AR074760A1 - Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. - Google Patents

Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico.

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Publication number
AR074760A1
AR074760A1 ARP090104925A ARP090104925A AR074760A1 AR 074760 A1 AR074760 A1 AR 074760A1 AR P090104925 A ARP090104925 A AR P090104925A AR P090104925 A ARP090104925 A AR P090104925A AR 074760 A1 AR074760 A1 AR 074760A1
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AR
Argentina
Prior art keywords
substituted
group
cycloalkyl
alkyl
independently selected
Prior art date
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ARP090104925A
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English (en)
Inventor
Jingyuan Ma
Jiangao Song
Aaron Novack
Xin Chen
Christopher J Rabbat
Phuongly Pham
Dong Fang Shi
Imad Fayek Nashashibi
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Metabolex Inc
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=41818563&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=AR074760(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Metabolex Inc filed Critical Metabolex Inc
Publication of AR074760A1 publication Critical patent/AR074760A1/es

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    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
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    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
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    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Endocrinology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Emergency Medicine (AREA)
  • Child & Adolescent Psychology (AREA)
  • Reproductive Health (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyridine Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Secondary Cells (AREA)

Abstract

Se proporcionan agonistas GPR120. Estos compuestos son de utilidad para el tratamiento de enfermedades metabólicas, inclusive diabetes Tipo II y enfermedades asociadas con un control pobre de la glucemia. Reivindicación 1: Un compuesto caracterizado porque responde a la fórmula (1) o una sal aceptable farmacéuticamente del mismo, donde: el grupo J se encuentra ausente o se selecciona entre el grupo que consiste en fórmulas (2); el anillo Q se selecciona entre el grupo que consiste en arilo, heteroarilo, grupo de fórmulas 3, donde Q se sustituye opcionalmente con (R6)k; A1, A2, A3 y A4 se seleccionan de manera independiente entre el grupo que consiste en N y C, con la condición de que sólo 0, 1 o 2 de A1, A2, A3 y A4 es N; T1, T2, T3 y T4 se seleccionan de manera independiente entre el grupo que consiste en N, O, CR1 y CR1R2, con la condición de que sólo 0, 1 o 2 de T1, T2, T3 y T4 se selecciona entre N y O; W1, W2, W3 y W4 se seleccionan de manera independiente entre el grupo que consiste en N, NRa, CR1, CR1R2, O, S, S(O) y S(O)2, con la condición de que el anillo J no es 1,3-dioxolano; E1, E2 y E3 se seleccionan de manera independiente entre el grupo que consiste en C y N; uno de X e Y es una unión, -CH2-, -CHD-, o -CD2-, y el otro de X e Y se selecciona entre el grupo que consiste en -CH2-, -CHD-, -CD2-, -C(O), -C(O)NRa, -NRa-, -O-, -S, -S(O)- y -S(O)2-; L es -(CR4R5)q- donde opcionalmente un -(CR4R5)- se reemplaza con -N-, -O-, -S-, -CR4=CR5-, o -fenil-; G se selecciona entre el grupo que consiste en -C(O)OZ y -C(O)NZ2; cada Z se selecciona de manera independiente entre el grupo que consiste en H, alquilo y alquilo sustituido; cada R1 y R2 se selecciona de manera independiente entre el grupo que consiste en H, deuterio, halo, alquilo, alquilo sustituido, cicloalquilo, cicloalquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, oxo, alcoxi, alcoxi sustituido, CN, -NRaRb, -C(O)Ra, -C(O)ORa, -C(O)NRaRb, NRaC(O)Rb, -SRa, -S(O)Ra y -S(O)2Ra, y opcionalmente R1 y R2 se pueden ciclizar para formar un heterociclilo C3-7, heterociclilo C3-7 sustituido, espiro heterociclilo C3-7, espiro heterociclilo C3-7 sustituido, cicloalquilo C3-7, cicloalquilo C3-7 sustituido, espiro cicloalquilo C3-7 o espiro cicloalquilo C3-7 sustituido; cada R3 se selecciona de manera independiente entre el grupo que consiste en H, halo, alquilo, alquilo sustituido, alcoxi, alcoxi sustituido, -C(O)NRaRb, -NRaC(O)Rb, -NRaRb, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, ariloxi, ariloxi sustituido y -CN; cada R4 y R5 se selecciona de manera independiente entre el grupo que consiste en H, deuterio, flúor, alquilo, alquilo sustituido, alcoxi y alcoxi sustituido, y opcionalmente R4 y R5 se pueden ciclizar para formar un heterociclilo C3-7, heterociclilo C3-7 sustituido, espiro heterociclilo C3-7, espiro heterociclilo C3-7 sustituido, cicloalquilo C3-7, cicloalquilo C3-7 sustituido, espiro cicloalquilo C3-7 o espiro cicloalquilo C3-7sustituido; cada R6 se selecciona de manera independiente entre el grupo que consiste en H, halo, alquilo, alquilo sustituido, arilo, arilo sustituido, heteroarilo, heteroarilo sustituido, cicloalquilo, cicloalquilo sustituido, alquenilo, alquenilo sustituido, alquinilo, alquinilo sustituido, CN, -ORa, -NRaRb, -C(O)Ra, -C(O)ORa, -C(O)NRaRb, -NRaC(O)Rb, -SRa, -S(O)Ra y S(O)2Ra; cada uno de Ra y Rb se selecciona de manera independiente entre el grupo que consiste en H, alquilo, alquilo sustituido, cicloalquilo, heterociclilo, heterociclo sustituido, alquenilo, alquinilo, arilo, arilo sustituido, heteroarilo y heteroarilo sustituido, el subíndice k es 0, 1, 2 o 3; el subíndice m es 0, 1, 2 o 3; y el subíndice q es 0, 1, 2, 3 o 4.
ARP090104925A 2008-12-18 2009-12-16 Agonistas del receptor gpr120 y usos de los mismos en medicamentos para el tratamiento de diabetes y el sindrome metabolico. AR074760A1 (es)

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