ES8500226A1 - Un procedimiento de preparacion de imino-2-pirrolidinas. - Google Patents

Un procedimiento de preparacion de imino-2-pirrolidinas.

Info

Publication number
ES8500226A1
ES8500226A1 ES529223A ES529223A ES8500226A1 ES 8500226 A1 ES8500226 A1 ES 8500226A1 ES 529223 A ES529223 A ES 529223A ES 529223 A ES529223 A ES 529223A ES 8500226 A1 ES8500226 A1 ES 8500226A1
Authority
ES
Spain
Prior art keywords
pyrrolidines
imino
preparation
therapeutical use
therapeutical
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES529223A
Other languages
English (en)
Other versions
ES529223A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Laboratoires Jacques Logeais SA
Original Assignee
Laboratoires Jacques Logeais SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratoires Jacques Logeais SA filed Critical Laboratoires Jacques Logeais SA
Publication of ES8500226A1 publication Critical patent/ES8500226A1/es
Publication of ES529223A0 publication Critical patent/ES529223A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms
    • C07D207/267—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to the ring nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Diabetes (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE IMINO-2-PIRROLIDINAS DE FORMULA GENERAL (I), Y SUS SALES DE ADICION DE ACIDOS FARMACEUTICAMENTE ACEPTABLES.COMPRENDE LAS SIGUIENTES OPERACIONES: PRIMERA, SE EFECTUA UNA ALQUILACION DE UNA PIRROLIDINONA-2; SEGUNDA, LA PIRROLIDINONA-2 OBTENIDA ANTERIORMENTE SE CONVIERTE EN UNA ALCOXI-2-Q2-PIRROLINA, DE FORMULA (II); Y POR ULTIMO, EL COMPUESTO DE FORMULA (II) SE HACE REACCIONAR CON UNA AMINA DE FORMULA: RL-NH2.DE APLICACION EN TERAPEUTICA DE TIPO CARDIOVASCULAR.
ES529223A 1983-01-28 1984-01-27 Un procedimiento de preparacion de imino-2-pirrolidinas. Granted ES529223A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR8301360A FR2540109B1 (fr) 1983-01-28 1983-01-28 Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique

Publications (2)

Publication Number Publication Date
ES8500226A1 true ES8500226A1 (es) 1984-10-01
ES529223A0 ES529223A0 (es) 1984-10-01

Family

ID=9285402

Family Applications (1)

Application Number Title Priority Date Filing Date
ES529223A Granted ES529223A0 (es) 1983-01-28 1984-01-27 Un procedimiento de preparacion de imino-2-pirrolidinas.

Country Status (15)

Country Link
US (2) US4556674A (es)
EP (1) EP0117771B1 (es)
JP (1) JPS59141558A (es)
AT (1) ATE30719T1 (es)
AU (1) AU562183B2 (es)
CA (1) CA1223597A (es)
DE (1) DE3467346D1 (es)
DK (1) DK39084A (es)
ES (1) ES529223A0 (es)
FI (1) FI77021C (es)
FR (1) FR2540109B1 (es)
HU (1) HU189402B (es)
IE (1) IE56547B1 (es)
OA (1) OA07642A (es)
ZA (1) ZA84562B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2540109B1 (fr) * 1983-01-28 1985-08-30 Logeais Labor Jacques Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique
RU2136661C1 (ru) * 1993-10-21 1999-09-10 Джи Ди Сирл энд Ко. Амидинопроизводные, их применение и фармацевтическая композиция
WO1996033175A1 (en) * 1995-04-20 1996-10-24 G.D. Searle & Co. Cyclic amidino agents useful as nitric oxide synthase inhibitors
US5981556A (en) * 1997-07-22 1999-11-09 G.D. Searle & Co. 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric oxide synthase inhibitors
US6489323B1 (en) 1998-06-10 2002-12-03 G.D. Searle & Co. Heterobicyclic and tricyclic nitric oxide synthase inhibitors
US6344473B1 (en) 2000-08-07 2002-02-05 G.D. Searle & Co. Imidazoles useful as nitric oxide synthase inhibitors
DE10214832A1 (de) * 2002-04-04 2003-10-16 Merck Patent Gmbh Phenylderivate 4
EP2077262A4 (en) * 2006-10-23 2011-12-28 Takeda Pharmaceutical IMINOPYRIDINE DERIVATIVES AND THEIR USE
US8481569B2 (en) * 2008-04-23 2013-07-09 Takeda Pharmaceutical Company Limited Iminopyridine derivatives and use thereof
NZ588909A (en) * 2008-04-23 2012-08-31 Takeda Pharmaceutical Iminopyridine derivatives and use thereof
US20110039892A1 (en) * 2008-04-23 2011-02-17 Takeda Pharmaceutical Company Limited Iminopyridine derivative and use thereof
US11465988B2 (en) 2018-12-15 2022-10-11 Natco Pharma Limited Process for the preparation of Tipiracil hydrochloride and intermediates thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1516776A (fr) * 1966-07-21 1968-03-15 Rhone Poulenc Sa Nouveaux dérivés du pyrrole et leur préparation
DE1770752A1 (de) * 1968-06-29 1971-11-25 Mcneilab Inc 2-Imino-methylenimine
GB1210848A (en) * 1968-07-01 1970-11-04 Mcneilab Inc 2-imino-methyleneimines
US3632604A (en) * 1970-04-09 1972-01-04 Sandoz Ag 2-substituted-4-phenyl and substituted phenyl-1-pyrrolines
US3887569A (en) * 1970-10-30 1975-06-03 Mcneilab Inc 2-Imino-piperidines
US3725435A (en) * 1970-11-05 1973-04-03 Mc Neil Labor Inc 2-imino-pyrrolidines
FR2186236B1 (es) * 1972-05-03 1975-08-01 Logeais Labor Jacques
US4055561A (en) * 1973-04-25 1977-10-25 Richardson-Merrell Inc. α-Alkylbenzyl lactamimides
NZ179580A (en) * 1974-12-30 1978-04-03 Mcneilab Inc 2-or 3-(w-tertiaryaminoalkyl)-thioindoles and the corresponding sulfinyl and sulfonyl analogs
FR2431494A1 (fr) * 1978-07-17 1980-02-15 Logeais Labor Jacques Nouveaux derives du benzofuranne, leur procede de preparation et leur application en therapeutique
FR2540109B1 (fr) * 1983-01-28 1985-08-30 Logeais Labor Jacques Imino-2 pyrrolidines, leur procede de preparation et leurs applications en therapeutique

Also Published As

Publication number Publication date
FI840322A (fi) 1984-07-29
FI77021B (fi) 1988-09-30
EP0117771A1 (fr) 1984-09-05
ES529223A0 (es) 1984-10-01
US4699918A (en) 1987-10-13
AU562183B2 (en) 1987-06-04
US4556674A (en) 1985-12-03
ZA84562B (en) 1984-09-26
FI77021C (fi) 1989-01-10
DE3467346D1 (en) 1987-12-17
IE840085L (en) 1984-07-28
FR2540109A1 (fr) 1984-08-03
HU189402B (en) 1986-07-28
JPS59141558A (ja) 1984-08-14
EP0117771B1 (fr) 1987-11-11
CA1223597A (en) 1987-06-30
AU2371184A (en) 1984-08-02
FI840322A0 (fi) 1984-01-26
DK39084D0 (da) 1984-01-27
FR2540109B1 (fr) 1985-08-30
OA07642A (fr) 1985-05-23
ATE30719T1 (de) 1987-11-15
DK39084A (da) 1984-07-29
IE56547B1 (en) 1991-08-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19960603