AU2002228664A1 - Microfabricated elastomeric valve and pump systems - Google Patents

Microfabricated elastomeric valve and pump systems

Info

Publication number
AU2002228664A1
AU2002228664A1 AU2002228664A AU2866402A AU2002228664A1 AU 2002228664 A1 AU2002228664 A1 AU 2002228664A1 AU 2002228664 A AU2002228664 A AU 2002228664A AU 2866402 A AU2866402 A AU 2866402A AU 2002228664 A1 AU2002228664 A1 AU 2002228664A1
Authority
AU
Australia
Prior art keywords
pump systems
elastomeric valve
microfabricated elastomeric
microfabricated
valve
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002228664A
Inventor
Mark L. Adams
Hou-Pu Chou
Carl L. Hansen
Jian Liu
Stephen R. Quake
Axel Scherer
Todd A. Thorsen
Marc A. Unger
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
California Institute of Technology CalTech
Original Assignee
California Institute of Technology CalTech
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/724,784 external-priority patent/US7144616B1/en
Application filed by California Institute of Technology CalTech filed Critical California Institute of Technology CalTech
Publication of AU2002228664A1 publication Critical patent/AU2002228664A1/en
Abandoned legal-status Critical Current

Links

Classifications

    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F04—POSITIVE - DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS FOR LIQUIDS OR ELASTIC FLUIDS
    • F04B—POSITIVE-DISPLACEMENT MACHINES FOR LIQUIDS; PUMPS
    • F04B43/00—Machines, pumps, or pumping installations having flexible working members
    • F04B43/02—Machines, pumps, or pumping installations having flexible working members having plate-like flexible members, e.g. diaphragms
    • F04B43/04—Pumps having electric drive
    • F04B43/043—Micropumps
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502738—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by integrated valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L9/00—Supporting devices; Holding devices
    • B01L9/52—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips
    • B01L9/527—Supports specially adapted for flat sample carriers, e.g. for plates, slides, chips for microfluidic devices, e.g. used for lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B05—SPRAYING OR ATOMISING IN GENERAL; APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D—PROCESSES FOR APPLYING FLUENT MATERIALS TO SURFACES, IN GENERAL
    • B05D3/00—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials
    • B05D3/04—Pretreatment of surfaces to which liquids or other fluent materials are to be applied; After-treatment of applied coatings, e.g. intermediate treating of an applied coating preparatory to subsequent applications of liquids or other fluent materials by exposure to gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65B—MACHINES, APPARATUS OR DEVICES FOR, OR METHODS OF, PACKAGING ARTICLES OR MATERIALS; UNPACKING
    • B65B31/00—Packaging articles or materials under special atmospheric or gaseous conditions; Adding propellants to aerosol containers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B81—MICROSTRUCTURAL TECHNOLOGY
    • B81C—PROCESSES OR APPARATUS SPECIALLY ADAPTED FOR THE MANUFACTURE OR TREATMENT OF MICROSTRUCTURAL DEVICES OR SYSTEMS
    • B81C1/00—Manufacture or treatment of devices or systems in or on a substrate
    • B81C1/00015—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems
    • B81C1/00023—Manufacture or treatment of devices or systems in or on a substrate for manufacturing microsystems without movable or flexible elements
    • B81C1/00119—Arrangement of basic structures like cavities or channels, e.g. suitable for microfluidic systems
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6832—Enhancement of hybridisation reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6869—Methods for sequencing
    • C12Q1/6874—Methods for sequencing involving nucleic acid arrays, e.g. sequencing by hybridisation
    • C—CHEMISTRY; METALLURGY
    • C30—CRYSTAL GROWTH
    • C30B—SINGLE-CRYSTAL GROWTH; UNIDIRECTIONAL SOLIDIFICATION OF EUTECTIC MATERIAL OR UNIDIRECTIONAL DEMIXING OF EUTECTOID MATERIAL; REFINING BY ZONE-MELTING OF MATERIAL; PRODUCTION OF A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; SINGLE CRYSTALS OR HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; AFTER-TREATMENT OF SINGLE CRYSTALS OR A HOMOGENEOUS POLYCRYSTALLINE MATERIAL WITH DEFINED STRUCTURE; APPARATUS THEREFOR
    • C30B29/00—Single crystals or homogeneous polycrystalline material with defined structure characterised by the material or by their shape
    • C30B29/54—Organic compounds
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C1/00—Circuit elements having no moving parts
    • F15C1/02—Details, e.g. special constructional devices for circuits with fluid elements, such as resistances, capacitive circuit elements; devices preventing reaction coupling in composite elements ; Switch boards; Programme devices
    • F15C1/06—Constructional details; Selection of specified materials ; Constructional realisation of one single element; Canal shapes; Jet nozzles; Assembling an element with other devices, only if the element forms the main part
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C3/00—Circuit elements having moving parts
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F15—FLUID-PRESSURE ACTUATORS; HYDRAULICS OR PNEUMATICS IN GENERAL
    • F15C—FLUID-CIRCUIT ELEMENTS PREDOMINANTLY USED FOR COMPUTING OR CONTROL PURPOSES
    • F15C5/00—Manufacture of fluid circuit elements; Manufacture of assemblages of such elements integrated circuits
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0003—Constructional types of microvalves; Details of the cutting-off member
    • F16K99/0015—Diaphragm or membrane valves
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0046—Electric operating means therefor using magnets
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0042—Electric operating means therefor
    • F16K99/0051—Electric operating means therefor using electrostatic means
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16K—VALVES; TAPS; COCKS; ACTUATING-FLOATS; DEVICES FOR VENTING OR AERATING
    • F16K99/00—Subject matter not provided for in other groups of this subclass
    • F16K99/0001—Microvalves
    • F16K99/0034—Operating means specially adapted for microvalves
    • F16K99/0055—Operating means specially adapted for microvalves actuated by fluids
    • F16K99/0059—Operating means specially adapted for microvalves actuated by fluids actuated by a pilot fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00274—Sequential or parallel reactions; Apparatus and devices for combinatorial chemistry or for making arrays; Chemical library technology
    • B01J2219/00277—Apparatus
    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00353—Pumps
    • B01J2219/00355—Pumps peristaltic
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
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    • B01J2219/00378—Piezoelectric or ink jet dispensers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00351—Means for dispensing and evacuation of reagents
    • B01J2219/00389—Feeding through valves
    • B01J2219/00396—Membrane valves
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01J2219/00389—Feeding through valves
    • B01J2219/00396—Membrane valves
    • B01J2219/00398—Membrane valves in multiple arrangements
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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • General Engineering & Computer Science (AREA)
  • Dispersion Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Clinical Laboratory Science (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Fluid Mechanics (AREA)
  • Theoretical Computer Science (AREA)
  • Microelectronics & Electronic Packaging (AREA)
  • Manufacturing & Machinery (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
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  • Biophysics (AREA)
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  • Computer Hardware Design (AREA)
  • Metallurgy (AREA)
  • Materials Engineering (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Micromachines (AREA)
  • Reciprocating Pumps (AREA)
  • Fluid-Driven Valves (AREA)
AU2002228664A 2000-11-28 2001-11-28 Microfabricated elastomeric valve and pump systems Abandoned AU2002228664A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US09/724,784 US7144616B1 (en) 1999-06-28 2000-11-28 Microfabricated elastomeric valve and pump systems
US09/724,784 2000-11-28
US09/826,583 2001-04-06
US09/826,583 US6899137B2 (en) 1999-06-28 2001-04-06 Microfabricated elastomeric valve and pump systems
PCT/US2001/044549 WO2002043615A2 (en) 2000-11-28 2001-11-28 Microfabricated elastomeric valve and pump systems

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EP (1) EP1345551B1 (en)
JP (2) JP2004526578A (en)
AU (1) AU2002228664A1 (en)
WO (1) WO2002043615A2 (en)

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EP1060395B1 (en) 1998-02-04 2008-04-30 Invitrogen Corporation Microarrays and uses therefor
US7282240B1 (en) 1998-04-21 2007-10-16 President And Fellows Of Harvard College Elastomeric mask and use in fabrication of devices
US20030138973A1 (en) * 1998-07-14 2003-07-24 Peter Wagner Microdevices for screening biomolecules
US6406921B1 (en) * 1998-07-14 2002-06-18 Zyomyx, Incorporated Protein arrays for high-throughput screening
US6576478B1 (en) * 1998-07-14 2003-06-10 Zyomyx, Inc. Microdevices for high-throughput screening of biomolecules
US20020119579A1 (en) * 1998-07-14 2002-08-29 Peter Wagner Arrays devices and methods of use thereof
US20020164812A1 (en) * 1999-04-06 2002-11-07 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
US7250305B2 (en) * 2001-07-30 2007-07-31 Uab Research Foundation Use of dye to distinguish salt and protein crystals under microcrystallization conditions
US7247490B2 (en) * 1999-04-06 2007-07-24 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
JP3866043B2 (en) * 1999-04-06 2007-01-10 ザ ユーエービー リサーチ ファウンデイション Method for screening crystallization conditions in solution crystal growth
US7244396B2 (en) * 1999-04-06 2007-07-17 Uab Research Foundation Method for preparation of microarrays for screening of crystal growth conditions
US7214540B2 (en) * 1999-04-06 2007-05-08 Uab Research Foundation Method for screening crystallization conditions in solution crystal growth
ES2609594T3 (en) 1999-04-26 2017-04-21 Glaukos Corporation Drainage device to treat glaucoma
US6630006B2 (en) 1999-06-18 2003-10-07 The Regents Of The University Of California Method for screening microcrystallizations for crystal formation
US8550119B2 (en) * 1999-06-28 2013-10-08 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US8052792B2 (en) * 2001-04-06 2011-11-08 California Institute Of Technology Microfluidic protein crystallography techniques
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7306672B2 (en) 2001-04-06 2007-12-11 California Institute Of Technology Microfluidic free interface diffusion techniques
US7144616B1 (en) * 1999-06-28 2006-12-05 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7244402B2 (en) * 2001-04-06 2007-07-17 California Institute Of Technology Microfluidic protein crystallography
US7217321B2 (en) * 2001-04-06 2007-05-15 California Institute Of Technology Microfluidic protein crystallography techniques
US8709153B2 (en) 1999-06-28 2014-04-29 California Institute Of Technology Microfludic protein crystallography techniques
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7459022B2 (en) * 2001-04-06 2008-12-02 California Institute Of Technology Microfluidic protein crystallography
AU779988B2 (en) * 1999-06-28 2005-02-24 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US7195670B2 (en) 2000-06-27 2007-03-27 California Institute Of Technology High throughput screening of crystallization of materials
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
US6696022B1 (en) * 1999-08-13 2004-02-24 U.S. Genomics, Inc. Methods and apparatuses for stretching polymers
US6432290B1 (en) 1999-11-26 2002-08-13 The Governors Of The University Of Alberta Apparatus and method for trapping bead based reagents within microfluidic analysis systems
CA2290731A1 (en) * 1999-11-26 2001-05-26 D. Jed Harrison Apparatus and method for trapping bead based reagents within microfluidic analysis system
DE10005735A1 (en) * 2000-02-09 2001-08-23 Evotec Biosystems Ag Withdrawing liquid stream containing suspended cells from liquid microsystem, comprises feeding stream at end of exit channel into decoupling stream to form discharge stream which is discharged through outlet
US7485454B1 (en) * 2000-03-10 2009-02-03 Bioprocessors Corp. Microreactor
AU4365601A (en) * 2000-03-17 2001-10-03 Harvard College Cell patterning technique
US7867763B2 (en) * 2004-01-25 2011-01-11 Fluidigm Corporation Integrated chip carriers with thermocycler interfaces and methods of using the same
US6638239B1 (en) 2000-04-14 2003-10-28 Glaukos Corporation Apparatus and method for treating glaucoma
US20040111050A1 (en) * 2000-04-14 2004-06-10 Gregory Smedley Implantable ocular pump to reduce intraocular pressure
US7867186B2 (en) 2002-04-08 2011-01-11 Glaukos Corporation Devices and methods for treatment of ocular disorders
EP1283909A4 (en) * 2000-05-04 2006-06-07 Univ Yale High density protein arrays for screening of protein activity
US6627159B1 (en) * 2000-06-28 2003-09-30 3M Innovative Properties Company Centrifugal filling of sample processing devices
US8097471B2 (en) * 2000-11-10 2012-01-17 3M Innovative Properties Company Sample processing devices
US7378280B2 (en) 2000-11-16 2008-05-27 California Institute Of Technology Apparatus and methods for conducting assays and high throughput screening
US7670429B2 (en) * 2001-04-05 2010-03-02 The California Institute Of Technology High throughput screening of crystallization of materials
EP1384022A4 (en) 2001-04-06 2004-08-04 California Inst Of Techn Nucleic acid amplification utilizing microfluidic devices
US7431710B2 (en) 2002-04-08 2008-10-07 Glaukos Corporation Ocular implants with anchors and methods thereof
EP2982354A1 (en) 2001-04-07 2016-02-10 Glaukos Corporation System for treating ocular disorders
US20040132166A1 (en) * 2001-04-10 2004-07-08 Bioprocessors Corp. Determination and/or control of reactor environmental conditions
US20040058437A1 (en) * 2001-04-10 2004-03-25 Rodgers Seth T. Materials and reactor systems having humidity and gas control
US20040058407A1 (en) * 2001-04-10 2004-03-25 Miller Scott E. Reactor systems having a light-interacting component
US7158888B2 (en) 2001-05-04 2007-01-02 Takeda San Diego, Inc. Determining structures by performing comparisons between molecular replacement results for multiple different biomolecules
US6780240B2 (en) 2001-06-08 2004-08-24 Syrrx, Inc. Method for causing fluid movement by centrifugal force
US6994749B2 (en) * 2001-06-08 2006-02-07 Syrrx, Inc. Microfluidic device for parallel delivery and mixing of fluids
US6811609B2 (en) * 2001-06-08 2004-11-02 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force in different directions
US6916372B2 (en) 2001-06-08 2005-07-12 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force
US6837927B2 (en) 2001-06-08 2005-01-04 Syrrx, Inc. Microvolume device employing fluid movement by centrifugal force
US6719840B2 (en) 2001-06-08 2004-04-13 Syrrx, Inc. In situ crystal growth and crystallization
US6797056B2 (en) * 2001-06-08 2004-09-28 Syrrx, Inc. Microfluidic method employing delivery of plural different fluids to same lumen
US6761766B2 (en) 2001-06-08 2004-07-13 Syrrx, Inc. Method for parallel delivery and mixing of fluids by rotating a microfluidic device
US6837926B2 (en) * 2001-06-08 2005-01-04 Syrrx, Inc. Device for detecting precipitate formation in microvolumes
US7014705B2 (en) * 2001-06-08 2006-03-21 Takeda San Diego, Inc. Microfluidic device with diffusion between adjacent lumens
US7331984B2 (en) 2001-08-28 2008-02-19 Glaukos Corporation Glaucoma stent for treating glaucoma and methods of use
US20030108664A1 (en) * 2001-10-05 2003-06-12 Kodas Toivo T. Methods and compositions for the formation of recessed electrical features on a substrate
US8440093B1 (en) 2001-10-26 2013-05-14 Fuidigm Corporation Methods and devices for electronic and magnetic sensing of the contents of microfluidic flow channels
JP4355210B2 (en) 2001-11-30 2009-10-28 フルイディグム コーポレイション Microfluidic device and method of using microfluidic device
US7691333B2 (en) * 2001-11-30 2010-04-06 Fluidigm Corporation Microfluidic device and methods of using same
US7524459B2 (en) * 2002-01-24 2009-04-28 California Institute Of Technology In Pasadena Optoelectronic and microfluidic integration for miniaturized spectroscopic devices
AU2003216254A1 (en) * 2002-02-12 2003-09-04 Kionix, Inc. Fabrication of ultra-shallow channels for microfluidic devices and systems
AU2003215340A1 (en) * 2002-02-22 2003-09-09 Nanostream, Inc. Ratiometric dilution devices and methods
AU2003224817B2 (en) 2002-04-01 2008-11-06 Fluidigm Corporation Microfluidic particle-analysis systems
AU2003221830A1 (en) * 2002-04-08 2003-10-27 Rosemount Inc. Implantable pressure-activated micro-valve
US20050026134A1 (en) * 2002-04-10 2005-02-03 Bioprocessors Corp. Systems and methods for control of pH and other reactor environment conditions
ATE543100T1 (en) * 2002-04-30 2012-02-15 Arkray Inc ANALYSIS TOOL
US9919472B1 (en) * 2002-05-07 2018-03-20 Microfabrica Inc. Stacking and bonding methods for forming multi-layer, three-dimensional, millimeter scale and microscale structures
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
US20030217923A1 (en) * 2002-05-24 2003-11-27 Harrison D. Jed Apparatus and method for trapping bead based reagents within microfluidic analysis systems
US20070026528A1 (en) * 2002-05-30 2007-02-01 Delucas Lawrence J Method for screening crystallization conditions in solution crystal growth
US20050106714A1 (en) * 2002-06-05 2005-05-19 Zarur Andrey J. Rotatable reactor systems and methods
US20040005247A1 (en) * 2002-07-03 2004-01-08 Nanostream, Inc. Microfluidic closed-end metering systems and methods
WO2004005898A1 (en) * 2002-07-10 2004-01-15 Uab Research Foundation Method for distinguishing between biomolecule and non-biomolecule crystals
US7235164B2 (en) * 2002-10-18 2007-06-26 Eksigent Technologies, Llc Electrokinetic pump having capacitive electrodes
US7201881B2 (en) * 2002-07-26 2007-04-10 Applera Corporation Actuator for deformable valves in a microfluidic device, and method
US7198759B2 (en) * 2002-07-26 2007-04-03 Applera Corporation Microfluidic devices, methods, and systems
US7135147B2 (en) * 2002-07-26 2006-11-14 Applera Corporation Closing blade for deformable valve in a microfluidic device and method
CA2500283A1 (en) * 2002-09-25 2004-04-08 California Institute Of Technology Microfluidic large scale integration
AU2003299541A1 (en) 2002-10-02 2004-05-25 California Institute Of Technology Microfluidic nucleic acid analysis
KR101216828B1 (en) * 2002-12-30 2013-01-04 더 리전트 오브 더 유니버시티 오브 캘리포니아 Methods and apparatus for pathogen detection and analysis
FR2852889A1 (en) * 2003-03-28 2004-10-01 Michelin Soc Tech TIRE COMPRISING A COLORED PATTERN AND PROCESS FOR OBTAINING IT
WO2006102264A1 (en) 2005-03-18 2006-09-28 Fluidigm Corporation Thermal reaction device and method for using the same
CA2521171C (en) 2003-04-03 2013-05-28 Fluidigm Corp. Microfluidic devices and methods of using same
US20050145496A1 (en) 2003-04-03 2005-07-07 Federico Goodsaid Thermal reaction device and method for using the same
US8828663B2 (en) * 2005-03-18 2014-09-09 Fluidigm Corporation Thermal reaction device and method for using the same
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same
US7604965B2 (en) 2003-04-03 2009-10-20 Fluidigm Corporation Thermal reaction device and method for using the same
JP2006522940A (en) * 2003-04-10 2006-10-05 ユー．エス． ジェノミクス， インコーポレイテッド Manipulating polymers in microchannels
US20050026273A1 (en) * 2003-06-05 2005-02-03 Zarur Andrey J. Reactor with memory component
US7309467B2 (en) 2003-06-24 2007-12-18 Hewlett-Packard Development Company, L.P. Fluidic MEMS device
US7413712B2 (en) * 2003-08-11 2008-08-19 California Institute Of Technology Microfluidic rotary flow reactor matrix
US7284966B2 (en) 2003-10-01 2007-10-23 Agency For Science, Technology & Research Micro-pump
US8011388B2 (en) * 2003-11-24 2011-09-06 Microstaq, INC Thermally actuated microvalve with multiple fluid ports
US20050164373A1 (en) * 2004-01-22 2005-07-28 Oldham Mark F. Diffusion-aided loading system for microfluidic devices
AU2005208879B2 (en) * 2004-01-25 2010-06-03 Fluidigm Corporation Crystal forming devices and systems and methods for making and using the same
US20050182312A1 (en) * 2004-02-12 2005-08-18 Medtronic Xomed, Inc. Contact tonometer using MEMS technology
CN1942590B (en) * 2004-02-18 2012-09-05 周小川 Fluidic devices and methods for multiplex chemical and biochemical reactions
US20060206049A1 (en) * 2005-03-14 2006-09-14 Rodgers M S MEMS flow module with piston-type pressure regulating structure
KR20070012375A (en) * 2004-02-27 2007-01-25 알루미나 마이크로 엘엘씨 Hybrid micro/macro plate valve
US7694694B2 (en) * 2004-05-10 2010-04-13 The Aerospace Corporation Phase-change valve apparatuses
US8642353B2 (en) * 2004-05-10 2014-02-04 The Aerospace Corporation Microfluidic device for inducing separations by freezing and associated method
US7799553B2 (en) 2004-06-01 2010-09-21 The Regents Of The University Of California Microfabricated integrated DNA analysis system
WO2005120698A2 (en) * 2004-06-07 2005-12-22 Bioprocessors Corp. Control of reactor environmental conditions
CN100583434C (en) 2004-06-07 2010-01-20 先锋生物科技股份有限公司 Optical lens system and method for microfluidic devices
US20050277187A1 (en) * 2004-06-07 2005-12-15 Bioprocessors Corp. Creation of shear in a reactor
WO2005120691A1 (en) * 2004-06-07 2005-12-22 Bioprocessors Corp. Reactor mixing
US20050271560A1 (en) * 2004-06-07 2005-12-08 Bioprocessors Corp. Gas control in a reactor
US7686040B2 (en) * 2004-06-24 2010-03-30 The Aerospace Corporation Electro-hydraulic devices
US7721762B2 (en) * 2004-06-24 2010-05-25 The Aerospace Corporation Fast acting valve apparatuses
US7650910B2 (en) * 2004-06-24 2010-01-26 The Aerospace Corporation Electro-hydraulic valve apparatuses
CN101073002B (en) 2004-09-15 2012-08-08 英特基因有限公司 Microfluidic devices
EP1793743B1 (en) 2004-09-22 2009-11-18 Dendron GmbH Micro-spiral implantation device
GB0421529D0 (en) 2004-09-28 2004-10-27 Landegren Gene Technology Ab Microfluidic structure
WO2006047757A1 (en) * 2004-10-26 2006-05-04 Massachusetts Institute Of Technology Systems and methods for transferring a fluid sample
WO2006060748A2 (en) 2004-12-03 2006-06-08 California Institute Of Technology Microfluidic sieve valves
US20060153745A1 (en) * 2005-01-11 2006-07-13 Applera Corporation Fluid processing device for oligonucleotide synthesis and analysis
US7601936B2 (en) * 2005-01-11 2009-10-13 William Thomas Joines Microwave system and method for controling the sterlization and infestation of crop soils
FR2880880B1 (en) * 2005-01-18 2008-06-20 Bertin Technologies Soc Par Ac FILLING A MICROCANAL OF A COMPONENT OF A FLUIDIC MICROSYSTEM
WO2006083833A2 (en) * 2005-01-31 2006-08-10 President And Fellows Of Harvard College Valves and reservoirs for microfluidic systems
DE102005019782A1 (en) * 2005-04-28 2006-11-09 Dendron Gmbh Device for implantation of occlusion coils with internal securing means
US7918244B2 (en) * 2005-05-02 2011-04-05 Massachusetts Institute Of Technology Microfluidic bubble logic devices
EP2477029A1 (en) 2005-06-02 2012-07-18 Fluidigm Corporation Analysis using microfluidic partitioning devices
US8197231B2 (en) 2005-07-13 2012-06-12 Purity Solutions Llc Diaphragm pump and related methods
US20070128083A1 (en) * 2005-07-18 2007-06-07 U.S. Genomics, Inc. Microfluidic methods and apparatuses for sample preparation and analysis
US20090139576A1 (en) * 2005-08-11 2009-06-04 Eksigent Technologies, Llc Microfluidic systems, devices and methods for reducing noise generated by mechanical instabilities
WO2007024485A2 (en) * 2005-08-11 2007-03-01 Eksigent Technologies, Llc Microfluidic reduction of diffusion and complience effect in a fluid mixing region
US20090053814A1 (en) * 2005-08-11 2009-02-26 Eksigent Technologies, Llc Microfluidic apparatus and method for sample preparation and analysis
CA2620285C (en) 2005-08-23 2016-08-16 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
AU2012200887B2 (en) * 2005-08-23 2015-02-12 University Of Virginia Patent Foundation Passive components for micro-fluidic flow profile shaping and related method thereof
US8822206B2 (en) * 2005-10-11 2014-09-02 The Johns Hopkins University Device for high-throughput stimulation, immunostaining, and visualization of single cells
US8449837B2 (en) * 2005-10-11 2013-05-28 The Johns Hopkins University Microfluidic device for high-throughput cellular gradient and dose response studies
US8206975B2 (en) * 2005-10-28 2012-06-26 California Institute Of Technology Method and device for regulating fluid flow in microfluidic devices
US20070224055A1 (en) 2005-11-23 2007-09-27 Anex Deon S Electrokinetic pump designs and drug delivery systems
US7992587B2 (en) * 2005-11-30 2011-08-09 California Institute Of Technology Microfluidic autoregulator devices and arrays for operation with newtonian fluids
US9056291B2 (en) 2005-11-30 2015-06-16 Micronics, Inc. Microfluidic reactor system
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US7059351B1 (en) * 2005-12-05 2006-06-13 National Taiwan University Surface-tension-guided liquid transportation device
US8039269B2 (en) * 2006-01-26 2011-10-18 California Institute Of Technology Mechanically induced trapping of molecular interactions
US7749365B2 (en) 2006-02-01 2010-07-06 IntegenX, Inc. Optimized sample injection structures in microfluidic separations
US8124015B2 (en) 2006-02-03 2012-02-28 Institute For Systems Biology Multiplexed, microfluidic molecular assay device and assay method
WO2008030631A2 (en) 2006-02-03 2008-03-13 Microchip Biotechnologies, Inc. Microfluidic devices
US7815868B1 (en) 2006-02-28 2010-10-19 Fluidigm Corporation Microfluidic reaction apparatus for high throughput screening
CA2833354C (en) 2006-03-14 2015-12-15 University Of Southern California Mems device and method for delivery of therapeutic agents
US7766033B2 (en) * 2006-03-22 2010-08-03 The Regents Of The University Of California Multiplexed latching valves for microfluidic devices and processors
KR100773552B1 (en) * 2006-04-28 2007-11-07 삼성전자주식회사 Micro-fluid reaction vessel, method for manufacturing the vessel, and method of micro-fluid reaction using the vessel
US7959876B2 (en) 2006-07-17 2011-06-14 Industrial Technology Research Institute Fluidic device
US20080021364A1 (en) * 2006-07-17 2008-01-24 Industrial Technology Research Institute Fluidic device
US7794665B2 (en) 2006-07-17 2010-09-14 Industrial Technology Research Institute Fluidic device
WO2008091294A2 (en) * 2006-07-28 2008-07-31 California Institute Of Technology Polymer nems for cell physiology and microfabricated cell positioning system for micro-biocalorimeter
WO2008016703A1 (en) * 2006-08-02 2008-02-07 The Regents Of The University Of Michigan Multiplexed microfluidic valve activator
US8656949B2 (en) 2006-08-15 2014-02-25 University Of Maryland College Park Microfluidic devices and methods of fabrication
US8050516B2 (en) 2006-09-13 2011-11-01 Fluidigm Corporation Methods and systems for determining a baseline during image processing
US8055034B2 (en) 2006-09-13 2011-11-08 Fluidigm Corporation Methods and systems for image processing of microfluidic devices
EP1905514A1 (en) * 2006-09-30 2008-04-02 Roche Diagnostics GmbH Device having a reversibly closable fluid valve
US7790118B2 (en) * 2006-10-18 2010-09-07 California Institute Of Technology Microfluidic devices and related methods and systems
US8123192B2 (en) * 2006-10-18 2012-02-28 California Institute Of Technology Control arrangement for microfluidic devices and related methods and systems
US8841116B2 (en) * 2006-10-25 2014-09-23 The Regents Of The University Of California Inline-injection microdevice and microfabricated integrated DNA analysis system using same
JP5748407B2 (en) 2006-11-10 2015-07-15 グローコス コーポレーション Uveal sclera shunt
US8074598B2 (en) * 2006-11-30 2011-12-13 Eastman Kodak Company Fluid management system and method for fluid dispensing and coating
US8473216B2 (en) 2006-11-30 2013-06-25 Fluidigm Corporation Method and program for performing baseline correction of amplification curves in a PCR experiment
DE112007003035T5 (en) * 2006-12-15 2009-11-05 Microstaq, Inc., Austin Microvalve device
US8999636B2 (en) * 2007-01-08 2015-04-07 Toxic Report Llc Reaction chamber
US7867592B2 (en) 2007-01-30 2011-01-11 Eksigent Technologies, Inc. Methods, compositions and devices, including electroosmotic pumps, comprising coated porous surfaces
EP2109666A4 (en) 2007-02-05 2011-09-14 Integenx Inc Microfluidic and nanofluidic devices, systems, and applications
AU2008226694B8 (en) 2007-03-13 2013-06-20 Covidien Lp An implant including a coil and a stretch-resistant member
CN101675280B (en) * 2007-03-30 2013-05-15 盾安美斯泰克公司(美国) Pilot operated micro spool valve
CN101668973B (en) * 2007-03-31 2013-03-13 盾安美斯泰克公司(美国) Pilot operated spool valve
WO2009009127A2 (en) * 2007-07-12 2009-01-15 U.S. Genomics, Inc. Method and system for transferring and/or concentrating a sample
WO2009015296A1 (en) * 2007-07-24 2009-01-29 The Regents Of The University Of California Microfabricated dropley generator
DE102007035721B4 (en) * 2007-07-30 2019-02-07 Robert Bosch Gmbh Microvalve, method of manufacturing a microvalve and micropump
JP2009042103A (en) * 2007-08-09 2009-02-26 Sony Corp Base, reaction processor using it and reaction control method
KR101321912B1 (en) * 2007-08-28 2013-10-30 삼성전자주식회사 Elastic valve and microfluidic device with the same
EA018555B1 (en) 2007-09-07 2013-08-30 Флуидигм Корпорейшн Copy number variation determination, methods and systems
JP2009069051A (en) * 2007-09-14 2009-04-02 Canon Inc Manufacturing method of microfluid device
CA2705213C (en) * 2007-11-07 2016-10-04 The University Of British Columbia Microfluidic device and method of using same
US8251672B2 (en) 2007-12-11 2012-08-28 Eksigent Technologies, Llc Electrokinetic pump with fixed stroke volume
JP5542691B2 (en) 2007-12-20 2014-07-09 ユニバーシティ オブ サザン カリフォルニア Devices and methods for delivering therapeutic agents
US9720501B2 (en) 2008-01-04 2017-08-01 Tactus Technology, Inc. Dynamic tactile interface
US8154527B2 (en) 2008-01-04 2012-04-10 Tactus Technology User interface system
US9588683B2 (en) 2008-01-04 2017-03-07 Tactus Technology, Inc. Dynamic tactile interface
US9274612B2 (en) 2008-01-04 2016-03-01 Tactus Technology, Inc. User interface system
US9557915B2 (en) 2008-01-04 2017-01-31 Tactus Technology, Inc. Dynamic tactile interface
US9052790B2 (en) 2008-01-04 2015-06-09 Tactus Technology, Inc. User interface and methods
US20160187981A1 (en) 2008-01-04 2016-06-30 Tactus Technology, Inc. Manual fluid actuator
US9280224B2 (en) 2012-09-24 2016-03-08 Tactus Technology, Inc. Dynamic tactile interface and methods
US8922510B2 (en) 2008-01-04 2014-12-30 Tactus Technology, Inc. User interface system
US8456438B2 (en) 2008-01-04 2013-06-04 Tactus Technology, Inc. User interface system
US8179375B2 (en) 2008-01-04 2012-05-15 Tactus Technology User interface system and method
US9423875B2 (en) 2008-01-04 2016-08-23 Tactus Technology, Inc. Dynamic tactile interface with exhibiting optical dispersion characteristics
US9430074B2 (en) 2008-01-04 2016-08-30 Tactus Technology, Inc. Dynamic tactile interface
US8947383B2 (en) 2008-01-04 2015-02-03 Tactus Technology, Inc. User interface system and method
US9367132B2 (en) 2008-01-04 2016-06-14 Tactus Technology, Inc. User interface system
US8553005B2 (en) 2008-01-04 2013-10-08 Tactus Technology, Inc. User interface system
US9552065B2 (en) 2008-01-04 2017-01-24 Tactus Technology, Inc. Dynamic tactile interface
US9063627B2 (en) 2008-01-04 2015-06-23 Tactus Technology, Inc. User interface and methods
US9013417B2 (en) 2008-01-04 2015-04-21 Tactus Technology, Inc. User interface system
US8243038B2 (en) 2009-07-03 2012-08-14 Tactus Technologies Method for adjusting the user interface of a device
US8547339B2 (en) 2008-01-04 2013-10-01 Tactus Technology, Inc. System and methods for raised touch screens
US9298261B2 (en) 2008-01-04 2016-03-29 Tactus Technology, Inc. Method for actuating a tactile interface layer
US8928621B2 (en) 2008-01-04 2015-01-06 Tactus Technology, Inc. User interface system and method
US8570295B2 (en) 2008-01-04 2013-10-29 Tactus Technology, Inc. User interface system
US9612659B2 (en) 2008-01-04 2017-04-04 Tactus Technology, Inc. User interface system
KR20110030415A (en) 2008-01-22 2011-03-23 인터젠엑스 인크. Universal sample preparation system and use in an integrated analysis system
US9849238B2 (en) 2008-05-08 2017-12-26 Minipumps, Llc Drug-delivery pump with intelligent control
EP2898911A1 (en) 2008-05-08 2015-07-29 MiniPumps, LLC Implantable pumps and cannulas therefor
EP2323716B1 (en) * 2008-05-08 2015-03-04 MiniPumps, LLC Drug-delivery pumps
JP2010011747A (en) * 2008-07-01 2010-01-21 Canon Inc Cell culture container and cell culture method
US7976789B2 (en) * 2008-07-22 2011-07-12 The Board Of Trustees Of The University Of Illinois Microfluidic device for preparing mixtures
WO2010019329A2 (en) * 2008-08-09 2010-02-18 Microstaq, Inc. Improved microvalve device
US8113482B2 (en) * 2008-08-12 2012-02-14 DunAn Microstaq Microvalve device with improved fluid routing
US8082810B2 (en) * 2008-09-29 2011-12-27 Ysi Incorporated Microfluidic elastic micro-aliquotter
US8361716B2 (en) * 2008-10-03 2013-01-29 Pathogenetix, Inc. Focusing chamber
US8382460B2 (en) * 2008-10-31 2013-02-26 The Board Of Trustees Of The Leland Stanford Junior University Peristaltic pump with constrictions at fixed locations
US8540207B2 (en) 2008-12-06 2013-09-24 Dunan Microstaq, Inc. Fluid flow control assembly
US20100143194A1 (en) * 2008-12-08 2010-06-10 Electronics And Telecommunications Research Institute Microfluidic device
US8424560B2 (en) * 2008-12-16 2013-04-23 University Of Southern California Multi-valve microfluidic devices and methods
CN102341691A (en) 2008-12-31 2012-02-01 尹特根埃克斯有限公司 Instrument with microfluidic chip
US9588684B2 (en) 2009-01-05 2017-03-07 Tactus Technology, Inc. Tactile interface for a computing device
WO2010078596A1 (en) 2009-01-05 2010-07-08 Tactus Technology, Inc. User interface system
WO2010078597A1 (en) 2009-01-05 2010-07-08 Tactus Technology, Inc. User interface system
US9010329B2 (en) * 2009-02-10 2015-04-21 Aerophase Electronically-controlled, high pressure flow control valve and method of use
US9700038B2 (en) 2009-02-25 2017-07-11 Genea Limited Cryopreservation of biological cells and tissues
SG10201402770YA (en) 2009-04-02 2014-08-28 Fluidigm Corp Multi-primer amplification method for barcoding of target nucleic acids
WO2010117874A2 (en) 2009-04-05 2010-10-14 Microstaq, Inc. Method and structure for optimizing heat exchanger performance
US10206813B2 (en) 2009-05-18 2019-02-19 Dose Medical Corporation Implants with controlled drug delivery features and methods of using same
DE102009023430B4 (en) * 2009-05-29 2013-07-25 Siemens Aktiengesellschaft Apparatus and method for controlling fluid flows in lab-on-a-chip systems and method of manufacturing the apparatus
EP2438154A1 (en) 2009-06-02 2012-04-11 Integenx Inc. Fluidic devices with diaphragm valves
CN102803147B (en) 2009-06-05 2015-11-25 尹特根埃克斯有限公司 Universal sample preparation system and the purposes in integrated analysis system
US8528602B2 (en) * 2009-06-26 2013-09-10 Nikola Pekas Microvalve system
CN105260110A (en) 2009-07-03 2016-01-20 泰克图斯科技公司 User interface enhancement system
US9364831B2 (en) 2009-08-08 2016-06-14 The Regents Of The University Of California Pulsed laser triggered high speed microfluidic switch and applications in fluorescent activated cell sorting
WO2011022267A2 (en) 2009-08-17 2011-02-24 Microstaq, Inc. Micromachined device and control method
AU2010284216B2 (en) 2009-08-18 2015-10-15 Minipumps, Llc Electrolytic drug-delivery pump with adaptive control
EP2295096B1 (en) 2009-09-11 2016-02-10 F. Hoffmann-La Roche AG Micro-fluidic chambers for use in liquid medicament delivery systems
US20110081677A1 (en) * 2009-09-30 2011-04-07 University Of Maryland, College Park Active Microfluidic Membranes
DE102009045404B4 (en) * 2009-10-06 2012-04-19 INSTITUT FüR MIKROTECHNIK MAINZ GMBH Discharge channel and microfluidic structure and method for measuring and / or positioning a volume of a liquid
US8145114B2 (en) 2009-10-29 2012-03-27 Eastman Kodak Company Digital manufacture of a microfluidic device
US20110143378A1 (en) * 2009-11-12 2011-06-16 CyVek LLC. Microfluidic method and apparatus for high performance biological assays
US9216412B2 (en) 2009-11-23 2015-12-22 Cyvek, Inc. Microfluidic devices and methods of manufacture and use
US10065403B2 (en) 2009-11-23 2018-09-04 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9700889B2 (en) 2009-11-23 2017-07-11 Cyvek, Inc. Methods and systems for manufacture of microarray assay systems, conducting microfluidic assays, and monitoring and scanning to obtain microfluidic assay results
US9651568B2 (en) 2009-11-23 2017-05-16 Cyvek, Inc. Methods and systems for epi-fluorescent monitoring and scanning for microfluidic assays
US9855735B2 (en) 2009-11-23 2018-01-02 Cyvek, Inc. Portable microfluidic assay devices and methods of manufacture and use
US9500645B2 (en) 2009-11-23 2016-11-22 Cyvek, Inc. Micro-tube particles for microfluidic assays and methods of manufacture
EP2504701B1 (en) 2009-11-23 2017-09-13 Cyvek, Inc. Method and apparatus for performing assays
US9759718B2 (en) 2009-11-23 2017-09-12 Cyvek, Inc. PDMS membrane-confined nucleic acid and antibody/antigen-functionalized microlength tube capture elements, and systems employing them, and methods of their use
WO2011066588A1 (en) 2009-11-30 2011-06-03 Fluidigm Corporation Microfluidic device regeneration
US8584703B2 (en) 2009-12-01 2013-11-19 Integenx Inc. Device with diaphragm valve
EP2517089A4 (en) 2009-12-21 2016-03-09 Tactus Technology User interface system
CN102725716B (en) 2009-12-21 2016-04-13 泰克图斯科技公司 User interface system
US8574842B2 (en) 2009-12-22 2013-11-05 The Board Of Trustees Of The Leland Stanford Junior University Direct molecular diagnosis of fetal aneuploidy
US9298262B2 (en) 2010-01-05 2016-03-29 Tactus Technology, Inc. Dynamic tactile interface
US9006844B2 (en) 2010-01-28 2015-04-14 Dunan Microstaq, Inc. Process and structure for high temperature selective fusion bonding
US8956884B2 (en) 2010-01-28 2015-02-17 Dunan Microstaq, Inc. Process for reconditioning semiconductor surface to facilitate bonding
US9132423B2 (en) 2010-01-29 2015-09-15 Micronics, Inc. Sample-to-answer microfluidic cartridge
US8619035B2 (en) 2010-02-10 2013-12-31 Tactus Technology, Inc. Method for assisting user input to a device
EP4378584A2 (en) * 2010-02-19 2024-06-05 Pacific Biosciences Of California, Inc. Integrated analytical system and method for fluorescence measurement
CA2791905A1 (en) 2010-03-01 2011-09-09 Caris Life Sciences Luxembourg Holdings, S.A.R.L. Biomarkers for theranostics
JP2013526852A (en) 2010-04-06 2013-06-27 カリス ライフ サイエンシズ ルクセンブルク ホールディングス Circulating biomarkers for disease
WO2011133605A1 (en) 2010-04-19 2011-10-27 Tactus Technology Method of actuating a tactile interface layer
US8512538B2 (en) 2010-05-28 2013-08-20 Integenx Inc. Capillary electrophoresis device
WO2011146998A1 (en) 2010-05-28 2011-12-01 Sydney Ivf Limited Improved micromanipulation and storage apparatus and methods
DE102011015184B4 (en) * 2010-06-02 2013-11-21 Thinxxs Microtechnology Ag Device for transporting small volumes of a fluid, in particular micropump or microvalve
KR20120015593A (en) * 2010-08-12 2012-02-22 삼성전자주식회사 Microfluidic device having microvalve
WO2012024657A1 (en) 2010-08-20 2012-02-23 IntegenX, Inc. Microfluidic devices with mechanically-sealed diaphragm valves
US9121058B2 (en) 2010-08-20 2015-09-01 Integenx Inc. Linear valve arrays
US8996141B1 (en) 2010-08-26 2015-03-31 Dunan Microstaq, Inc. Adaptive predictive functional controller
JP5647353B2 (en) 2010-10-20 2014-12-24 タクタス テクノロジーＴａｃｔｕｓ Ｔｅｃｈｎｏｌｏｇｙ User interface system
US9176504B2 (en) 2011-02-11 2015-11-03 The Regents Of The University Of California High-speed on demand droplet generation and single cell encapsulation driven by induced cavitation
CA2830103C (en) 2011-03-15 2020-03-24 National Research Council Of Canada Microfluidic system having monolithic nanoplasmonic structures
US8857275B2 (en) 2011-05-02 2014-10-14 California Institute Of Technology NEMS sensors for cell force application and measurement
CA2834708A1 (en) 2011-05-05 2012-11-08 Eksigent Technologies, Llc Gel coupling for electrokinetic delivery systems
US9162226B2 (en) 2011-05-12 2015-10-20 The United States Of America, As Represented By The Secretary Of Commerce Foldable microfluidic devices using double-sided tape
JP4934750B1 (en) * 2011-05-31 2012-05-16 株式会社メトラン Pump unit, breathing assistance device
US10245178B1 (en) 2011-06-07 2019-04-02 Glaukos Corporation Anterior chamber drug-eluting ocular implant
TWM426766U (en) * 2011-10-13 2012-04-11 Chin-Feng Wan Microfluidic chip
US8894946B2 (en) 2011-10-21 2014-11-25 Integenx Inc. Sample preparation, processing and analysis systems
US10865440B2 (en) 2011-10-21 2020-12-15 IntegenX, Inc. Sample preparation, processing and analysis systems
US20150136604A1 (en) 2011-10-21 2015-05-21 Integenx Inc. Sample preparation, processing and analysis systems
CN102425538A (en) * 2011-12-08 2012-04-25 厦门大学 Electromagnetic driven reflux-free micro-liter precision micro pump
US8925793B2 (en) 2012-01-05 2015-01-06 Dunan Microstaq, Inc. Method for making a solder joint
US20130196053A1 (en) * 2012-01-10 2013-08-01 State of Oregon acting by and through the State Board of Higher Education on behalf of Oregon Stat Flow cell design for uniform residence time fluid flow
US9371965B2 (en) * 2012-02-21 2016-06-21 Fluidigm Corporation Method and systems for microfluidic logic devices
SG10201608159XA (en) 2012-02-29 2016-11-29 Fluidigm Corp Methods, systems, and devices for multiple single-cell capturing and processing using microfluidics
EP2822688B1 (en) 2012-03-08 2019-09-25 Cyvek, Inc. Microfluidic assay assemblies and methods of manufacture
US9140613B2 (en) 2012-03-16 2015-09-22 Zhejiang Dunan Hetian Metal Co., Ltd. Superheat sensor
US9554940B2 (en) 2012-03-26 2017-01-31 Glaukos Corporation System and method for delivering multiple ocular implants
US8906320B1 (en) 2012-04-16 2014-12-09 Illumina, Inc. Biosensors for biological or chemical analysis and systems and methods for same
US8685708B2 (en) 2012-04-18 2014-04-01 Pathogenetix, Inc. Device for preparing a sample
US9028776B2 (en) 2012-04-18 2015-05-12 Toxic Report Llc Device for stretching a polymer in a fluid sample
WO2013166857A1 (en) * 2012-05-07 2013-11-14 Capitalbio Corporation Microfluidic devices for multi-index biochemical detection
SG11201407901PA (en) 2012-05-21 2015-01-29 Fluidigm Corp Single-particle analysis of particle populations
US9610392B2 (en) 2012-06-08 2017-04-04 Fresenius Medical Care Holdings, Inc. Medical fluid cassettes and related systems and methods
GB2504668C (en) * 2012-07-26 2020-03-04 Atomjet Ltd Micro pumps
EP3791834A3 (en) 2012-09-17 2021-06-02 President And Fellows Of Harvard College Soft exosuit for assistance with human motion
US9405417B2 (en) 2012-09-24 2016-08-02 Tactus Technology, Inc. Dynamic tactile interface and methods
US9181086B1 (en) 2012-10-01 2015-11-10 The Research Foundation For The State University Of New York Hinged MEMS diaphragm and method of manufacture therof
US10942184B2 (en) 2012-10-23 2021-03-09 Caris Science, Inc. Aptamers and uses thereof
BR112015009138A2 (en) 2012-10-23 2020-10-20 Caris Life Sciences Switzerland Holdings, S.A.R.L. methods for characterizing cancer
WO2014093360A1 (en) 2012-12-10 2014-06-19 Landers James P Frequency-based filtering of mechanical actuation using fluidic device
AU2013361323B2 (en) 2012-12-19 2018-09-06 Caris Science, Inc. Compositions and methods for aptamer screening
US10518262B2 (en) 2012-12-21 2019-12-31 Perkinelmer Health Sciences, Inc. Low elasticity films for microfluidic use
WO2014100732A1 (en) 2012-12-21 2014-06-26 Micronics, Inc. Fluidic circuits and related manufacturing methods
EP2935559B1 (en) 2012-12-21 2020-09-16 PerkinElmer Health Sciences, Inc. Fluorescence detection system
WO2014106286A1 (en) 2013-01-07 2014-07-10 Genea Limited Method, system and apparatus for improved micromanipulation and storage
US10052631B2 (en) 2013-03-05 2018-08-21 Board Of Regents, The University Of Texas System Microfluidic devices for the rapid and automated processing of sample populations
US9039993B2 (en) 2013-03-14 2015-05-26 Formulatrix, Inc. Microfluidic device
US9163277B2 (en) 2013-03-14 2015-10-20 Formulatrix, Inc. Microfluidic device
KR102168053B1 (en) 2013-03-15 2020-10-20 더 리전트 오브 더 유니버시티 오브 캘리포니아 High-speed on demand microfluidic droplet generation and manipulation
US10517759B2 (en) 2013-03-15 2019-12-31 Glaukos Corporation Glaucoma stent and methods thereof for glaucoma treatment
US9592151B2 (en) 2013-03-15 2017-03-14 Glaukos Corporation Systems and methods for delivering an ocular implant to the suprachoroidal space within an eye
WO2014144789A2 (en) 2013-03-15 2014-09-18 Fluidigm Corporation Methods and devices for analysis of defined multicellular combinations
JP6472788B2 (en) 2013-05-07 2019-02-20 マイクロニクス， インコーポレイテッド Method for preparing nucleic acid-containing samples using clay minerals and alkaline solutions
US10386377B2 (en) 2013-05-07 2019-08-20 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
US10087440B2 (en) 2013-05-07 2018-10-02 Micronics, Inc. Device for preparation and analysis of nucleic acids
KR20160016925A (en) 2013-05-31 2016-02-15 프레지던트 앤드 펠로우즈 오브 하바드 칼리지 Soft exosuit for assistance with human motion
US9557813B2 (en) 2013-06-28 2017-01-31 Tactus Technology, Inc. Method for reducing perceived optical distortion
JP2016533752A (en) 2013-08-28 2016-11-04 カリス ライフ サイエンシズ スウィッツァーランド ホー Oligonucleotide probes and uses thereof
US9151652B2 (en) * 2013-09-20 2015-10-06 Teledyne Instruments, Inc. Coriolis flow sensor fabricated with laminated films processes
WO2015050998A2 (en) 2013-10-01 2015-04-09 The Broad Institute, Inc. Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte
US10136636B2 (en) 2013-10-15 2018-11-27 The Regents Of The University Of Michigan Vitrification of biological material
CN114471756B (en) 2013-11-18 2024-04-16 尹特根埃克斯有限公司 Cartridge and instrument for sample analysis
US9188375B2 (en) 2013-12-04 2015-11-17 Zhejiang Dunan Hetian Metal Co., Ltd. Control element and check valve assembly
CN105992554A (en) 2013-12-09 2016-10-05 哈佛大学校长及研究员协会 Assistive flexible suits, flexible suit systems, and methods for making and control thereof to assist human mobility
EP3080585B1 (en) 2013-12-10 2023-12-06 Illumina, Inc. Biosensors for biological or chemical analysis and methods of manufacturing the same
US10344753B2 (en) 2014-02-28 2019-07-09 Encite Llc Micro pump systems
WO2015157731A1 (en) 2014-04-10 2015-10-15 President And Fellows Of Harvard College Orthopedic device including protruding members
WO2015179098A1 (en) 2014-05-21 2015-11-26 Integenx Inc. Fluidic cartridge with valve mechanism
JP6655610B2 (en) 2014-05-29 2020-02-26 グローコス コーポレーション IMPLANT WITH CONTROLLED DRUG DELIVERY FUNCTION AND METHOD OF USING THE SAME
PT3152059T (en) * 2014-06-04 2020-08-18 System Ceramics S P A A device for the inkjet printing of fluids, in particular glazes, onto tiles
WO2016061125A1 (en) 2014-10-15 2016-04-21 California Institute Of Technology Contact lens with metered liquid system
EP3209410A4 (en) 2014-10-22 2018-05-02 IntegenX Inc. Systems and methods for sample preparation, processing and analysis
US10330095B2 (en) * 2014-10-31 2019-06-25 Encite Llc Microelectromechanical systems fabricated with roll to roll processing
AU2016229076B2 (en) 2015-03-09 2022-01-20 Caris Science, Inc. Oligonucleotide probes and uses thereof
CN108136388A (en) * 2015-04-30 2018-06-08 奥菲迪亚有限公司 Microfluidic valve and device
NL2014801B1 (en) * 2015-05-13 2017-01-27 Berkin Bv Fluid flow device, comprising a valve unit, as well as method of manufacturing the same.
US10136563B2 (en) 2015-06-25 2018-11-20 International Business Machines Corporation Active perforation for advanced server cooling
US9907210B2 (en) * 2015-06-25 2018-02-27 International Business Machines Corporation Active perforation for advanced server cooling
AU2016287499B2 (en) 2015-06-29 2022-08-04 Caris Science, Inc. Therapeutic oligonucleotides
US10941176B2 (en) 2015-07-28 2021-03-09 Caris Science, Inc. Therapeutic oligonucleotides
WO2017040853A1 (en) 2015-09-02 2017-03-09 Glaukos Corporation Drug delivery implants with bi-directional delivery capacity
WO2017053885A1 (en) 2015-09-25 2017-03-30 Glaukos Corporation Punctal implants with controlled drug delivery features and methods of using same
WO2017070528A1 (en) 2015-10-23 2017-04-27 California Institute Of Technology Reliable deposition of thin parylene
US10228367B2 (en) 2015-12-01 2019-03-12 ProteinSimple Segmented multi-use automated assay cartridge
US20170156623A1 (en) * 2015-12-08 2017-06-08 The Regents Of The University Of California Self-adhesive microfluidic and sensor devices
WO2017149308A1 (en) * 2016-03-04 2017-09-08 Renishaw Plc An additive manufacturing method and system
WO2017155894A1 (en) 2016-03-07 2017-09-14 Cfgenome, Llc Noninvasive molecular controls
EP3429512A4 (en) 2016-03-13 2019-10-30 President and Fellows of Harvard College Flexible members for anchoring to the body
WO2017161357A1 (en) 2016-03-18 2017-09-21 Caris Science, Inc. Oligonucleotide probes and uses thereof
WO2017165535A1 (en) * 2016-03-24 2017-09-28 Kansas State University Research Foundation Integrated dielectric elastomeric actuators
JP7003110B2 (en) 2016-04-20 2022-01-20 ドーズ メディカル コーポレーション Bioabsorbable eye drug delivery device
EP3452404A4 (en) * 2016-05-06 2019-12-25 The Board of Trustees of the Leland Stanford Junior University Elastomeric focusing valves
AU2017203429B2 (en) * 2016-05-20 2022-06-02 Platts, Shane Phillip MR Fluid Testing Device
CA3025486A1 (en) 2016-05-25 2017-11-30 Caris Science, Inc. Oligonucleotide probes and uses thereof
US11498203B2 (en) 2016-07-22 2022-11-15 President And Fellows Of Harvard College Controls optimization for wearable systems
EP3494376B1 (en) 2016-08-05 2021-06-09 Marsh, Stephen Alan Micro pressure sensor
WO2018051242A1 (en) 2016-09-14 2018-03-22 Ecole Polytechnique Federale De Lausanne (Epfl) Device for high throughput single-cell studies
US10632461B2 (en) * 2016-09-30 2020-04-28 Canon Medical Systems Corporation Chemical container
US11660571B2 (en) 2016-11-18 2023-05-30 The Regents Of The University Of California Microscale device and method for purification of radiopharmaceuticals
CN110741161A (en) 2017-03-13 2020-01-31 斯蒂芬.A.马什 Micropump system and process technology
US11014804B2 (en) 2017-03-14 2021-05-25 President And Fellows Of Harvard College Systems and methods for fabricating 3D soft microstructures
US11686327B2 (en) 2017-04-07 2023-06-27 Hewlett-Packard Development Company, L.P. Inertial pumps
EP3635412A4 (en) 2017-06-06 2021-03-10 The Regents of The University of California Systems and methods for rapid generation of droplet libraries
CN107061863B (en) * 2017-06-13 2019-09-06 河北工业大学 It is a kind of to generate the micro-valve system for controlling parked bubble and generate control method
US10739170B2 (en) 2017-08-04 2020-08-11 Encite Llc Micro flow measurement devices and devices with movable features
US11116625B2 (en) 2017-09-28 2021-09-14 Glaukos Corporation Apparatus and method for controlling placement of intraocular implants
TWI623487B (en) * 2017-10-24 2018-05-11 友達光電股份有限公司 Microfluid sensing device and method for fabricating the same
US11046575B2 (en) 2017-10-31 2021-06-29 Encite Llc Broad range micro pressure sensor
US20190136296A1 (en) * 2017-11-09 2019-05-09 E.I. Spectra, Llc Ultra-Sensitive Platform for Nucleic acid detection using a novel method, Scanning Digital polymerase chain reaction (PCR)
EP3489619A1 (en) * 2017-11-28 2019-05-29 Koh Young Technology Inc. Apparatus for inspecting substrate and method thereof
AU2017444624B2 (en) 2017-12-26 2021-07-22 Illumina, Inc. Sensor system
US10415721B2 (en) 2018-01-12 2019-09-17 International Business Machines Corporation Micro electrical mechanical system (MEMS) valve
US10612691B2 (en) 2018-01-12 2020-04-07 International Business Machines Corporation Micro electrical mechanical system (MEMS) valve
US11154864B2 (en) 2018-01-17 2021-10-26 Qiagen Sciences, Llc Microfluidic device with vented microchambers
US11331618B2 (en) 2018-03-07 2022-05-17 Encite Llc R2R microelectromechanical gas concentrator
WO2019186569A1 (en) 2018-03-29 2019-10-03 Yeda Research And Development Co. Ltd. Use of electric field gradients to control gene expression
US11523939B2 (en) * 2018-05-22 2022-12-13 California Institute Of Technology Miniature fixed and adjustable flow restrictor for the body
US11245344B2 (en) 2018-06-07 2022-02-08 Encite Llc Micro electrostatic motor and micro mechanical force transfer devices
US11051977B2 (en) 2018-06-11 2021-07-06 California Institute Of Technology Eye treatment device having a ring like shape
US11125689B2 (en) * 2018-07-13 2021-09-21 The Government Of The United States Of America, As Represented By The Secretary Of The Navy Highly stable semiconductor lasers and sensors for III-V and silicon photonic integrated circuits
CN111318218B (en) * 2018-12-14 2022-01-28 深圳先进技术研究院 Microfluidic device and methods of making and using the same
DE102018222749A1 (en) * 2018-12-21 2020-06-25 Robert Bosch Gmbh Method for closing access in a MEMS element
USD919833S1 (en) 2019-03-06 2021-05-18 Princeton Biochemicals, Inc Micro valve for controlling path of fluids in miniaturized capillary connections
EP3941630A4 (en) * 2019-03-18 2023-04-05 Cellular Research, Inc. Precise delivery of components into fluids
US10871407B2 (en) * 2019-04-25 2020-12-22 Measurement Specialties, Inc. Sensor assemblies with multirange construction
CN110185681B (en) * 2019-06-28 2021-06-29 云谷（固安）科技有限公司 Bonding apparatus and bonding method
CN110516357B (en) * 2019-08-27 2020-12-08 西安电子科技大学 Gold belt flexible interconnection thermosensitive parameter determination method for electric performance of microwave assembly
GB201913529D0 (en) * 2019-09-19 2019-11-06 Tanriverdi Ugur Method And Apparatus
IL269674B (en) 2019-09-25 2020-08-31 Roy Bar Ziv Assembly of protein complexes on a chip
CA3157134A1 (en) 2019-11-07 2021-05-14 Renjith MENON Saliva collection and testing system
CN111111019B (en) * 2019-12-25 2021-10-19 北京森科医药有限公司 Protective device for heating radiopharmaceuticals
JP2023514388A (en) * 2020-02-20 2023-04-05 スタンダード バイオツールズ インコーポレイテッド Parallelized sample processing and library preparation
EP4220118A1 (en) * 2020-04-30 2023-08-02 Precision Planting LLC Agricultural sampling system and related methods
US20230321653A1 (en) 2020-06-01 2023-10-12 Dimensiongen Devices and methods for cytogenetic analysis
CN113351269B (en) * 2021-06-25 2022-03-11 清华大学深圳国际研究生院 Preparation process of hemispherical cavity on PDMS (polydimethylsiloxane) micro-fluidic chip
CN113477455B (en) * 2021-07-16 2022-04-15 平显智能装备(深圳)有限责任公司 OCR full-lamination assembly process production line
WO2023035003A1 (en) 2021-09-03 2023-03-09 Elegen Corp. Multi-way bead-sorting devices, systems, and methods of use thereof using pressure sources
WO2023238132A1 (en) 2022-06-07 2023-12-14 Yeda Research And Development Co. Ltd. Microfluidic device for analyzing steady state biological reactions

Family Cites Families (133)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US577371A (en) * 1897-02-16 patten
US2620938A (en) * 1949-09-02 1952-12-09 Package Devices Inc Container closure
US3043080A (en) * 1960-04-20 1962-07-10 Mott Corp Blade connection for mowers
US3424063A (en) * 1964-11-19 1969-01-28 Ibm Apparatus using diaphragm - type fluidcontrolled logic devices and method of making same
US3407833A (en) * 1965-08-16 1968-10-29 Aro Corp Fluid logic circuit mechanism
US3495608A (en) * 1967-05-04 1970-02-17 Pitney Bowes Inc Fluidic elements and devices thereof
US3570515A (en) * 1969-06-19 1971-03-16 Foxboro Co Aminar stream cross-flow fluid diffusion logic gate
US3626965A (en) * 1970-01-09 1971-12-14 Bell Telephone Labor Inc Fluidic and/or gate
US3670753A (en) * 1970-07-06 1972-06-20 Bell Telephone Labor Inc Multiple output fluidic gate
GB1362952A (en) * 1970-07-21 1974-08-07 Rasmussen O B Conjugate fibre and method of manufacturing same
US3712323A (en) * 1970-09-08 1973-01-23 Bell Telephone Labor Inc Fluidic half-adder
US3680590A (en) * 1970-10-19 1972-08-01 Ibm Fluid-operated diaphragm logic devices
NL7102074A (en) * 1971-02-17 1972-08-21
FR2287606A1 (en) * 1974-10-08 1976-05-07 Pegourie Jean Pierre PNEUMATIC LOGIC CIRCUITS AND THEIR INTEGRATED CIRCUITS
JPS5941169B2 (en) * 1975-12-25 1984-10-05 シチズン時計株式会社 Elastomer
US4188977A (en) * 1976-12-15 1980-02-19 Johnson Controls, Inc. Fluid system circuit board
US4153855A (en) * 1977-12-16 1979-05-08 The United States Of America As Represented By The Secretary Of The Army Method of making a plate having a pattern of microchannels
US4245673A (en) * 1978-03-01 1981-01-20 La Telemechanique Electrique Pneumatic logic circuit
US4245873A (en) 1979-03-08 1981-01-20 Markowitz Isral J Adjustably positionable electrical outlet
US4434704A (en) * 1980-04-14 1984-03-06 Halliburton Company Hydraulic digital stepper actuator
US4581624A (en) 1984-03-01 1986-04-08 Allied Corporation Microminiature semiconductor valve
US5088515A (en) * 1989-05-01 1992-02-18 Kamen Dean L Valve system with removable fluid interface
US4845722A (en) * 1987-10-16 1989-07-04 Digital Equipment Corporation Computer interconnect coupler employing crossbar switching
DE3882011T2 (en) * 1987-10-27 1993-09-30 Fujitsu Ltd Method and device for producing biopolymer single crystal.
US4848722A (en) * 1987-12-11 1989-07-18 Integrated Fluidics, Inc. Valve with flexible sheet member
US4898582A (en) * 1988-08-09 1990-02-06 Pharmetrix Corporation Portable infusion device assembly
US4992312A (en) * 1989-03-13 1991-02-12 Dow Corning Wright Corporation Methods of forming permeation-resistant, silicone elastomer-containing composite laminates and devices produced thereby
CH679555A5 (en) * 1989-04-11 1992-03-13 Westonbridge Int Ltd
DE3917396A1 (en) * 1989-05-29 1990-12-06 Buerkert Gmbh MICRO VALVE
EP0429591B1 (en) * 1989-06-14 1994-08-17 Westonbridge International Limited Improved micro-pump
US5238223A (en) * 1989-08-11 1993-08-24 Robert Bosch Gmbh Method of making a microvalve
KR910012538A (en) * 1989-12-27 1991-08-08 야마무라 가쯔미 Micro pump and its manufacturing method
DE4006152A1 (en) * 1990-02-27 1991-08-29 Fraunhofer Ges Forschung MICROMINIATURIZED PUMP
US5096388A (en) * 1990-03-22 1992-03-17 The Charles Stark Draper Laboratory, Inc. Microfabricated pump
US5429856A (en) * 1990-03-30 1995-07-04 Minnesota Mining And Manufacturing Company Composite materials and process
SE470347B (en) * 1990-05-10 1994-01-31 Pharmacia Lkb Biotech Microstructure for fluid flow systems and process for manufacturing such a system
US5216115A (en) * 1990-06-12 1993-06-01 Rutgers, The State University Of New Jersey Polyarylate containing derivatives of the natural amino acid L-tyrosine
US5259737A (en) * 1990-07-02 1993-11-09 Seiko Epson Corporation Micropump with valve structure
US5085582A (en) 1990-07-24 1992-02-04 Eaton Corporation Silicon nitride containers for the sintering of silicon nitride ceramics
US5158230A (en) * 1990-08-21 1992-10-27 Curran John R Air flow control apparatus
US5164558A (en) * 1991-07-05 1992-11-17 Massachusetts Institute Of Technology Micromachined threshold pressure switch and method of manufacture
JP3328300B2 (en) * 1991-07-18 2002-09-24 アイシン精機株式会社 Fluid control device
DE4135655A1 (en) * 1991-09-11 1993-03-18 Fraunhofer Ges Forschung MICROMINIATURIZED, ELECTROSTATICALLY OPERATED DIAPHRAGM PUMP
US5265327A (en) * 1991-09-13 1993-11-30 Faris Sadeg M Microchannel plate technology
US5384261A (en) * 1991-11-22 1995-01-24 Affymax Technologies N.V. Very large scale immobilized polymer synthesis using mechanically directed flow paths
US5637469A (en) * 1992-05-01 1997-06-10 Trustees Of The University Of Pennsylvania Methods and apparatus for the detection of an analyte utilizing mesoscale flow systems
DE4220077A1 (en) * 1992-06-19 1993-12-23 Bosch Gmbh Robert Micro-pump for delivery of gases - uses working chamber warmed by heating element and controlled by silicon wafer valves.
US5364742A (en) 1992-09-21 1994-11-15 International Business Machines Corporation Micro-miniature structures and method of fabrication thereof
JP2812629B2 (en) * 1992-11-25 1998-10-22 宇宙開発事業団 Crystal growth cell
US5290240A (en) * 1993-02-03 1994-03-01 Pharmetrix Corporation Electrochemical controlled dispensing assembly and method for selective and controlled delivery of a dispensing fluid
US5358844A (en) * 1993-02-18 1994-10-25 Brigham And Women's Hospital, Inc. Preservation of blood platelets
US5387329A (en) 1993-04-09 1995-02-07 Ciba Corning Diagnostics Corp. Extended use planar sensors
US5400741A (en) * 1993-05-21 1995-03-28 Medical Foundation Of Buffalo, Inc. Device for growing crystals
ATE156895T1 (en) * 1993-05-27 1997-08-15 Fraunhofer Ges Forschung MICRO VALVE
SE501713C2 (en) * 1993-09-06 1995-05-02 Pharmacia Biosensor Ab Diaphragm-type valve, especially for liquid handling blocks with micro-flow channels
US5642015A (en) * 1993-07-14 1997-06-24 The University Of British Columbia Elastomeric micro electro mechanical systems
US5659171A (en) * 1993-09-22 1997-08-19 Northrop Grumman Corporation Micro-miniature diaphragm pump for the low pressure pumping of gases
DE4332720C2 (en) * 1993-09-25 1997-02-13 Karlsruhe Forschzent Micro diaphragm pump
CH689836A5 (en) * 1994-01-14 1999-12-15 Westonbridge Int Ltd Micropump.
WO1996006815A1 (en) 1994-08-31 1996-03-07 Prodevco (N.Z.) Limited Improvements in or relating to a composter
DE4433894A1 (en) 1994-09-22 1996-03-28 Fraunhofer Ges Forschung Method and device for controlling a micropump
EP0706004B1 (en) 1994-10-07 2003-08-06 Bayer Corporation Relief valve
US5788468A (en) * 1994-11-03 1998-08-04 Memstek Products, Llc Microfabricated fluidic devices
EP0791238B1 (en) 1994-11-10 2004-09-22 Orchid BioSciences, Inc. Liquid distribution system
US5593120A (en) * 1994-11-21 1997-01-14 Minnesota Mining And Manufacturing Company Quick-mounting fastening assembly
JP3094880B2 (en) * 1995-03-01 2000-10-03 住友金属工業株式会社 Method for controlling crystallization of organic compound and solid state element for controlling crystallization used therein
US5775371A (en) 1995-03-08 1998-07-07 Abbott Laboratories Valve control
US5876187A (en) * 1995-03-09 1999-03-02 University Of Washington Micropumps with fixed valves
US5856174A (en) * 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6168948B1 (en) * 1995-06-29 2001-01-02 Affymetrix, Inc. Miniaturized genetic analysis systems and methods
CA2183478C (en) * 1995-08-17 2004-02-24 Stephen A. Carter Digital gas metering system using tri-stable and bi-stable solenoids
US6130098A (en) 1995-09-15 2000-10-10 The Regents Of The University Of Michigan Moving microdroplets
US5598033A (en) * 1995-10-16 1997-01-28 Advanced Micro Devices, Inc. Micro BGA stacking scheme
US5958344A (en) * 1995-11-09 1999-09-28 Sarnoff Corporation System for liquid distribution
US5705018A (en) 1995-12-13 1998-01-06 Hartley; Frank T. Micromachined peristaltic pump
KR100207410B1 (en) 1995-12-19 1999-07-15 전주범 Fabrication method for lightpath modulation device
US5660370A (en) * 1996-03-07 1997-08-26 Integrated Fludics, Inc. Valve with flexible sheet member and two port non-flexing backer member
US5724677A (en) * 1996-03-08 1998-03-10 Minnesota Mining And Manufacturing Company Multi-part headband and respirator mask assembly and process for making same
US5766784A (en) * 1996-04-08 1998-06-16 Battelle Memorial Institute Thin films and uses
US5885470A (en) * 1997-04-14 1999-03-23 Caliper Technologies Corporation Controlled fluid transport in microfabricated polymeric substrates
US5942443A (en) * 1996-06-28 1999-08-24 Caliper Technologies Corporation High throughput screening assay systems in microscale fluidic devices
US5810325A (en) * 1996-06-25 1998-09-22 Bcam International, Inc. Microvalve
EP0913507A4 (en) * 1996-07-15 2002-03-13 Sumitomo Metal Ind Equipment for crystal growth and crystal-growing method using the same
US6136212A (en) 1996-08-12 2000-10-24 The Regents Of The University Of Michigan Polymer-based micromachining for microfluidic devices
US5738799A (en) 1996-09-12 1998-04-14 Xerox Corporation Method and materials for fabricating an ink-jet printhead
US5865417A (en) * 1996-09-27 1999-02-02 Redwood Microsystems, Inc. Integrated electrically operable normally closed valve
US5971355A (en) 1996-11-27 1999-10-26 Xerox Corporation Microdevice valve structures to fluid control
WO1998031935A1 (en) * 1997-01-17 1998-07-23 Phallen Iver J Linear peristaltic pump
US6436529B1 (en) * 1997-01-21 2002-08-20 3M Innovative Properties Company Elatomeric laminates and composites
US7034432B1 (en) * 1997-02-07 2006-04-25 Sri International Electroactive polymer generators
US6069392A (en) * 1997-04-11 2000-05-30 California Institute Of Technology Microbellows actuator
US5922604A (en) * 1997-06-05 1999-07-13 Gene Tec Corporation Thin reaction chambers for containing and handling liquid microvolumes
US6304364B1 (en) * 1997-06-11 2001-10-16 President & Fellows Of Harvard College Elastomeric light valves
AU8275998A (en) 1997-06-27 1999-01-19 Immunetics, Inc. Rapid flow-through binding assay apparatus and method
US6529612B1 (en) 1997-07-16 2003-03-04 Diversified Scientific, Inc. Method for acquiring, storing and analyzing crystal images
US5932799A (en) * 1997-07-21 1999-08-03 Ysi Incorporated Microfluidic analyzer module
US6073482A (en) 1997-07-21 2000-06-13 Ysi Incorporated Fluid flow module
US5876675A (en) 1997-08-05 1999-03-02 Caliper Technologies Corp. Microfluidic devices and systems
US5965410A (en) 1997-09-02 1999-10-12 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US5999307A (en) 1997-09-04 1999-12-07 The University Of British Columbia Method and apparatus for controllable frustration of total internal reflection
US5842787A (en) * 1997-10-09 1998-12-01 Caliper Technologies Corporation Microfluidic systems incorporating varied channel dimensions
US5836750A (en) * 1997-10-09 1998-11-17 Honeywell Inc. Electrostatically actuated mesopump having a plurality of elementary cells
US5958694A (en) * 1997-10-16 1999-09-28 Caliper Technologies Corp. Apparatus and methods for sequencing nucleic acids in microfluidic systems
US6134558A (en) * 1997-10-31 2000-10-17 Oracle Corporation References that indicate where global database objects reside
AU1522299A (en) * 1997-11-12 1999-05-31 California Institute Of Technology Micromachined parylene membrane valve and pump
US6174675B1 (en) * 1997-11-25 2001-01-16 Caliper Technologies Corp. Electrical current for controlling fluid parameters in microchannels
US6155282A (en) * 1998-01-20 2000-12-05 Triconex, Incorporated Two out of three voting solenoid arrangement
US6376619B1 (en) * 1998-04-13 2002-04-23 3M Innovative Properties Company High density, miniaturized arrays and methods of manufacturing same
WO1999052633A1 (en) 1998-04-14 1999-10-21 Ivd Systems Test cartridge with a single inlet port
WO2000000678A1 (en) 1998-06-26 2000-01-06 University Of Washington Crystallization media
US6225243B1 (en) * 1998-08-03 2001-05-01 Bba Nonwovens Simpsonville, Inc. Elastic nonwoven fabric prepared from bi-component filaments
US6221483B1 (en) 1998-09-10 2001-04-24 Avery Dennison Corporation Reversibly extensible film
RU2143343C1 (en) 1998-11-03 1999-12-27 Самсунг Электроникс Ко., Лтд. Microinjector and microinjector manufacture method
EP1144890A2 (en) * 1998-11-16 2001-10-17 California Institute of Technology Parylene micro check valve and fabrication method thereof
US6401376B2 (en) * 1998-11-25 2002-06-11 Holly S. Cumberland Frame type photograph mounting assembly
AU3508600A (en) * 1999-02-26 2000-09-14 Orchid Biosciences, Inc. Microstructures for use in biological assays and reactions
JP3866043B2 (en) 1999-04-06 2007-01-10 ザ ユーエービー リサーチ ファウンデイション Method for screening crystallization conditions in solution crystal growth
US6296673B1 (en) * 1999-06-18 2001-10-02 The Regents Of The University Of California Methods and apparatus for performing array microcrystallizations
US6706519B1 (en) * 1999-06-22 2004-03-16 Tecan Trading Ag Devices and methods for the performance of miniaturized in vitro amplification assays
US7052545B2 (en) * 2001-04-06 2006-05-30 California Institute Of Technology High throughput screening of crystallization of materials
AU779988B2 (en) * 1999-06-28 2005-02-24 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6929030B2 (en) * 1999-06-28 2005-08-16 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6899137B2 (en) * 1999-06-28 2005-05-31 California Institute Of Technology Microfabricated elastomeric valve and pump systems
US6811608B1 (en) 1999-08-02 2004-11-02 Emerald Biostructures, Inc. Method and system for creating a crystallization results database
CA2404008A1 (en) * 2000-03-31 2001-10-11 Jurgen Sygusch Protein crystallization in microfluidic structures
US7351376B1 (en) * 2000-06-05 2008-04-01 California Institute Of Technology Integrated active flux microfluidic devices and methods
WO2002000343A2 (en) * 2000-06-27 2002-01-03 Fluidigm Corporation A microfluidic design automation method and system
US6561479B1 (en) * 2000-08-23 2003-05-13 Micron Technology, Inc. Small scale actuators and methods for their formation and use
US6508988B1 (en) * 2000-10-03 2003-01-21 California Institute Of Technology Combinatorial synthesis system
US6802342B2 (en) * 2001-04-06 2004-10-12 Fluidigm Corporation Microfabricated fluidic circuit elements and applications
US6418968B1 (en) * 2001-04-20 2002-07-16 Nanostream, Inc. Porous microfluidic valves
US6679279B1 (en) * 2002-07-10 2004-01-20 Motorola, Inc. Fluidic valve having a bi-phase valve element
US7476363B2 (en) * 2003-04-03 2009-01-13 Fluidigm Corporation Microfluidic devices and methods of using same

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US7754010B2 (en) 2010-07-13
US20150276089A1 (en) 2015-10-01

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