EA033084B1 - Бигетероарильные соединения и их применения - Google Patents

Бигетероарильные соединения и их применения

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Publication number
EA033084B1
EA033084B1 EA201792471A EA201792471A EA033084B1 EA 033084 B1 EA033084 B1 EA 033084B1 EA 201792471 A EA201792471 A EA 201792471A EA 201792471 A EA201792471 A EA 201792471A EA 033084 B1 EA033084 B1 EA 033084B1
Authority
EA
Eurasian Patent Office
Prior art keywords
compounds
biheteroaryl compounds
biheteroaryl
formula
diseases
Prior art date
Application number
EA201792471A
Other languages
English (en)
Other versions
EA201792471A1 (ru
Inventor
Кевин С. Чэнь
Литин Дун
Энтони Эстрада
Пол Гиббонс
Малкольм Хуэстис
Терри Келлар
Вэнь Лю
Джозеф П. Лиссикатос
Чаню Ма
Алан Оливеро
Снахель Патель
Даниэль Шор
Майкл Сиу
Original Assignee
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг
Publication of EA201792471A1 publication Critical patent/EA201792471A1/ru
Publication of EA033084B1 publication Critical patent/EA033084B1/ru

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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/4545—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring hetero atom, e.g. pipamperone, anabasine
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  • Urology & Nephrology (AREA)
  • Anesthesiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)

Abstract

В настоящем изобретении предложены соединения формулы I-I и их воплощения и соли для лечения заболеваний (например, нейродегенеративных заболеваний). Все переменные R, R, R, X, X, A и Cy в формуле I-I имеют значение, определенное в данном документе.
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