ES370540A1 - A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding) - Google Patents

A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding)

Info

Publication number
ES370540A1
ES370540A1 ES370540A ES370540A ES370540A1 ES 370540 A1 ES370540 A1 ES 370540A1 ES 370540 A ES370540 A ES 370540A ES 370540 A ES370540 A ES 370540A ES 370540 A1 ES370540 A1 ES 370540A1
Authority
ES
Spain
Prior art keywords
alkyl
methyl
halo
alkoxy
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES370540A
Other languages
Spanish (es)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Eli Lilly and Co
Original Assignee
Eli Lilly and Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US752800A external-priority patent/US3649679A/en
Priority claimed from US828756A external-priority patent/US3600437A/en
Application filed by Eli Lilly and Co filed Critical Eli Lilly and Co
Publication of ES370540A1 publication Critical patent/ES370540A1/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
    • C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D257/04—Five-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
    • C07C275/20—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton
    • C07C275/24—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/257—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings
    • C07C43/295—Ethers having an ether-oxygen atom bound to carbon atoms both belonging to six-membered aromatic rings containing hydroxy or O-metal groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
    • C07C45/67—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton
    • C07C45/68—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
    • C07C45/70—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form
    • C07C45/71—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by reaction with functional groups containing oxygen only in singly bound form being hydroxy groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Novel compounds I in which X is O or S Y 1 is H, OH, NH 2 , NO 2 , halo, CH 3 , C 2 H 5 , 1-3C alkoxy, CH 3 SO 2 , CH 3 SO 2 NH, CF 3 , CH 9 CONH, CH 3 S or phenoxy R 1 is H, 1-5C alkyl, 2-5C alkenyl, 2-5C alkynyl or 3-6C cycloalkyl and when the moiety C 6 H 5 X is in the para position, n is 0 Y 2 is H, OH, halo, 1-5C alkyl or 1-3C alkoxy and both of Y 1 and Y 2 cannot be H when R 1 is H or CH 3 Z is (a) COOR 2 (R 2 is H, 1-5C alkyl, di-(1-3C alkyl) amino-(1-4C alkyl) or a metal or optionally substituted ammonium cation), (b) CON(R 3 ) 2 (R 3 is H, OH, 1-5C alkyl, cyclopropylmethyl or CH 2 COOR 2 ), (c) CH 2 OR 4 (R 4 is H, 1-5C alkyl, acetyl, propionyl, carbamyl, N-methyl or N,N-dimethyl-carbamyl or 3-6C alkoxyalkyl, or (d) tetrazolyl and when the moiety C 6 H 5 X is in the meta position, n is 0-3 Y 1 is as defined above, but is H when Y 2 is OH Y 2 is H, OH halo, methyl or ethyl, but is H when Y 1 is OH or 1-3C alkoxy Z is as defined above R 2 is 2-(3-phenyl-X-phenyl) propyl in addition to the values given above and Z may also be (e) when n is 1-3 N(R 5 ) 2 (R 5 =(1) H, 1-5C alkyl, cyclopropyl or cyclopropylmethyl or (2) acetyl, propionyl, or N- methyl or N,N-dimethylcarbamyl) and their salts are prepared by methods well known in the art for preparation of phenylalkanoic acids and their derivatives. Intermediates isolated are 3-phenoxy-acetophenone 4 - chloro - 5 - methyl - diphenyl ether 2 - chloro - 5 - methyl - diphenyl ether 4 - fluoro- 5 - methyl - diphenyl ether, 4 - methyl - 5 - phenoxyacetophenone, and 2 - methoxy - 5 - phenoxyacetophenone all prepared by an Ullman diaryl ether synthesis. Pharmaceutical compositions comprise a compound I together with a suitable excipient and are administered as analgesics and antiinflammatory agents.
ES370540A 1968-08-15 1969-08-14 A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding) Expired ES370540A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75280168A 1968-08-15 1968-08-15
US752800A US3649679A (en) 1968-08-15 1968-08-15 Substituted phenylalkanoic acid derivatives ii
US828756A US3600437A (en) 1969-05-28 1969-05-28 Substituted phenylalkanoic acids and derivatives thereof

Publications (1)

Publication Number Publication Date
ES370540A1 true ES370540A1 (en) 1971-07-01

Family

ID=27419433

Family Applications (2)

Application Number Title Priority Date Filing Date
ES370540A Expired ES370540A1 (en) 1968-08-15 1969-08-14 A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding)
ES390805A Expired ES390805A1 (en) 1968-08-15 1971-04-30 A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding)

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES390805A Expired ES390805A1 (en) 1968-08-15 1971-04-30 A procedure for the preparation of substitute phenylalcanic compounds. (Machine-translation by Google Translate, not legally binding)

Country Status (16)

Country Link
JP (2) JPS5144938B1 (en)
AR (1) AR197075A1 (en)
BE (1) BE737417A (en)
CH (1) CH527155A (en)
CY (1) CY743A (en)
DE (1) DE1941625C3 (en)
DK (1) DK145778C (en)
ES (2) ES370540A1 (en)
FI (1) FI54099C (en)
GB (1) GB1264340A (en)
IE (1) IE33573B1 (en)
IL (1) IL32825A (en)
LU (1) LU59302A1 (en)
NL (2) NL155820B (en)
NO (2) NO137824C (en)
SE (2) SE363818B (en)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1307284A (en) * 1970-03-16 1973-02-14 Boots Co Ltd 2-substituted phenyl propionic acids
JPS52168775U (en) * 1976-06-11 1977-12-21
JPS5327662U (en) * 1976-08-14 1978-03-09
DE2950608A1 (en) * 1978-12-29 1980-07-10 Chinoin Gyogyszer Es Vegyeszet METHOD FOR PRODUCING 2- (3-PHENOXY-PHENYL) -PROPIONIC ACID
CA1195691A (en) * 1980-01-28 1985-10-22 Ikuo Ueda Phenyl-alkanoic acid derivative and preparation thereof
AU542420B2 (en) * 1980-02-07 1985-02-21 Richardson-Merrell Inc. Anti-rhinovirus agents
US4792560A (en) * 1985-04-03 1988-12-20 Rorer Pharmaceutical Corporation Quinoline hydroxamates and their use as modulators of arachidonic acid metabolic pathways
JPS6221294U (en) * 1985-07-23 1987-02-07
DE3610892A1 (en) * 1986-03-24 1987-10-08 Hubert Kurz Sectional sliding wall
JPS6412403A (en) * 1987-07-07 1989-01-17 Kuroi Electric Ind Co Light shielding panel
DE3816450A1 (en) * 1988-05-13 1989-11-16 Hubert Kurz Sectional sliding wall
DE3905518A1 (en) * 1989-02-23 1990-10-11 Bayer Ag SUBSTITUTED PHENOXYPHENYL PROPIONIC ACID DERIVATIVES
WO1993022269A1 (en) * 1992-05-01 1993-11-11 Pfizer Inc. Process for the preparation of 3(s)-methylheptanoic acid and intermediates therefor
SE0103325D0 (en) * 2001-10-04 2001-10-04 Astrazeneca Ab Novel compounds
EP2272817A4 (en) * 2008-04-11 2011-12-14 Inst Med Molecular Design Inc Pai-1 inhibitor

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL274139A (en) *
GB971700A (en) * 1961-02-02 1964-09-30 Boots Pure Drug Co Ltd Anti-Inflammatory Agents

Also Published As

Publication number Publication date
DK145778C (en) 1983-08-22
NO139127C (en) 1979-01-10
NO139127B (en) 1978-10-02
NL6912504A (en) 1970-02-17
NO137824B (en) 1978-01-23
IE33573B1 (en) 1974-08-21
DE1941625A1 (en) 1970-11-19
NL155820B (en) 1978-02-15
GB1264340A (en) 1972-02-23
IE33573L (en) 1970-02-15
NO137824C (en) 1978-05-03
IL32825A (en) 1973-03-30
DE1941625B2 (en) 1981-05-07
DK145778B (en) 1983-02-28
CH527155A (en) 1972-08-31
BE737417A (en) 1970-02-13
AR197075A1 (en) 1974-03-15
LU59302A1 (en) 1970-05-18
JPS5144938B1 (en) 1976-12-01
FI54099C (en) 1978-10-10
SE398639B (en) 1978-01-09
NO773495L (en) 1970-02-16
FI54099B (en) 1978-06-30
ES390805A1 (en) 1974-03-16
NL7905644A (en) 1979-11-30
DE1941625C3 (en) 1982-03-18
SE363818B (en) 1974-02-04
JPS5145586B1 (en) 1976-12-04
IL32825A0 (en) 1969-11-12
CY743A (en) 1974-04-30

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