ZA989720B - Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenyl-methyl) piperazines dopamine receptor subtype specific ligands - Google Patents
Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenyl-methyl) piperazines dopamine receptor subtype specific ligandsInfo
- Publication number
- ZA989720B ZA989720B ZA989720A ZA989720A ZA989720B ZA 989720 B ZA989720 B ZA 989720B ZA 989720 A ZA989720 A ZA 989720A ZA 989720 A ZA989720 A ZA 989720A ZA 989720 B ZA989720 B ZA 989720B
- Authority
- ZA
- South Africa
- Prior art keywords
- azanaphthyl
- piperazines
- naphthyl
- phenyl
- methyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
- C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
- C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D215/38—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
- C07D239/84—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
- C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
- C07D241/40—Benzopyrazines
- C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
- C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
- C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US95435397A | 1997-10-24 | 1997-10-24 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA989720B true ZA989720B (en) | 1999-04-26 |
Family
ID=25495312
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA989720A ZA989720B (en) | 1997-10-24 | 1998-10-26 | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenyl-methyl) piperazines dopamine receptor subtype specific ligands |
Country Status (11)
| Country | Link |
|---|---|
| EP (1) | EP1025097B1 (fr) |
| CN (1) | CN1191248C (fr) |
| AR (1) | AR015983A1 (fr) |
| AT (1) | ATE294173T1 (fr) |
| AU (1) | AU9810498A (fr) |
| CA (1) | CA2308057A1 (fr) |
| CO (1) | CO4970840A1 (fr) |
| DE (1) | DE69829989T2 (fr) |
| ES (1) | ES2241172T3 (fr) |
| WO (1) | WO1999021850A1 (fr) |
| ZA (1) | ZA989720B (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6040448A (en) * | 1997-10-24 | 2000-03-21 | Neurogen Corporation | Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands |
| WO2000012500A2 (fr) * | 1998-09-02 | 2000-03-09 | Neurogen Corporation | 2-aryl-4-[4-heteroaryl]piperazin-1-yl methylimidazoles: ligands pour le sous-type de recepteur d4 de la dopamine |
| EP1177792A3 (fr) | 2000-07-27 | 2002-10-23 | Pfizer Products Inc. | Ligands dopamine d4 destines au traitement des troubles associees a la cherche de la nouveaute |
| PE20060115A1 (es) | 2004-07-23 | 2006-03-23 | Basf Ag | 2-(piridin-2-il)-pirimidinas como agentes fungicidas |
| EP1869000A1 (fr) | 2005-03-31 | 2007-12-26 | Pfizer Products Incorporated | Derives de cyclopentapyridine et de tetrahydroquinoline |
| CN101208309B (zh) * | 2005-06-27 | 2010-12-08 | 弗·哈夫曼-拉罗切有限公司 | 氯取代的胍类化合物 |
| CN103992270B (zh) * | 2014-05-13 | 2016-06-08 | 泸州医学院 | 2-氯-5,6,7,8-四氢喹啉的制备方法 |
| SG11201701315VA (en) | 2014-08-28 | 2017-03-30 | Asceneuron Sa | Glycosidase inhibitors |
| CA3012624A1 (fr) | 2016-02-25 | 2017-08-31 | Asceneuron S.A. | Inhibiteurs de glycosidases |
| KR20180132060A (ko) | 2016-02-25 | 2018-12-11 | 아셰뉴론 에스아 | 피페라진 유도체의 산 부가 염 |
| US11261183B2 (en) | 2016-02-25 | 2022-03-01 | Asceneuron Sa | Sulfoximine glycosidase inhibitors |
| CN108884077A (zh) | 2016-02-25 | 2018-11-23 | 阿森纽荣股份公司 | 糖苷酶抑制剂 |
| AU2017400271B2 (en) | 2017-02-24 | 2020-09-24 | Asceneuron S.A. | Sulfoximine glycosidase inhibitors |
| EP3672959A1 (fr) | 2017-08-24 | 2020-07-01 | Asceneuron SA | Inhibiteurs linéaires de la glycosidase |
| EP3672958B1 (fr) | 2017-08-24 | 2023-08-02 | Asceneuron SA | Inhibiteurs de glycosidases annelés |
| WO2020039027A1 (fr) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Inhibiteurs de pyrrolidine glycosidase |
| US11731972B2 (en) | 2018-08-22 | 2023-08-22 | Asceneuron Sa | Spiro compounds as glycosidase inhibitors |
| WO2020039028A1 (fr) | 2018-08-22 | 2020-02-27 | Asceneuron S. A. | Inhibiteurs de tétrahydro-benzoazépine glycosidase |
| US20220143042A1 (en) | 2019-02-22 | 2022-05-12 | Asceneuron Sa | Fused glycosidase inhibitors |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3576809A (en) * | 1968-05-06 | 1971-04-27 | Miles Lab | 2-substituted derivatives of 6-methoxyquinoline |
| US3629418A (en) * | 1969-02-14 | 1971-12-21 | Miles Lab | Process for producing an anti-depressant effect with piperazine quinolines |
| FI193974A (fr) * | 1973-07-13 | 1975-01-14 | Merck & Co Inc | |
| US4091098A (en) * | 1977-04-25 | 1978-05-23 | Merck & Co., Inc. | 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides |
| DE2811312A1 (de) * | 1978-03-16 | 1979-09-27 | Hoechst Ag | Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln |
| FR2692264B1 (fr) * | 1992-06-12 | 1994-08-05 | Adir | Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant. |
| FR2734819B1 (fr) * | 1995-05-31 | 1997-07-04 | Adir | Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant |
| US5859246A (en) * | 1997-01-30 | 1999-01-12 | Neurogen Corporation | 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands |
| NZ337183A (en) * | 1997-03-04 | 2001-05-25 | Neurogen Corp | 1-(isoquinolin-1-yl)-4-(1-phenylmethyl)piperazines; dopamine receptor subtype specific ligands useful for the treatment of psychotic disorders |
-
1998
- 1998-10-21 ES ES98952391T patent/ES2241172T3/es not_active Expired - Lifetime
- 1998-10-21 CA CA002308057A patent/CA2308057A1/fr not_active Abandoned
- 1998-10-21 DE DE69829989T patent/DE69829989T2/de not_active Expired - Fee Related
- 1998-10-21 AT AT98952391T patent/ATE294173T1/de not_active IP Right Cessation
- 1998-10-21 WO PCT/US1998/022233 patent/WO1999021850A1/fr active IP Right Grant
- 1998-10-21 EP EP98952391A patent/EP1025097B1/fr not_active Expired - Lifetime
- 1998-10-21 AU AU98104/98A patent/AU9810498A/en not_active Abandoned
- 1998-10-21 CN CNB988126583A patent/CN1191248C/zh not_active Expired - Fee Related
- 1998-10-26 ZA ZA989720A patent/ZA989720B/xx unknown
- 1998-10-26 CO CO98062496A patent/CO4970840A1/es unknown
- 1998-10-26 AR ARP980105336A patent/AR015983A1/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CO4970840A1 (es) | 2000-11-07 |
| CN1283195A (zh) | 2001-02-07 |
| ATE294173T1 (de) | 2005-05-15 |
| AR015983A1 (es) | 2001-05-30 |
| CA2308057A1 (fr) | 1999-05-06 |
| EP1025097A1 (fr) | 2000-08-09 |
| AU9810498A (en) | 1999-05-17 |
| DE69829989T2 (de) | 2006-02-23 |
| CN1191248C (zh) | 2005-03-02 |
| DE69829989D1 (en) | 2005-06-02 |
| EP1025097B1 (fr) | 2005-04-27 |
| WO1999021850A1 (fr) | 1999-05-06 |
| ES2241172T3 (es) | 2005-10-16 |
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