ZA9710419B - Compositions and methods for regulating apoptosis - Google Patents

Compositions and methods for regulating apoptosis

Info

Publication number
ZA9710419B
ZA9710419B ZA9710419A ZA9710419A ZA9710419B ZA 9710419 B ZA9710419 B ZA 9710419B ZA 9710419 A ZA9710419 A ZA 9710419A ZA 9710419 A ZA9710419 A ZA 9710419A ZA 9710419 B ZA9710419 B ZA 9710419B
Authority
ZA
South Africa
Prior art keywords
compositions
methods
regulating apoptosis
apoptosis
regulating
Prior art date
Application number
ZA9710419A
Other languages
English (en)
Inventor
David J Granville
Julia G Levy
David W C Hunt
Original Assignee
Qlt Phototherapeutics Inc
Univ British Columbia
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Qlt Phototherapeutics Inc, Univ British Columbia filed Critical Qlt Phototherapeutics Inc
Publication of ZA9710419B publication Critical patent/ZA9710419B/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A61K31/37—Coumarins, e.g. psoralen

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA9710419A 1996-11-20 1997-11-19 Compositions and methods for regulating apoptosis ZA9710419B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/754,491 US6180402B1 (en) 1996-11-20 1996-11-20 Method for inhibiting apoptosis induced by photodynamic therapy using a cysteine or serine protease inhibitor

Publications (1)

Publication Number Publication Date
ZA9710419B true ZA9710419B (en) 1998-07-17

Family

ID=25035041

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9710419A ZA9710419B (en) 1996-11-20 1997-11-19 Compositions and methods for regulating apoptosis

Country Status (4)

Country Link
US (1) US6180402B1 (xx)
AU (1) AU4939497A (xx)
WO (1) WO1998022098A2 (xx)
ZA (1) ZA9710419B (xx)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2336108A1 (en) * 1998-06-29 2000-01-06 Parker Hughes Institute Alkyl ketones as potent anti-cancer agents
US6251882B1 (en) 1998-06-29 2001-06-26 Parker Hughes Institute Alkyl ketones as potent anti-cancer agents
AU3731400A (en) 1999-03-05 2000-09-21 Trustees Of University Technology Corporation, The Methods and compositions useful in inhibiting apoptosis
US6303374B1 (en) 2000-01-18 2001-10-16 Isis Pharmaceuticals Inc. Antisense modulation of caspase 3 expression
CA2714081C (en) * 2000-02-10 2013-08-06 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
US20040146918A1 (en) * 2000-02-18 2004-07-29 Weiner Michael L. Hybrid nucleic acid assembly
JP2004521080A (ja) 2000-09-08 2004-07-15 メルク フロスト カナダ アンド カンパニー カスパーゼ−３阻害薬としてのγ−ケト酸ジペプチド類
US20030082183A1 (en) * 2000-11-01 2003-05-01 Wheeler Larry A. Methods and compositions for treatment of ocular neovascularization and neural injury
JP2005502618A (ja) * 2001-06-04 2005-01-27 ザ・ジェネラル・ホスピタル・コーポレイション 光力学的化合物を用いて脆弱なプラークを検出および治療する方法
AU2003209297A1 (en) * 2002-01-18 2003-09-02 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
CA2484551A1 (en) * 2002-04-30 2003-11-13 Trustees Of Tufts College Smart pro-drugs of serine protease inhibitors
US7220778B2 (en) * 2003-04-15 2007-05-22 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
US7659301B2 (en) * 2003-04-15 2010-02-09 The General Hospital Corporation Methods and devices for epithelial protection during photodynamic therapy
CA2527522A1 (en) * 2003-05-29 2004-12-09 Kenneth Chang Methods of using nitroxides in conjunction with photosensitizers and sonosensitizers
CA2536918A1 (en) 2003-08-26 2005-03-03 Leland Shapiro Compositions of, and methods for, alpha-1 antitrypsin fc fusion molecules
US7803375B2 (en) * 2005-02-23 2010-09-28 Massachusetts Eye And Ear Infirmary Methods and compositions for treating conditions of the eye
US7592330B2 (en) * 2005-08-08 2009-09-22 Massachusetts Eye And Ear Infirmary Methods and compositions for preserving the viability of photoreceptor cells
ES2454974T3 (es) * 2007-06-27 2014-04-14 The General Hospital Corporation Aparato para la inhibición óptica de la terapia fotodinámica
US20130230458A1 (en) * 2010-09-01 2013-09-05 President And Fellows Of Harvard College Cell Permeable Inhibitors of Anaphase Promoting Complex
CN102218057B (zh) * 2011-04-24 2012-08-08 吉林大学 3,4-二氯异香豆素在制备抗球虫病药物中的用途
CN103945856A (zh) 2011-08-30 2014-07-23 塔夫茨大学信托人 用于治疗实体瘤的fap-活化的蛋白酶体抑制剂
IL264283B2 (en) * 2016-07-19 2023-12-01 Accellta Ltd A medium for growing pluripotent stem cells in suspension

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5281721A (en) 1984-08-20 1994-01-25 Georgia Tech Research Corporation Heterocyclic inhibitors of serine proteases
ES2097766T3 (es) 1989-08-16 1997-04-16 Chiron Corp Composiciones para la inhibicion de la formacion de hormonas proteicas y sus usos.
US5500432A (en) 1990-08-01 1996-03-19 The Scripps Research Institute Induction and inhibition of apoptosis
AU4634993A (en) * 1992-06-24 1994-01-24 Merck & Co., Inc. Dna encoding precursor interleukin 1beta converting enzyme
CA2121148A1 (en) 1992-08-19 1994-03-03 Satoru Nakai Apoptosis regulator
TW494094B (en) * 1993-04-29 2002-07-11 Vertex Pharma Peptide analogs as irreversible interleukin-1β protease inhibitors and pharmaceutical compositions comprising the same
US5550019A (en) 1993-05-26 1996-08-27 La Jolla Cancer Research Foundation Methods of identifying compounds which alter apoptosis
US5759548A (en) 1993-11-30 1998-06-02 Lxr Biotechnology Inc. Compositions which inhibit apoptosis, methods of purifying the compositions and uses thereof
WO1996026280A1 (en) 1995-02-21 1996-08-29 Basf Aktiengesellschaft NOVEL CYSTEINE PROTEASE RELATED TO INTERLEUKIN-1β CONVERTING ENZYME
CA2218679A1 (en) * 1995-04-21 1996-10-24 Merck & Co., Inc. Apopain
US5798442A (en) * 1995-04-21 1998-08-25 Merck Frosst Canada, Inc. Peptidyl derivatives as inhibitors of pro-apoptotic cysteine proteinases

Also Published As

Publication number Publication date
WO1998022098A2 (en) 1998-05-28
WO1998022098A3 (en) 1998-07-09
AU4939497A (en) 1998-06-10
US6180402B1 (en) 2001-01-30

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