JP7100454B2 - 装着型血液潅流デバイス - Google Patents
装着型血液潅流デバイス Download PDFInfo
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- JP7100454B2 JP7100454B2 JP2017515161A JP2017515161A JP7100454B2 JP 7100454 B2 JP7100454 B2 JP 7100454B2 JP 2017515161 A JP2017515161 A JP 2017515161A JP 2017515161 A JP2017515161 A JP 2017515161A JP 7100454 B2 JP7100454 B2 JP 7100454B2
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3679—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits by absorption
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36225—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit with blood pumping means or components thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3622—Extra-corporeal blood circuits with a cassette forming partially or totally the blood circuit
- A61M1/36226—Constructional details of cassettes, e.g. specific details on material or shape
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
- A61M1/36—Other treatment of blood in a by-pass of the natural circulatory system, e.g. temperature adaptation, irradiation ; Extra-corporeal blood circuits
- A61M1/3621—Extra-corporeal blood circuits
- A61M1/3653—Interfaces between patient blood circulation and extra-corporal blood circuit
- A61M1/3659—Cannulae pertaining to extracorporeal circulation
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/10—Location thereof with respect to the patient's body
- A61M60/104—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body
- A61M60/109—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems
- A61M60/113—Extracorporeal pumps, i.e. the blood being pumped outside the patient's body incorporated within extracorporeal blood circuits or systems in other functional devices, e.g. dialysers or heart-lung machines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
- A61M60/232—Centrifugal pumps
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/30—Medical purposes thereof other than the enhancement of the cardiac output
- A61M60/36—Medical purposes thereof other than the enhancement of the cardiac output for specific blood treatment; for specific therapy
- A61M60/37—Haemodialysis, haemofiltration or diafiltration
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J20/00—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof
- B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/0057—Special media to be introduced, removed or treated retained by adsorption
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/04—Liquids
- A61M2202/0468—Liquids non-physiological
- A61M2202/049—Toxic
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2202/00—Special media to be introduced, removed or treated
- A61M2202/20—Pathogenic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/12—General characteristics of the apparatus with interchangeable cassettes forming partially or totally the fluid circuit
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8206—Internal energy supply devices battery-operated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2209/00—Ancillary equipment
- A61M2209/08—Supports for equipment
- A61M2209/088—Supports for equipment on the body
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/20—Type thereof
- A61M60/205—Non-positive displacement blood pumps
- A61M60/216—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller
- A61M60/226—Non-positive displacement blood pumps including a rotating member acting on the blood, e.g. impeller the blood flow through the rotating member having mainly radial components
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M60/00—Blood pumps; Devices for mechanical circulatory actuation; Balloon pumps for circulatory assistance
- A61M60/80—Constructional details other than related to driving
- A61M60/845—Constructional details other than related to driving of extracorporeal blood pumps
- A61M60/847—Constructional details other than related to driving of extracorporeal blood pumps arranged in a cassette
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2220/00—Aspects relating to sorbent materials
- B01J2220/50—Aspects relating to the use of sorbent or filter aid materials
- B01J2220/62—In a cartridge
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Mechanical Engineering (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Analytical Chemistry (AREA)
- Urology & Nephrology (AREA)
- Pulmonology (AREA)
- Organic Chemistry (AREA)
- External Artificial Organs (AREA)
Description
本出願は、2015年2月17日に出願された米国特許仮出願第62/117108号明細書、2014年9月22日に出願された米国特許仮出願第62/053706号明細書の利益を主張するものであり、該仮出願は、参照により本明細書に全体として全ての目的に対し組み込まれる。
I.定義
II.実施形態の詳細な説明
A. 吸着媒体
B.使用方法
III.実施例
デュアルルーメンニードルによる静脈アクセスを要する、前記ユニットと一体化可能な小型再使用可能バッテリー作動ポンプ、本発明のフィルターを介した血流生成に血圧差を使用する動脈から静脈への血流(任意の昇圧剤使用に伴う)、及び前記血液チューブに挿入した吸着剤「フィルター」を有する標準血液バッグの使用によるシングルニードル静脈ラインを介した治療。(血液採取時の低流速は、より速い流速での再注入により相殺されるが、血圧低下に対して昇圧剤を使用可能である。)
Claims (6)
- 毒素及び/又は病原体に感染した個体の血液から前記毒素及び/又は病原体を体外で除去するための、ポンプを伴わない携帯型及び/又は装着型デバイスであって、前記デバイスは:
フィルターを有する、シングルニードル静脈ラインチューブを伴う血液バッグを備え、前記フィルターは吸着媒体を備え、かつ前記静脈ラインチューブに挿入されており、
前記吸着媒体は、前記毒素及び/又は病原体に対する結合親和性又は結合部位を持つ少なくとも一つの多糖類吸着剤を面上に有する高表面積の固体基板であり、血流が前記吸着媒体に接触すると、前記毒素及び/又は病原体が前記少なくとも一つの多糖類吸着剤上の結合部位に結合して血液から分離される、前記携帯型及び/又は装着型デバイス。 - 前記少なくとも一つの多糖類吸着剤が、ヘパリン、ヘパラン硫酸、ヒアルロン酸、シアル酸、マンノース配列を有する炭水化物、キトサン及びそれらの組み合わせから成る群から選択される、請求項1に記載の携帯型及び/又は装着型デバイス。
- 前記固体基板が複数の硬質ポリマービーズを備える、請求項1に記載の携帯型及び/又は装着型デバイス。
- 前記固体基板が、一つ又は複数の中空ファイバーを備える、請求項1に記載の携帯型及び/又は装着型デバイス。
- 前記デバイスが装着型である、請求項1に記載の携帯型及び/又は装着型デバイス。
- 請求項1に記載の前記デバイス及び取扱説明書を備えるキット。
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462053706P | 2014-09-22 | 2014-09-22 | |
US62/053,706 | 2014-09-22 | ||
US201562117108P | 2015-02-17 | 2015-02-17 | |
US62/117,108 | 2015-02-17 | ||
PCT/US2015/051239 WO2016048901A1 (en) | 2014-09-22 | 2015-09-21 | Wearable hemoperfusion device |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2020177477A Division JP2021035511A (ja) | 2014-09-22 | 2020-10-22 | 装着型血液潅流デバイス |
Publications (3)
Publication Number | Publication Date |
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JP2017528253A JP2017528253A (ja) | 2017-09-28 |
JP2017528253A5 JP2017528253A5 (ja) | 2018-10-18 |
JP7100454B2 true JP7100454B2 (ja) | 2022-07-13 |
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ID=55524778
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JP2017515161A Active JP7100454B2 (ja) | 2014-09-22 | 2015-09-21 | 装着型血液潅流デバイス |
JP2020177477A Pending JP2021035511A (ja) | 2014-09-22 | 2020-10-22 | 装着型血液潅流デバイス |
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JP2020177477A Pending JP2021035511A (ja) | 2014-09-22 | 2020-10-22 | 装着型血液潅流デバイス |
Country Status (11)
Country | Link |
---|---|
US (2) | US10857283B2 (ja) |
EP (1) | EP3197342B1 (ja) |
JP (2) | JP7100454B2 (ja) |
KR (1) | KR20170060062A (ja) |
CN (1) | CN106714669B (ja) |
AU (1) | AU2015321601B2 (ja) |
BR (1) | BR112017004059A2 (ja) |
CA (1) | CA2959975A1 (ja) |
ES (1) | ES2821698T3 (ja) |
MX (1) | MX2017003723A (ja) |
WO (1) | WO2016048901A1 (ja) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2021035511A (ja) * | 2014-09-22 | 2021-03-04 | エクスセラ メディカル コーポレイション | 装着型血液潅流デバイス |
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WO2007069983A1 (en) | 2005-12-13 | 2007-06-21 | Exthera Ab | Method for extracorporeal removal of a pathogenic microbe, an inflammatory cell or an inflammatory protein from blood |
WO2008155683A1 (en) | 2007-06-18 | 2008-12-24 | Firmenich Sa | Malodor counteracting compositions and method for their use |
US8758286B2 (en) | 2009-12-01 | 2014-06-24 | Exthera Medical Corporation | Method for removing cytokines from blood with surface immobilized polysaccharides |
WO2012112724A1 (en) | 2011-02-15 | 2012-08-23 | Exthera Medical, Llc | Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines |
ES2647577T3 (es) | 2012-06-13 | 2017-12-22 | Exthera Medical Corporation | Uso de heparina y carbohidratos para tratar el cáncer |
CN110772677A (zh) | 2013-06-24 | 2020-02-11 | 艾克塞拉医疗公司 | 含有涂覆甘露糖的基质的血液过滤系统 |
WO2015069942A1 (en) | 2013-11-08 | 2015-05-14 | Exthera Medical Corporation | Methods for diagnosing infectious diseases using adsorption media |
JP2017513636A (ja) | 2014-04-24 | 2017-06-01 | エクスセラ メディカル コーポレイション | 高流量を用いて血液から細菌を除去するための方法 |
US11911551B2 (en) | 2016-03-02 | 2024-02-27 | Exthera Medical Corporation | Method for treating drug intoxication |
WO2017151797A1 (en) * | 2016-03-02 | 2017-09-08 | Exthera Medical Corporation | Method for treating drug intoxication |
DE102016208024A1 (de) * | 2016-05-10 | 2017-11-16 | B. Braun Avitum Ag | Adsorbermaterial zur Prävention oder Behandlung von schweren Verläufen von Infektionskrankheiten |
JP2022534191A (ja) * | 2019-05-16 | 2022-07-28 | エクスセラ メディカル コーポレイション | 内皮糖衣構造を調節するための方法 |
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US20140012097A1 (en) | 2011-02-15 | 2014-01-09 | Exthera Medical Corporation | Device and method for removal of blood-borne pathogens, toxins and inflammatory cytokines |
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US20200338256A1 (en) | 2020-10-29 |
EP3197342A4 (en) | 2018-10-31 |
EP3197342B1 (en) | 2020-08-05 |
CA2959975A1 (en) | 2016-03-31 |
KR20170060062A (ko) | 2017-05-31 |
BR112017004059A2 (pt) | 2017-12-05 |
CN106714669B (zh) | 2021-05-14 |
WO2016048901A1 (en) | 2016-03-31 |
US20160082177A1 (en) | 2016-03-24 |
ES2821698T3 (es) | 2021-04-27 |
JP2017528253A (ja) | 2017-09-28 |
JP2021035511A (ja) | 2021-03-04 |
AU2015321601B2 (en) | 2020-04-23 |
EP3197342A1 (en) | 2017-08-02 |
US10857283B2 (en) | 2020-12-08 |
CN106714669A (zh) | 2017-05-24 |
MX2017003723A (es) | 2017-06-30 |
AU2015321601A1 (en) | 2017-04-06 |
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