CN109662703A - Medical intervention apparatus and blood flow parameter measurement method with MEMS mass sensor - Google Patents
Medical intervention apparatus and blood flow parameter measurement method with MEMS mass sensor Download PDFInfo
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- CN109662703A CN109662703A CN201910001695.8A CN201910001695A CN109662703A CN 109662703 A CN109662703 A CN 109662703A CN 201910001695 A CN201910001695 A CN 201910001695A CN 109662703 A CN109662703 A CN 109662703A
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- blood flow
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- temperature sensor
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- 230000017531 blood circulation Effects 0.000 title claims abstract description 35
- 238000000691 measurement method Methods 0.000 title abstract description 6
- 230000002792 vascular Effects 0.000 claims abstract description 12
- 239000012530 fluid Substances 0.000 claims description 18
- 210000004204 blood vessel Anatomy 0.000 claims description 11
- 238000005259 measurement Methods 0.000 claims description 11
- 238000000034 method Methods 0.000 claims description 11
- 238000011144 upstream manufacturing Methods 0.000 claims description 6
- 239000004065 semiconductor Substances 0.000 claims description 5
- 239000008280 blood Substances 0.000 claims description 3
- 210000004369 blood Anatomy 0.000 claims description 3
- 238000002583 angiography Methods 0.000 claims description 2
- 210000004351 coronary vessel Anatomy 0.000 description 5
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 description 4
- 230000004089 microcirculation Effects 0.000 description 3
- 230000002107 myocardial effect Effects 0.000 description 3
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- 208000018672 Dilatation Diseases 0.000 description 2
- 229960005305 adenosine Drugs 0.000 description 2
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/02—Detecting, measuring or recording pulse, heart rate, blood pressure or blood flow; Combined pulse/heart-rate/blood pressure determination; Evaluating a cardiovascular condition not otherwise provided for, e.g. using combinations of techniques provided for in this group with electrocardiography or electroauscultation; Heart catheters for measuring blood pressure
- A61B5/026—Measuring blood flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/68—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient
- A61B5/6846—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive
- A61B5/6867—Arrangements of detecting, measuring or recording means, e.g. sensors, in relation to patient specially adapted to be brought in contact with an internal body part, i.e. invasive specially adapted to be attached or implanted in a specific body part
- A61B5/6876—Blood vessel
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B2562/00—Details of sensors; Constructional details of sensor housings or probes; Accessories for sensors
- A61B2562/02—Details of sensors specially adapted for in-vivo measurements
- A61B2562/028—Microscale sensors, e.g. electromechanical sensors [MEMS]
Abstract
The invention discloses a kind of medical intervention apparatus and blood flow parameter measurement method with MEMS mass sensor, including upper temperature sensor S and downflow temperature sensor R, micro-heater is equipped at upper temperature sensor, it is packaged into microsheet, it is compounded in the surface of intervention equipment, blood flow velocity is directly measured, to obtain blood flow parameter.Endovascular flow velocity can be directly measured, directly at hemadostewnosis and intravascular each point directly measures flow velocity；The vascular flow surveyed directly has functional relation with institute's measuring point vascular cross-section product.
Description
Technical field
The present invention relates to a kind of blood vessel intervention diagnosis and treatment technologies more particularly to a kind of with MEMS mass sensor
Medical intervention apparatus and blood flow parameter measurement method.
Background technique
FFR (fractional flow reserve) is known as " artery blood flow deposit score ", refers to and deposits in such as coronary artery
In stenotic lesion, no narrow situation is assumed for the obtainable maximum blood flow of myocardial region and the same area by blood vessel institute
It is lower to obtain the ratio between maximum blood flow.FFR is for diagnosing hemadostewnosis degree.Existing such interventional technique has following methods:
Seal wire with micro pressure sensor measures FFR: being index derived from a pressure.According to hydrodynamics public affairs
Formula: pressure (P)=flow (Q) X resistance (R) releases cardiac muscular tissue's blood flow Q=pressure P/ resistance R, the i.e. blood flow of cardiac muscular tissue
Amount is proportional with perfusion pressure, is in inverse ratio with microcirculation resistance in cardiac muscle.If clinically using induction Myocardial Microcirculation maximum journey
Degree is congested (the blood vessel dilatations drug such as injection adenosine), Myocardial Microcirculation resistance R can be made small to ignoring.Clinically with leading
Pipe measures blood vessel proximal pressure (Paortic, close to ostium) and measures the subsequent pressure of hemadostewnosis with this Pressure wire
(Pdistal), FFR=Pdistal/Paortic.FFR value is the absolute number between 0 and 1, wherein the instruction of value 0.50 is given
It is narrow cause blood pressure to decline 50%, and diagnose the stenosis of blood vessel.(US 6767327–Volcano Company)；
Seal wire with micro pressure sensing measures instantaneously without waveform ratio (Instantaneous Wave-free
Ratio) iFR: not being resistant to those the patient of the blood vessel dilatations drug such as adenosine, and iFR is defined as in diastole without waveform
Interphase narrow remote end average pressure (Pdistal)/diastole is without waveform interphase mean arterial pressure (Paortic).IFR reduces
FFR's uses obstacle, and expands Pressure wire in clinical application.(US 9820660–Volcano Company)；
Non-pressure seal wire dependence-coronary artery computerized tomography FFR (FFR derived from
Coronary computed tomography, FFRCT): first with coronary artery computerized tomography (coronary
Computed tomography, CCTA) coronary artery 3-D image is obtained, computer aided fluid principle of dynamics, mould are used later
Intend intracoronary pressure and flow, and utilizes intracoronary pressure and flow under lumped parameter model simulation congestive state
Variation, to derive lesion function assessment index-FFRCT similar to invasive FFR.FFRCT guidance selection needs coronary artery to make
The patient of shadow and PCI can reduce medical expense and improve clinical prognosis.The appearance of FFRCT evaluates non-invasive property coronary artery function assessment
Become possibility.(US 20140088414)；
Non-pressure seal wire relies on-quantify blood flow score (quantitative flow ratio, QFR): QFR passes through radiography
Three-dimensional reconstruction and hydromechanical computer Simulation calculation obtain, the FFR that noninvasive QFR and invasive Pressure wire are calculated
There is certain consistency.At present in clinical trial.
Summary of the invention
Medical intervention apparatus and blood flow parameter measurement with MEMS mass sensor that the object of the present invention is to provide a kind of
Method.
The purpose of the present invention is what is be achieved through the following technical solutions:
Medical intervention apparatus with MEMS mass sensor of the invention is equipped with base in the proximal end of intervention apparatus or distal end
In the fluid velocity sensor device of MEMS, the fluid velocity sensor device based on MEMS includes upper
Temperature sensor and downflow temperature sensor are flowed, micro-heater is equipped at the upstream temperature sensor, the upstream temperature passes
Sensor and downflow temperature sensor are semiconductor transducer.
The method of medical intervention apparatus measurement blood flow parameter with MEMS mass sensor of the invention, comprising:
By being equipped with the Vascular interventional devices of the fluid velocity sensor device based on MEMS, directly measure
Blood flow velocity, to obtain blood flow parameter.
As seen from the above technical solution provided by the invention, provided in an embodiment of the present invention to have MEMS mass sensitivity
The medical intervention apparatus and blood flow parameter measurement method of device, can directly measure endovascular flow velocity, directly to hemadostewnosis at
Flow velocity is directly measured with intravascular each point, the vascular flow surveyed directly has functional relation with institute's measuring point vascular cross-section product.
Detailed description of the invention
Fig. 1 is the medical intervention apparatus and blood flow parameter measurement provided in an embodiment of the present invention with MEMS mass sensor
Method And Principle schematic diagram.
Specific embodiment
The embodiment of the present invention will be described in further detail below.What is be not described in detail in the embodiment of the present invention is interior
Appearance belongs to the prior art well known to professional and technical personnel in the field.
Medical intervention apparatus with MEMS mass sensor of the invention, preferable specific embodiment is:
It is equipped with the fluid velocity sensor device based on MEMS in the proximal end of intervention apparatus or distal end, it is described to be based on
The fluid velocity sensor device of MEMS includes upstream temperature sensor S and downflow temperature sensor R, the upper temperature
It spends and is equipped with micro-heater at sensor, the upstream temperature sensor and downflow temperature sensor are semiconductor transducer.
The fluid velocity sensor device based on MEMS is packaged into microsheet, is compounded in the interposers
The surface of material.
The intervention apparatus includes any of following Vascular interventional devices: guide wire, foley's tube, microtubular, radiography
Conduit, guiding catheter.
The method of medical intervention apparatus measurement blood flow parameter with MEMS mass sensor of the invention, preferably has
Body embodiment is:
Include:
By being equipped with the Vascular interventional devices of the fluid velocity sensor device based on MEMS, directly measure
Blood flow velocity, to obtain blood flow parameter.
The micro-heater generates a narrow temperature pulse T1, this temperature pulse in the upstream temperature sensor S
As blood flow is transmitted at downflow temperature sensor R, downflow temperature sensor receives the temperature change T2, T2 generated by T1
Time interval with T1 is that the distance of T, S and R are D, thus the flow velocity V of blood and available: V=D/T, the blood stream in blood vessel
Amount Q is the function of flow velocity V and vessel cross-sections product A: Q=VA.
Specific embodiment:
As shown in Figure 1, the medical intervention apparatus and blood flow parameter measurement method of MEMS mass sensor are had, using being based on
The fluid velocity sensor technology of MEMS (MEMS, Micro-Electro-Mechanical System) is situated between in blood vessel
Enter the proximal end or distal end of instrument, directly measurement blood flow velocity, to obtain blood flow parameter.Blood vessel intervention equipment includes but unlimited
In: guide wire, foley's tube, microtubular, angiography catheter, guiding catheter, etc..MEMS fluid speed measurement sensor can be with a step and straight
It connects and measures blood flow velocity, the working principle of MEMS flow sensor are as follows: S is that small semiconductor element generates a narrow temperature
Pulse T1 is spent, this temperature pulse is transmitted at semiconductor transducer R with fluid (blood flow), and R receives the temperature generated by T1
The time interval of variation T2.T2 and T1 is that the distance of T, S and R are D.To the speed V of blood flow and available: V=D/T.In blood
Flow in pipe is the function of flow velocity and vessel cross-sections product (A): Q=VA.
Calorimetric mass flow principle is utilized in this microelectromechanical-systems sensor (MEMS), be on 2 temperature sensors stream and under
It placed a micro-heater between stream.When fluid passes through micro-heater, temperature will be transmitted with fluid, be flowed down in this way by upper
The temperature difference that arrives of temperature sensor measurement will be proportional to the flow of fluid.
Also, this mass flow MEMS sensor can be packaged into microsheet, be compounded in the surface of intervention equipment, in intervention equipment
Surface forms boundary layer and laminar flow, it is ensured that sensor flox condition stable within the scope of surveyed blood vessel.
Different from current pressure sensor method, benefit of the invention is that:
Endovascular flow velocity can be directly measured, is not indirect measurement pressure to estimate；
The process for directly measuring intravascular flow velocity, is not brought noise to be influenced by vascular resistence；
It can be directly at hemadostewnosis and intravascular each point directly measures flow velocity, rather than by before at hemadostewnosis
It holds with rear end pressure difference and estimates the flow at hemadostewnosis；
The vascular flow surveyed directly has functional relation with institute's measuring point vascular cross-section product.
The foregoing is only a preferred embodiment of the present invention, but scope of protection of the present invention is not limited thereto,
Within the technical scope of the present disclosure, any changes or substitutions that can be easily thought of by anyone skilled in the art,
It should be covered by the protection scope of the present invention.Therefore, protection scope of the present invention should be with the protection model of claims
Subject to enclosing.
Claims (5)
1. a kind of medical intervention apparatus with MEMS mass sensor, which is characterized in that in the proximal end or distal end of intervention apparatus
Equipped with the fluid velocity sensor device based on MEMS, the fluid velocity sensor device based on MEMS
Including upper temperature sensor (S) and downflow temperature sensor (R), micro-heater, institute are equipped at the upstream temperature sensor
Stating upper temperature sensor and downflow temperature sensor is semiconductor transducer.
2. the medical intervention apparatus according to claim 1 with MEMS mass sensor, which is characterized in that described to be based on
The fluid velocity sensor device of MEMS is packaged into microsheet, is compounded in the surface of the intervention equipment.
3. the medical intervention apparatus according to claim 2 with MEMS mass sensor, which is characterized in that the intervention
Instrument includes any of following Vascular interventional devices: guide wire, foley's tube, microtubular, angiography catheter, guiding catheter.
4. a kind of medical intervention apparatus measurement blood flow parameter described in claim 1,2 or 3 with MEMS mass sensor
Method characterized by comprising
By being equipped with the Vascular interventional devices of the fluid velocity sensor device based on MEMS, directly measurement blood flow
Speed, to obtain blood flow parameter.
5. the method for the medical intervention apparatus measurement blood flow parameter according to claim 4 with MEMS mass sensor,
It is characterised by comprising:
The micro-heater generates a narrow temperature pulse T1 in the upper temperature sensor (S), this temperature pulse with
Blood flow be transmitted at downflow temperature sensor (R), downflow temperature sensor receive by T1 generate temperature change T2, T2 and
The time interval of T1 is that the distance of T, S and R are D, thus the flow velocity V of blood and available: V=D/T, the blood flow in blood vessel
Q is the function of flow velocity V and vessel cross-sections product A: Q=VA.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910001695.8A CN109662703A (en) | 2019-01-02 | 2019-01-02 | Medical intervention apparatus and blood flow parameter measurement method with MEMS mass sensor |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201910001695.8A CN109662703A (en) | 2019-01-02 | 2019-01-02 | Medical intervention apparatus and blood flow parameter measurement method with MEMS mass sensor |
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| CN109662703A true CN109662703A (en) | 2019-04-23 |
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| CN201910001695.8A Pending CN109662703A (en) | 2019-01-02 | 2019-01-02 | Medical intervention apparatus and blood flow parameter measurement method with MEMS mass sensor |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114366859A (en) * | 2021-10-29 | 2022-04-19 | 首都医科大学宣武医院 | Cerebrospinal fluid drainage and brain temperature automatic monitoring device |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11244248A (en) * | 1998-02-27 | 1999-09-14 | Nippon Bxi Kk | Guide wire type stromuhr |
| US20060235314A1 (en) * | 2003-01-31 | 2006-10-19 | Michele Migliuolo | Medical and surgical devices with an integrated sensor |
| US20110196255A1 (en) * | 2010-02-05 | 2011-08-11 | Kassab Ghassan S | Devices, systems, and methods for measuring parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determining plaque vulnerability using temperature |
| CN103561641A (en) * | 2011-06-01 | 2014-02-05 | 皇家飞利浦有限公司 | System for distributed blood flow measurement |
| CN105828709A (en) * | 2014-01-03 | 2016-08-03 | Mc10股份有限公司 | Catheter or guidewire device including flow sensing and use thereof |
| CN106456026A (en) * | 2014-04-04 | 2017-02-22 | 圣犹达医疗系统公司 | Intravascular pressure and flow data diagnostic systems, devices, and methods |
| CN210277154U (en) * | 2019-01-02 | 2020-04-10 | 迪泰医学科技（苏州）有限公司 | Medical interventional instrument with MEMS mass sensor |
-
2019
- 2019-01-02 CN CN201910001695.8A patent/CN109662703A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH11244248A (en) * | 1998-02-27 | 1999-09-14 | Nippon Bxi Kk | Guide wire type stromuhr |
| US20060235314A1 (en) * | 2003-01-31 | 2006-10-19 | Michele Migliuolo | Medical and surgical devices with an integrated sensor |
| US20110196255A1 (en) * | 2010-02-05 | 2011-08-11 | Kassab Ghassan S | Devices, systems, and methods for measuring parallel tissue conductance, luminal cross-sectional areas, fluid velocity, and/or determining plaque vulnerability using temperature |
| CN103561641A (en) * | 2011-06-01 | 2014-02-05 | 皇家飞利浦有限公司 | System for distributed blood flow measurement |
| CN105828709A (en) * | 2014-01-03 | 2016-08-03 | Mc10股份有限公司 | Catheter or guidewire device including flow sensing and use thereof |
| CN106456026A (en) * | 2014-04-04 | 2017-02-22 | 圣犹达医疗系统公司 | Intravascular pressure and flow data diagnostic systems, devices, and methods |
| CN210277154U (en) * | 2019-01-02 | 2020-04-10 | 迪泰医学科技（苏州）有限公司 | Medical interventional instrument with MEMS mass sensor |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114366859A (en) * | 2021-10-29 | 2022-04-19 | 首都医科大学宣武医院 | Cerebrospinal fluid drainage and brain temperature automatic monitoring device |
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