CO4970840A1 - Ciertas 1-(2-naftil) y 1-(azanaftil)-4-(1-fenilmetil) pipe- razinas; ligandos especificos del subtipo receptor de la dopamina - Google Patents

Ciertas 1-(2-naftil) y 1-(azanaftil)-4-(1-fenilmetil) pipe- razinas; ligandos especificos del subtipo receptor de la dopamina

Info

Publication number
CO4970840A1
CO4970840A1 CO98062496A CO98062496A CO4970840A1 CO 4970840 A1 CO4970840 A1 CO 4970840A1 CO 98062496 A CO98062496 A CO 98062496A CO 98062496 A CO98062496 A CO 98062496A CO 4970840 A1 CO4970840 A1 CO 4970840A1
Authority
CO
Colombia
Prior art keywords
alkyl
hydrogen
razinas
fenilmetil
azanaftil
Prior art date
Application number
CO98062496A
Other languages
English (en)
Inventor
William Greenlee
Jan W F Wasley
Original Assignee
Neurogen Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurogen Corp filed Critical Neurogen Corp
Publication of CO4970840A1 publication Critical patent/CO4970840A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/84—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
    • C07D241/36—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems
    • C07D241/38—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings condensed with carbocyclic rings or ring systems with only hydrogen or carbon atoms directly attached to the ring nitrogen atoms
    • C07D241/40—Benzopyrazines
    • C07D241/44—Benzopyrazines with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/06—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals
    • C07D295/073—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by halogen atoms or nitro radicals with the ring nitrogen atoms and the substituents separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

Unos compuesto de la fórmula: o sales de adición farmacéuticamente aceptables de estas, en donde: X, Y, y Z son iguales o diferentes y representan CRc o nitrógeno; Rc representa hidrógeno, halógeno o alquilo C1 -C6 ; R1 y R2 independientemente representan hidrógeno, halógeno, hidroxi, alquilo C1 -C6 , trifluorometilo, trifluorometoxi o SO2 NH2 , dado que, cuando Y y Z representan CH, y R3 y R4 son los dos hidrógeno, R1 y R2 no son hidrógeno simultáneamente; o R1 y R2 juntos representan un grupo dioxialquileno C1 -C2 o un grupo oxialquileno C1 -C3 ; R3 y R4 son iguales o diferentes y representan hidrógeno, halógeno, alquilo C1 -C6 , alcoxi C1 -C4 ; alquiltio, hidroxi, amino, mono o dialquilamino donde cada alquilo es alquilo C1 -C6 , ciano o trifluorometilo; A representa alquileno C1 -C4 ; y R5 , R6 y R7 independientemente representan hidrógeno o alquilo C1 -C6 .
CO98062496A 1997-10-24 1998-10-26 Ciertas 1-(2-naftil) y 1-(azanaftil)-4-(1-fenilmetil) pipe- razinas; ligandos especificos del subtipo receptor de la dopamina CO4970840A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US95435397A 1997-10-24 1997-10-24

Publications (1)

Publication Number Publication Date
CO4970840A1 true CO4970840A1 (es) 2000-11-07

Family

ID=25495312

Family Applications (1)

Application Number Title Priority Date Filing Date
CO98062496A CO4970840A1 (es) 1997-10-24 1998-10-26 Ciertas 1-(2-naftil) y 1-(azanaftil)-4-(1-fenilmetil) pipe- razinas; ligandos especificos del subtipo receptor de la dopamina

Country Status (11)

Country Link
EP (1) EP1025097B1 (es)
CN (1) CN1191248C (es)
AR (1) AR015983A1 (es)
AT (1) ATE294173T1 (es)
AU (1) AU9810498A (es)
CA (1) CA2308057A1 (es)
CO (1) CO4970840A1 (es)
DE (1) DE69829989T2 (es)
ES (1) ES2241172T3 (es)
WO (1) WO1999021850A1 (es)
ZA (1) ZA989720B (es)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6040448A (en) * 1997-10-24 2000-03-21 Neurogen Corporation Certain 1-(2-naphthyl) and 1-(2-azanaphthyl)-4-(1-phenylmethyl) piperazines, dopamine receptor subtype specific ligands
WO2000012500A2 (en) * 1998-09-02 2000-03-09 Neurogen Corporation 2-aryl-4-(1-[4-heteroaryl]piperazin-1-yl) methylimidazoles: dopamine d4 receptor subtype ligands
EP1177792A3 (en) 2000-07-27 2002-10-23 Pfizer Products Inc. Dopamine D4 Ligands for the treatment of novelty-seeking disorders
PE20060115A1 (es) 2004-07-23 2006-03-23 Basf Ag 2-(piridin-2-il)-pirimidinas como agentes fungicidas
EP1869000A1 (en) 2005-03-31 2007-12-26 Pfizer Products Incorporated Cyclopentapyridine and tetrahydroquinoline derivatives
AU2006263924A1 (en) * 2005-06-27 2007-01-04 F. Hoffmann-La Roche Ag Chloro-substituted guanidines
CN103992270B (zh) * 2014-05-13 2016-06-08 泸州医学院 2-氯-5,6,7,8-四氢喹啉的制备方法
US10336775B2 (en) 2014-08-28 2019-07-02 Asceneuron Sa Glycosidase inhibitors
US11261183B2 (en) 2016-02-25 2022-03-01 Asceneuron Sa Sulfoximine glycosidase inhibitors
WO2017144633A1 (en) 2016-02-25 2017-08-31 Asceneuron S. A. Glycosidase inhibitors
EP3585783A2 (en) 2016-02-25 2020-01-01 Asceneuron SA Sulfoximine glycosidase inhibitors
MX2018010191A (es) 2016-02-25 2019-05-20 Asceneuron S A Inhibidores de glucosidasa.
IL260638B1 (en) 2016-02-25 2024-09-01 Asceneuron S A Acidic addition salts of piperazine derivatives
EP3672958B1 (en) 2017-08-24 2023-08-02 Asceneuron SA Annulated glycosidase inhibitors
WO2019037860A1 (en) 2017-08-24 2019-02-28 Asceneuron S.A. LINEAR INHIBITORS OF GLYCOSIDASE
US11731972B2 (en) 2018-08-22 2023-08-22 Asceneuron Sa Spiro compounds as glycosidase inhibitors
WO2020039027A1 (en) 2018-08-22 2020-02-27 Asceneuron S. A. Pyrrolidine glycosidase inhibitors
US11795165B2 (en) 2018-08-22 2023-10-24 Asceneuron Sa Tetrahydro-benzoazepine glycosidase inhibitors
US20220143042A1 (en) 2019-02-22 2022-05-12 Asceneuron Sa Fused glycosidase inhibitors

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3576809A (en) * 1968-05-06 1971-04-27 Miles Lab 2-substituted derivatives of 6-methoxyquinoline
US3629418A (en) * 1969-02-14 1971-12-21 Miles Lab Process for producing an anti-depressant effect with piperazine quinolines
FI193974A (es) * 1973-07-13 1975-01-14 Merck & Co Inc
US4091098A (en) * 1977-04-25 1978-05-23 Merck & Co., Inc. 3-(1-PIPERAZINYL)-1,2,4-BENZOTRIAZINES AND N-oxides
DE2811312A1 (de) * 1978-03-16 1979-09-27 Hoechst Ag Neue isochinolinderivate, verfahren zu ihrer herstellung und ihre verwendung zur herstellung von arzneimitteln
FR2692264B1 (fr) * 1992-06-12 1994-08-05 Adir Nouvelles piperazines 1,4-disubstituees, leur procede de preparation et les compositions pharmaceutiques les contenant.
FR2734819B1 (fr) * 1995-05-31 1997-07-04 Adir Nouveaux composes de la piperazine, de la piperidine et de la 1,2,5,6-tetrahydropyridine, leur procede de preparation et les compositions pharmaceutiques les contenant
US5859246A (en) * 1997-01-30 1999-01-12 Neurogen Corporation 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands
CA2283256A1 (en) * 1997-03-04 1998-09-11 Neurogen Corporation 1-(isoquinolin-1-yl)-4-(1-phenylmethyl)piperazines; dopamine receptor subtype specific ligands

Also Published As

Publication number Publication date
DE69829989T2 (de) 2006-02-23
CA2308057A1 (en) 1999-05-06
CN1283195A (zh) 2001-02-07
WO1999021850A1 (en) 1999-05-06
DE69829989D1 (en) 2005-06-02
EP1025097A1 (en) 2000-08-09
ATE294173T1 (de) 2005-05-15
CN1191248C (zh) 2005-03-02
AR015983A1 (es) 2001-05-30
EP1025097B1 (en) 2005-04-27
ZA989720B (en) 1999-04-26
ES2241172T3 (es) 2005-10-16
AU9810498A (en) 1999-05-17

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