ZA978960B - Acridone derivatives and method of preparation of 8-hydroxy imidazoacridinone derivatives - Google Patents
Acridone derivatives and method of preparation of 8-hydroxy imidazoacridinone derivativesInfo
- Publication number
- ZA978960B ZA978960B ZA978960A ZA978960A ZA978960B ZA 978960 B ZA978960 B ZA 978960B ZA 978960 A ZA978960 A ZA 978960A ZA 978960 A ZA978960 A ZA 978960A ZA 978960 B ZA978960 B ZA 978960B
- Authority
- ZA
- South Africa
- Prior art keywords
- hydroxy
- derivatives
- dialkylamino
- omega
- formula
- Prior art date
Links
- FZEYVTFCMJSGMP-UHFFFAOYSA-N acridone Chemical class C1=CC=C2C(=O)C3=CC=CC=C3NC2=C1 FZEYVTFCMJSGMP-UHFFFAOYSA-N 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- AGQRWJOCXVXWBB-UHFFFAOYSA-N 8-hydroxyimidazo[4,5-a]acridin-2-one Chemical class C1=CC2=NC(=O)N=C2C2=CC3=CC=C(O)C=C3N=C12 AGQRWJOCXVXWBB-UHFFFAOYSA-N 0.000 title 1
- KDLHZDBZIXYQEI-UHFFFAOYSA-N Palladium Chemical compound [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 abstract 6
- 150000001875 compounds Chemical class 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 229910052763 palladium Inorganic materials 0.000 abstract 3
- -1 1-chloro-7-(protected hydroxy)-4-nitroacridin-9(10H)-one Chemical class 0.000 abstract 2
- 238000010438 heat treatment Methods 0.000 abstract 2
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 2
- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 150000003973 alkyl amines Chemical class 0.000 abstract 1
- 230000000118 anti-neoplastic effect Effects 0.000 abstract 1
- DZBUGLKDJFMEHC-UHFFFAOYSA-N benzoquinolinylidene Natural products C1=CC=CC2=CC3=CC=CC=C3N=C21 DZBUGLKDJFMEHC-UHFFFAOYSA-N 0.000 abstract 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 1
- 239000003054 catalyst Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 235000019253 formic acid Nutrition 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000007363 ring formation reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB9620751A GB2317888A (en) | 1996-10-07 | 1996-10-07 | Acridone derivatives and preparation of 8-hydroxy-imidazoacridinone derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA978960B true ZA978960B (en) | 1999-04-07 |
Family
ID=10800965
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA978960A ZA978960B (en) | 1996-10-07 | 1997-10-07 | Acridone derivatives and method of preparation of 8-hydroxy imidazoacridinone derivatives |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US6229015B1 (de) |
| EP (1) | EP0929552B1 (de) |
| JP (1) | JP4138883B2 (de) |
| AT (1) | ATE215542T1 (de) |
| CA (1) | CA2268157C (de) |
| DE (1) | DE69711654T2 (de) |
| DK (1) | DK0929552T3 (de) |
| ES (1) | ES2171993T3 (de) |
| GB (1) | GB2317888A (de) |
| WO (1) | WO1998015554A1 (de) |
| ZA (1) | ZA978960B (de) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006209225A1 (en) * | 2005-01-28 | 2006-08-03 | Xanthus Pharmaceuticals, Inc. | Compounds for treating inflammatory and demyelinating diseases |
| WO2007092436A2 (en) * | 2006-02-08 | 2007-08-16 | Xanthus Pharmaceuticals, Inc. | Compounds for treating inflammatory disorders, demyelinating disorders and cancers |
| US20080108641A1 (en) * | 2006-02-08 | 2008-05-08 | Ajami Alfred M | Compounds for treating inflammatory disorders, demyelinating disdorders and cancers |
| PL3070078T3 (pl) | 2015-03-20 | 2018-02-28 | Politechnika Gdańska | Niesymetryczne bisakrydyny o działaniu przeciwnowotworowym i ich zastosowania |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9104548D0 (en) * | 1991-03-05 | 1991-04-17 | Cholody Wienlaw M | Antineoplastic modified imidazoacridines |
-
1996
- 1996-10-07 GB GB9620751A patent/GB2317888A/en not_active Withdrawn
-
1997
- 1997-09-10 EP EP97939096A patent/EP0929552B1/de not_active Expired - Lifetime
- 1997-09-10 DK DK97939096T patent/DK0929552T3/da active
- 1997-09-10 ES ES97939096T patent/ES2171993T3/es not_active Expired - Lifetime
- 1997-09-10 AT AT97939096T patent/ATE215542T1/de not_active IP Right Cessation
- 1997-09-10 WO PCT/GB1997/002470 patent/WO1998015554A1/en not_active Ceased
- 1997-09-10 DE DE69711654T patent/DE69711654T2/de not_active Expired - Fee Related
- 1997-09-10 JP JP51727398A patent/JP4138883B2/ja not_active Expired - Fee Related
- 1997-09-10 CA CA002268157A patent/CA2268157C/en not_active Expired - Fee Related
- 1997-10-07 ZA ZA978960A patent/ZA978960B/xx unknown
-
1999
- 1999-04-06 US US09/286,655 patent/US6229015B1/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JP4138883B2 (ja) | 2008-08-27 |
| ES2171993T3 (es) | 2002-09-16 |
| DK0929552T3 (da) | 2002-07-22 |
| EP0929552B1 (de) | 2002-04-03 |
| ATE215542T1 (de) | 2002-04-15 |
| EP0929552A1 (de) | 1999-07-21 |
| GB9620751D0 (en) | 1996-11-20 |
| DE69711654D1 (de) | 2002-05-08 |
| DE69711654T2 (de) | 2002-09-19 |
| CA2268157C (en) | 2006-01-10 |
| GB2317888A (en) | 1998-04-08 |
| WO1998015554A1 (en) | 1998-04-16 |
| CA2268157A1 (en) | 1998-04-16 |
| US6229015B1 (en) | 2001-05-08 |
| JP2001516339A (ja) | 2001-09-25 |
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