ES390805A1 - A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents
A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding)Info
- Publication number
- ES390805A1 ES390805A1 ES390805A ES390805A ES390805A1 ES 390805 A1 ES390805 A1 ES 390805A1 ES 390805 A ES390805 A ES 390805A ES 390805 A ES390805 A ES 390805A ES 390805 A1 ES390805 A1 ES 390805A1
- Authority
- ES
- Spain
- Prior art keywords
- alkyl
- methyl
- halo
- alkoxy
- preparation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
- C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/02—Ethers
- C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
- C07C43/295—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
- C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
- C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Novel compounds I in which X is O or S Y 1 is H, OH, NH 2 , NO 2 , halo, CH 3 , C 2 H 5 , 1-3C alkoxy, CH 3 SO 2 , CH 3 SO 2 NH, CF 3 , CH 9 CONH, CH 3 S or phenoxy R 1 is H, 1-5C alkyl, 2-5C alkenyl, 2-5C alkynyl or 3-6C cycloalkyl and when the moiety C 6 H 5 X is in the para position, n is 0 Y 2 is H, OH, halo, 1-5C alkyl or 1-3C alkoxy and both of Y 1 and Y 2 cannot be H when R 1 is H or CH 3 Z is (a) COOR 2 (R 2 is H, 1-5C alkyl, di-(1-3C alkyl) amino-(1-4C alkyl) or a metal or optionally substituted ammonium cation), (b) CON(R 3 ) 2 (R 3 is H, OH, 1-5C alkyl, cyclopropylmethyl or CH 2 COOR 2 ), (c) CH 2 OR 4 (R 4 is H, 1-5C alkyl, acetyl, propionyl, carbamyl, N-methyl or N,N-dimethyl-carbamyl or 3-6C alkoxyalkyl, or (d) tetrazolyl and when the moiety C 6 H 5 X is in the meta position, n is 0-3 Y 1 is as defined above, but is H when Y 2 is OH Y 2 is H, OH halo, methyl or ethyl, but is H when Y 1 is OH or 1-3C alkoxy Z is as defined above R 2 is 2-(3-phenyl-X-phenyl) propyl in addition to the values given above and Z may also be (e) when n is 1-3 N(R 5 ) 2 (R 5 =(1) H, 1-5C alkyl, cyclopropyl or cyclopropylmethyl or (2) acetyl, propionyl, or N- methyl or N,N-dimethylcarbamyl) and their salts are prepared by methods well known in the art for preparation of phenylalkanoic acids and their derivatives. Intermediates isolated are 3-phenoxy-acetophenone 4 - chloro - 5 - methyl - diphenyl ether 2 - chloro - 5 - methyl - diphenyl ether 4 - fluoro- 5 - methyl - diphenyl ether, 4 - methyl - 5 - phenoxyacetophenone, and 2 - methoxy - 5 - phenoxyacetophenone all prepared by an Ullman diaryl ether synthesis. Pharmaceutical compositions comprise a compound I together with a suitable excipient and are administered as analgesics and antiinflammatory agents.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US75280168A | 1968-08-15 | 1968-08-15 | |
US752800A US3649679A (en) | 1968-08-15 | 1968-08-15 | Substituted phenylalkanoic acid derivatives ii |
US828756A US3600437A (en) | 1969-05-28 | 1969-05-28 | Substituted phenylalkanoic acids and derivatives thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
ES390805A1 true ES390805A1 (en) | 1974-03-16 |
Family
ID=27419433
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES370540A Expired ES370540A1 (en) | 1968-08-15 | 1969-08-14 | A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding) |
ES390805A Expired ES390805A1 (en) | 1968-08-15 | 1971-04-30 | A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding) |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES370540A Expired ES370540A1 (en) | 1968-08-15 | 1969-08-14 | A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding) |
Country Status (16)
Country | Link |
---|---|
JP (2) | JPS5144938B1 (en) |
AR (1) | AR197075A1 (en) |
BE (1) | BE737417A (en) |
CH (1) | CH527155A (en) |
CY (1) | CY743A (en) |
DE (1) | DE1941625C3 (en) |
DK (1) | DK145778C (en) |
ES (2) | ES370540A1 (en) |
FI (1) | FI54099C (en) |
GB (1) | GB1264340A (en) |
IE (1) | IE33573B1 (en) |
IL (1) | IL32825A (en) |
LU (1) | LU59302A1 (en) |
NL (2) | NL155820B (en) |
NO (2) | NO137824C (en) |
SE (2) | SE363818B (en) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1307284A (en) * | 1970-03-16 | 1973-02-14 | Boots Co Ltd | 2-substituted phenyl propionic acids |
JPS52168775U (en) * | 1976-06-11 | 1977-12-21 | ||
JPS5327662U (en) * | 1976-08-14 | 1978-03-09 | ||
DE2950608A1 (en) * | 1978-12-29 | 1980-07-10 | Chinoin Gyogyszer Es Vegyeszet | METHOD FOR PRODUCING 2- (3-PHENOXY-PHENYL) -PROPIONIC ACID |
CA1195691A (en) * | 1980-01-28 | 1985-10-22 | Ikuo Ueda | Phenyl-alkanoic acid derivative and preparation thereof |
AU542420B2 (en) * | 1980-02-07 | 1985-02-21 | Richardson-Merrell Inc. | Anti-rhinovirus agents |
US4792560A (en) * | 1985-04-03 | 1988-12-20 | Rorer Pharmaceutical Corporation | Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways |
JPS6221294U (en) * | 1985-07-23 | 1987-02-07 | ||
DE3610892A1 (en) * | 1986-03-24 | 1987-10-08 | Hubert Kurz | Sectional sliding wall |
JPS6412403A (en) * | 1987-07-07 | 1989-01-17 | Kuroi Electric Ind Co | Light shielding panel |
DE3816450A1 (en) * | 1988-05-13 | 1989-11-16 | Hubert Kurz | Sectional sliding wall |
DE3905518A1 (en) * | 1989-02-23 | 1990-10-11 | Bayer Ag | SUBSTITUTED PHENOXYPHENYL PROPIONIC ACID DERIVATIVES |
WO1993022269A1 (en) * | 1992-05-01 | 1993-11-11 | Pfizer Inc. | Process for the preparation of 3(s)-methylheptanoic acid and intermediates therefor |
SE0103325D0 (en) * | 2001-10-04 | 2001-10-04 | Astrazeneca Ab | Novel compounds |
EP2272817A4 (en) * | 2008-04-11 | 2011-12-14 | Inst Med Molecular Design Inc | Pai-1 inhibitor |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL274139A (en) * | ||||
GB971700A (en) * | 1961-02-02 | 1964-09-30 | Boots Pure Drug Co Ltd | Anti-Inflammatory Agents |
-
1969
- 1969-08-12 SE SE11181/69A patent/SE363818B/xx unknown
- 1969-08-13 BE BE737417D patent/BE737417A/xx not_active IP Right Cessation
- 1969-08-14 DK DK436169A patent/DK145778C/en active
- 1969-08-14 IL IL32825A patent/IL32825A/en unknown
- 1969-08-14 ES ES370540A patent/ES370540A1/en not_active Expired
- 1969-08-15 FI FI2392/69A patent/FI54099C/en active
- 1969-08-15 NL NL6912504.A patent/NL155820B/en not_active IP Right Cessation
- 1969-08-15 IE IE1161/69A patent/IE33573B1/en unknown
- 1969-08-15 CH CH1241369A patent/CH527155A/en not_active IP Right Cessation
- 1969-08-15 JP JP44064690A patent/JPS5144938B1/ja active Pending
- 1969-08-15 GB GB4097169A patent/GB1264340A/en not_active Expired
- 1969-08-16 DE DE1941625A patent/DE1941625C3/en not_active Expired
- 1969-08-18 LU LU59302D patent/LU59302A1/xx unknown
-
1970
- 1970-09-01 AR AR230992A patent/AR197075A1/en active
-
1971
- 1971-04-30 ES ES390805A patent/ES390805A1/en not_active Expired
-
1972
- 1972-06-16 SE SE7207958A patent/SE398639B/en unknown
-
1973
- 1973-04-19 JP JP48044630A patent/JPS5145586B1/ja active Pending
- 1973-09-25 NO NO3760/73A patent/NO137824C/en unknown
-
1974
- 1974-04-30 CY CY74374A patent/CY743A/en unknown
-
1977
- 1977-10-12 NO NO773495A patent/NO139127C/en unknown
-
1979
- 1979-07-20 NL NL7905644AA patent/NL7905644A/en not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
DK145778C (en) | 1983-08-22 |
NO139127C (en) | 1979-01-10 |
NO139127B (en) | 1978-10-02 |
NL6912504A (en) | 1970-02-17 |
ES370540A1 (en) | 1971-07-01 |
NO137824B (en) | 1978-01-23 |
IE33573B1 (en) | 1974-08-21 |
DE1941625A1 (en) | 1970-11-19 |
NL155820B (en) | 1978-02-15 |
GB1264340A (en) | 1972-02-23 |
IE33573L (en) | 1970-02-15 |
NO137824C (en) | 1978-05-03 |
IL32825A (en) | 1973-03-30 |
DE1941625B2 (en) | 1981-05-07 |
DK145778B (en) | 1983-02-28 |
CH527155A (en) | 1972-08-31 |
BE737417A (en) | 1970-02-13 |
AR197075A1 (en) | 1974-03-15 |
LU59302A1 (en) | 1970-05-18 |
JPS5144938B1 (en) | 1976-12-01 |
FI54099C (en) | 1978-10-10 |
SE398639B (en) | 1978-01-09 |
NO773495L (en) | 1970-02-16 |
FI54099B (en) | 1978-06-30 |
NL7905644A (en) | 1979-11-30 |
DE1941625C3 (en) | 1982-03-18 |
SE363818B (en) | 1974-02-04 |
JPS5145586B1 (en) | 1976-12-04 |
IL32825A0 (en) | 1969-11-12 |
CY743A (en) | 1974-04-30 |
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