ZA982808B - Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia - Google Patents

Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia

Info

Publication number
ZA982808B
ZA982808B ZA982808A ZA982808A ZA982808B ZA 982808 B ZA982808 B ZA 982808B ZA 982808 A ZA982808 A ZA 982808A ZA 982808 A ZA982808 A ZA 982808A ZA 982808 B ZA982808 B ZA 982808B
Authority
ZA
South Africa
Prior art keywords
cyclooxygenase
inhibitors
dementia
prevention
treatment
Prior art date
Application number
ZA982808A
Other languages
English (en)
Inventor
Phillip Needleman
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Searle & Co filed Critical Searle & Co
Publication of ZA982808B publication Critical patent/ZA982808B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/63—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide
    • A61K31/635—Compounds containing para-N-benzenesulfonyl-N-groups, e.g. sulfanilamide, p-nitrobenzenesulfonyl hydrazide having a heterocyclic ring, e.g. sulfadiazine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA982808A 1997-04-03 1998-04-02 Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia ZA982808B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US4391697P 1997-04-03 1997-04-03

Publications (1)

Publication Number Publication Date
ZA982808B true ZA982808B (en) 1999-04-06

Family

ID=21929578

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA982808A ZA982808B (en) 1997-04-03 1998-04-02 Method of using cyclooxygenase-2 inhibitors in the treatment and prevention of dementia

Country Status (13)

Country Link
EP (1) EP0971714B1 (da)
JP (1) JP2002514208A (da)
AT (1) ATE225660T1 (da)
AU (1) AU725697B2 (da)
BR (1) BR9807920A (da)
CA (1) CA2285434A1 (da)
DE (1) DE69808607T2 (da)
DK (1) DK0971714T3 (da)
ES (1) ES2185154T3 (da)
HK (1) HK1024872A1 (da)
PT (1) PT971714E (da)
WO (1) WO1998043648A1 (da)
ZA (1) ZA982808B (da)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6727238B2 (en) 1998-06-11 2004-04-27 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents
US6294558B1 (en) 1999-05-31 2001-09-25 Pfizer Inc. Sulfonylbenzene compounds as anti-inflammatory/analgesic agents

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9420616D0 (en) * 1994-10-12 1994-11-30 Merck Sharp & Dohme Method, compositions and use
DK0923933T3 (da) * 1993-11-30 2002-10-21 Searle & Co Substituerede pyrazolyl-benzensulfonamider til anvendelse ved behandling af inflammation
US5486534A (en) * 1994-07-21 1996-01-23 G. D. Searle & Co. 3,4-substituted pyrazoles for the treatment of inflammation
US5696143A (en) * 1994-09-20 1997-12-09 Talley; John J. Benz G! indazolyl derivatives for the treatment of inflammation
US5547975A (en) * 1994-09-20 1996-08-20 Talley; John J. Benzopyranopyrazolyl derivatives for the treatment of inflammation
US5643933A (en) * 1995-06-02 1997-07-01 G. D. Searle & Co. Substituted sulfonylphenylheterocycles as cyclooxygenase-2 and 5-lipoxygenase inhibitors
EP0828718A1 (en) * 1995-06-02 1998-03-18 G.D. SEARLE & CO. Heterocyclo substituted hydroxamic acid derivatives as cyclooxygenase-2 and 5-lipoxygenase inhibitors
AU6269496A (en) * 1995-06-12 1997-01-09 G.D. Searle & Co. Combination of a cyclooxygenase-2 inhibitor and a leukotrien e b4 receptor antagonist for the treatment of infla mmations
DE69635048T2 (de) * 1995-06-12 2006-02-16 G.D. Searle & Co. Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
US5700816A (en) * 1995-06-12 1997-12-23 Isakson; Peter C. Treatment of inflammation and inflammation-related disorders with a combination of a cyclooxygenase-2 inhibitor and a leukotriene A4 hydrolase inhibitor
CA2249009C (en) * 1996-04-12 2003-09-16 G.D. Searle & Co. Substituted benzenesulfonamide derivatives as prodrugs of cox-2 inhibitors

Also Published As

Publication number Publication date
EP0971714B1 (en) 2002-10-09
BR9807920A (pt) 2000-02-22
EP0971714A1 (en) 2000-01-19
ATE225660T1 (de) 2002-10-15
ES2185154T3 (es) 2003-04-16
PT971714E (pt) 2002-12-31
JP2002514208A (ja) 2002-05-14
DE69808607T2 (de) 2003-06-26
WO1998043648A1 (en) 1998-10-08
DK0971714T3 (da) 2002-11-04
DE69808607D1 (de) 2002-11-14
CA2285434A1 (en) 1998-10-08
AU725697B2 (en) 2000-10-19
HK1024872A1 (en) 2000-10-27
AU6590498A (en) 1998-10-22

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