ZA983394B - Process for the fermentative production of deacylated cephalosporins - Google Patents

Process for the fermentative production of deacylated cephalosporins

Info

Publication number
ZA983394B
ZA983394B ZA983394A ZA983394A ZA983394B ZA 983394 B ZA983394 B ZA 983394B ZA 983394 A ZA983394 A ZA 983394A ZA 983394 A ZA983394 A ZA 983394A ZA 983394 B ZA983394 B ZA 983394B
Authority
ZA
South Africa
Prior art keywords
fermentative production
deacylated
cephalosporins
deacylated cephalosporins
production
Prior art date
Application number
ZA983394A
Other languages
English (en)
Inventor
Maarten Nieboer
Erik De Vroom
Johannis Lugtenberg
Dirk Schipper
Adrianus Wilhelmus Vollebregt
Roelof Ary Lans Bovenberg
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of ZA983394B publication Critical patent/ZA983394B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
ZA983394A 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins ZA983394B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP97201196 1997-04-22

Publications (1)

Publication Number Publication Date
ZA983394B true ZA983394B (en) 1998-10-30

Family

ID=8228236

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA983394A ZA983394B (en) 1997-04-22 1998-04-22 Process for the fermentative production of deacylated cephalosporins

Country Status (14)

Country Link
US (1) US6518039B2 (fr)
EP (1) EP0912754B1 (fr)
JP (1) JP2000512511A (fr)
KR (1) KR20000022108A (fr)
CN (2) CN1224468A (fr)
AT (1) ATE278032T1 (fr)
AU (1) AU7648898A (fr)
BR (1) BR9804857A (fr)
DE (1) DE69826604D1 (fr)
PL (1) PL330759A1 (fr)
RU (1) RU2208644C2 (fr)
TW (1) TW565613B (fr)
WO (1) WO1998048034A1 (fr)
ZA (1) ZA983394B (fr)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6326204B1 (en) 1997-01-17 2001-12-04 Maxygen, Inc. Evolution of whole cells and organisms by recursive sequence recombination
WO2000009682A1 (fr) 1998-08-12 2000-02-24 Maxygen, Inc. Rearrangement d'adn de genes de monoxygenase en vue de la production de produits chimiques industriels
EP1119616A2 (fr) 1998-10-07 2001-08-01 Maxygen, Inc. Rearrangement d'adn pour produire des acides nucleiques de detoxication contre les mycotoxines
WO2000028018A1 (fr) 1998-11-10 2000-05-18 Maxygen, Inc. Adp-glucose pyrophosphorylase modifiee pour l'amelioration et l'optimisation de phenotypes vegetaux
US6376246B1 (en) 1999-02-05 2002-04-23 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
US6917882B2 (en) 1999-01-19 2005-07-12 Maxygen, Inc. Methods for making character strings, polynucleotides and polypeptides having desired characteristics
US6436675B1 (en) 1999-09-28 2002-08-20 Maxygen, Inc. Use of codon-varied oligonucleotide synthesis for synthetic shuffling
US6961664B2 (en) 1999-01-19 2005-11-01 Maxygen Methods of populating data structures for use in evolutionary simulations
AU3210200A (en) 1999-01-19 2000-08-01 Maxygen, Inc. Oligonucleotide mediated nucleic acid recombination
CA2361384A1 (fr) 1999-02-11 2000-08-17 Sun Ai Raillard Spectrometrie de masse a haut rendement
US6531316B1 (en) 1999-03-05 2003-03-11 Maxyag, Inc. Encryption of traits using split gene sequences and engineered genetic elements
US6686515B1 (en) 1999-11-23 2004-02-03 Maxygen, Inc. Homologous recombination in plants
EP1297146A2 (fr) 2000-06-23 2003-04-02 Maxygen, Inc. Nouveaux promoteurs chimeres
WO2002000717A2 (fr) 2000-06-23 2002-01-03 Maxygen, Inc. Nouvelles molecules costimulatrices
US6858422B2 (en) 2000-07-13 2005-02-22 Codexis, Inc. Lipase genes
CN101555463B (zh) * 2008-04-08 2012-05-30 中国科学院上海生命科学研究院湖州工业生物技术中心 表达头孢菌素脱乙酰酶的重组大肠杆菌菌株及其构建方法
EP2123772A1 (fr) 2008-04-29 2009-11-25 DSM IP Assets B.V. Souches produisant des antibiotiques bêta-lactamines
ES2396043T3 (es) 2008-08-05 2013-02-18 Dsm Sinochem Pharmaceuticals Netherlands B.V. Cepas que producen adipoil-7-ADCA
EP2392649A3 (fr) 2008-08-05 2012-01-11 DSM IP Assets B.V. Adipoyl-7-ADCA produisant des souches
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
HUE035540T2 (en) 2010-06-22 2018-05-02 Dsm Sinochem Pharm Nl Bv Air bubble fermentation process
EP2681224B1 (fr) 2011-03-03 2016-06-22 DSM Sinochem Pharmaceuticals Netherlands B.V. Dégradation de composés de pénicilline
WO2015091455A1 (fr) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioréacteur
US10208755B2 (en) 2014-08-08 2019-02-19 Baker Hughes, A Ge Company, Llc Magnetic coupling for motor drive shaft of electrical submersible pump

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT83746B (pt) 1985-11-15 1988-08-17 Gist Brocades Nv Processo para a preparacao de novos biocatalisadores imobilizados e para a producao de etanol por fermentacao
IE910956A1 (en) 1990-03-23 1991-09-25 Gist Brocades Nv A method of modulating the production of secondary¹metabolites
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
WO1993008287A1 (fr) * 1991-10-15 1993-04-29 Merck & Co., Inc. Nouveaux procedes biologiques de preparation de 7-aca et de 7-adac
JP3574453B2 (ja) 1993-07-30 2004-10-06 ギスト ブロカデス ベスローテン フェンノートシャップ ３‐（カルボキシエチルチオ）プロピオニル‐７‐ａｄｃａを経由した７‐ａｄｃａの効果的な製造法
KR100336174B1 (ko) * 1993-07-30 2002-11-01 디에스엠 기스트 베.파우. 2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법

Also Published As

Publication number Publication date
DE69826604D1 (de) 2004-11-04
TW565613B (en) 2003-12-11
US20020037547A1 (en) 2002-03-28
EP0912754B1 (fr) 2004-09-29
CN1224468A (zh) 1999-07-28
RU2208644C2 (ru) 2003-07-20
ATE278032T1 (de) 2004-10-15
EP0912754A1 (fr) 1999-05-06
BR9804857A (pt) 1999-08-24
PL330759A1 (en) 1999-05-24
WO1998048034A1 (fr) 1998-10-29
AU7648898A (en) 1998-11-13
JP2000512511A (ja) 2000-09-26
US6518039B2 (en) 2003-02-11
CN1706963A (zh) 2005-12-14
KR20000022108A (ko) 2000-04-25

Similar Documents

Publication Publication Date Title
ZA983394B (en) Process for the fermentative production of deacylated cephalosporins
ZA966433B (en) Process for the production of high purity carbon dioxide.
ZA983395B (en) Process for the fermentative production of deacylated cephalosporins
SG65049A1 (en) Process for the production of polyther polyols
IL128057A (en) Process for the production of contrast media
ZA972080B (en) Process for producing cephalosporin antibiotics.
IL123014A0 (en) Process for the production of halogeno-o-hydroxydiphenyl compounds
AU4114697A (en) Improved process for the production of adipoyl cephalosporins
HUP0002140A3 (en) Process for the production of sulphonamides
AU1626197A (en) Process for producing cephalosporin antibiotics
GB2345907B (en) A process for the production of synthetic dolomite
GB2310662B (en) Process for the production of trialkyl phosphites
EP0578016A3 (fr) Procédé enzymatique de résolution d'un mélange racémique de delta-valérolactones.
IL124178A (en) Process for the production of distryryl-biphenyl compounds
ZA961014B (en) Enzymatic process for producing penicillins and cephalosporins
AU9254398A (en) Improved process for the production of beta-lactams
AU3443299A (en) Process for producing cephem compounds
GR1002687B (el) Διαδικασια παραγωγης.
AU4617997A (en) Process for the production of 2h-1-benzopyrans
EP0670311A3 (fr) Procédé pour la préparation de pipérid-2-one.
IL124177A0 (en) A process for the production of distyryl-biphenyl compounds
IL125541A0 (en) Process for the production of 5-hydroxyoxazolidinones
HK1034064A1 (en) Process for the production of formylimidazoles
KR0159833B1 (en) Novel process for preparing cephalosporin derivatives
AU5515796A (en) Novel process for the n2-tritylation of tetrazole ring