CN101584602A - Multi-stage precooling cryoablation method and equipment - Google Patents
Multi-stage precooling cryoablation method and equipment Download PDFInfo
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- CN101584602A CN101584602A CNA2008100433746A CN200810043374A CN101584602A CN 101584602 A CN101584602 A CN 101584602A CN A2008100433746 A CNA2008100433746 A CN A2008100433746A CN 200810043374 A CN200810043374 A CN 200810043374A CN 101584602 A CN101584602 A CN 101584602A
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Abstract
The invention discloses a kind of method of multi-stage precooling cryoablation.In this method, cold-producing medium is sufficiently cooled in a plurality of precool heat exchanger devices, reaches final low temperature, and evaporates, expands, with this cryoablation target biology tissue, as tumor, cardiovascular organization or other pathological tissues at cryoprobe or catheter tip.The inventive method can improve refrigerating efficiency and refrigeration work consumption greatly, treatment is become fast, effectively.The invention also discloses the equipment of implementing above-mentioned multi-stage precooling cryoablation method.
Description
Technical field
The present invention relates to a kind ofly use a plurality of precool heat exchanger devices and make cold-producing medium reach final cryogenic method, be specifically related to a kind of method of multi-stage precooling cryoablation; The invention still further relates to the equipment of implementing said method.
Background technology
Cryoablation system can be used for excising the defective on focus or the reparation health, to recover and to improve the function of health.It is used in many departments of surgery, and as otorhinolaryngology position tumor, the cervix uteri tumor of gynecological, mastadenoma, urological prostate tumor etc. also are useful on excision gastric tumor, hepatoma, cerebroma etc.In addition, cryoablation also can be used for beauty treatment, treating skin disease, tonsil resection, hemorrhoid excision, cataractous excision etc.Compare with some other operation methods, the cryoablation therapy has following than obvious superiority: (1) low temperature can make vasoconstriction even condense, and good anastalsis is arranged, and can significantly reduce blood loss volume during the operation.(2) low temperature has the paralysis effect to teleneuron, can reduce patient's pain.Many cryoablation operations can be carried out under the situation of not anaesthetizing.(3) cryosurgery helps preventing the diffusion of cancerous cell.(4) freezing have a bactericidal action, and the aseptic condition of operation is good, can prevent postoperative infection.(5) thrombosis after the cryosurgery and issuable immunological effect help further killing and wounding the focus cell.(6) cryosurgery can combine with radiotherapy, chemotherapy, obtains better therapeutic.The Cryoablation system of using mainly contains two kinds at present: liquid nitrogen system and argon helium system.
Liquid nitrogen system is that the principle that need absorb a large amount of gasification latent heats when utilizing material to become gas by liquid reduces tissue temperature rapidly.In the operation liquid nitrogen is fed in the cryoprobe, gasification heat absorption when its contact tissue can make the temperature of treatment probe reduce rapidly, makes and organizes fast cooling, freezes, the air that passes to room temperature or heating then in probe makes organizes rewarming, through freeze-thaw cycle repeatedly tumor is killed.Argon helium knife is to utilize the adiabatic throttling effect of gas to finish the therapeutic process of cooling and rewarming, when the higher gas of pressure is flowed through the aperture adiabatic throttling, along with the decline temperature of pressure tends to change, some gas temperature descends, and some gas temperature rises, and the adiabatic throttling effect is also referred to as Joule-Thomson effect.When cryoprobe internal recycle argon, argon is in the point of a knife rapid expansion, and freezing in a short period of time pathological tissues is at subzero 140 degree, during rewarming, helium is in the point of a knife rapid expansion, and heating is in the pathological tissues of ultralow temperature state rapidly, colds and heat succeed each other to make the tumor cell death of breaking.
And for liquid nitrogen system, its biggest advantage is the cryogenic temperature that can provide lower, but also there is significant limitation in it, that is: (1) cryoprobe diameter is bigger, and generally more than 5mm, the wound of generation is big, is not easy to be inserted into human body.Because liquid nitrogen can produce a large amount of gases when arriving cryoprobe head place and undergo phase transition, the pressure of the generation liquid nitrogen flow velocity that can slow down.The cryoprobe diameter is more little, and the easy more cryoprobe the inside that is blocked in of flowing nitrogen stream causes refrigeration performance poor more.Therefore, for guaranteeing refrigeration, the diameter of general cryoprobe is difficult to accomplish below the 3mm.(2) cooling rate of cryoprobe is relatively slow, and pre-cool time is longer relatively, is unfavorable for killing the pathological tissues cell.(3) the liquid nitrogen cryotherapy apparatus relates to storage, output, circulation and the recovery of liquid nitrogen, and equipment is normally used, and this cyclic process can not have any obstacle.In addition, because liquid nitrogen temperature is very low, and device temperature is higher relatively, for preventing liquid nitrogen vaporization, often all has extra heat insulation layer on the equipment in order to avoid equipment absorbs heat from the external world, thereby the general volume of liquid nitrogen freezing equipment is bigger.
Though argon helium knife cooling programming rate is fast, refrigeration work consumption is not very big, and very limited by the rewarming effect of helium throttling generation, and differing in the operation of reality gets a desired effect surely.On the other hand, argon helium large usage quantity and source difficulty, high purity argon is expensive, does that once to perform the operation for the patient all be no small burden.And this complete equipment makes service pressure bigger, and generally in the 25-40Mpa scope, so big pressure lower pipeline leaks easily, and the requirement of various valves is improved greatly.
Summary of the invention
Technical problem to be solved by this invention is the above-mentioned deficiency at existing liquid nitrogen system and argon helium knife two big cold therapy systems, has proposed a kind of method of multi-stage precooling cryoablation.This method has not only guaranteed refrigerating capacity by using a plurality of precool heat exchanger devices, has accelerated refrigerating speed, and has utilized cold-producing medium to return the cold of agent fully, has improved refrigerating efficiency greatly, makes treatment become fast, effectively.
Another technical problem to be solved by this invention is the equipment that proposes to implement above-mentioned multi-stage precooling cryoablation method.
In order to solve the problems of the technologies described above, the multi-stage precooling cryoablation method that the present invention proposes comprises the steps:
A. providing pressure by pressure source is the cold-producing medium of 0.1MPa～50MPa;
B. using the 1st grade of precool heat exchanger device makes cold-producing medium return agent to begin to cool down cold-producing medium;
C. use refrigeration plant and make cold-producing medium cooled apparatus cools in the 2nd grade of precool heat exchanger device;
D. being applied in 3rd level precool heat exchanger device in transfer pipeline and the handle makes cold-producing medium be returned agent by the adverse current cold-producing medium further to cool off;
E. the 4th grade of precool heat exchanger device of using in cryoprobe or the conduit makes cooled dose time agent of cold-producing medium fully cool off;
F. by the cold-producing medium of continuously pre-cooling expand at cryoprobe or catheter tip, evaporation to pathological tissues cooling melt;
G. the cold-producing medium after cryoprobe or catheter tip expand, evaporate returns agent as cold-producing medium, plays the pre-cooling effect through the 4th, 3,2,1 grade of precool heat exchanger device successively.
The equipment of the above-mentioned multi-stage precooling cryoablation method of enforcement that the present invention proposes, pressure source links to each other with air inlet pipeline, and air inlet pipeline and outlet pipe constitute the 1st grade of precool heat exchanger device; The pipeline of air inlet pipeline and refrigeration plant constitutes the 2nd grade of precool heat exchanger device; Air inlet pipeline links to each other with transfer pipeline and handle, and transfer pipeline and handle and outlet pipe constitute 3rd level precool heat exchanger device; 3rd level precool heat exchanger device and cryoprobe or conduit join; Cryoprobe or catheter tip are treatment end, wherein include the 4th grade of precool heat exchanger device and expansion gear, and gas is discharged from outlet pipe by expansion gear after through the 4th grade of precool heat exchanger device.
The present invention can make cold-producing medium sufficiently cooled owing to adopt technique scheme, reaches final low temperature, and evaporates, expands, with this cryoablation target biology tissue, as tumor, cardiovascular organization or other pathological tissues at cryoprobe or catheter tip.This method can improve refrigerating efficiency and refrigeration work consumption greatly, makes treatment become convenient, fast.
Description of drawings
Fig. 1 is the system diagram of multi-stage precooling cryoablation method of the present invention and equipment.
Fig. 2 is the circuit configurations figure of multi-stage precooling cryoablation method of the present invention and equipment.
Wherein: 1 is the 1st grade of precool heat exchanger device; 2 is the 2nd grade of precool heat exchanger device; 3 is 3rd level precool heat exchanger device; 4 is the 4th grade of precool heat exchanger device; 5 is pressure source; 6 is air inlet pipeline; 7 is refrigeration plant; 8 is transfer pipeline and hands handle; 9 is cryoprobe or conduit; 10 is expansion gear; 11 are the treatment end.
The specific embodiment
For can clearer understanding purpose of the present invention, characteristics and advantage, below with reference to accompanying drawing preferred embodiment of the present invention is described in detail.
Shown in Fig. 1-2, the multi-stage precooling cryoablation equipment of a preferred embodiment of the present invention is made of the 1st grade of precool heat exchanger device 1, the 2nd grade of precool heat exchanger device 2,3rd level precool heat exchanger device the 3, the 4th grade of precool heat exchanger device 4, pressure source 5, air inlet pipeline 6, refrigeration plant 7, transfer pipeline and handle 8, cryoprobe or conduit 9, expansion gear 10 and treatment end 11, wherein: pressure source 5 is for being equipped with the gas cylinder of 0.1MPa～50MPa pressure cold-producing medium, and the 1st, 2,3,4 grade of precool heat exchanger device 1,2,3,4 is homemade pipe heat exchanger or plate type heat exchanger; Refrigeration plant 7 is liquid nitrogen plant or compression refrigeration equipment, or commercially available common other can cool to the equipment (produce as U.S. REVCO company, model is the ultra cold storage freezer of Ultima-IITM) of 300K to 0K.
Below in conjunction with description of drawings multi-stage precooling cryoablation method of the present invention.
Shown in Fig. 1-2, one-component cold-producing medium in the Cryoablation system is as N
2, O
2, A
r, CO
2Or multi-component cold-producing medium, mixture as nitrogen and alkanes gas, return agent and carry out heat exchange from pressure source 5 the circulate cold-producing medium that enters pressure source 5 of back and mode that comes out at the 1st grade of precool heat exchanger device 1 of air inlet pipeline 6 by compression, refrigerant temperature is chilled to 20 ℃ to-70 ℃ in advance, then with refrigeration plant 7 the 2nd grade of precool heat exchanger device 2 places pre-cooling, refrigerant temperature is chilled to 15 ℃ to-270 ℃ in advance, the cold-producing medium that enters transfer pipeline and handle 8 backs and lower temperature returns agent and finishes pre-cooling once more at 3rd level precool heat exchanger device 3 places, refrigerant temperature is chilled to 0 ℃ to-270 ℃ in advance, in cryoprobe or conduit 9, carry out the afterbody pre-cooling at last with the 4th grade of precool heat exchanger device, refrigerant temperature is chilled to-10 ℃ to-273 ℃ in advance, and fully the cold-producing medium after the pre-cooling carries out cryoablation through expansion gear 10 backs to treatment end 11.Cold-producing medium after cryoprobe or catheter tip expand, evaporate returns agent as cold-producing medium, plays the pre-cooling effect through the 4th, 3,1 grade of precool heat exchanger device successively.
Present embodiment by fully pre-cooled, reaches final low temperature by cold-producing medium in 4 precool heat exchanger devices, and evaporates, expands, with this cryoablation target biology tissue, as tumor, cardiovascular organization or other pathological tissues at cryoprobe or conduit 9 tips.
In the present embodiment, cold-producing medium returns agent also can directly be disposed to atmosphere or collection.
Below the present invention is specified, but the present invention is not limited to described embodiment, those of ordinary skill in the art also can make all modification that is equal to or replacement under the prerequisite of spirit of the present invention, modification that these are equal to or replacement all are included in the application's claim institute restricted portion.
Claims (9)
1, a kind of multi-stage precooling cryoablation method is characterized in that, comprises the steps:
A. providing pressure by pressure source is the cold-producing medium of 0.1MPa～50MPa;
B. using the 1st grade of precool heat exchanger device makes cold-producing medium return agent to begin to cool down cold-producing medium;
C. use refrigeration plant and make cold-producing medium cooled apparatus cools in the 2nd grade of precool heat exchanger device;
D. being applied in 3rd level precool heat exchanger device in transfer pipeline and the handle makes cold-producing medium be returned agent by the adverse current cold-producing medium further to cool off;
E. the 4th grade of precool heat exchanger device of using in cryoprobe or the conduit makes cooled dose time agent of cold-producing medium fully cool off;
F. by the cold-producing medium of continuously pre-cooling expand at cryoprobe or catheter tip, evaporation to pathological tissues cooling melt;
G. the cold-producing medium after cryoprobe or catheter tip expand, evaporate returns agent as cold-producing medium, plays the pre-cooling effect through the 4th, 3,2,1 grade of precool heat exchanger device successively.
2, multi-stage precooling cryoablation method according to claim 1 is characterized in that, pressure is that the cold-producing medium of 0.1MPa～50MPa is by compressing acquisition to gas.
3, multi-stage precooling cryoablation method according to claim 1 is characterized in that, pressure source is that the gas cylinder that pressure is the cold-producing medium of 0.1MPa～50MPa is housed.
4, multi-stage precooling cryoablation method according to claim 1 is characterized in that, cold-producing medium is N
2, O
2, Ar or CO
2, or the mixture of nitrogen and alkanes gas.
5, multi-stage precooling cryoablation method according to claim 1 is characterized in that, cold-producing medium returns agent can be disposed to atmosphere or collection.
6, multi-stage precooling cryoablation method according to claim 1 is characterized in that, cold-producing medium returns the mode of agent by compression and circulates and enter pressure source.
7, implement the equipment of any one multi-stage precooling cryoablation method among the claim 1-7, it is characterized in that pressure source links to each other with air inlet pipeline, air inlet pipeline and outlet pipe constitute the 1st grade of precool heat exchanger device; The pipeline of air inlet pipeline and refrigeration plant constitutes the 2nd grade of precool heat exchanger device; Air inlet pipeline links to each other with transfer pipeline and handle, and transfer pipeline and handle and outlet pipe constitute 3rd level precool heat exchanger device; 3rd level precool heat exchanger device and cryoprobe or conduit join; Cryoprobe or catheter tip are treatment end, wherein include the 4th grade of precool heat exchanger device and expansion gear, and gas is discharged from outlet pipe by expansion gear after through the 4th grade of precool heat exchanger device.
8, equipment according to claim 7 is characterized in that, the 1st, 2,3,4 grade of precool heat exchanger device is pipe heat exchanger or plate type heat exchanger.
9, equipment according to claim 7 is characterized in that, refrigeration plant is liquid nitrogen plant or compression refrigeration equipment, maybe can cool to the equipment of 300K to 0K.
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| CNA2008100433746A CN101584602A (en) | 2008-05-20 | 2008-05-20 | Multi-stage precooling cryoablation method and equipment |
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| CNA2008100433746A CN101584602A (en) | 2008-05-20 | 2008-05-20 | Multi-stage precooling cryoablation method and equipment |
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Cited By (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104758049A (en) * | 2015-04-13 | 2015-07-08 | 北京阳光易帮医疗科技有限公司 | Ultra-low temperature freezing probe and use method thereof |
| CN104814739A (en) * | 2015-05-11 | 2015-08-05 | 刘敬松 | Therapeutic apparatus for detecting BPH (Benign Prostate Hyperplasia) |
| CN105411665A (en) * | 2015-12-11 | 2016-03-23 | 北京阳光易帮医疗科技有限公司 | Cryosurgery system |
| CN105705108A (en) * | 2013-11-01 | 2016-06-22 | C2治疗公司 | Cryogenic balloon ablation system |
| CN106420039A (en) * | 2016-10-12 | 2017-02-22 | 上海导向医疗系统有限公司 | Cryotherapy system through natural orifice of human body |
| CN107951558A (en) * | 2017-11-10 | 2018-04-24 | 上海导向医疗系统有限公司 | The Cryoablation system of multifunctional gas pipeline control |
| US10098686B2 (en) | 2015-05-15 | 2018-10-16 | Pentax Of America, Inc. | Cryogenic balloon ablation system |
| CN109044523A (en) * | 2018-08-20 | 2018-12-21 | 宁波胜杰康生物科技有限公司 | Cryoablation system |
| CN109414284A (en) * | 2016-05-20 | 2019-03-01 | 美国宾得公司 | Cryogenic ablation system with rotatable and translatable conduit |
| CN109674525A (en) * | 2018-12-21 | 2019-04-26 | 海杰亚（北京）医疗器械有限公司 | A kind of therapeutic equipment for medical freezing sacculus |
| US10383676B2 (en) | 2008-11-21 | 2019-08-20 | Pentax Of America, Inc. | Cryogenic ablation system and method |
| EP3872417A4 (en) * | 2018-12-26 | 2022-08-17 | Accu Target Medipharma (Shanghai) Co., Ltd. | Precooling device for cryotherapy and cryotherapy system |
| WO2023226489A1 (en) * | 2022-05-26 | 2023-11-30 | 上海导向医疗系统有限公司 | Dual-system cryotherapeutic system based on pre-cooling with cryogenerator |
-
2008
- 2008-05-20 CN CNA2008100433746A patent/CN101584602A/en active Pending
Cited By (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10383676B2 (en) | 2008-11-21 | 2019-08-20 | Pentax Of America, Inc. | Cryogenic ablation system and method |
| US11298174B2 (en) | 2008-11-21 | 2022-04-12 | Pentax Of America, Inc. | Cryogenic ablation system and method |
| CN105705108A (en) * | 2013-11-01 | 2016-06-22 | C2治疗公司 | Cryogenic balloon ablation system |
| CN104758049A (en) * | 2015-04-13 | 2015-07-08 | 北京阳光易帮医疗科技有限公司 | Ultra-low temperature freezing probe and use method thereof |
| CN104814739A (en) * | 2015-05-11 | 2015-08-05 | 刘敬松 | Therapeutic apparatus for detecting BPH (Benign Prostate Hyperplasia) |
| US10098686B2 (en) | 2015-05-15 | 2018-10-16 | Pentax Of America, Inc. | Cryogenic balloon ablation system |
| CN105411665A (en) * | 2015-12-11 | 2016-03-23 | 北京阳光易帮医疗科技有限公司 | Cryosurgery system |
| CN105411665B (en) * | 2015-12-11 | 2017-12-12 | 北京阳光易帮医疗科技有限公司 | A kind of cryosurgery system |
| US11266456B2 (en) | 2016-05-20 | 2022-03-08 | Pentax Of America, Inc. | Cryogenic ablation system with rotatable and translatable catheter |
| CN109414284A (en) * | 2016-05-20 | 2019-03-01 | 美国宾得公司 | Cryogenic ablation system with rotatable and translatable conduit |
| US10251693B2 (en) | 2016-05-20 | 2019-04-09 | Pentax Of America, Inc. | Cryogenic ablation system with rotatable and translatable catheter |
| CN109414284B (en) * | 2016-05-20 | 2021-08-10 | 美国宾得公司 | Cryogenic ablation system with rotatable and translatable catheter |
| CN106420039A (en) * | 2016-10-12 | 2017-02-22 | 上海导向医疗系统有限公司 | Cryotherapy system through natural orifice of human body |
| CN107951558A (en) * | 2017-11-10 | 2018-04-24 | 上海导向医疗系统有限公司 | The Cryoablation system of multifunctional gas pipeline control |
| CN109044523B (en) * | 2018-08-20 | 2020-06-16 | 宁波胜杰康生物科技有限公司 | Cryoablation system |
| CN109044523A (en) * | 2018-08-20 | 2018-12-21 | 宁波胜杰康生物科技有限公司 | Cryoablation system |
| CN109674525A (en) * | 2018-12-21 | 2019-04-26 | 海杰亚（北京）医疗器械有限公司 | A kind of therapeutic equipment for medical freezing sacculus |
| EP3872417A4 (en) * | 2018-12-26 | 2022-08-17 | Accu Target Medipharma (Shanghai) Co., Ltd. | Precooling device for cryotherapy and cryotherapy system |
| WO2023226489A1 (en) * | 2022-05-26 | 2023-11-30 | 上海导向医疗系统有限公司 | Dual-system cryotherapeutic system based on pre-cooling with cryogenerator |
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Open date: 20091125 |