ZA9710182B - Use of GLP-1 peptides. - Google Patents

Use of GLP-1 peptides.

Info

Publication number
ZA9710182B
ZA9710182B ZA9710182A ZA9710182A ZA9710182B ZA 9710182 B ZA9710182 B ZA 9710182B ZA 9710182 A ZA9710182 A ZA 9710182A ZA 9710182 A ZA9710182 A ZA 9710182A ZA 9710182 B ZA9710182 B ZA 9710182B
Authority
ZA
South Africa
Prior art keywords
glp
peptides
satiety
appetite
analogue
Prior art date
Application number
ZA9710182A
Other languages
English (en)
Inventor
Liselotte Bjerre Knudsen
Lars Thim
Martin Edward Judge
Jens Juul Holst
Arne Vernon Astrup
Birgitte Schjellerup Wulff
Original Assignee
Novo Nordisk As
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8102971&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA9710182(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novo Nordisk As filed Critical Novo Nordisk As
Publication of ZA9710182B publication Critical patent/ZA9710182B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/26Glucagons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00Drugs for disorders of the metabolism
    • A61P3/04Anorexiants; Antiobesity agents

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Obesity (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Child & Adolescent Psychology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
ZA9710182A 1996-11-12 1997-11-12 Use of GLP-1 peptides. ZA9710182B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DK127096 1996-11-12

Publications (1)

Publication Number Publication Date
ZA9710182B true ZA9710182B (en) 1998-05-12

Family

ID=8102971

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA9710182A ZA9710182B (en) 1996-11-12 1997-11-12 Use of GLP-1 peptides.

Country Status (9)

Country Link
US (5) US20030232754A1 (fr)
EP (2) EP1529534B1 (fr)
JP (1) JP2001504105A (fr)
AT (2) ATE366584T1 (fr)
AU (1) AU4863797A (fr)
DE (2) DE69732572T2 (fr)
ES (2) ES2290799T3 (fr)
WO (1) WO1998020895A1 (fr)
ZA (1) ZA9710182B (fr)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6852690B1 (en) 1995-08-22 2005-02-08 Amylin Pharmaceuticals, Inc. Method and composition for enhanced parenteral nutrition
UA65549C2 (uk) 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
US6380357B2 (en) 1997-12-16 2002-04-30 Eli Lilly And Company Glucagon-like peptide-1 crystals
US6998387B1 (en) 1998-03-19 2006-02-14 Amylin Pharmaceuticals, Inc. Human appetite control by glucagon-like peptide receptor binding compounds
US7223727B2 (en) 1998-04-09 2007-05-29 Serono Genetics Institute S.A. GSSP4 polynucleotides and polypeptides and uses thereof
US6720407B1 (en) * 1998-08-28 2004-04-13 Eli Lilly And Company Method for administering insulinotropic peptides
US6927214B1 (en) 1999-01-15 2005-08-09 Novo Nordisk A/S Non-peptide GLP-1 agonists
US6514500B1 (en) * 1999-10-15 2003-02-04 Conjuchem, Inc. Long lasting synthetic glucagon like peptide {GLP-!}
WO2001000654A2 (fr) 1999-06-29 2001-01-04 Pharmaceutical Discovery Corporation Purification et stabilisation de produits pharmaceutiques a base de peptides et de proteines
US9006175B2 (en) 1999-06-29 2015-04-14 Mannkind Corporation Potentiation of glucose elimination
AU1130501A (en) * 1999-11-03 2001-05-14 Novo Nordisk A/S Use of a growth hormone or a growth hormone secretagogue for appetite-suppression or induction of satiety
AU5675701A (en) * 2000-05-16 2001-11-26 Sanwa Kagaku Kenkyusho Co Agents for preventing or ameliorating insulin resistance and/or obesity
EP1357973B1 (fr) * 2001-02-09 2008-08-20 Serono Genetics Institute S.A. Polynucleotides et polypeptides gssp4 et utilisations de ces derniers
NZ532427A (en) 2001-09-24 2008-07-31 Imp Innovations Ltd Modification of feeding behavior using PYY (peptide YY) and its agonists such as NPY (neuropeptide Y)
EP1463751B1 (fr) 2001-12-21 2013-05-22 Human Genome Sciences, Inc. Proteines hybrides d'albumine
WO2003059934A2 (fr) 2001-12-21 2003-07-24 Human Genome Sciences, Inc. Proteines de fusion d'albumine
EP2409569B1 (fr) 2002-02-20 2017-08-16 Emisphere Technologies, Inc. Méthode d'adminstration de molécules peptidiques du type glucagon (GLP-1)
DE60318938T2 (de) 2002-03-20 2009-01-22 Mannkind Corp., Valencia Inhalationsgerät
US7407955B2 (en) 2002-08-21 2008-08-05 Boehringer Ingelheim Pharma Gmbh & Co., Kg 8-[3-amino-piperidin-1-yl]-xanthines, the preparation thereof and their use as pharmaceutical compositions
EP1694356B1 (fr) 2003-12-09 2011-02-16 Novo Nordisk A/S Regulation d'une preference alimentaire au moyen d'agonistes de glp-1
US20060286129A1 (en) 2003-12-19 2006-12-21 Emisphere Technologies, Inc. Oral GLP-1 formulations
EP1729795B1 (fr) 2004-02-09 2016-02-03 Human Genome Sciences, Inc. Proteines hybrides d'albumine
DE602005022239D1 (de) 2004-04-23 2010-08-19 Conjuchem Biotechnologies Inc Festphase zur Verwendung in einem Verfahren zur Reinigung von Albuminkonjugaten
WO2005120492A1 (fr) * 2004-06-11 2005-12-22 Novo Nordisk A/S Remede contre l'obesite induite par les medicaments au moyen d'agonistes glp-1
EP1786784B1 (fr) 2004-08-20 2010-10-27 MannKind Corporation Catalyse de la synthese de dicetopiperazine
CA2578175C (fr) 2004-08-23 2014-10-14 Mannkind Corporation Sels de dicetopiperazine, sels de dicetomorpholine ou sels de dicetodioxane permettant l'administration de medicaments
DE102004054054A1 (de) 2004-11-05 2006-05-11 Boehringer Ingelheim Pharma Gmbh & Co. Kg Verfahren zur Herstellung chiraler 8-(3-Amino-piperidin-1-yl)-xanthine
CA2617859A1 (fr) 2005-06-30 2007-01-11 Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R Compositions pharmaceutiques de glp-1
US7803404B2 (en) 2005-09-14 2010-09-28 Mannkind Corporation Method of drug formulation based on increasing the affinity of active agents for crystalline microparticle surfaces
PL1767545T3 (pl) 2005-09-22 2010-04-30 Biocompatibles Uk Ltd Polipeptydy fuzyjne GLP-1 (glukagonopodobny peptyd-1) o zwiększonej odporności na peptydazy
US8039432B2 (en) 2005-11-09 2011-10-18 Conjuchem, Llc Method of treatment of diabetes and/or obesity with reduced nausea side effect
EP2364735A3 (fr) 2005-12-16 2012-04-11 Nektar Therapeutics Conjugé de GLP-1 et de PEG ramafié
BRPI0707991B8 (pt) 2006-02-22 2021-05-25 Mannkind Corp métodos de preparação de um medicamento em pó seco com uma propriedade farmacêutica melhorada, dito pó seco e uso de uma quantidade efetiva do pó seco
PE20110235A1 (es) 2006-05-04 2011-04-14 Boehringer Ingelheim Int Combinaciones farmaceuticas que comprenden linagliptina y metmorfina
NZ619413A (en) 2006-05-04 2015-08-28 Boehringer Ingelheim Int Polymorphs of a dpp-iv enzyme inhibitor
EP1852108A1 (fr) 2006-05-04 2007-11-07 Boehringer Ingelheim Pharma GmbH & Co.KG Compositions d'inhibiteurs de la DPP IV
EP1854455B1 (fr) 2006-05-10 2009-10-07 Biocompatibles UK Limited Microcapsules sphériques contenant des peptides du type GLP-1, leur production et leur utilisation
JP5102833B2 (ja) * 2006-07-24 2012-12-19 バイオレクシス ファーマシューティカル コーポレーション エキセンディン融合タンパク質
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
WO2009030738A1 (fr) 2007-09-05 2009-03-12 Novo Nordisk A/S Dérivés de glucagon-like peptide-1 et leur utilisation pharmaceutique
JP2010538049A (ja) 2007-09-05 2010-12-09 ノボ・ノルデイスク・エー/エス 切断型glp−1誘導体及びその治療的使用
CN101969927A (zh) * 2007-10-24 2011-02-09 曼金德公司 预防glp-1不良影响的方法
US8785396B2 (en) 2007-10-24 2014-07-22 Mannkind Corporation Method and composition for treating migraines
JP5813323B2 (ja) * 2007-10-24 2015-11-17 マンカインド コーポレイション 活性薬剤の送達方法
AR071175A1 (es) 2008-04-03 2010-06-02 Boehringer Ingelheim Int Composicion farmaceutica que comprende un inhibidor de la dipeptidil-peptidasa-4 (dpp4) y un farmaco acompanante
EP2570147B1 (fr) 2008-06-13 2017-10-18 MannKind Corporation Inhalateur de poudre sèche et système d'administration de médicament
US8485180B2 (en) 2008-06-13 2013-07-16 Mannkind Corporation Dry powder drug delivery system
US9364619B2 (en) 2008-06-20 2016-06-14 Mannkind Corporation Interactive apparatus and method for real-time profiling of inhalation efforts
KR20190016601A (ko) 2008-08-06 2019-02-18 베링거 인겔하임 인터내셔날 게엠베하 메트포르민 요법이 부적합한 환자에서의 당뇨병 치료
TWI614024B (zh) 2008-08-11 2018-02-11 曼凱公司 超快起作用胰島素之用途
US20200155558A1 (en) 2018-11-20 2020-05-21 Boehringer Ingelheim International Gmbh Treatment for diabetes in patients with insufficient glycemic control despite therapy with an oral antidiabetic drug
US8314106B2 (en) 2008-12-29 2012-11-20 Mannkind Corporation Substituted diketopiperazine analogs for use as drug delivery agents
EP2216042A1 (fr) 2009-02-09 2010-08-11 Ipsen Pharma S.A.S. Compositions pharmaceutiques analogues au GLP-1
PL2405963T3 (pl) 2009-03-11 2014-04-30 Mannkind Corp Urządzenie, układ i sposób pomiaru oporu inhalatora
KR20180079458A (ko) 2009-06-12 2018-07-10 맨카인드 코포레이션 한정된 비표면적을 갖는 디케토피페라진 마이크로입자
US20120148586A1 (en) 2009-08-27 2012-06-14 Joyce Ching Tsu Chou Glucagon-like protein-1 receptor (glp-1r) agonists for treating autoimmune disorders
EP2496295A1 (fr) 2009-11-03 2012-09-12 MannKind Corporation Appareil et méthode de simulation d'efforts d'inhalation
JP2013512229A (ja) 2009-11-27 2013-04-11 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 遺伝子型が同定された糖尿病患者のリナグリプチン等のddp−iv阻害薬による治療
BR112012028136A2 (pt) 2010-05-05 2016-08-09 Boehringer Ingelheim Int terapia de combinaçao
RU2531455C2 (ru) 2010-06-21 2014-10-20 Маннкайнд Корпорейшн Системы и способы доставки сухих порошковых лекарств
EP2588490B1 (fr) 2010-07-02 2017-02-22 Angiochem Inc. Polypeptides courts contenant des acides aminés d pour conjugués thérapeutiques et leurs utilisations
US9034883B2 (en) 2010-11-15 2015-05-19 Boehringer Ingelheim International Gmbh Vasoprotective and cardioprotective antidiabetic therapy
EP3326620B1 (fr) 2010-12-16 2020-03-04 Novo Nordisk A/S Compositions solides comportant un agoniste glp-1 et du sel de n-(8-(2-hydroxybenzoyl)amino)caprylate
CN105667994B (zh) 2011-04-01 2018-04-06 曼金德公司 用于药物药盒的泡罩包装
HUE031405T2 (en) 2011-04-12 2017-07-28 Novo Nordisk As Double-acylated GLP-1 derivatives
WO2012174472A1 (fr) 2011-06-17 2012-12-20 Mannkind Corporation Microparticules de dicétopipérazine de capacité élevée
AU2012328885B2 (en) 2011-10-24 2017-08-31 Mannkind Corporation Methods and compositions for treating pain
US20130172244A1 (en) * 2011-12-29 2013-07-04 Thomas Klein Subcutaneous therapeutic use of dpp-4 inhibitor
US9555001B2 (en) 2012-03-07 2017-01-31 Boehringer Ingelheim International Gmbh Pharmaceutical composition and uses thereof
MY171146A (en) 2012-03-22 2019-09-27 Novo Nordisk As Compositions of glp-1 peptides and preparation thereof
PT2827845T (pt) 2012-03-22 2019-03-29 Novo Nordisk As Composições compreendendo um agente de entrega e sua preparação
EP3685839A1 (fr) 2012-05-14 2020-07-29 Boehringer Ingelheim International GmbH Linagliptin pour son utilisation dans le traitement de l'albuminurie et des maladies liees au rein
WO2013174767A1 (fr) 2012-05-24 2013-11-28 Boehringer Ingelheim International Gmbh Dérivé de xanthine en tant qu'inhibiteur de la dpp-4 à utiliser dans la modification de l'apport alimentaire et dans la régulation des préférences alimentaires
EP2863895B1 (fr) 2012-06-20 2021-04-14 Novo Nordisk A/S Composition de comprimé comprenant un peptide et un agent délivrant
CN108057154B (zh) 2012-07-12 2021-04-16 曼金德公司 干粉药物输送系统和方法
US10159644B2 (en) 2012-10-26 2018-12-25 Mannkind Corporation Inhalable vaccine compositions and methods
CA2906817C (fr) 2013-03-15 2022-01-18 Mannkind Corporation Compositions de dicetopiperazine microcristallines et procedes
ES2900744T3 (es) 2013-05-28 2022-03-18 Takeda Pharmaceuticals Co Compuesto de péptidos
US9925144B2 (en) 2013-07-18 2018-03-27 Mannkind Corporation Heat-stable dry powder pharmaceutical compositions and methods
JP2016530930A (ja) 2013-08-05 2016-10-06 マンカインド コーポレイション 通気装置及び方法
EP3110449B1 (fr) 2014-02-28 2023-06-28 Boehringer Ingelheim International GmbH Utilisation médicale d'un inhibiteur de dpp-4
US10307464B2 (en) 2014-03-28 2019-06-04 Mannkind Corporation Use of ultrarapid acting insulin
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
JP6995042B2 (ja) 2016-05-24 2022-02-04 武田薬品工業株式会社 ペプチド化合物
MX2018015089A (es) 2016-06-10 2019-05-13 Boehringer Ingelheim Int Combinacion de linagliptina y metformina.
KR102647171B1 (ko) 2018-02-02 2024-03-15 노보 노르디스크 에이/에스 Glp-1 작용제 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형 조성물
CN110237239A (zh) 2018-03-09 2019-09-17 上海仁会生物制药股份有限公司 用于治疗肥胖和体重管理的glp-1组合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5118666A (en) * 1986-05-05 1992-06-02 The General Hospital Corporation Insulinotropic hormone
US5120712A (en) * 1986-05-05 1992-06-09 The General Hospital Corporation Insulinotropic hormone
US5418218A (en) * 1992-07-10 1995-05-23 The University Of Maryland At Baltimore Histidyl-proline diketopiperazine (cyclo his-pro) a cns-active pharmacologic agent
US5380872A (en) * 1992-07-14 1995-01-10 Glaxo Inc. Modulators of cholecystokinin
EP1231218B1 (fr) * 1996-03-01 2008-05-14 Novo Nordisk A/S Peptide coupe-faim, ses compositions et son utilisation
US5912229A (en) * 1996-03-01 1999-06-15 Novo Nordisk Als Use of a pharmaceutical composition comprising an appetite-suppressing peptide
US6268343B1 (en) * 1996-08-30 2001-07-31 Novo Nordisk A/S Derivatives of GLP-1 analogs
US7235627B2 (en) * 1996-08-30 2007-06-26 Novo Nordisk A/S Derivatives of GLP-1 analogs
US6458924B2 (en) * 1996-08-30 2002-10-01 Novo Nordisk A/S Derivatives of GLP-1 analogs
UA65549C2 (uk) * 1996-11-05 2004-04-15 Елі Ліллі Енд Компані Спосіб регулювання ожиріння шляхом периферійного введення аналогів та похідних glp-1 (варіанти) та фармацевтична композиція
WO1998030231A1 (fr) * 1997-01-07 1998-07-16 Amylin Pharmaceuticals, Inc. Utilisation d'exendines et de leurs agonistes pour reduire la consommation alimentaire
DE69900026T2 (de) * 1998-01-30 2001-05-10 Novo Nordisk As Eine injektionsspritze
US6420137B1 (en) * 1998-11-25 2002-07-16 American Home Products Corporation Nucleic acid encoding human neurotensin subtype 2 receptor
US6528486B1 (en) * 1999-07-12 2003-03-04 Zealand Pharma A/S Peptide agonists of GLP-1 activity
US6399089B1 (en) * 2000-05-15 2002-06-04 A. Glenn Braswell Compositions and methods for regulating metabolism and balancing body weight
US20020187926A1 (en) * 2001-03-07 2002-12-12 Knudsen Liselotte Bjerre Combined use of derivatives of GLP-1 analogs and PPAR ligands
US7041646B2 (en) * 2001-10-05 2006-05-09 Bayer Pharmaceuticals Corporation Methods of treating type 2 diabetes with peptides acting as both GLP-1 receptor agonists and glucagon receptor antagonists

Also Published As

Publication number Publication date
ATE366584T1 (de) 2007-08-15
DE69737916D1 (de) 2007-08-23
US20110028391A1 (en) 2011-02-03
US20100113363A1 (en) 2010-05-06
EP0941114B1 (fr) 2005-02-23
EP1529534A2 (fr) 2005-05-11
EP1529534A3 (fr) 2005-06-08
US20070161568A1 (en) 2007-07-12
DE69737916T2 (de) 2008-04-03
EP0941114A1 (fr) 1999-09-15
ES2290799T3 (es) 2008-02-16
DE69732572D1 (de) 2005-03-31
ATE289517T1 (de) 2005-03-15
AU4863797A (en) 1998-06-03
JP2001504105A (ja) 2001-03-27
EP1529534B1 (fr) 2007-07-11
WO1998020895A1 (fr) 1998-05-22
US20090149387A1 (en) 2009-06-11
US20030232754A1 (en) 2003-12-18
ES2237790T3 (es) 2005-08-01
DE69732572T2 (de) 2005-12-29

Similar Documents

Publication Publication Date Title
ZA9710182B (en) Use of GLP-1 peptides.
AU8402691A (en) Dental curing lamp and apparatus
GB2282811B (en) Vaccine for the prevention of porcine reproductive and respiratory syndrome
EP0605442A4 (fr) Anticorps de recombinaison pour therapie humaine.
IL125361A0 (en) Pharmaceutical composition for immunomodulation based on peptides and adjuvants
GB0123381D0 (en) Factor
AU4564696A (en) Recombinant agents affecting haemophilia
GB2318055A (en) Dosage form comprising oxybutynin
BG100974A (en) Vaccines against papillomavirus
PL294269A1 (en) Two-part fistula apparatus and uniting ring therefor
AU6027190A (en) Elevating table for pelvis correction
ZA971663B (en) Porcine reproductive and respiratory syndrome vaccine.
AU6856094A (en) Oxadiazole derivative and medicinal composition thereof
AU9088891A (en) Diagnostic and therapeutic compositions and methods for lipoprotein(a)
AU7617791A (en) Recombinant immunocastration vaccine
MY129782A (en) Novel medical use
GB2317109B (en) A therapeutic composition for the treatment and repair of connective tissue in mammals
EP0318091A3 (en) Resolved amino pyrrolidine neuroprotective agents
AU2004595A (en) Process for preparing recombinant aprotinin and recombinant aprotinin variants having the natural N-terminal sequence
HUP9903340A3 (en) Novel devices for transdermal administering of trimegestone and producing these
AU2623088A (en) New anti-receptor peptides and therapeutic agents
AU6446190A (en) Process for inducing analgesia, peptides and therapeutic compositions
HK44597A (en) Use of chlormethiazole in the manufacture of a medicament for the prevention and/or treatment of neurodegeneration
AU3152089A (en) Method and composition for ophthalmic anesthesia using rodocaine
AU1649592A (en) Recombinant immunocastration vaccine and polypeptides useful for same