ZA989249B - Heteroaromatic compounds and their use in medicine. - Google Patents

Heteroaromatic compounds and their use in medicine.

Info

Publication number
ZA989249B
ZA989249B ZA9809249A ZA989249A ZA989249B ZA 989249 B ZA989249 B ZA 989249B ZA 9809249 A ZA9809249 A ZA 9809249A ZA 989249 A ZA989249 A ZA 989249A ZA 989249 B ZA989249 B ZA 989249B
Authority
ZA
South Africa
Prior art keywords
medicine
heteroaromatic compounds
heteroaromatic
compounds
Prior art date
Application number
ZA9809249A
Inventor
Mui Cheung
Kimberly Caroline Glennon
Karen Elizabeth Lackey
Michael Robert Peel
Original Assignee
Glaxo Group Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxo Group Ltd filed Critical Glaxo Group Ltd
Publication of ZA989249B publication Critical patent/ZA989249B/en

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9809249A 1997-10-10 1998-10-09 Heteroaromatic compounds and their use in medicine. ZA989249B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9721437.3A GB9721437D0 (en) 1997-10-10 1997-10-10 Heteroaromatic compounds and their use in medicine

Publications (1)

Publication Number Publication Date
ZA989249B true ZA989249B (en) 2000-04-10

Family

ID=10820303

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9809249A ZA989249B (en) 1997-10-10 1998-10-09 Heteroaromatic compounds and their use in medicine.

Country Status (7)

Country Link
AR (1) AR017311A1 (en)
AU (1) AU1151099A (en)
GB (1) GB9721437D0 (en)
MA (1) MA26550A1 (en)
PE (1) PE120199A1 (en)
WO (1) WO1999021859A1 (en)
ZA (1) ZA989249B (en)

Families Citing this family (86)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE69838172T2 (en) 1997-08-22 2008-04-10 Astrazeneca Ab OXINDOLYLCHINAZOLE DERIVATIVES AS ANGIOGENESEHEMMER
ATE482946T1 (en) 1999-02-10 2010-10-15 Astrazeneca Ab QUINAZOLINE DERIVATIVES AS ANGIOGENESIS INHIBITORS AND INTERMEDIATE PRODUCTS THEREFOR
US20030143676A1 (en) * 1999-03-25 2003-07-31 Genesis Research And Development Corporation Limited Fibroblast growth factor receptors and methods for their use
US7083791B2 (en) 1999-03-25 2006-08-01 Genesis Research & Development Corporation Limited Methods for enhancing immune responses by fibroblast growth factor receptor 5 polypeptides
GB9918057D0 (en) * 1999-07-30 1999-10-06 Univ Bristol Therapeutic agents
EP1088821A1 (en) * 1999-09-28 2001-04-04 Applied Research Systems ARS Holding N.V. Pharmaceutically active sulfonamide derivatives
SE9904177D0 (en) * 1999-11-18 1999-11-18 Astra Ab Novel compounds
EP1244672B1 (en) * 1999-12-21 2005-07-20 Sugen, Inc. 4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
EP1110957A1 (en) * 1999-12-24 2001-06-27 Applied Research Systems ARS Holding N.V. Benzazole derivatives and their use as JNK modulators
US6323029B1 (en) 2000-01-19 2001-11-27 Isis Pharmaceuticals, Inc. Antisense modulation of glycogen synthase kinase 3 beta expression
US6316259B1 (en) 2000-01-21 2001-11-13 Isis Pharmaceuticals, Inc. Antisense inhibition of glycogen synthase kinase 3 alpha expression
AU2001236720A1 (en) 2000-02-05 2001-08-14 Bemis, Guy Compositions useful as inhibitors of erk
FR2804959B1 (en) 2000-02-15 2006-04-28 Centre Nat Rech Scient USE OF PAULLON DERIVATIVES FOR THE MANUFACTURE OF MEDICAMENTS
EP1259514B9 (en) * 2000-02-28 2005-11-09 Sugen, Inc. 3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
ES2317923T3 (en) 2000-08-09 2009-05-01 Astrazeneca Ab CINOLINE COMPOUNDS.
WO2002012226A1 (en) 2000-08-09 2002-02-14 Astrazeneca Ab Quinoline derivatives having vegf inhibiting activity
US7105532B2 (en) 2000-12-19 2006-09-12 Smithkline Beecham Corporation Pyrazolo[3,4-c]pyridines as gsk-3 inhibitors
CA2432642A1 (en) 2000-12-21 2002-08-08 Subhash P. Khanapure Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
GB0108770D0 (en) 2001-04-06 2001-05-30 Eisai London Res Lab Ltd Inhibitors
SE0101230L (en) * 2001-04-06 2002-10-07 Innoventus Project Ab New use of a tyrosine kinase inhibitor
EP1435957B1 (en) * 2001-04-30 2009-06-17 Vertex Pharmaceuticals Incorporated Inhibitors of gsk-3 and crystal structures of gsk-3beta protein and protein complexes
EP1471907B1 (en) * 2001-06-29 2008-07-16 AB Science Use of c-kit inhibitors for treating autoimmune diseases
JP2005500041A (en) 2001-06-29 2005-01-06 アブ サイエンス Potent, selective and non-toxic C-KIT inhibitor
PT1401413E (en) 2001-06-29 2007-02-28 Ab Science Use of tyrosine kinase inhibitions for treating allergic diseases
WO2003004006A2 (en) * 2001-06-29 2003-01-16 Ab Science Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis
ATE343415T1 (en) 2001-06-29 2006-11-15 Ab Science THE USE OF C-KIT INHIBITORS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
ATE330608T1 (en) * 2001-06-29 2006-07-15 Ab Science THE USE OF N-PHENYL-2-PYRIMIDINE-AMINE DERIVATIVES FOR THE TREATMENT OF INFLAMMATORY DISEASES
JP2005508337A (en) * 2001-09-27 2005-03-31 スミスクライン ビーチャム コーポレーション Compound
EP1474420B1 (en) 2002-02-01 2012-03-14 AstraZeneca AB Quinazoline compounds
JP2005534619A (en) 2002-03-28 2005-11-17 エーザイ株式会社 Azaindole as C-JUNN-terminal kinase inhibitor
IL164187A0 (en) 2002-03-28 2005-12-18 Eisai Co Ltd 7-Azaindole derivatives and pharmaceutical compositions containing the same
AU2003241398A1 (en) * 2002-05-06 2003-11-17 Washington University Methods of treatment of glaucoma and other conditions mediated by nos-2 expression via inhibition of the egfr pathway
GB0305142D0 (en) 2003-03-06 2003-04-09 Eisai London Res Lab Ltd Synthesis
EP2295433A3 (en) 2003-03-06 2011-07-06 Eisai R&D Management Co., Ltd. JNK inhibitors
EP1628975A2 (en) 2003-05-16 2006-03-01 Eisai Co., Ltd. Jnk inhibitors
AR045037A1 (en) 2003-07-10 2005-10-12 Aventis Pharma Sa TETRAHIDRO-1H-PIRAZOLO [3,4-C] SUBSTITUTED PYRIDINS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE.
GB0330002D0 (en) 2003-12-24 2004-01-28 Astrazeneca Ab Quinazoline derivatives
GB0402137D0 (en) * 2004-01-30 2004-03-03 Smithkline Beecham Corp Novel compounds
ATE508129T1 (en) 2004-03-30 2011-05-15 Vertex Pharma AZAINDOLS SUITABLE AS INHIBITORS OF JAK AND OTHER PROTEIN KINASES
JP4099212B2 (en) * 2004-05-14 2008-06-11 ファイザー・プロダクツ・インク Pyrimidine derivatives for treating abnormal cell proliferation
WO2005113561A1 (en) * 2004-05-20 2005-12-01 Sugen, Inc. Cyclicsulfonate pyrrole indolinones as kinase inhibitors
GB0423554D0 (en) 2004-10-22 2004-11-24 Cancer Rec Tech Ltd Therapeutic compounds
CA2614157A1 (en) * 2005-08-01 2007-02-08 F. Hoffmann-La Roche Ag Heterocyclic benzylamino derivatives, their manufacture and use as pharmaceutical agents
GB0516156D0 (en) 2005-08-05 2005-09-14 Eisai London Res Lab Ltd JNK inhibitors
JP2009506069A (en) 2005-08-26 2009-02-12 ブレインセルス,インコーポレイティド Neurogenesis through modulation of muscarinic receptors
EP2258359A3 (en) 2005-08-26 2011-04-06 Braincells, Inc. Neurogenesis by muscarinic receptor modulation with sabcomelin
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
JP5324785B2 (en) 2005-10-28 2013-10-23 武田薬品工業株式会社 Heterocyclic amide compounds and uses thereof
US20070112017A1 (en) 2005-10-31 2007-05-17 Braincells, Inc. Gaba receptor mediated modulation of neurogenesis
BRPI0722364A2 (en) 2006-01-17 2011-08-16 Vertex Pharma azaindoles, pharmaceutical composition and uses of said compounds
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
CA2649994A1 (en) 2006-04-26 2007-11-08 Cancer Research Technology Limited Imidazo[4,5-b]pyridin-2-one and oxazolo[4,5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
EP2377531A2 (en) 2006-05-09 2011-10-19 Braincells, Inc. Neurogenesis by modulating angiotensin
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
EP2815750A1 (en) 2006-12-21 2014-12-24 Vertex Pharmaceuticals Incorporated 5-cyano-4-(pyrrolo [2,3b] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
JP5511680B2 (en) 2007-12-19 2014-06-04 キャンサー・リサーチ・テクノロジー・リミテッド Pyrido [2,3-B] pyrazine-8-substituted compounds and uses thereof
GB0807609D0 (en) 2008-04-25 2008-06-04 Cancer Rec Tech Ltd Therapeutic compounds and their use
AU2009324894B2 (en) 2008-11-25 2015-04-09 University Of Rochester MLK inhibitors and methods of use
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations
GEP20156325B (en) 2009-06-17 2015-07-10 Vertex Pharma Inhibitors of influenza viruses replication
CN104945401B (en) 2010-02-01 2017-09-05 癌症研究技术有限公司 IP compounds and their applications in the treatment
EP2576549A4 (en) 2010-05-24 2013-12-18 Univ Rochester Bicyclic heteroaryl kinase inhibitors and methods of use
MX2013006836A (en) 2010-12-16 2013-09-26 Vertex Pharma Inhibitors of influenza viruses replication.
CN102115469A (en) * 2011-03-21 2011-07-06 浙江大学 Preparation method for indoline-2-one derivative and application of same
US9493452B2 (en) * 2011-03-24 2016-11-15 Southern Methodist University Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
US8669363B2 (en) 2011-03-24 2014-03-11 Southern Methodist University Quinoxaline compounds and derivatives
CA2839937C (en) 2011-07-05 2020-11-03 Vertex Pharmaceuticals Incorporated Processes and intermediates for producing azaindoles
UA118010C2 (en) 2011-08-01 2018-11-12 Вертекс Фармасьютікалз Інкорпорейтед INFLUENCES OF INFLUENZA VIRUS REPLICATION
EP3604307A1 (en) 2012-01-26 2020-02-05 Angion Biomedica Corp. Anti-fibrotic compounds and uses thereof
WO2013142831A1 (en) 2012-03-23 2013-09-26 Southern Methodist University Methods of making and using thioxothiazolidine and rhodanine derivatives as hiv-1 and jsp-1 inhibitors
EP2925319B1 (en) 2012-11-30 2019-01-09 University Of Rochester Mixed lineage kinase inhibitors for hiv/aids therapies
RS59144B1 (en) 2013-11-13 2019-09-30 Vertex Pharma Inhibitors of influenza viruses replication
EP3421468B1 (en) 2013-11-13 2020-11-04 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
GB201320732D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Methods of chemical synthesis
GB201320729D0 (en) 2013-11-25 2014-01-08 Cancer Rec Tech Ltd Therapeutic compounds and their use
CN104447733B (en) * 2015-01-05 2016-08-17 中国药科大学 1-benzyl-2-pyrrolinone-4-amides compound and preparation method and application
CN104876928B (en) * 2015-05-07 2016-09-14 浙江司太立制药股份有限公司 7-azaindole quinoline-2-ketone compounds and preparation method thereof
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
WO2016183120A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Inhibitors of influenza viruses replication
KR102109869B1 (en) * 2015-11-12 2020-05-13 영남대학교 산학협력단 Pharmaceutical composition comprising 7-azaindolin-2-one derivative or a pharmaceutically acceptable salt
AU2017275209C1 (en) 2016-05-31 2020-01-23 Taiho Pharmaceutical Co., Ltd. Sulfonamide compound or salt thereof
US10889555B2 (en) 2016-05-31 2021-01-12 Taiho Pharmaceutical Co., Ltd. Sulfonamide compound or salt thereof
CN106432228A (en) * 2016-09-06 2017-02-22 浙江司太立制药股份有限公司 4-oximido-1-piperidyl fragment containing 7-azaindolin-2-one compound and preparation method therefor
CN106397436A (en) * 2016-09-06 2017-02-15 浙江司太立制药股份有限公司 5-bromo-7-azaindoline-2-one compounds and preparation method thereof
PT3691620T (en) 2017-10-05 2022-10-06 Fulcrum Therapeutics Inc P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
US10342786B2 (en) 2017-10-05 2019-07-09 Fulcrum Therapeutics, Inc. P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9423997D0 (en) * 1994-11-28 1995-01-11 Erba Carlo Spa Substituted 3-arylidene-7-azaoxindole compounds and process for their preparation

Also Published As

Publication number Publication date
PE120199A1 (en) 1999-12-15
WO1999021859A1 (en) 1999-05-06
GB9721437D0 (en) 1997-12-10
AR017311A1 (en) 2001-09-05
MA26550A1 (en) 2004-12-20
AU1151099A (en) 1999-05-17

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