedadrettet trykk på filterinnsatsen. In the drawing, the channels 2 are shown with a mainly triangular cross-sectional shape. However, other cross-sectional shapes can also be used, e.g. rectangular or trapezoidal. The spring 5 can be connected to the filter body in a different way than shown, e.g. in that the disc at its center has a hole in which the upper end of the thread forming the spring is attached. Optionally, the spring can be replaced with other organs to provide downward pressure on the filter insert.

Claims (1)

Filterinnsats til kaffekolber, bestående av et til anbringelse 1 bunnen av kaffekolbens filtertrakt over traktrørets munning bestemt filterlegeme av kunststoff som på sin underside er utformet med kanaler av slike dimensjoner at væske fritt kan strøm-me gjennom, mens den i trakten værende malte kaffe tilbakeholdes i trakten, karakterisert ved at filterlegemet har form av en hovedsakelig flat, tynn skive (1) som har en mot skivens rand gradvis avtagende tykkelse og består av et i og for seg kjent koketast og ved vannets kokepunkt elastisk deformerbart kunststoff.Filter insert for coffee flasks, consisting of a filter body made of plastic that is placed on the bottom of the coffee flask's filter funnel above the mouth of the funnel tube, which is designed on its underside with channels of such dimensions that liquid can flow freely through, while the ground coffee in the funnel is retained in the funnel, characterized in that the filter body has the form of a mainly flat, thin disk (1) which has a gradually decreasing thickness towards the edge of the disk and consists of a boiling key known per se and elastically deformable plastic at the water's boiling point.
NO773495A 1968-08-15 1977-10-12 ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PHENYLALYLAMINES NO139127C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75280168A 1968-08-15 1968-08-15
US752800A US3649679A (en) 1968-08-15 1968-08-15 Substituted phenylalkanoic acid derivatives ii
US828756A US3600437A (en) 1969-05-28 1969-05-28 Substituted phenylalkanoic acids and derivatives thereof

Publications (3)

Publication Number Publication Date
NO773495L NO773495L (en) 1970-02-16
NO139127B true NO139127B (en) 1978-10-02
NO139127C NO139127C (en) 1979-01-10

Family

ID=27419433

Family Applications (2)

Application Number Title Priority Date Filing Date
NO3760/73A NO137824C (en) 1968-08-15 1973-09-25 ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PHENYLALYLTETRAZOLES
NO773495A NO139127C (en) 1968-08-15 1977-10-12 ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PHENYLALYLAMINES

Family Applications Before (1)

Application Number Title Priority Date Filing Date
NO3760/73A NO137824C (en) 1968-08-15 1973-09-25 ANALOGICAL PROCEDURE FOR THE PREPARATION OF THERAPEUTICALLY ACTIVE PHENYLALYLTETRAZOLES

Country Status (16)

Country Link
JP (2) JPS5144938B1 (en)
AR (1) AR197075A1 (en)
BE (1) BE737417A (en)
CH (1) CH527155A (en)
CY (1) CY743A (en)
DE (1) DE1941625C3 (en)
DK (1) DK145778C (en)
ES (2) ES370540A1 (en)
FI (1) FI54099C (en)
GB (1) GB1264340A (en)
IE (1) IE33573B1 (en)
IL (1) IL32825A (en)
LU (1) LU59302A1 (en)
NL (2) NL155820B (en)
NO (2) NO137824C (en)
SE (2) SE363818B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1307284A (en) * 1970-03-16 1973-02-14 Boots Co Ltd 2-substituted phenyl propionic acids
JPS52168775U (en) * 1976-06-11 1977-12-21
JPS5327662U (en) * 1976-08-14 1978-03-09
DE2950608A1 (en) * 1978-12-29 1980-07-10 Chinoin Gyogyszer Es Vegyeszet METHOD FOR PRODUCING 2- (3-PHENOXY-PHENYL) -PROPIONIC ACID
US4367238A (en) * 1980-01-28 1983-01-04 Fujisawa Pharmaceutical Company, Ltd. Phenyl-alkanoic acid derivative and preparation thereof
CA1181760A (en) * 1980-02-07 1985-01-29 Roger A. Parker Anti-rhinovirus agents
US4792560A (en) * 1985-04-03 1988-12-20 Rorer Pharmaceutical Corporation Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways
JPS6221294U (en) * 1985-07-23 1987-02-07
DE3610892A1 (en) * 1986-03-24 1987-10-08 Hubert Kurz Sectional sliding wall
JPS6412403A (en) * 1987-07-07 1989-01-17 Kuroi Electric Ind Co Light shielding panel
DE3816450A1 (en) * 1988-05-13 1989-11-16 Hubert Kurz Sectional sliding wall
DE3905518A1 (en) * 1989-02-23 1990-10-11 Bayer Ag SUBSTITUTED PHENOXYPHENYL PROPIONIC ACID DERIVATIVES
JPH07502538A (en) * 1992-05-01 1995-03-16 ファイザー インク. Method for producing 3(S)-methylheptanoic acid and its intermediates
SE0103325D0 (en) * 2001-10-04 2001-10-04 Astrazeneca Ab Novel compounds
RU2010145916A (en) * 2008-04-11 2012-05-20 Инститьют Оф Медисинал Молекьюлар Дизайн, Инк. (Jp) PAI-1 INHIBITOR

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL274139A (en) *
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents

Also Published As

Publication number Publication date
SE363818B (en) 1974-02-04
AR197075A1 (en) 1974-03-15
BE737417A (en) 1970-02-13
NO137824C (en) 1978-05-03
DK145778C (en) 1983-08-22
IE33573B1 (en) 1974-08-21
JPS5145586B1 (en) 1976-12-04
DE1941625B2 (en) 1981-05-07
NO137824B (en) 1978-01-23
NL7905644A (en) 1979-11-30
FI54099B (en) 1978-06-30
IL32825A (en) 1973-03-30
ES390805A1 (en) 1974-03-16
NO139127C (en) 1979-01-10
IL32825A0 (en) 1969-11-12
IE33573L (en) 1970-02-15
DE1941625A1 (en) 1970-11-19
NO773495L (en) 1970-02-16
GB1264340A (en) 1972-02-23
JPS5144938B1 (en) 1976-12-01
DK145778B (en) 1983-02-28
FI54099C (en) 1978-10-10
DE1941625C3 (en) 1982-03-18
CY743A (en) 1974-04-30
NL155820B (en) 1978-02-15
CH527155A (en) 1972-08-31
ES370540A1 (en) 1971-07-01
SE398639B (en) 1978-01-09
LU59302A1 (en) 1970-05-18
NL6912504A (en) 1970-02-17

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