ZA971849B - Oligonucleotide analogues. - Google Patents

Oligonucleotide analogues.

Info

Publication number
ZA971849B
ZA971849B ZA9701849A ZA971849A ZA971849B ZA 971849 B ZA971849 B ZA 971849B ZA 9701849 A ZA9701849 A ZA 9701849A ZA 971849 A ZA971849 A ZA 971849A ZA 971849 B ZA971849 B ZA 971849B
Authority
ZA
South Africa
Prior art keywords
attached
group
unsubstituted
cycloalkyl
alkenyl
Prior art date
Application number
ZA9701849A
Other languages
English (en)
Inventor
Anthony David Baxter
Stephen Paul Collingwood
Mark Edward Douglas
Roger John Taylor
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ZA971849B publication Critical patent/ZA971849B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
ZA9701849A 1996-03-05 1997-03-04 Oligonucleotide analogues. ZA971849B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9604669.3A GB9604669D0 (en) 1996-03-05 1996-03-05 Chemical compounds

Publications (1)

Publication Number Publication Date
ZA971849B true ZA971849B (en) 1997-09-05

Family

ID=10789879

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9701849A ZA971849B (en) 1996-03-05 1997-03-04 Oligonucleotide analogues.

Country Status (12)

Country Link
US (1) US6562960B1 (ja)
EP (1) EP0885237B1 (ja)
JP (1) JP2000506849A (ja)
CN (1) CN1212701A (ja)
AT (1) ATE249475T1 (ja)
AU (1) AU1886797A (ja)
BR (1) BR9707918A (ja)
CA (1) CA2247480A1 (ja)
DE (1) DE69724768T2 (ja)
GB (1) GB9604669D0 (ja)
WO (1) WO1997032887A1 (ja)
ZA (1) ZA971849B (ja)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6639061B1 (en) 1999-07-07 2003-10-28 Isis Pharmaceuticals, Inc. C3′-methylene hydrogen phosphonate oligomers and related compounds
US6414135B1 (en) 1999-07-07 2002-07-02 Isis Pharmaceuticals, Inc. C3′-methylene hydrogen phosphonate monomers and related compounds
AU2002358463A1 (en) * 2001-12-18 2003-06-30 Human Genetic Signatures Pty Ltd Oligonucleotide analogues comprising intercalator pseudonucleotides
FR2858976B1 (fr) * 2003-08-22 2006-02-10 Isochem Sa Procede d'obtention de n-carboxyanhydrides d'alpha-aminoacides a protection urethane
ES2439591T3 (es) * 2007-08-15 2014-01-23 Isis Pharmaceuticals, Inc. Análogos de ácido nucleico de tetrahidropirano
CA2744987C (en) 2008-12-02 2018-01-16 Chiralgen, Ltd. Method for the synthesis of phosphorus atom modified nucleic acids
BR112012000828A8 (pt) 2009-07-06 2017-10-10 Ontorii Inc Novas pró-drogas de ácido nucleico e métodos de uso das mesmas
US10428019B2 (en) 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
RU2014105311A (ru) 2011-07-19 2015-08-27 Уэйв Лайф Сайенсес Пте. Лтд. Способы синтеза функционализованных нуклеиновых кислот
MX356830B (es) 2012-07-13 2018-06-15 Shin Nippon Biomedical Laboratories Ltd Adyuvante de acido nucleico quiral.
SG10201912895PA (en) 2012-07-13 2020-02-27 Wave Life Sciences Ltd Chiral control
JP6268157B2 (ja) 2012-07-13 2018-01-24 株式会社Ｗａｖｅ Ｌｉｆｅ Ｓｃｉｅｎｃｅｓ Ｊａｐａｎ 不斉補助基
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
WO2015108048A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
JPWO2015108047A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
KR102423317B1 (ko) 2014-01-16 2022-07-22 웨이브 라이프 사이언시스 리미티드 키랄 디자인

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4469863A (en) * 1980-11-12 1984-09-04 Ts O Paul O P Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
US4507433A (en) * 1983-10-07 1985-03-26 The Johns Hopkins University Preparation of oligodeoxyribonucleoside alkyl or arylphosphonates
US4806463A (en) 1986-05-23 1989-02-21 Worcester Foundation For Experimental Biology Inhibition of HTLV-III by exogenous oligonucleotides
EP0266099A3 (en) 1986-10-28 1990-09-19 The Johns Hopkins University Oligonucleoside alkyl or arylphosphonate derivatives capable of crosslinking with or cleaving nucleic acids
GB8721442D0 (en) 1987-09-11 1987-10-21 Ciba Geigy Ag Process
EP0402402B1 (en) 1988-02-26 1995-12-27 Worcester Foundation For Biomedical Research, Inc. Inhibition of htlv-iii by exogenous oligonucleotides
EP0942000B1 (en) 1989-10-24 2004-06-23 Isis Pharmaceuticals, Inc. 2'-Modified oligonucleotides
US5378825A (en) 1990-07-27 1995-01-03 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogs
US5610289A (en) * 1990-07-27 1997-03-11 Isis Pharmaceuticals, Inc. Backbone modified oligonucleotide analogues
US6033909A (en) * 1992-01-22 2000-03-07 Hoechst Aktiengesellschaft Oligonucleotide analogs, their preparation and use
US5681747A (en) 1992-03-16 1997-10-28 Isis Pharmaceuticals, Inc. Nucleic acid sequences encoding protein kinase C and antisense inhibition of expression thereof
US5625050A (en) * 1994-03-31 1997-04-29 Amgen Inc. Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
US5563255A (en) * 1994-05-31 1996-10-08 Isis Pharmaceuticals, Inc. Antisense oligonucleotide modulation of raf gene expression
GB9417746D0 (en) 1994-09-03 1994-10-19 Ciba Geigy Ag Chemical compounds

Also Published As

Publication number Publication date
EP0885237B1 (en) 2003-09-10
EP0885237A1 (en) 1998-12-23
GB9604669D0 (en) 1996-05-01
JP2000506849A (ja) 2000-06-06
DE69724768D1 (de) 2003-10-16
ATE249475T1 (de) 2003-09-15
AU1886797A (en) 1997-09-22
DE69724768T2 (de) 2004-08-05
CN1212701A (zh) 1999-03-31
US6562960B1 (en) 2003-05-13
WO1997032887A1 (en) 1997-09-12
CA2247480A1 (en) 1997-09-12
BR9707918A (pt) 1999-07-27

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