ZA987550B - Processes and intermediates useful to make antifolates. - Google Patents
Processes and intermediates useful to make antifolates.Info
- Publication number
- ZA987550B ZA987550B ZA9807550A ZA987550A ZA987550B ZA 987550 B ZA987550 B ZA 987550B ZA 9807550 A ZA9807550 A ZA 9807550A ZA 987550 A ZA987550 A ZA 987550A ZA 987550 B ZA987550 B ZA 987550B
- Authority
- ZA
- South Africa
- Prior art keywords
- processes
- intermediates useful
- antifolates
- make
- make antifolates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
- C07C309/01—Sulfonic acids
- C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
- C07C309/24—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
- C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US93838597A | 1997-09-26 | 1997-09-26 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA987550B true ZA987550B (en) | 2000-02-21 |
Family
ID=25471339
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA9807550A ZA987550B (en) | 1997-09-26 | 1998-08-20 | Processes and intermediates useful to make antifolates. |
Country Status (15)
| Country | Link |
|---|---|
| EP (1) | EP0905128B1 (de) |
| AR (1) | AR017152A1 (de) |
| AT (1) | ATE213494T1 (de) |
| CO (1) | CO4970706A1 (de) |
| CY (1) | CY2005003I2 (de) |
| DE (1) | DE69803909T2 (de) |
| DK (1) | DK0905128T3 (de) |
| ES (1) | ES2169481T3 (de) |
| HK (1) | HK1020437A1 (de) |
| MY (1) | MY116775A (de) |
| PE (1) | PE120699A1 (de) |
| PT (1) | PT905128E (de) |
| SI (1) | SI0905128T1 (de) |
| TW (1) | TW442457B (de) |
| ZA (1) | ZA987550B (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1259513E (pt) * | 2000-02-25 | 2004-02-27 | Lilly Co Eli | Nova forma cristalina de acido n-¬4- ¬2-amino-4,7-dihidro -4-oxo-3h-pirrolo¬2,3-d|pirimidin-5-il)etil| - benzoil|-l-glutamico e processo para a sua obtencao |
| CN100395246C (zh) * | 2005-06-15 | 2008-06-18 | 江苏豪森药业股份有限公司 | 用于制造叶酸拮抗剂及其中间体的方法 |
| CN101591247B (zh) | 2008-05-30 | 2012-09-05 | 上海希迪制药有限公司 | 合成4-(4-甲酯基苯基)丁醛的方法 |
| WO2010028105A2 (en) * | 2008-09-08 | 2010-03-11 | Dr. Reddy's Laboratories Ltd. | Amorphous pemetrexed disodium |
| US9051322B2 (en) | 2011-03-23 | 2015-06-09 | Scinopharm Taiwan, Ltd. | Process for the production of a pemetrexed salt |
| KR101767713B1 (ko) * | 2011-03-25 | 2017-08-11 | 시노팜 타이완 리미티드 | 페메트렉세드 염의 제조 방법 |
| ITRM20120398A1 (it) | 2012-08-08 | 2014-02-09 | Berlin Chemie Ag | Procedimento di sintesi pemetrexed e suo sale di lisina. |
| KR101578093B1 (ko) * | 2013-09-05 | 2015-12-16 | 주식회사 삼양바이오팜 | 고순도 페메트렉세드 제조를 위한 향상된 중간체 제조 방법 및 이를 사용하여 고순도 페메트렉세드를 제조하는 방법 |
| CN107628947B (zh) * | 2017-09-14 | 2020-07-28 | 浙江工业大学 | 一种培美曲塞二钠关键中间体的制备方法 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5416211A (en) * | 1992-09-25 | 1995-05-16 | Eli Lilly And Company | Process for preparing 5-substituted pyrrolo-[2,3-d]pyrimidines |
-
1998
- 1998-08-20 ZA ZA9807550A patent/ZA987550B/xx unknown
- 1998-08-21 TW TW087113828A patent/TW442457B/zh not_active IP Right Cessation
- 1998-09-21 DE DE69803909T patent/DE69803909T2/de not_active Expired - Fee Related
- 1998-09-21 PT PT98307631T patent/PT905128E/pt unknown
- 1998-09-21 DK DK98307631T patent/DK0905128T3/da active
- 1998-09-21 ES ES98307631T patent/ES2169481T3/es not_active Expired - Lifetime
- 1998-09-21 EP EP98307631A patent/EP0905128B1/de not_active Expired - Lifetime
- 1998-09-21 AT AT98307631T patent/ATE213494T1/de not_active IP Right Cessation
- 1998-09-21 SI SI9830173T patent/SI0905128T1/xx unknown
- 1998-09-24 MY MYPI98004383A patent/MY116775A/en unknown
- 1998-09-24 CO CO98055679A patent/CO4970706A1/es unknown
- 1998-09-24 PE PE1998000912A patent/PE120699A1/es not_active Application Discontinuation
- 1998-09-25 AR ARP980104805A patent/AR017152A1/es active IP Right Grant
-
1999
- 1999-09-28 HK HK99104200A patent/HK1020437A1/xx not_active IP Right Cessation
-
2005
- 2005-03-18 CY CY2005003C patent/CY2005003I2/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AR017152A1 (es) | 2001-08-22 |
| DK0905128T3 (da) | 2002-03-25 |
| ES2169481T3 (es) | 2002-07-01 |
| MY116775A (en) | 2004-03-31 |
| CY2005003I1 (el) | 2011-02-02 |
| DE69803909D1 (de) | 2002-03-28 |
| DE69803909T2 (de) | 2002-10-10 |
| HK1020437A1 (en) | 2000-04-20 |
| PT905128E (pt) | 2002-07-31 |
| EP0905128A1 (de) | 1999-03-31 |
| ATE213494T1 (de) | 2002-03-15 |
| TW442457B (en) | 2001-06-23 |
| EP0905128B1 (de) | 2002-02-20 |
| CO4970706A1 (es) | 2000-11-07 |
| CY2005003I2 (el) | 2011-02-02 |
| SI0905128T1 (en) | 2002-08-31 |
| PE120699A1 (es) | 1999-12-01 |
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