CN110051420A - Low temperature sacculus ablation system - Google Patents

Low temperature sacculus ablation system Download PDF

Info

Publication number
CN110051420A
CN110051420A CN201910265462.9A CN201910265462A CN110051420A CN 110051420 A CN110051420 A CN 110051420A CN 201910265462 A CN201910265462 A CN 201910265462A CN 110051420 A CN110051420 A CN 110051420A
Authority
CN
China
Prior art keywords
sacculus
cryogenic ablation
refrigerant
connector
catheter shaft
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CN201910265462.9A
Other languages
Chinese (zh)
Other versions
CN110051420B (en
Inventor
P·P·吴
T·D·霍兰德
C·A·艾科
R·S·威廉姆斯
G·F·W·纽维尔
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
PENTAX CORP
Original Assignee
PENTAX CORP
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by PENTAX CORP filed Critical PENTAX CORP
Publication of CN110051420A publication Critical patent/CN110051420A/en
Application granted granted Critical
Publication of CN110051420B publication Critical patent/CN110051420B/en
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/04—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating
    • A61B18/12—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by heating by passing a current through the tissue to be heated, e.g. high-frequency current
    • A61B18/14—Probes or electrodes therefor
    • A61B18/1492—Probes or electrodes therefor having a flexible, catheter-like structure, e.g. for heart ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00005—Cooling or heating of the probe or tissue immediately surrounding the probe
    • A61B2018/00011—Cooling or heating of the probe or tissue immediately surrounding the probe with fluids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00184—Moving parts
    • A61B2018/00196—Moving parts reciprocating lengthwise
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00053—Mechanical features of the instrument of device
    • A61B2018/00214—Expandable means emitting energy, e.g. by elements carried thereon
    • A61B2018/0022—Balloons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A61B2018/00488—Esophagus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00315—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for treatment of particular body parts
    • A61B2018/00482—Digestive system
    • A61B2018/00494—Stomach, intestines or bowel
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00571—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body for achieving a particular surgical effect
    • A61B2018/00577—Ablation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00642—Sensing and controlling the application of energy with feedback, i.e. closed loop control
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00696—Controlled or regulated parameters
    • A61B2018/00744—Fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00773—Sensed parameters
    • A61B2018/00863—Fluid flow
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00636—Sensing and controlling the application of energy
    • A61B2018/00898—Alarms or notifications created in response to an abnormal condition
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B2018/00982—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body combined with or comprising means for visual or photographic inspections inside the body, e.g. endoscopes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0212—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques using an instrument inserted into a body lumen, e.g. catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/02—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by cooling, e.g. cryogenic techniques
    • A61B2018/0231—Characteristics of handpieces or probes
    • A61B2018/0262—Characteristics of handpieces or probes using a circulating cryogenic fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B90/00—Instruments, implements or accessories specially adapted for surgery or diagnosis and not covered by any of the groups A61B1/00 - A61B50/00, e.g. for luxation treatment or for protecting wound edges
    • A61B90/90—Identification means for patients or instruments, e.g. tags
    • A61B90/98—Identification means for patients or instruments, e.g. tags using electromagnetic means, e.g. transponders

Landscapes

  • Health & Medical Sciences (AREA)
  • Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medical Informatics (AREA)
  • Otolaryngology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Physics & Mathematics (AREA)
  • Plasma & Fusion (AREA)
  • Cardiology (AREA)
  • Media Introduction/Drainage Providing Device (AREA)
  • Surgical Instruments (AREA)
  • Thermotherapy And Cooling Therapy Devices (AREA)

Abstract

Embodiment of the disclosure is related to a kind of low temperature sacculus ablation system.Cryogenic ablation component includes that cryogenic ablation conduit cryogenic ablation conduit (12) includes: catheter shaft (16)；The sacculus (24) and connector (22) being respectively at catheter shaft proximal end (18) and distal end (20)；Conveying pipe of refrigerant component, it includes can be in the conveying pipe of refrigerant (30) of the intracavitary translation of catheter shaft and with the refrigerant delivery element (36,44) positioned at the outlet (40) of balloon interior, the outlet guides refrigerant against sacculus at axially different position when it is translated outward.Low temperature sacculus ablation system (10) includes cryogenic ablation conduit, catheter coupling (78), linear movement component (120) and connecting line (118) with connector cooperation, connecting line is fluidly coupled with refrigerant fluid source (100), for supplying refrigerant fluid to conveying pipe of refrigerant.

Description

Low temperature sacculus ablation system
It is on May 12nd, 2016 that the application, which is the applying date, application No. is 201680024610.2, entitled " low temperature The divisional application of the patent application of sacculus ablation system ".
Background technique
There is the chamber of such as esophagus and colon etc in entire human body, can have be likely to become metaplasia or tumour at Point.It is generally desirable to remove or destroy these undesired tissues.It is expected that tissue removal and/or ablation these situations first is that bar Lei Te (Barrett) esophagus, this is the precancerosis disease of general esophagus often associated with gastric reflux sick (GERD).Although GERD can To carry out medical management, once but GERD mitigate, Barrett esophagus will not be with regard to spontaneous regression.However, it has been shown that if bar Thunder spy's esophagus is ablated to, then normal esophagus liner can restore, to reduce the risk of esophagus carcinogenesis.
Various technologies are had evaluated to the ablation of this illness.These technologies include the low temperature directly sprayed via liquid nitrogen Ablation.It is related to foot of the conveying for ablation on macrolesion region with the challenge that cryogenic ablation handles the damage of these types Enough refrigerants.
Summary of the invention
One embodiment of cryogenic ablation conduit includes catheter shaft, inflatable and contractile sacculus, connector and refrigeration Agent conveys tube assembly.Catheter shaft has the conduit axocoel proximally and distally and between the ends extended.Sacculus, which is mounted to, leads The distal end of pipe axis, and there is the inner surface for limiting balloon interior.Connector is located at the proximal end of catheter shaft.In catheter shaft It is the pressure detecting pipe that the position towards catheter shaft distal end is extended to from connector.Conveying pipe of refrigerant component include delivery pipe, Plug and diffuser.A part of delivery pipe is located at the intracavitary of pressure detecting pipe, and is configured for relative to pressure detecting pipe The axial movement of length.The first end of delivery pipe is fixed to plug, and second end is fixed to diffuser.The axial fortune of delivery pipe It is dynamic that diffuser is caused to translate between the position close to catheter shaft distal end and the position close to balloon distal.The movement of diffuser by To the limitation of guide rail, which has the first end fixed to sacculus flexibility top and the second end in catheter shaft.Diffusion Device can be configured as towards the surface of balloon interior and guide refrigerant radially outward.During processing, refrigerant can expand The surface that balloon interior is outwardly directed to during dissipating device translation is conveyed.Compared to the stationary diffuser with identical refrigerant flow rate, This translation is so that refrigerant is transported to the greater portion of balloon interior.
By the way that connector is engaged with the connector connector for being fixed to Handleset shell, and by plug and handle group Plug connector engagement in part, cryogenic ablation conduit are connected to Handleset.Plug connector is configured as in Handleset It is interior to translate position relative to connector connector.This translation of plug connector causes the translation of conveying tube assembly.Linearly Moving parts are connected to plug connector.In embodiment, linear movement component includes being configured for the intracorporal plug of shell The driving screw and motor of the translation of connector.
Pressure detecting pipe in catheter shaft has the distal end for the air pressure sense channel being fluidically coupled in connector.Air pressure Sense channel is fluidically coupled to the pressure transducer in Handleset.Catheter shaft and pressure detecting pipe are fixed to connector, because The proximal end of this pressure detecting pipe and catheter shaft are concentric.In the proximate distal ends of catheter shaft, bracket is fixed to the inner wall and pressure of catheter shaft The outer wall of power detection pipe.The distal end of pressure detecting pipe is positioned as concentric with catheter shaft by the bracket.In the outer wall of pressure detecting pipe The chamber formed between the inner wall of catheter shaft forms discharge chamber.Bracket is configured as having minimum to the area of section of discharge chamber Influence.Discharge chamber allows discharge gas to release from the Exhaust assembly in Handleset from balloon interior by connector.Row The drain valve that component includes at least one user's control is put, can mechanically or electrically be activated with actuator.Exhaust assembly is also Including pressure reducing valve, pressure reducing valve is configured as being higher than the feelings of holding pressure (hold pressure) in the intracavitary pressure of pressure detecting It is opened under condition.
Handleset further includes refrigerant fluid source, flow control valve (such as solenoid valve), connecting line and controller.Control Device can be used for controlling the conveying of refrigerant and convey the translation of tube assembly.Controller includes being connected to flow control valve and linear fortune The circuit of dynamic component.When user, which starts, to be handled, controller can signal to flow control valve, to start the refrigerant from source Stream.Refrigerant from refrigerant fluid source, by flow control valve, by connecting line, by channel in plug connector, pass through Plug flowing, and flow into delivery pipe.Connecting line is configured with following shape, which allows connecting line to couple in plug Buckling and non-buckling during device translates, while keeping the consistent fluid channel for being used for refrigerant.
In embodiment, controller further includes the circuit for receiving input, which allows to determine the axial direction of conveying tube assembly Position, translational velocity, balloon pressure, the flow rate of refrigerant, the specification of conduit tube component.Input value can be used in Processing Algorithm Combination, to determine the control to flow control valve and linear electrical thermomechanical components.
Other features, aspects and advantages of the invention can in consideration of the drawings, detailed description and appended claims see Out.
Detailed description of the invention
Fig. 1 be include low temperature sacculus ablation member and endoscope one of ablation system exemplary simplified schematic it is overall View.
Fig. 2A shows the ablation catheter with the deflated sacculus upheld.
Fig. 2 B shows the ablation catheter with the sacculus that swells, and wherein diffuser is located in the intermediate region of sacculus.
Fig. 2 C shows the ablation catheter with the sacculus that swells, and wherein diffuser is located in the proximal end region of sacculus.
Fig. 3 A is the section view obtained along the line 3A-3A of Fig. 2A.
Fig. 4 A is the section view obtained along the line 4A-4A of Fig. 2A.
Fig. 4 B is the section view obtained along the line 4B-4B of Fig. 2A.
Fig. 5 A illustrates the external view of diffuser.
Fig. 5 B is the section of the diffuser of Fig. 5 A.
Fig. 5 C is the section for showing the diffuser of Fig. 5 A of flow path.
Fig. 6 A is the specific view of the sacculus of Fig. 2A.
Fig. 6 B is the specific section view of the sacculus of Fig. 2 B, wherein delivery pipe and diffuser is omitted in order to clear.
Fig. 6 C is the specific section view of the sacculus of Fig. 2 B.
Fig. 6 D is the specific section view of the sacculus of Fig. 2 C.
Fig. 7 A shows the external view of connector.
Fig. 7 B is the section view of the connector of Fig. 7 A.
Fig. 7 C is the section view of the diffuser for Fig. 7 B that delivery pipe is omitted and shows flow path.
Fig. 8 A is the section view of Handleset.
Fig. 8 B corresponds to the simplified schematic section of Fig. 8 A.
The specific section view of a part for the Handleset that Fig. 8 C is and connector is attached.
Fig. 8 D corresponds to the simplified schematic section of Fig. 8 C.
Fig. 8 E is the simplified schematic section of Handleset, and wherein plug connector is in and the plug position in Fig. 2A Corresponding position.
Fig. 8 F is the simplified schematic section of Handleset, and wherein plug connector is in and the plug position in Fig. 2 C Corresponding position.
Fig. 9 is simplified controller hardware architecture design figure.
Specific embodiment
Following description will be typically referenced to specific constructive embodiment and method.It is appreciated that be not intended to will be of the invention It is limited to specifically disclosed embodiments and methods, but is that the present invention can be used other features, element, method and embodiment and come Implement.Preferred embodiment is described to illustrate the present invention, and the range being not intended to limit the present invention, the scope of the present invention is by claim It limits.It will be appreciated by those of ordinary skill in the art that various equivalent variationss described below.Unless otherwise stated, in this Shen Please in, particular kind of relationship (such as parallel, alignment or in same plane) mean the particular kind of relationship in the limitation of manufacturing process, and And in manufacturing variation.When component is described as coupling, connect, contact or being in contact with each other, they are not needed physically each other It directly touches, unless particularly so description.Similar elements in each embodiment are usually referred to identical reference.
One embodiment of ablation system with improved refrigerant conveyor zones is shown in FIG. 1, and including interior Sight glass 1 and low temperature sacculus ablation member 10.Endoscope 1 can be it is conventional, and including with proximal end 5 and distal end 7 in peep Mirror tube 3, to define the access 8 extended between proximally and distally.
In embodiment, ablation member 10 includes being installed to Handleset 14 and disappearing from the low temperature that Handleset 14 extends Melt conduit 12.Fig. 2A, 2B and 2C show an implementation of the cryogenic ablation conduit in three kinds of states being discussed below Example.Conduit 12 includes the catheter shaft 16 with proximal end 18 and distal end 20.At proximal end 18 is that will be received in Handleset Connector 22 in 14.Positioned at distal end 20 at be can be because of the sacculus 24 that refrigerant swells, refrigerant is from Handleset 14 Refrigerant fluid source is fed to diffuser 36, and diffuser 36 is located in sacculus and fluidly couples with delivery pipe 30.Diffuser 36 translate in sacculus along guide rail 56, and guide rail 56 is fixed to the flexible top 48 of the far-end positioned at sacculus 24, this will be below It discusses in more detail.The translation of diffuser 36 is caused by the translation of plug 38, and plug 38 is fixed at the connector end of conduit 12 And it is fluidically coupled to delivery pipe 30,.
Catheter shaft 16 includes the round tube with circular central chamber.The length range of catheter shaft 16 can from 120 centimetres to 200 centimetres, and can have the overall diameter of range from 0.100 " to 0.138 ".Catheter shaft 16 is proximally secured to connector 22, and distal end is fixed to sacculus 24.
Fig. 3 A shows the section 3A-3A of Fig. 2A.As shown, being located in catheter shaft 16 is pressure detecting pipe 26.It leads Chamber between the inner wall of pipe axis and the outer wall of pressure detecting pipe defines that discharge chamber 28, discharge chamber 28 are used to come from balloon interior Gas pass through, to be discharged by connector 22 and Exhaust assembly 108, this be will be discussed in greater detail below.Pressure detecting pipe 26 include the circular central chamber for accommodating delivery pipe 30.Chamber limit between the inner wall of pressure detecting pipe 26 and the outer wall of delivery pipe 30 The pressure detecting chamber 32 for detecting the static pressure in sacculus 24 is determined.
Pressure detecting pipe 26 extends from the nearly sacculus end of catheter shaft 16 to connector 22.Pressure detecting pipe 26 is in catheter shaft 16 Distal end 20 nearby be fixed to catheter shaft 16, so as to concentric with conduit axocoel.As illustrated in figures 4 a and 4b, fixed device includes bracket 34, have and the minimum stream of discharge chamber is blocked.In embodiment, bracket 34 is positioned at the spacing in the end of catheter shaft 16 From place, so that a part of of diffuser 36 can be into a part of catheter shaft 16, to allow for refrigerant to be conveyed to close lead The part for the sacculus 24 that the distal end 20 of pipe axis 16 positions.
It as shown in Figure 3A, in pressure detecting pipe 26 is delivery pipe 30.Pressure detecting pipe 26 is drawing for delivery pipe 30 It leads, so that it is guaranteed that delivery pipe consistent 1:1 translation in pressure detecting pipe, without gap (backlash).For example, when defeated When the plug end of pipe 30 being sent to translate 4mm, then diffuser end also translates 4mm.
Delivery pipe 30 extends through connector 22 from plug 38；By pressure detecting pipe 26, diffuser 36 is reached.Delivery pipe 30 are made of strong flexible pipe or tube assembly.For example, delivery pipe can be made of tube assembly, the tube assembly include very it is flexible simultaneously And it is not easy the external Nitinol tube and inner thin-walled polyimide tube of plastic deformation (such as kink).Nitinol tube is pipe Component provides structural support.Nitinol tube is provided prevents intensity required for buckling during delivery pipe axial translation.In addition, Nitinol tube transmits torque well, this allows the rotary motion of delivery pipe.In embodiment, the outer tube for conveying tube assembly is packet The torque tube of stainless steel wire is included, technique of the stainless steel wire Jing Guo such as die forging, stretching, annealing is then wound around around inner tube, with Form the tube assembly with good rotation and axial translation ability.Thin-walled polyimides inner tube is manufactured with tighter tolerances, this permission Refrigerant passes through the consistent flowing of delivery pipe.Delivery pipe can undergo the internal pressure of 600psi to 1200psi during use, And it is configurable to be up to the wall thickness of the internal pressure of 1500psi with tolerance.Delivery pipe 30 in response to plug 38 relative to The movement of connector 22 and translated in pressure detecting pipe 26.
Fig. 2A shows a kind of state of plug 38, wherein the adjacent connector 22 of plug 38, and diffuser 36 is located at court To the position of 24 distal end of sacculus, sacculus 24 is shown with deflated state.Fig. 2 B shows a kind of state of plug 38, wherein plug 38 It is located relative to the first middle position of connector 22, and diffuser 36 is located at the position in 24 intermediate region of sacculus, sacculus 24 are shown with the state of swelling.Fig. 2 C shows a kind of state of plug 38, and wherein plug 38 is located towards the position of 24 proximal end of sacculus It sets.
As shown in Figure 5 A and 5B, diffuser 36 is fixed to the distal end of delivery pipe 30.Diffuser 36 is defeated including being fluidly connected to Hollow cavity room and the nozzle ports 40 of pipe 30 are sent, nozzle ports 40 allow the refrigerant fluid source from Handleset to supply Refrigerant be ejected on the inner wall of sacculus 24.The path 42 of the indoor refrigerant in inner cavity is illustrated in Fig. 5 C.Inner cavity chamber's packet Include the fluid chamber limited by the inner wall of diffuser outer tube 44 and the outer wall of diffuser inner tube 46.Nozzle ports 40 are by diffuser outer tube 44 wall is formed.Nozzle ports 40 can be made of the one or more slits being located at around diffuser outer tube 44.Such as it is wanting 360 degree conveying injection embodiment in, slit can be stacked into it is multiple rows of, to allow opening in the wall at all radial positions Mouthful.In embodiment, the angled conveyor of desired injection can be such as 90 degree or 180 degree less than 360 degree.At these In embodiment, nozzle ports 40 will be sized and position, to convey desired spray angle.In embodiment, nozzle end Mouth 40 includes the slit that height is 4/1000ths inches.As shown in Figure 5 C, path 42 is configured to allow to be located at diffusion in refrigerant Refrigerant is uniformly distributed when the nozzle ports end of device 36, so that pressure is radially about equal in inner cavity chamber.
Sacculus 24 is distal end that is expandable and contractile, and being mounted to catheter shaft 16.Fig. 2A is shown in flat Fall the schematic diagram of the sacculus 24 of stretched condition, and Fig. 2 B and 2C show the sacculus 24 in the state that swells.Sacculus 24 can be The elastic material of such as polyurethane, and when to swell less than 5psi, it can have the operation diameter within the scope of 20 to 35mm. Sacculus 24 has the inner surface for limiting balloon interior.In embodiment, sacculus 24 includes the tapered distal fixed to flexible top 48 End.During operation, refrigerant is essentially radially flowed outwardly by the nozzle ports 40 of diffuser 36, is directed along ball to generate The refrigerant injection of the target site of 24 inner surface of capsule.The target site of sacculus of swelling is contacted with tissue, and refrigerant is defeated Send the cryogenic ablation for typically resulting in the tissue of adjacent 24 target site of sacculus.In embodiment, target site is greater than to sacculus 24 The injection of inner wall conveys area, and while injection is to convey refrigerant to entire target site, diffuser 36 is along ball The length of capsule 24 translates.Refrigerant injection can be received and the balloon portion for being configured to contact tissue is referred to as sacculus Active length.As illustrated by figures 2 b and 2 c, in embodiment, the active length of sacculus 24 includes vertical wall section.Such as Fig. 2 B and 2C institute Show, sacculus can also include the conical wall portion for not contacting tissue usually or receiving refrigerant injection.In embodiment, sacculus 24 It may include using the deformeter for accomplishing the input in controller 50, this will be discussed in greater detail below.
Sacculus 24 is shown specifically in Fig. 6 A, 6B, 6C and 6D.Flexible top 48 is configured to: all inserting the device into As endoscope equipment in or insertion such as esophagus body passage in while, help the sacculus end of guiding catheter.Example Such as, endoscope usually has kink in the port of insertion conduit.Flexible top 48 is more more flexible than delivery pipe 30, and in conduit The damage of delivery pipe 30 and sacculus 24 is prevented during 12 insertion.For example, flexible top 48 is likely encountered during being initially inserted into Lead to its a large amount of curved barrier.This amount of bow may cause the damage of delivery pipe 30, cause its inoperable.Therefore, Flexible top 48 may be used as sacrifice bending point, during being initially inserted into, can cause its a large amount of bendings, without right The operability of whole equipment has an impact, because flexible top 48 is inserted into the farther place in path on edge and being capable of guiding catheter 12 rest part, thus delivery pipe 30 will be curved through barrier with softer.In addition, if pushing up during insertion Impinging tissue is held, flexible top 48 can prevent the damage to the tissue in body.As shown in Figure 6B, flexible top 48 includes circle Shape end 52 and spring body part 54.Be fixed on flexible top 48 is guide rail 56, and guide rail 56 is used for diffuser 36 substantially It is positioned along the central axis of sacculus 24, and guides diffuser 36 during the translation in sacculus 24.
Fig. 6 B depicts the sacculus 24 to swell, and omits diffuser 36 and delivery pipe 30 in order to check guide rail 56, such as Shown in Fig. 6 B, guide rail 56 extends through sacculus 24 from flexible top 48 and enters discharge chamber 28.Guide rail 56 is not attached to discharge chamber 28 inside, and can be moved freely together with discharge chamber 28.In embodiment, guide rail is by stainless steel or even if colder At a temperature of also have including plasticity_resistant deformation good nature other materials composition.
As shown in Figure 6 C, guide rail 56 is also located in diffuser inner tube 46 and guiding piece 58.Guiding piece 58 is fixed to delivery pipe 30 distal end.Guiding piece 58 can be polyimide tube, is attached to using the material contracting with heat 60 around guiding piece and delivery pipe Delivery pipe 30.Guiding piece 58 and diffuser inner tube 46 are configured to translate along the length of guide rail 56, so that diffuser can To contact the point on flexible top from the end of diffuser as shown in Figure 2 A, it is close to move to guiding piece 58 as shown in Figure 6 D Or the point of touching pressure detecting pipe 26 or bracket 34.Delivery pipe 30 is set to stretch sacculus 24 towards the translation of flexible top 48 At position is upheld shown in Fig. 2A, wherein diffuser 36 contacts flexible top 48, makes its translation further from catheter shaft 16, wherein soft Property top 48 be also caught to be translated away from catheter shaft 16 together with being fixed to its guide rail 56 because at these locations, expanding Device 36 is dissipated no longer to slide along guide rail 56.The purposes and benefit of this stretch position will be described in detail below.
In one embodiment, guide rail 56 can be the telescopic component being made of the multiple tube elements telescopically connected, Wherein diffuser is fixed to the end pipe of telescopic component.Similar with guide assembly disclosed above, telescopic element determines diffuser Positioned at the center of sacculus.In another embodiment, guide rail can be fixed to the end of diffuser, and sacculus is equipped with long Hollow tip part, with the guiding rail on the end of diffuser, therefore diffuser is in balloon center.
Fig. 7 A shows connector 22.As shown in Figure 7 B, the proximal end of catheter shaft 16 and pressure detecting pipe 26 are fixed to connection Position in device 22.Connector 22 includes discharge-channel 62, and discharge chamber 28 is fluidically coupled to connector 22 by discharge-channel 62 Radial discharge port 64 on outside.Connector 22 includes pressure sensing channel 66, and pressure sensing channel 66 is by pressure detecting chamber 32 are fluidically coupled to the radial pressure detection port 68 on 22 outside of connector.As shown in Figure 7 B, connector 22 further include Central passage 70 between pressure sensing channel 66 and the proximal end of connector 22, delivery pipe 30 pass through central passage 70.Delivery pipe 30 pass through center cavity free shift.Central passage 70 passes through one or more sealing elements 72 and separates with pressure sensing channel 66, and one A or multiple sealing elements 72 allow delivery pipes 30 to translate in pressure detecting pipe 26 and pressure sensing channel 66, but prevent gas from Pressure sensing channel 66 is revealed to central passage 70.
Fig. 8 A shows the section of the Handleset 14 before attached conduit 12, and Fig. 8 B is shown corresponding to Fig. 8 A's Simplify schematic cross-section.In order to which conduit 12 is attached to Handleset 14 (as shown in Figure 1), the plug end of connector 22 is inserted into In opening 81 in shell 80, and be inserted into in the connector connector 78 of the opening adjacent positioned in shell 80.Connector The socket cavity 86 of connector 78 and the formation (as shown in Figure 7 A) of the O-ring 88 of connector 22 seal.The proximal end of connector 22 includes Axial lock feature.In embodiment, axial lock is characterized in circumferentially extending groove 74, which passes through in handle group The lock-in feature of 76 form of retaining clip in the connector connector 78 of part 14 engages, and as illustrated by fig. 8 c and fig. 8d, Fig. 8 D shows The simplified schematic section corresponding to Fig. 8 C is gone out.Connector 22, which is inserted through, to be open and is inserted into socket cavity 86, Until circumferentially extending groove 74 is engaged with one or more retaining clips 76.Handleset 14 further includes plug connector 82.Plug connection The retaining clip 85 for connecing device 82 receives and engage 84 feature of circumferentially extending groove of plug 38 with locking.Plug connector 82 includes O shape Ring 83, O-ring 83 forms sealing between plug 38 and plug connector 82, so that being transported to the refrigerant of plug connector It is transmitted, and is not leak into plug 38 and delivery pipe 30.
Shown in Fig. 8 A and 8B, Handleset 14 further include: the handle portion 90 of the shell of the power supply comprising 92 form of battery； It is oriented in a generally vertical anteriorly 94 in handle portion 90；With define the screw thread cylindricality for receiving refrigerant fluid source 100 The top 96 of socket 98.Cylindrical refrigerant fluid source 100 is fixed in cylindrical socket 98 using threaded cap 99.In embodiment In, the content of heated cylinder is used for around the heater of a part of cylindrical socket.In response to by being coupled to controller 50 Trigger 104 actuating starting processing, from cylindricality gas source 100 distribute refrigerant.Controller is discussed more fully below 50。
Pressure in sacculus 24 is communicated to the pressure transducer 106 in connector connector 78.Pressure detecting chamber 32 is logical Excess pressure sense channel 66 and pressure detecting port 68 are fluidically coupled to pressure transducer 106.For detecting the fluid of pressure Path 130 is shown in fig. 7 c.As in fig. 8d, the O-ring 88 of 68 two sides of pressure detecting port is in connector connector 78 Form sealing.Pressure transducer 106 is coupled to controller 50 to provide it pressure signal.For clarity, being omitted in attached drawing 50 connecting line from component to controller.
The refrigerant for being conveyed to sacculus 24 is discharged into discharge radial discharge port 64 by discharge chamber 28.If discharging diameter Pressure is kept more than threshold value to the pressure at discharge port 64, then 110 discharge gas of pressure reducing valve.In normal operation condition, come Connector connector 78 and Exhaust assembly 108 are flowed through from the discharge gas of radial discharge port 64.Exhaust assembly 108 includes discharge Pipe 112 and controlled discharge valve 114.In one embodiment, controlled discharge valve 114 is attached mechanically to trigger 104, and right The pressing of trigger causes controlled discharge valve to be opened.In one embodiment, controlled discharge valve 114 may include such as solenoid valve Electric actuator, wherein electric actuator control drain valve 114 be connected to controller and controlled by controller.
Handleset 14 further includes flow control valve 116 and connecting line 118.Flow control valve 116 and connecting line 118 flow Body it is coupled to cylindrical refrigerant fluid source 100 and plug connector 82, so that refrigerant be allowed to be conveyed to by delivery pipe 30 Diffuser 36.The control of flow control valve 116 is conveyed from cylindrical refrigerant fluid source 100 to the refrigerant of diffuser 36.Implementing In example, flow control valve is the solenoid valve that can switch between on-position and closed position.Flow control valve 116 is coupled to Controller 50, and receive signal of the instruction for the flow velocity of processing.In embodiment, controller 50 can be to flow control valve 116 send signal, to interrupt refrigerant conveying based on system pressure.Connecting line 118 is configured with following shape, the shape Allow connecting line buckling and non-buckling during plug connector translates, while keeping the consistent fluid for refrigerant logical Road.For example, connecting line can be heat-treated as with initial curved shape.Fig. 8 E and 8F are respectively illustrated when plug connector 82 be located towards and position when far from connector connector 78 at connecting line 118 schematic diagram.
The translation of plug connector 82 causes the translation of the diffuser 36 in delivery pipe 30 and sacculus 24.Linear movement component 120 are connected to plug connector 82.In embodiment, linear movement component 120 can make delivery pipe 30 and diffuser 36 with 0.25 mm/second is to the rate translation between 2.5 mm/seconds, wherein the rate of translation for therapeutical uses is in 0.5 mm/second And 1.5 between mm/second.In embodiment, linear movement component 120 includes 122 He of motor for being connected to driving screw 124 Track 126.Plug connector 82 includes the threaded portion for surrounding driving screw 124 and engaging.Motor 122 rotates and makes Driving screw 124 rotates.The rotation of driving screw 124 causes the translation of plug connector 82.In embodiment, plug connector is also Including the rail guide engaged with track 126, so that plug connector 82 or not when driving screw rotates, and limited To be translated on the longitudinal direction of driving screw 124.In embodiment, linear movement component may include the linear cause of other forms Dynamic device, the linear actuators of the other forms is including such as rack pinion component and with component.
Controller 50 can be used for controlling the flat of the diffuser 36 in the conveying and delivery pipe 30 and sacculus 24 of refrigerant It moves.Controller 50 includes being connected to flow control valve 116, linear movement component 120 and pressure transducer 106 described above Circuit.In order to start processing, user can press trigger 104, trigger 104 then pressing be connected to controller 50 by Button 128.In embodiment, during being discharged into refrigerant in sacculus 24, controller 50 is from from pressure transducer 106 Pressure data generates pressure response curve, and the pressure response curve is related to the interior diameter of chamber to be processed.Controller 50 uses Pressure algorithm is suitable for the rate of the linear actuators handled to determine.In embodiment, the one or more on sacculus 24 is answered Become the balloon diameter that instrument can be used to obtain the interior diameter of the chamber corresponding to processing by controller 50.In embodiment, controller Can be attached to the user interface of other forms, the user interface of the other forms include button on the shell of Handleset, Floor push and touch display.Fig. 9 is the simplification figure for showing the elementary organization of controlling electronic devices of controller 50.Implementing Example in, controlling electronic devices may be coupled to additional component, the additional component include: including the user of lamp and display output, Temperature sensor, heater controller, accelerometer, detector switch and solenoid valve.Controller may include Processing Algorithm, and And the input of component can be by algorithm for adjusting such as duration, refrigerant flow rate, translation distance and translational velocity Manage parameter.
In embodiment, conduit may include RFID label tag, and RFID label tag identifies the size including sacculus of conduit, diffusion The property of the spray angle of device.Controller in handle can receive the information from the RFID reader in Handleset, and will The information input is into Processing Algorithm, to adjust processing parameter according to the property of attached conduit.RFID can be used for authenticating Purpose.It (such as is reused or the conduit that excessively uses or by being made without card for example, controller can detecte underproof conduit Make the conduit of quotient's manufacture), and controller is by locking device, in order to avoid work in the case where being attached unqualified conduit.RFID is also It can be used for the purpose oriented, to ensure that conduit is appropriately directed.
In embodiment, user can select Processing Algorithm before starting processing.In addition, user can input by The various parameters used in selected Processing Algorithm.The information may include patient data, catheter information and performed Treating number.User interface for select andding set processing may include display on Handleset or touch display, The array of lamp, or can remotely program, and wirelessly, wiredly or via removable storage card received by controller.
Controller can recorde the use number of conduit and save the information, or transmit this information to central data Library, to ensure excessively use conduit.In embodiment, supravasal RFID label tag can be writable, therefore control Device can program conduit, to be read in the future.The material being written may include locking or the time that last time uses.
It is the instantiation procedure of ablation procedure below.Endoscope is inserted into the esophagus of patient.Plug 38 as shown in Figure 2 A In the proximal end 5 for the access 8 that the ablation catheter 12 of distal-most position is inserted into endoscope tube 3.In the plug 38 of distal-most position Cause diffuser 36 that flexible top 48 is pushed away catheter shaft 16, is in so as to cause deflated sacculus 24 in upholding.Conduit 12 passes through Access 8 is inserted into, until sacculus 24 leaves distal end 7.Using the monitor for being attached to endoscope, user is it can be seen that sacculus leaves. Conduit 12 is placed on initial desired position, and Handleset 14 is attached as described above.
User selects Processing Algorithm, inputs any necessary parameter, and press trigger to make sacculus 24 initially It swells.Need it is this initially swell, to visualize position of the target site relative to damage to be ablated.This initially swell can To include that diffuser is moved to a position, to allow sacculus relaxation and be no longer in extension.The example of the position exists It is shown in Fig. 2 B.Then, the short burst of refrigerant injection is transported on the inner surface of sacculus 24, this makes sacculus swell, and Since the freezing at the tissue near target site occurs, user is allowed visually to determine the position of target site using endoscope It sets.If desired, ablation member can be relocated axially；This may need or may not be needed the deflated sacculus 24 in part, with Sacculus swells again afterwards.In the embodiment sprayed with the directionality opposite with 360 degree, during repositioning, Ke Yixuan Tube assembly of transduceing is so that nozzle ports 40 rotate.In embodiment, component can have the energy for rotating delivery pipe and diffuser Power, to relocate the radial direction of refrigerant injection.
Once sacculus 24 is properly positioned and swells so that nozzle ports 40 be directed toward damage a part or sacculus most Its hetero-organization to low-temperature treatment of distal end, refrigerant are fed to diffuser just to be injected on the inner wall of sacculus 24.Work as system When cryogen is just sprayed, diffuser is translated towards the proximal end of sacculus.The flow rate of refrigerant and the rate of translation of diffuser are by ideally Setting, so that the cooling power of ideal quantity is received by each part damaged, to ensure the ablation of entire desired region.It is sending out When the translation of raw conveying tube assembly is blocked due to any, controller will stop the conveying of refrigerant, to prevent from may cause The excessive ablation to tissue of damage.
Due to the direction of discharge, ablation is beneficial since the distal end of sacculus disclosed above, because of cooling discharge For gas by by the part of sacculus inner surface, which then will be by refrigerant injection.Therefore, this exhaust gas flow has pre- Cooling effect, this reduces temperature before conveying, this allows using less refrigerant to realize desired ablation temperature.It is this Effect is precooled to be counted into Processing Algorithm as factor.
Above description may have been used the term of close, remote, top, lower section, top, bottom, above, below etc..This A little terms can be with helping to understand the present invention in the specification and in the claims, without being used with restrictive sense.
Following clause describes each exemplary aspect of low temperature sacculus ablation member.
1. a kind of low temperature sacculus ablation member, comprising:
Cryogenic ablation conduit, comprising:
Catheter shaft has the conduit axocoel proximally and distally and between the proximal and distal ends extended；
It is installed to the inflatable and contractile sacculus of the distal end of catheter shaft, sacculus has the interior table for limiting balloon interior Face；And
Convey tube assembly, comprising:
The delivery pipe being contained in catheter shaft is used for the axial movement relative to catheter shaft, and
Diffuser in sacculus, is fluidically coupled to delivery pipe.
2. the low temperature sacculus ablation member of clause 1, further includes:
Guide rail, the first end and the second end in catheter shaft with the tip portion fixed to sacculus；And
Wherein diffuser is configured as along guide rail axial translation.
3. it further include the pressure detecting pipe being contained in catheter shaft according to the low temperature sacculus ablation member of clause 1 or 2, it is defeated Tube capacity is sent to be contained in pressure detecting pipe.
4. the low temperature sacculus ablation member of any one of clause 1 or 2, further includes:
Pressure detecting pipe is fluidically coupled to pressure detecting energy converter；
Wherein delivery pipe is configured as translating in pressure detecting inner axial tube.
5. according to the low temperature sacculus ablation member of any one of clause 1-4, further includes:
Handleset comprising be fluidically coupled to the refrigerant fluid source of conveying tube assembly.
6. wherein diffuser is configured to the axial translation in sacculus, expands simultaneously according to the low temperature sacculus ablation member of clause 5 The outlet for dissipating device guides the inner surface of the refrigerant from refrigerant fluid source towards sacculus outward.
7. the low temperature sacculus ablation member of clause 5 or 6, wherein cryogenic ablation conduit further includes the proximal end in catheter shaft Connector；And
Conveying tube assembly further includes plug, and plug is close to connector and is fluidically coupled to delivery pipe and refrigerant fluid Source,
Wherein plug leads to the axial movement of the diffuser in sacculus relative to the translation of connector.
8. the low temperature sacculus ablation member of clause 5, further includes:
Linear actuators in Handleset is configured as that delivery pipe is made axially to translate across connector.
9. the low temperature sacculus ablation member of clause 8, further includes:
Controller；
Wherein controller is configured as control flow control valve, flow control valve be fluidly in refrigerant fluid source and In line between diffuser；And
Wherein controller is configured as control linear actuators.
10. the low temperature sacculus ablation member of clause 9, wherein controller is configured with the pressure from detection ball intraluminal pressure The received input of power energy converter, so as to the interrupt processing if detecting abnormal pressure.
11. the low temperature sacculus ablation member of clause 9, wherein controller is configured as changing from the pressure of detection ball intraluminal pressure Energy device receives input, to determine the diameter of the sacculus in the state that swells.
12. the low temperature sacculus ablation member of clause 11, wherein controller is configured with the sacculus in the state that swells Diameter determine the rate of linear actuators.
13. the low temperature sacculus ablation member of clause 9, wherein controller uses the received information about cryogenic ablation conduit To determine the rate of linear actuators.
14. the low temperature sacculus ablation member of clause 13, wherein the received information about cryogenic ablation conduit is from handle group RFID reader in part receives, and RFID reader is configured as reading the RFID label tag of cryogenic ablation.
15. a kind of low temperature sacculus ablation member, comprising:
Cryogenic ablation conduit comprising:
Catheter shaft has the conduit axocoel proximally and distally and between the proximal and distal ends extended；
It is installed to the inflatable and contractile sacculus of the distal end of catheter shaft, sacculus has the interior table for limiting balloon interior Face；
Convey tube assembly comprising:
The delivery pipe being contained in catheter shaft is used for the axial movement relative to catheter shaft；And
Diffuser in sacculus, is fluidically coupled to delivery pipe；And
It is fluidically coupled to the pressure detecting pipe of pressure detecting energy converter, wherein delivery pipe is configured in pressure detecting pipe Axial translation；And
Handleset comprising:
It is fluidically coupled to the refrigerant fluid source of conveying tube assembly,
Wherein diffuser is configured to the axial translation in sacculus, while the outlet of diffuser will be from refrigerant fluid source The inner surface of refrigerant towards sacculus guides outward.
Although disclosing the present invention by reference to preferred embodiment described above in detail and example, it is to be appreciated that this A little examples are intended to illustrative rather than restrictive sense.It is contemplated that those skilled in the art will expect modifications and combinations, these Modifications and combinations will be within the spirit of the invention and in scope of the appended claims.

Claims (11)

1. a kind of cryogenic ablation component, including cryogenic ablation conduit, the cryogenic ablation conduit include:
Catheter shaft has the conduit axocoel extended proximally and distally and between the proximal end and the distal end；
Inflatable and contractile sacculus is mounted to the distal end of the catheter shaft, and the sacculus, which has, to be limited in sacculus The inner surface in portion；
Pressure detecting pipe is accommodated in the catheter shaft, and the pressure detecting pipe includes:
Distally, it positioned at the proximate distal ends of the catheter shaft and is configured as fluidly being coupled to pressure detecting energy converter； With
Proximal end is fluidly coupled to the balloon interior；And
Convey tube assembly, comprising:
Delivery pipe is accommodated in the pressure detecting pipe；With
Diffuser is fluidly coupled to the delivery pipe in the sacculus.
2. cryogenic ablation component according to claim 1:
The cryogenic ablation conduit further include:
The connector of the proximal end in the catheter shaft；
Refrigerant fluid source；And
The conveying tube assembly further includes plug, and the plug close to the connector and is fluidly coupled to described defeated Pipe and the refrigerant fluid source are sent,
Wherein the plug leads to the axial movement of the diffuser in the sacculus relative to the translation of the connector.
3. cryogenic ablation component according to claim 1, further includes:
Guide rail, the first end and the second end in the catheter shaft with the tip portion for being fixed to the sacculus；
Wherein the diffuser is configured as moving along the track axial direction Horizon.
4. cryogenic ablation component according to claim 2, further includes:
Handleset；And
Linear actuators in the Handleset is configured as that the delivery pipe is made axially to translate across the connection Device.
5. cryogenic ablation component according to claim 4, further includes:
Refrigerant fluid source；
Controller；
Wherein the controller is configured as control fluidly in the line between the refrigerant fluid source and the diffuser On flow control valve；And
Wherein controller is configured as controlling the linear actuators.
6. cryogenic ablation component according to claim 5, wherein the controller is configured with from the detection ball The received input of the pressure transducer of intraluminal pressure, so as to the interrupt processing if abnormal pressure is detected.
7. cryogenic ablation component according to claim 5, wherein the controller is configured as out of detection the sacculus The pressure transducer of pressure receives input, to determine the diameter of the sacculus in the state that swells.
8. cryogenic ablation component according to claim 7 swells wherein the controller is configured in described The diameter of the sacculus of state determines the rate of the linear actuators.
9. cryogenic ablation component according to claim 5, wherein the controller is disappeared using received about the low temperature Melt the information of conduit to determine the rate of the linear actuators.
10. cryogenic ablation component according to claim 9, wherein the received letter about the cryogenic ablation conduit The RFID reader ceased from the Handleset receives, and the RFID reader is configured as reading RFID mark Label.
11. cryogenic ablation component according to claim 1, wherein the delivery pipe is configured as in the pressure detecting pipe Interior axial direction Horizon moves.
CN201910265462.9A 2015-05-15 2016-05-12 Cryogenic balloon ablation system Active CN110051420B (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14/714,101 US9414878B1 (en) 2015-05-15 2015-05-15 Cryogenic balloon ablation system
US14/714,101 2015-05-15
CN201680024610.2A CN107530116B (en) 2015-05-15 2016-05-12 Low temperature sacculus ablation system

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
CN201680024610.2A Division CN107530116B (en) 2015-05-15 2016-05-12 Low temperature sacculus ablation system

Publications (2)

Publication Number Publication Date
CN110051420A true CN110051420A (en) 2019-07-26
CN110051420B CN110051420B (en) 2021-08-24

Family

ID=56610599

Family Applications (2)

Application Number Title Priority Date Filing Date
CN201680024610.2A Active CN107530116B (en) 2015-05-15 2016-05-12 Low temperature sacculus ablation system
CN201910265462.9A Active CN110051420B (en) 2015-05-15 2016-05-12 Cryogenic balloon ablation system

Family Applications Before (1)

Application Number Title Priority Date Filing Date
CN201680024610.2A Active CN107530116B (en) 2015-05-15 2016-05-12 Low temperature sacculus ablation system

Country Status (5)

Country Link
US (2) US9414878B1 (en)
EP (1) EP3294170B1 (en)
JP (2) JP6403031B2 (en)
CN (2) CN107530116B (en)
WO (1) WO2016186964A1 (en)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112263383A (en) * 2020-09-25 2021-01-26 安徽新虹纺织有限公司 Womb warming and weight losing conditioning pad formed by spinning
WO2021248939A1 (en) * 2020-06-09 2021-12-16 上海导向医疗系统有限公司 Double-layer freezing expansion balloon
CN114343821A (en) * 2021-11-26 2022-04-15 上海玮启医疗器械有限公司 Structure capable of detecting internal pressure of balloon

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8382746B2 (en) 2008-11-21 2013-02-26 C2 Therapeutics, Inc. Cryogenic ablation system and method
US9687288B2 (en) 2013-09-30 2017-06-27 Arrinex, Inc. Apparatus and methods for treating rhinitis
JP6402317B2 (en) 2013-11-01 2018-10-10 ペンタックス・オブ・アメリカ・インコーポレイテッドＰｅｎｔａｘ Ｏｆ Ａｍｅｒｉｃａ， Ｉｎｃ． Frozen balloon ablation system
US9763743B2 (en) 2014-07-25 2017-09-19 Arrinex, Inc. Apparatus and method for treating rhinitis
US9414878B1 (en) * 2015-05-15 2016-08-16 C2 Therapeutics, Inc. Cryogenic balloon ablation system
US9568918B1 (en) * 2015-08-27 2017-02-14 Southwest Research Institute Balloon system
US10675442B2 (en) 2016-02-08 2020-06-09 Nextern, Inc. Robotically augmented catheter manipulation handle
EP3413822B1 (en) 2016-02-11 2023-08-30 Arrinex, Inc. Device for image guided post-nasal nerve ablation
US10299795B2 (en) * 2016-04-28 2019-05-28 Mayo Foundation For Medical Education And Research Devices and methods for esophageal lengthening and anastomosis formation
WO2017200877A1 (en) 2016-05-20 2017-11-23 C2 Therapeutics, Inc. Cryogenic ablation system with rotatable and translatable catheter
JP6948351B2 (en) 2016-06-15 2021-10-13 アリネックス， インコーポレイテッド Devices and methods for treating the sides of the nasal cavity
US10939965B1 (en) 2016-07-20 2021-03-09 Arrinex, Inc. Devices and methods for treating a nerve of the nasal cavity using image guidance
US11253312B2 (en) 2016-10-17 2022-02-22 Arrinex, Inc. Integrated nasal nerve detector ablation-apparatus, nasal nerve locator, and methods of use
EP3551107B1 (en) 2016-12-09 2023-01-18 St. Jude Medical, Cardiology Division, Inc. Pulmonary vein isolation balloon catheter
US11116657B2 (en) 2017-02-02 2021-09-14 Zoll Circulation, Inc. Devices, systems and methods for endovascular temperature control
US11185440B2 (en) * 2017-02-02 2021-11-30 Zoll Circulation, Inc. Devices, systems and methods for endovascular temperature control
AU2018256964B2 (en) 2017-04-28 2023-11-30 Arrinex, Inc. Systems and methods for locating blood vessels in the treatment of rhinitis
EP3672509A4 (en) * 2017-08-21 2021-05-12 Boston Scientific Scimed Inc. Method for controlling pressure within inflatable balloon of intravascular catheter system
WO2019050617A1 (en) * 2017-09-07 2019-03-14 Cryterion Medical, Inc. Cryogenic balloon with greater size adjustability at lower inflation pressures
WO2019083764A1 (en) * 2017-10-27 2019-05-02 St. Jude Medical, Cardiology Division, Inc. Cryogenic ablation system
US20210315460A1 (en) 2018-10-18 2021-10-14 Osaka University Optical dental caries diagnostic device, optical dental caries diagnostic method, and dental caries diagnostic system
US11737745B2 (en) 2018-10-24 2023-08-29 Mayo Foundation For Medical Education And Research Medical devices and methods for body conduit lengthening and anastomosis formation
KR102205624B1 (en) * 2018-11-27 2021-02-23 주식회사 소노마메드 Refrigerant supply system and method using vascular information
WO2020163854A1 (en) * 2019-02-08 2020-08-13 Emory University Devices, systems, and methods for cryoablation
CN220344551U (en) * 2019-10-31 2024-01-16 杭州启明医疗器械股份有限公司 Interventional instrument conveying system with protective tube
CN111084658B (en) * 2020-03-23 2020-07-24 上海导向医疗系统有限公司 Freezing adhesion device
CN112370147B (en) * 2021-01-15 2021-04-09 上海安钛克医疗科技有限公司 Control handle of balloon catheter, balloon catheter and cryoablation system
US20240130775A1 (en) * 2022-10-20 2024-04-25 Ryme Medical, Inc. Cryotherapeutic systems and methods for targeted lung neuromodulation therapies

Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000066020A1 (en) * 1999-05-04 2000-11-09 Curon Medical, Inc. Assemblies to visualize and treat sphincters and adjoining tissue regions
US20020045894A1 (en) * 1999-02-24 2002-04-18 Cryovascular Systems, Inc. Safety cryotherapy catheter
US20050209587A1 (en) * 1997-12-02 2005-09-22 Cryovascular Systems,Inc. Apparatus and method for cryogenic inhibition of hyperplasia
US7201731B1 (en) * 1992-08-12 2007-04-10 Lundquist Ingemar H Treatment device with guidable needle
CN101332083A (en) * 2007-06-28 2008-12-31 韦伯斯特生物官能公司 Optical pyrometric catheter for tissue temperature monitoring during cardiac ablation
CN101563039A (en) * 2006-12-19 2009-10-21 爱尔伯电子医疗设备公司 Cryosurgical instrument for separating a tissue sample from surrounding tissue of a biological tissue that is to be treated
US20090299356A1 (en) * 2008-05-29 2009-12-03 Boston Scientific Scimed, Inc. Regulating internal pressure of a cryotherapy balloon catheter
US20100121270A1 (en) * 2008-11-12 2010-05-13 Gunday Erhan H Resector Balloon System
CN102166136A (en) * 2010-01-22 2011-08-31 韦伯斯特生物官能公司 Catheter having a force sensing distal tip
CN102245258A (en) * 2008-11-12 2011-11-16 美敦力 Coolant injection tube
CN102387755A (en) * 2009-04-06 2012-03-21 克莱米迪克斯有限责任公司 Single phase liquid refrigerant cryoablation system with multitubular distal section and related method
JP2012509146A (en) * 2008-11-21 2012-04-19 シートゥー・セラピューティクス・インコーポレイテッド Cryogenic ablation system and method
CN103917185A (en) * 2011-09-14 2014-07-09 波士顿科学西美德公司 Ablation device with ionically conductive balloon
CN103961177A (en) * 2008-07-22 2014-08-06 因西特医疗技术有限公司 Tissue modification devices and methods of using the same
US20150045781A1 (en) * 2004-03-23 2015-02-12 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
JP2015509791A (en) * 2012-03-02 2015-04-02 シーエスエイ・メディカル・インコーポレイテッドＣｓａ Ｍｅｄｉｃａｌ， Ｉｎｃ． Cryosurgery system
US20150126985A1 (en) * 2013-11-01 2015-05-07 C2 Therapeutics, Inc. Cryogenic balloon ablation system

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4333452A (en) 1977-06-24 1982-06-08 Au Anthony S Pressure control systems
US4924862A (en) 1987-08-19 1990-05-15 Gary Levinson Pressure controller and leak detector for tracheal tube cuff
US5035705A (en) 1989-01-13 1991-07-30 Scimed Life Systems, Inc. Method of purging a balloon catheter
US5342301A (en) 1992-08-13 1994-08-30 Advanced Polymers Incorporated Multi-lumen balloons and catheters made therewith
US6623516B2 (en) 1992-08-13 2003-09-23 Mark A. Saab Method for changing the temperature of a selected body region
US5800487A (en) 1996-07-23 1998-09-01 Endocare, Inc. Cryoprobe
US6464697B1 (en) 1998-02-19 2002-10-15 Curon Medical, Inc. Stomach and adjoining tissue regions in the esophagus
JP2001511690A (en) 1997-02-21 2001-08-14 インテラ インターヴェンショナル システムズ インコーポレイテッド Plasticized nylon balloon for medical devices
US6669689B2 (en) 1997-02-27 2003-12-30 Cryocath Technologies Inc. Cryosurgical catheter
US5868735A (en) 1997-03-06 1999-02-09 Scimed Life Systems, Inc. Cryoplasty device and method
US7220257B1 (en) 2000-07-25 2007-05-22 Scimed Life Systems, Inc. Cryotreatment device and method
US6027499A (en) 1997-05-23 2000-02-22 Fiber-Tech Medical, Inc. (Assignee Of Jennifer B. Cartledge) Method and apparatus for cryogenic spray ablation of gastrointestinal mucosa
US7025762B2 (en) 1997-05-23 2006-04-11 Crymed Technologies, Inc. Method and apparatus for cryogenic spray ablation of gastrointestinal mucosa
AU2114299A (en) 1998-01-14 1999-08-02 Conway-Stuart Medical, Inc. Electrosurgical device for sphincter treatment
US6231595B1 (en) 1998-03-31 2001-05-15 Innercool Therapies, Inc. Circulating fluid hypothermia method and apparatus
US6626861B1 (en) 1998-04-22 2003-09-30 Applied Medical Resources Balloon catheter apparatus and method
CA2236049C (en) 1998-04-27 2006-07-25 Computer Controlled Syringe Inc. Syringe with detachable syringe barrel
JP4117958B2 (en) 1998-12-28 2008-07-16 シチズンミヨタ株式会社 IC tag structure
US6428534B1 (en) 1999-02-24 2002-08-06 Cryovascular Systems, Inc. Cryogenic angioplasty catheter
US6468297B1 (en) 1999-02-24 2002-10-22 Cryovascular Systems, Inc. Cryogenically enhanced intravascular interventions
US6514245B1 (en) 1999-03-15 2003-02-04 Cryovascular Systems, Inc. Safety cryotherapy catheter
US6432102B2 (en) 1999-03-15 2002-08-13 Cryovascular Systems, Inc. Cryosurgical fluid supply
US7527622B2 (en) 1999-08-23 2009-05-05 Cryocath Technologies Inc. Endovascular cryotreatment catheter
US6283959B1 (en) 1999-08-23 2001-09-04 Cyrocath Technologies, Inc. Endovascular cryotreatment catheter
US6575966B2 (en) 1999-08-23 2003-06-10 Cryocath Technologies Inc. Endovascular cryotreatment catheter
JP2001087303A (en) 1999-09-27 2001-04-03 Nidek Co Ltd Ophthalmic surgery apparatus
US20040215296A1 (en) 1999-11-16 2004-10-28 Barrx, Inc. System and method for treating abnormal epithelium in an esophagus
US6551274B2 (en) 2000-02-29 2003-04-22 Biosense Webster, Inc. Cryoablation catheter with an expandable cooling chamber
US6443947B1 (en) 2000-03-01 2002-09-03 Alexei Marko Device for thermal ablation of a cavity
US7156860B2 (en) 2000-05-26 2007-01-02 Wallsten Medical S.A. Balloon catheter
US6537271B1 (en) 2000-07-06 2003-03-25 Cryogen, Inc. Balloon cryogenic catheter
JP4021141B2 (en) 2000-10-20 2007-12-12 株式会社ニデック Vitreous surgery device
US6666858B2 (en) 2001-04-12 2003-12-23 Scimed Life Systems, Inc. Cryo balloon for atrial ablation
US6953469B2 (en) 2001-08-30 2005-10-11 Ethicon, Inc, Device and method for treating intraluminal tissue
US20030060813A1 (en) 2001-09-22 2003-03-27 Loeb Marvin P. Devices and methods for safely shrinking tissues surrounding a duct, hollow organ or body cavity
JP2005503241A (en) 2001-09-27 2005-02-03 ガリル メディカル リミテッド Cryoplasty apparatus and method
US20030088240A1 (en) 2001-11-02 2003-05-08 Vahid Saadat Methods and apparatus for cryo-therapy
US6746465B2 (en) 2001-12-14 2004-06-08 The Regents Of The University Of California Catheter based balloon for therapy modification and positioning of tissue
US6709431B2 (en) 2001-12-18 2004-03-23 Scimed Life Systems, Inc. Cryo-temperature monitoring
TWI235073B (en) 2002-08-20 2005-07-01 Toray Industries Catheter for treating cardiac arrhythmias
US6929639B2 (en) 2002-08-30 2005-08-16 Scimed Life Systems, Inc. Cryo ablation coil
US7758623B2 (en) 2003-03-17 2010-07-20 The Board Of Trustees Of The Leland Stanford Junior University Transesophageal heat exchange catheter for cooling of the heart
US8172747B2 (en) 2003-09-25 2012-05-08 Hansen Medical, Inc. Balloon visualization for traversing a tissue wall
US20050137619A1 (en) 2003-12-19 2005-06-23 Scott Schewe Molds and related methods and articles
US20060086362A1 (en) 2004-10-22 2006-04-27 Stephen Solomon Intestinal ablation to limit food absorption
US7604631B2 (en) 2004-12-15 2009-10-20 Boston Scientific Scimed, Inc. Efficient controlled cryogenic fluid delivery into a balloon catheter and other treatment devices
US7860555B2 (en) 2005-02-02 2010-12-28 Voyage Medical, Inc. Tissue visualization and manipulation system
US20070066961A1 (en) 2005-09-21 2007-03-22 Rutter Michael J Airway balloon dilator
US8038598B2 (en) 2006-05-15 2011-10-18 Baystate Health, Inc. Balloon endoscope device
US8123751B2 (en) 2006-06-09 2012-02-28 Zimmer Spine, Inc. Methods and apparatus for access to and/or treatment of the spine
JP4978953B2 (en) 2006-06-26 2012-07-18 朝日インテック株式会社 Balloon catheter manufacturing method
US20070299433A1 (en) 2006-06-27 2007-12-27 C2 Therapeutics Barrett's Esophagus Cryogenic Ablation System
US8617149B2 (en) 2006-10-02 2013-12-31 Boston Scientific Scimed, Inc. Common bond, double-balloon catheter
WO2008084286A2 (en) 2006-10-25 2008-07-17 Arterial Remodeling Technologies, S.A. Method for expansion and deployment of polymeric structures including stents
JP2008245954A (en) 2007-03-30 2008-10-16 Dgs Computer:Kk Cryogenic medical instrument
AU2008242981B2 (en) 2007-04-16 2014-06-12 Smith & Nephew, Inc. Powered surgical system
US20080312644A1 (en) 2007-06-14 2008-12-18 Boston Scientific Scimed, Inc. Cryogenic balloon ablation instruments and systems
JP5562869B2 (en) * 2008-01-11 2014-07-30 ボストン サイエンティフィック サイムド，インコーポレイテッド Ablation device and method of use
EP2259739B1 (en) 2008-02-19 2015-04-01 Boston Scientific Scimed, Inc. Apparatus for uniformly distributing coolant within a cryo-ablation device
CA2719093A1 (en) 2008-03-13 2009-09-17 Boston Scientific Scimed, Inc. Cryo-ablation refrigerant distribution catheter
CN101584602A (en) 2008-05-20 2009-11-25 上海导向医疗系统有限公司 Multi-stage precooling cryoablation method and equipment
WO2010111785A1 (en) 2009-03-31 2010-10-07 Sunnybrook Health Science Centre Medical device with means to improve transmission of torque along a rotational drive shaft
GB2485512B (en) 2009-08-02 2015-02-11 Cameron Int Corp A mineral extraction system using one or more arcuate radio frequency identification (RFID) antennas.
CN104856757B (en) 2009-10-27 2017-06-23 赫莱拉公司 Delivery apparatus with coolable energy transmitting device
US8986293B2 (en) * 2010-01-27 2015-03-24 Medtronic Cryocath Lp Cryoballoon refrigerant dispersion control
CA2806892A1 (en) 2010-08-26 2012-03-01 Cryomedix, Llc Cryoablation balloon catheter and related method
US8911434B2 (en) 2010-10-22 2014-12-16 Medtronic Cryocath Lp Balloon catheter with deformable fluid delivery conduit
US20120143294A1 (en) 2010-10-26 2012-06-07 Medtronic Adrian Luxembourg S.a.r.l. Neuromodulation cryotherapeutic devices and associated systems and methods
US11246653B2 (en) 2010-12-07 2022-02-15 Boaz Avitall Catheter systems for cardiac arrhythmia ablation
ES2759611T3 (en) 2011-02-01 2020-05-11 Channel Medsystems Inc Apparatus for cryogenic treatment of a cavity or lumen of the body
CN105920717B (en) 2011-05-27 2019-05-21 科纳维医疗有限公司 Medical probe with fluid rotary joint
US20130018366A1 (en) 2011-07-11 2013-01-17 C2 Therapeutics Focal Ablation Assembly
US9314588B2 (en) 2011-10-28 2016-04-19 Medtronic Cryocath Lp Systems and methods for variable injection flow
US9144449B2 (en) * 2012-03-02 2015-09-29 Csa Medical, Inc. Cryosurgery system
US9241752B2 (en) 2012-04-27 2016-01-26 Medtronic Ardian Luxembourg S.A.R.L. Shafts with pressure relief in cryotherapeutic catheters and associated devices, systems, and methods
WO2013169340A1 (en) 2012-05-11 2013-11-14 Medtronic Ardian Luxembourg Sarl Multi-electrode catheter assemblies for renal neuromodulation and associated systems and methods
JP6652838B2 (en) 2013-03-04 2020-02-26 シーエスエー メディカル， インコーポレイテッド Cryogenic spray catheter
US9511209B2 (en) 2013-08-06 2016-12-06 Intervalve, Inc. Bulbous balloon with mechanical pressure regulator
US9510743B2 (en) 2013-12-17 2016-12-06 Biovision Technologies, Llc Stabilized surgical device for performing a sphenopalatine ganglion block procedure
US9855089B2 (en) 2014-03-21 2018-01-02 Medtronic Cryocath Lp Shape changing ablation balloon
US9936997B2 (en) 2014-05-28 2018-04-10 Kyphon SÀRL Cryogenic kyphoplasty instrument and methods of use
US10088083B2 (en) 2014-08-14 2018-10-02 Novartis Ag Multi lumen co-radial pneumatic connector
US9414878B1 (en) * 2015-05-15 2016-08-16 C2 Therapeutics, Inc. Cryogenic balloon ablation system

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7201731B1 (en) * 1992-08-12 2007-04-10 Lundquist Ingemar H Treatment device with guidable needle
US20050209587A1 (en) * 1997-12-02 2005-09-22 Cryovascular Systems,Inc. Apparatus and method for cryogenic inhibition of hyperplasia
US20020045894A1 (en) * 1999-02-24 2002-04-18 Cryovascular Systems, Inc. Safety cryotherapy catheter
WO2000066020A1 (en) * 1999-05-04 2000-11-09 Curon Medical, Inc. Assemblies to visualize and treat sphincters and adjoining tissue regions
US20150045781A1 (en) * 2004-03-23 2015-02-12 Medtronic Cryocath Lp Method and apparatus for inflating and deflating balloon catheters
CN101563039A (en) * 2006-12-19 2009-10-21 爱尔伯电子医疗设备公司 Cryosurgical instrument for separating a tissue sample from surrounding tissue of a biological tissue that is to be treated
CN101332083A (en) * 2007-06-28 2008-12-31 韦伯斯特生物官能公司 Optical pyrometric catheter for tissue temperature monitoring during cardiac ablation
US20090299356A1 (en) * 2008-05-29 2009-12-03 Boston Scientific Scimed, Inc. Regulating internal pressure of a cryotherapy balloon catheter
CN103961177A (en) * 2008-07-22 2014-08-06 因西特医疗技术有限公司 Tissue modification devices and methods of using the same
US20100121270A1 (en) * 2008-11-12 2010-05-13 Gunday Erhan H Resector Balloon System
CN102245258A (en) * 2008-11-12 2011-11-16 美敦力 Coolant injection tube
JP2012509146A (en) * 2008-11-21 2012-04-19 シートゥー・セラピューティクス・インコーポレイテッド Cryogenic ablation system and method
CN102387755A (en) * 2009-04-06 2012-03-21 克莱米迪克斯有限责任公司 Single phase liquid refrigerant cryoablation system with multitubular distal section and related method
CN102166136A (en) * 2010-01-22 2011-08-31 韦伯斯特生物官能公司 Catheter having a force sensing distal tip
CN103917185A (en) * 2011-09-14 2014-07-09 波士顿科学西美德公司 Ablation device with ionically conductive balloon
JP2015509791A (en) * 2012-03-02 2015-04-02 シーエスエイ・メディカル・インコーポレイテッドＣｓａ Ｍｅｄｉｃａｌ， Ｉｎｃ． Cryosurgery system
US20150126985A1 (en) * 2013-11-01 2015-05-07 C2 Therapeutics, Inc. Cryogenic balloon ablation system

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021248939A1 (en) * 2020-06-09 2021-12-16 上海导向医疗系统有限公司 Double-layer freezing expansion balloon
US11679239B2 (en) 2020-06-09 2023-06-20 Accutarget Medipharma (Shanghai) Co., Ltd. Double-layer cryogenic inflatable balloon
CN112263383A (en) * 2020-09-25 2021-01-26 安徽新虹纺织有限公司 Womb warming and weight losing conditioning pad formed by spinning
CN112263383B (en) * 2020-09-25 2022-05-10 安徽新虹纺织有限公司 Womb warming and weight losing conditioning pad formed by spinning
CN114343821A (en) * 2021-11-26 2022-04-15 上海玮启医疗器械有限公司 Structure capable of detecting internal pressure of balloon

Also Published As

Publication number Publication date
EP3294170B1 (en) 2020-02-26
EP3294170A1 (en) 2018-03-21
CN107530116A (en) 2018-01-02
JP6403031B2 (en) 2018-10-10
US9414878B1 (en) 2016-08-16
JP6738869B2 (en) 2020-08-12
US20160331433A1 (en) 2016-11-17
JP2018516660A (en) 2018-06-28
US10098686B2 (en) 2018-10-16
CN110051420B (en) 2021-08-24
JP2018196773A (en) 2018-12-13
EP3294170A4 (en) 2019-01-30
CN107530116B (en) 2019-04-23
WO2016186964A1 (en) 2016-11-24

Similar Documents

Publication Publication Date Title
CN107530116B (en) Low temperature sacculus ablation system
JP7239659B2 (en) Infusate delivery device, system and method
CN109414284A (en) Cryogenic ablation system with rotatable and translatable conduit
EP2352451B1 (en) Cryogenic ablation system
JP5667185B2 (en) Cryoablation catheter assembly and cryoablation system
US20170196615A1 (en) Cryo-therapy spray device
EP3576656A1 (en) Cryotherapy device flow control
US9168079B2 (en) Method and system to prevent complete obstruction in catheter in case of a kink
JP6984109B2 (en) Systems and methods to enhance radial spray from catheters

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant