DE69838172T2
(en)
|
1997-08-22 |
2008-04-10 |
Astrazeneca Ab |
OXINDOLYLCHINAZOLE DERIVATIVES AS ANGIOGENESEHEMMER
|
HU230000B1
(en)
|
1999-02-10 |
2015-04-28 |
Astrazeneca Ab |
Intermediates for the preparation of angiogenesis inhibitory quinazoline derivatives
|
US20030143676A1
(en)
*
|
1999-03-25 |
2003-07-31 |
Genesis Research And Development Corporation Limited |
Fibroblast growth factor receptors and methods for their use
|
US7083791B2
(en)
|
1999-03-25 |
2006-08-01 |
Genesis Research & Development Corporation Limited |
Methods for enhancing immune responses by fibroblast growth factor receptor 5 polypeptides
|
GB9918057D0
(en)
*
|
1999-07-30 |
1999-10-06 |
Univ Bristol |
Therapeutic agents
|
EP1088821A1
(en)
*
|
1999-09-28 |
2001-04-04 |
Applied Research Systems ARS Holding N.V. |
Pharmaceutically active sulfonamide derivatives
|
SE9904177D0
(en)
*
|
1999-11-18 |
1999-11-18 |
Astra Ab |
Novel compounds
|
EP1244672B1
(en)
*
|
1999-12-21 |
2005-07-20 |
Sugen, Inc. |
4-substituted 7-aza-indolin-2-ones and their use as protein kinase inhibitors
|
EP1110957A1
(en)
*
|
1999-12-24 |
2001-06-27 |
Applied Research Systems ARS Holding N.V. |
Benzazole derivatives and their use as JNK modulators
|
US6323029B1
(en)
|
2000-01-19 |
2001-11-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of glycogen synthase kinase 3 beta expression
|
US6316259B1
(en)
|
2000-01-21 |
2001-11-13 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of glycogen synthase kinase 3 alpha expression
|
WO2001056557A2
(en)
*
|
2000-02-05 |
2001-08-09 |
Vertex Pharmaceuticals Incorporated |
Compositions useful as inhibitors of erk
|
FR2804959B1
(en)
*
|
2000-02-15 |
2006-04-28 |
Centre Nat Rech Scient |
USE OF PAULLON DERIVATIVES FOR THE MANUFACTURE OF MEDICAMENTS
|
US6465507B2
(en)
|
2000-02-28 |
2002-10-15 |
Sugen, Inc. |
3-(pyrolyllactone)-2-indolinone compounds as kinase inhibitors
|
AU2001276521B2
(en)
|
2000-08-09 |
2006-05-25 |
Astrazeneca Ab |
Cinnoline compounds
|
CA2415469A1
(en)
|
2000-08-09 |
2002-02-14 |
Astrazeneca Ab |
Quinoline derivatives having vegf inhibiting activity
|
JP2004518662A
(en)
*
|
2000-12-19 |
2004-06-24 |
スミスクライン ビーチャム パブリック リミテッド カンパニー |
Pyrazolo [3,4-C] pyridines as GSK-3 inhibitors
|
US6706724B2
(en)
|
2000-12-21 |
2004-03-16 |
Nitromed, Inc. |
Substituted aryl compounds as novel cyclooxygenase-2 selective inhibitors, compositions and methods of use
|
SE0101230L
(en)
*
|
2001-04-06 |
2002-10-07 |
Innoventus Project Ab |
New use of a tyrosine kinase inhibitor
|
GB0108770D0
(en)
|
2001-04-06 |
2001-05-30 |
Eisai London Res Lab Ltd |
Inhibitors
|
US7390808B2
(en)
*
|
2001-04-30 |
2008-06-24 |
Vertex Pharmaceuticals Incorporated |
Inhibitors of GSK-3 and crystal structures of GSK-3β protein and protein complexes
|
EP1401415B1
(en)
|
2001-06-29 |
2006-06-21 |
AB Science |
Use of n-phenyl-2-pyrimidine-amine derivatives for treating inflammatory diseases
|
WO2003002109A2
(en)
*
|
2001-06-29 |
2003-01-09 |
Ab Science |
Use of tyrosine kinase inhibitors for treating autoimmune diseases
|
CA2452366A1
(en)
*
|
2001-06-29 |
2003-01-16 |
Ab Science |
Use of potent, selective and non toxic c-kit inhibitors for treating tumor angiogenesis
|
ATE343415T1
(en)
|
2001-06-29 |
2006-11-15 |
Ab Science |
THE USE OF C-KIT INHIBITORS FOR THE TREATMENT OF INFLAMMATORY BOWEL DISEASE
|
EP1434991B1
(en)
|
2001-06-29 |
2007-10-17 |
AB Science |
New potent, selective and non toxic c-kit inhibitors
|
WO2003002106A2
(en)
*
|
2001-06-29 |
2003-01-09 |
Ab Science |
Use of tyrosine kinase inhibitions for treating allergic diseases
|
EP1430053B1
(en)
*
|
2001-09-27 |
2006-10-25 |
SmithKline Beecham Corporation |
AZAOXOINDOLE DERIVATIVES AS Trk PROTEIN KINASE INHIBITORS FOR THE TREATMENT OF CANCER AND CHRONIC PAIN
|
AU2003202094B2
(en)
|
2002-02-01 |
2009-10-08 |
Astrazeneca Ab |
Quinazoline compounds
|
WO2003082868A1
(en)
|
2002-03-28 |
2003-10-09 |
Eisai Co., Ltd. |
7-azaindoles as inhibitors of c-jun n-terminal kinases for the treatment of neurodegenerative disorders
|
AU2003214414B2
(en)
|
2002-03-28 |
2008-10-09 |
Eisai R & D Management Co., Ltd. |
Azaindoles as inhibitors of c-Jun N-terminal kinases
|
CA2484797A1
(en)
*
|
2002-05-06 |
2003-11-13 |
Washington University |
Methods of treatment of glaucoma and other conditions mediated by nos-2 expression via inhibition of the egfr pathway
|
GB0305142D0
(en)
|
2003-03-06 |
2003-04-09 |
Eisai London Res Lab Ltd |
Synthesis
|
WO2004078756A2
(en)
|
2003-03-06 |
2004-09-16 |
Eisai Co., Ltd. |
Jnk inhibitors
|
WO2004101565A2
(en)
|
2003-05-16 |
2004-11-25 |
Eisai Co., Ltd. |
Jnk inhibitors
|
AR045037A1
(en)
|
2003-07-10 |
2005-10-12 |
Aventis Pharma Sa |
TETRAHIDRO-1H-PIRAZOLO [3,4-C] SUBSTITUTED PYRIDINS, COMPOSITIONS THAT CONTAIN THEM AND ITS USE.
|
GB0330002D0
(en)
|
2003-12-24 |
2004-01-28 |
Astrazeneca Ab |
Quinazoline derivatives
|
GB0402137D0
(en)
*
|
2004-01-30 |
2004-03-03 |
Smithkline Beecham Corp |
Novel compounds
|
EP2332940B1
(en)
*
|
2004-03-30 |
2012-10-31 |
Vertex Pharmaceuticals Incorporated |
Azaindoles useful as inhibitors of JAK and other protein kinases
|
CN1953974A
(en)
*
|
2004-05-14 |
2007-04-25 |
辉瑞产品有限公司 |
Pyrimidine derivatives for the treatment of abnormal cell growth
|
WO2005113561A1
(en)
*
|
2004-05-20 |
2005-12-01 |
Sugen, Inc. |
Cyclicsulfonate pyrrole indolinones as kinase inhibitors
|
GB0423554D0
(en)
|
2004-10-22 |
2004-11-24 |
Cancer Rec Tech Ltd |
Therapeutic compounds
|
JP2009503001A
(en)
*
|
2005-08-01 |
2009-01-29 |
エフ.ホフマン−ラ ロシュ アーゲー |
Heterocyclic benzylamino derivatives, their production and use as pharmaceuticals
|
GB0516156D0
(en)
|
2005-08-05 |
2005-09-14 |
Eisai London Res Lab Ltd |
JNK inhibitors
|
US7678363B2
(en)
|
2005-08-26 |
2010-03-16 |
Braincells Inc |
Methods of treating psychiatric conditions comprising administration of muscarinic agents in combination with SSRIs
|
EP2258358A3
(en)
|
2005-08-26 |
2011-09-07 |
Braincells, Inc. |
Neurogenesis with acetylcholinesterase inhibitor
|
JP2009512711A
(en)
|
2005-10-21 |
2009-03-26 |
ブレインセルス,インコーポレイティド |
Regulation of neurogenesis by PDE inhibition
|
ES2380236T3
(en)
|
2005-10-28 |
2012-05-09 |
Takeda Pharmaceutical Company Limited |
Heterocyclic amide compound and use thereof
|
AU2006308889A1
(en)
|
2005-10-31 |
2007-05-10 |
Braincells, Inc. |
GABA receptor mediated modulation of neurogenesis
|
CN102532134A
(en)
|
2006-01-17 |
2012-07-04 |
沃泰克斯药物股份有限公司 |
Azaindoles useful as inhibitors of janus kinases
|
US20100216734A1
(en)
|
2006-03-08 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis by nootropic agents
|
EP2013207B1
(en)
|
2006-04-26 |
2012-04-25 |
Cancer Research Technology Limited |
Imidazo[4,5-b]pyridin-2-one compounds and analogs thereof as cancer therapeutic compounds
|
EP2377531A2
(en)
|
2006-05-09 |
2011-10-19 |
Braincells, Inc. |
Neurogenesis by modulating angiotensin
|
US20100184806A1
(en)
|
2006-09-19 |
2010-07-22 |
Braincells, Inc. |
Modulation of neurogenesis by ppar agents
|
US8247421B2
(en)
|
2006-12-21 |
2012-08-21 |
Vertex Pharmaceuticals Incorporated |
5-cyano-4-(pyrrolo [2,3B] pyridine-3-yl)-pyrimidine derivatives useful as protein kinase inhibitors
|
KR101665143B1
(en)
|
2007-12-19 |
2016-10-11 |
캔써 리서치 테크놀로지 리미티드 |
Pyrido[2,3-b]pyrazine-8-substituted compounds and their use
|
GB0807609D0
(en)
|
2008-04-25 |
2008-06-04 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
WO2010068483A2
(en)
|
2008-11-25 |
2010-06-17 |
University Of Rochester |
Mlk inhibitors and methods of use
|
US20100216805A1
(en)
|
2009-02-25 |
2010-08-26 |
Braincells, Inc. |
Modulation of neurogenesis using d-cycloserine combinations
|
TWI574963B
(en)
|
2009-06-17 |
2017-03-21 |
維泰克斯製藥公司 |
Inhibitors of influenza viruses replication
|
CN102906090B
(en)
|
2010-02-01 |
2015-06-24 |
癌症研究技术有限公司 |
1-(5-tert-butyl-2-phenyl-2h-pyrazol-3-yl)-3-[2-fluoro-4-(1-methyl-2-oxo-2,3-dihydro-1h-imidazo[4,5-b]pyridin-7-yloxy)-phenyl]-urea and related compounds and their use in therapy
|
US8846909B2
(en)
|
2010-05-24 |
2014-09-30 |
University Of Rochester |
Bicyclic heteroaryl kinase inhibitors and methods of use
|
RU2013132681A
(en)
|
2010-12-16 |
2015-01-27 |
Вертекс Фармасьютикалз Инкорпорейтед |
INFLUENZA VIRUS REPLICATION INHIBITORS
|
CN102115469A
(en)
*
|
2011-03-21 |
2011-07-06 |
浙江大学 |
Preparation method for indoline-2-one derivative and application of same
|
US8669363B2
(en)
|
2011-03-24 |
2014-03-11 |
Southern Methodist University |
Quinoxaline compounds and derivatives
|
US9493452B2
(en)
*
|
2011-03-24 |
2016-11-15 |
Southern Methodist University |
Compounds and derivatives of 2H-pyrido (3,2-b)(1, 4) oxazin 3)4H)-ones as raf kinase and LRRK2 inhibitors
|
CA2839937C
(en)
|
2011-07-05 |
2020-11-03 |
Vertex Pharmaceuticals Incorporated |
Processes and intermediates for producing azaindoles
|
UA118010C2
(en)
|
2011-08-01 |
2018-11-12 |
Вертекс Фармасьютікалз Інкорпорейтед |
INFLUENCES OF INFLUENZA VIRUS REPLICATION
|
ES2748873T3
(en)
|
2012-01-26 |
2020-03-18 |
Angion Biomedica Corp |
Antifibrotic compounds and uses thereof
|
WO2013142831A1
(en)
|
2012-03-23 |
2013-09-26 |
Southern Methodist University |
Methods of making and using thioxothiazolidine and rhodanine derivatives as hiv-1 and jsp-1 inhibitors
|
WO2014085795A1
(en)
|
2012-11-30 |
2014-06-05 |
University Of Rochester |
Mixed lineage kinase inhibitors for hiv/aids therapies
|
ES2741444T3
(en)
|
2013-11-13 |
2020-02-11 |
Vertex Pharma |
Inhibitors of influenza virus replication
|
SI3421468T1
(en)
|
2013-11-13 |
2021-03-31 |
Vertex Pharmaceuticals Incorporated |
Methods of preparing inhibitors of influenza viruses replication
|
GB201320732D0
(en)
|
2013-11-25 |
2014-01-08 |
Cancer Rec Tech Ltd |
Methods of chemical synthesis
|
GB201320729D0
(en)
|
2013-11-25 |
2014-01-08 |
Cancer Rec Tech Ltd |
Therapeutic compounds and their use
|
CN104447733B
(en)
*
|
2015-01-05 |
2016-08-17 |
中国药科大学 |
1-benzyl-2-pyrrolinone-4-amides compound and preparation method and application
|
CN104876928B
(en)
*
|
2015-05-07 |
2016-09-14 |
浙江司太立制药股份有限公司 |
7-azaindole quinoline-2-ketone compounds and preparation method thereof
|
WO2016183116A1
(en)
|
2015-05-13 |
2016-11-17 |
Vertex Pharmaceuticals Incorporated |
Methods of preparing inhibitors of influenza viruses replication
|
MA42422A
(en)
|
2015-05-13 |
2018-05-23 |
Vertex Pharma |
INHIBITORS OF INFLUENZA VIRUS REPLICATION
|
NZ742228A
(en)
*
|
2015-11-12 |
2019-09-27 |
Lg Chemical Ltd |
Pharmaceutical composition containing, as active ingredient, 7-azaindolin-2-one derivative or pharmaceutically acceptable salt thereof
|
SG11201810704WA
(en)
|
2016-05-31 |
2018-12-28 |
Taiho Pharmaceutical Co Ltd |
Sulfonamide compound or salt thereof
|
US10889555B2
(en)
|
2016-05-31 |
2021-01-12 |
Taiho Pharmaceutical Co., Ltd. |
Sulfonamide compound or salt thereof
|
CN106432228A
(en)
*
|
2016-09-06 |
2017-02-22 |
浙江司太立制药股份有限公司 |
4-oximido-1-piperidyl fragment containing 7-azaindolin-2-one compound and preparation method therefor
|
CN106397436A
(en)
*
|
2016-09-06 |
2017-02-15 |
浙江司太立制药股份有限公司 |
5-bromo-7-azaindoline-2-one compounds and preparation method thereof
|
CA3128468A1
(en)
|
2017-10-05 |
2019-04-11 |
Fulcrum Therapeutics, Inc. |
P38 kinase inhibitors reduce dux4 and downstream gene expression for the treatment of fshd
|
US10342786B2
(en)
|
2017-10-05 |
2019-07-09 |
Fulcrum Therapeutics, Inc. |
P38 kinase inhibitors reduce DUX4 and downstream gene expression for the treatment of FSHD
|