ZA978758B - Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents - Google Patents

Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents

Info

Publication number
ZA978758B
ZA978758B ZA978758A ZA978758A ZA978758B ZA 978758 B ZA978758 B ZA 978758B ZA 978758 A ZA978758 A ZA 978758A ZA 978758 A ZA978758 A ZA 978758A ZA 978758 B ZA978758 B ZA 978758B
Authority
ZA
South Africa
Prior art keywords
gpiib
technetium
bind
imaging agents
cyclic peptides
Prior art date
Application number
ZA978758A
Other languages
English (en)
Inventor
Milind Rajopadhye
Prahlad Ramadhar Singh
Original Assignee
Du Pont Merck Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Du Pont Merck Pharma filed Critical Du Pont Merck Pharma
Publication of ZA978758B publication Critical patent/ZA978758B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/082—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins the peptide being a RGD-containing peptide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • C07K14/75—Fibrinogen

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
ZA978758A 1996-10-02 1997-09-30 Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents ZA978758B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US2735996P 1996-10-02 1996-10-02

Publications (1)

Publication Number Publication Date
ZA978758B true ZA978758B (en) 1999-03-30

Family

ID=21837260

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA978758A ZA978758B (en) 1996-10-02 1997-09-30 Technetium-99m-labeled chelator incorporated cyclic peptides that bind to the GPIIb/IIIa receptor as imaging agents

Country Status (7)

Country Link
US (1) US5888970A (xx)
EP (1) EP0993307A2 (xx)
JP (1) JP2001506583A (xx)
AU (1) AU727656B2 (xx)
CA (1) CA2267467A1 (xx)
WO (1) WO1998014220A2 (xx)
ZA (1) ZA978758B (xx)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6083481A (en) * 1992-05-21 2000-07-04 Diatide, Inc. Thrombus imaging agents
DE19728524A1 (de) * 1997-07-04 1999-01-07 Merck Patent Gmbh Cyclische Azapeptide
US6524553B2 (en) 1998-03-31 2003-02-25 Bristol-Myers Squibb Pharma Company Quinolone vitronectin receptor antagonist pharmaceuticals
US6537520B1 (en) 1998-03-31 2003-03-25 Bristol-Myers Squibb Pharma Company Pharmaceuticals for the imaging of angiogenic disorders
BR9909420A (pt) 1998-03-31 2001-09-25 Du Pont Pharm Co Composto, kit, composição metalofarmacêutica de diagnóstico ou terapêutica, composição de agente de contraste de ultrassom, composição radiofarmacêutica terapêutica e composição radiofarmacêutica de diagnóstico
US6548663B1 (en) 1998-03-31 2003-04-15 Bristol-Myers Squibb Pharma Company Benzodiazepine vitronectin receptor antagonist pharmaceuticals
US6522930B1 (en) 1998-05-06 2003-02-18 Atrionix, Inc. Irrigated ablation device assembly
CA2341672A1 (en) * 1998-10-13 2000-04-20 Milind Rajopadhye Chelator incorporated arg-gly-asp (rgd) mimetic synthetic disintegrins as imaging agents
US6511649B1 (en) 1998-12-18 2003-01-28 Thomas D. Harris Vitronectin receptor antagonist pharmaceuticals
EP1140203B1 (en) * 1998-12-18 2007-05-23 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
CN1356913A (zh) 1998-12-18 2002-07-03 杜邦药品公司 玻连蛋白受体拮抗剂药物
US6569402B1 (en) 1998-12-18 2003-05-27 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
EP1140864A2 (en) 1998-12-18 2001-10-10 Du Pont Pharmaceuticals Company Vitronectin receptor antagonist pharmaceuticals
US6794518B1 (en) 1998-12-18 2004-09-21 Bristol-Myers Squibb Pharma Company Vitronectin receptor antagonist pharmaceuticals
DK2658831T3 (en) * 2010-12-29 2017-04-24 Ge Healthcare Ltd elution

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443816A (en) * 1990-08-08 1995-08-22 Rhomed Incorporated Peptide-metal ion pharmaceutical preparation and method
US5229363A (en) * 1991-02-19 1993-07-20 Merck & Co., Inc. Cyclic hexapeptide compounds
US5635477A (en) * 1991-09-30 1997-06-03 The Dupont Merck Pharmaceutical Company Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA
AU682857B2 (en) * 1993-03-29 1997-10-23 Du Pont Pharmaceuticals Company Novel processes and intermediate compounds for the preparation of platelet clycoprotein IIb/IIIa inhibitors
JPH08509709A (ja) * 1993-03-29 1996-10-15 ザ・デュポン・メルク・ファーマシュウティカル・カンパニー Ｎ▲上α▼−メチルアルギニンを含有する血小板糖たんぱく▲ＩＩ▼ｂ／▲ＩＩＩ▼ａ抑制剤の製造方法およびそれに用いる中間体化合物
US5879657A (en) * 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
WO1995023811A1 (en) * 1994-03-04 1995-09-08 The Du Pont Merck Pharmaceutical Company Novel carbocyclic compounds which inhibit platelet aggregation by interaction with the gpiib/iiia receptor complex

Also Published As

Publication number Publication date
WO1998014220A2 (en) 1998-04-09
CA2267467A1 (en) 1998-04-09
AU4892597A (en) 1998-04-24
WO1998014220A3 (en) 1998-07-02
AU727656B2 (en) 2000-12-21
JP2001506583A (ja) 2001-05-22
US5888970A (en) 1999-03-30
EP0993307A2 (en) 2000-04-19

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