ZA969177B - 4-Phenyl-4-oxo-2-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity - Google Patents

4-Phenyl-4-oxo-2-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Info

Publication number
ZA969177B
ZA969177B ZA969177A ZA969177A ZA969177B ZA 969177 B ZA969177 B ZA 969177B ZA 969177 A ZA969177 A ZA 969177A ZA 969177 A ZA969177 A ZA 969177A ZA 969177 B ZA969177 B ZA 969177B
Authority
ZA
South Africa
Prior art keywords
kynurenine
oxo
phenyl
acid derivatives
butanoic acid
Prior art date
Application number
ZA969177A
Other languages
English (en)
Inventor
Antonio Giordani
Paolo Pevarello
Carmela Speciale
Mario Varasi
Original Assignee
Pharmacia & Upjohn Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia & Upjohn Spa filed Critical Pharmacia & Upjohn Spa
Publication of ZA969177B publication Critical patent/ZA969177B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/90—Unsaturated compounds containing keto groups containing singly bound oxygen-containing groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/56—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups bound to carbon atoms of six-membered aromatic rings and carboxyl groups bound to acyclic carbon atoms of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
ZA969177A 1995-11-03 1996-10-31 4-Phenyl-4-oxo-2-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity ZA969177B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB9522615.5A GB9522615D0 (en) 1995-11-03 1995-11-03 4-Phenyl-4-oxo-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Publications (1)

Publication Number Publication Date
ZA969177B true ZA969177B (en) 1997-06-02

Family

ID=10783385

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA969177A ZA969177B (en) 1995-11-03 1996-10-31 4-Phenyl-4-oxo-2-butanoic acid derivatives with kynurenine-3-hydroxylase inhibiting activity

Country Status (7)

Country Link
US (1) US6323240B1 (de)
EP (1) EP0858443A1 (de)
JP (1) JP2000500743A (de)
AU (1) AU7295196A (de)
GB (1) GB9522615D0 (de)
WO (1) WO1997017317A1 (de)
ZA (1) ZA969177B (de)

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6420108B2 (en) 1998-02-09 2002-07-16 Affymetrix, Inc. Computer-aided display for comparative gene expression
JP2001511529A (ja) 1997-07-25 2001-08-14 アフィメトリックス インコーポレイテッド バイオインフォマティクスデータベースを提供するための方法および装置
US6826296B2 (en) 1997-07-25 2004-11-30 Affymetrix, Inc. Method and system for providing a probe array chip design database
US7068830B2 (en) 1997-07-25 2006-06-27 Affymetrix, Inc. Method and system for providing a probe array chip design database
GB9725055D0 (en) * 1997-11-26 1998-01-28 Pharmacia & Upjohn Spa 1,3,4-thiadiazoles compounds
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
GB9816358D0 (en) 1998-07-27 1998-09-23 Angeletti P Ist Richerche Bio Enzyme inhibitors
AU756627B2 (en) 1998-07-27 2003-01-16 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Diketoacid-derivatives as inhibitors of polymerases
US6185561B1 (en) 1998-09-17 2001-02-06 Affymetrix, Inc. Method and apparatus for providing and expression data mining database
US6489096B1 (en) 1998-10-15 2002-12-03 Princeton University Quantitative analysis of hybridization patterns and intensities in oligonucleotide arrays
ATE528000T1 (de) * 2000-06-30 2011-10-15 Abdulla Badawy Verfahren und zubereitungen zur behandlung des alkoholismus und der alkoholabhängigkeit
KR101009472B1 (ko) * 2001-06-12 2011-01-19 웰스테트 테라퓨틱스 코포레이션 대사 질환의 치료용 화합물
FR2832925B1 (fr) * 2001-12-03 2006-07-14 Lipha Utilisation de derives de l'acide 4-oxobutanoique dans le traitement de l'inflammation
FR2849598B1 (fr) * 2003-01-07 2006-09-22 Merck Sante Sas Utilisation d'inhibiteurs de la kynurenine-3-hydroxylase pour le traitement du diabete, par augmentation du nombre de cellules des ilots de langerhans
EP1475088A1 (de) * 2003-05-05 2004-11-10 Newron Pharmaceuticals S.p.A. Kynurenine-3-hydroxylase Hemmer zur Behandlung von L-DOPA bedingten Bewegungsstörungen, Dyskinesien, Sucht, Schmerzen und Katarakt
ES2368692T3 (es) * 2007-12-03 2011-11-21 Merck Patent Gmbh Utilización de derivados del ácido 4-oxobutanoico en el tratamiento de patologías asociadas con trastornos inmunológicos.
US9822058B2 (en) 2012-04-05 2017-11-21 Chdi Foundation, Inc. Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
CN105164100B (zh) * 2013-03-14 2017-09-15 维斯塔津治疗公司 用于合成手性犬尿氨酸化合物的方法
GB201508857D0 (en) * 2015-05-22 2015-07-01 Glaxosmithkline Ip Dev Ltd Compounds
GB201508864D0 (en) * 2015-05-22 2015-07-01 Glaxosmithkline Ip Dev Ltd Compounds

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE650081A (de) * 1963-07-03
US3876800A (en) * 1969-05-12 1975-04-08 Clin Midy Pharmaceutical compositions and methods for treating inflammation and pain
GB1498903A (en) * 1974-03-25 1978-01-25 Fabre Sa Pierre Aromatic keto-acids and their derivatives
FR2378741A1 (fr) * 1977-02-01 1978-08-25 Fabre Sa Pierre Acides garyl goxo isovaleriques doues de proprietes antiphlogistiques et antalgiques
FR2503140A1 (fr) * 1981-03-31 1982-10-08 Fabre Sa Pierre Acides biphenyl-4 oxo-4 methylene-3 butyriques, leur procede de preparation et leur utilisation comme medicaments
US5519055A (en) 1993-08-06 1996-05-21 University Of Maryland At Baltimore Substituted kynurenines and process for their preparation

Also Published As

Publication number Publication date
EP0858443A1 (de) 1998-08-19
US6323240B1 (en) 2001-11-27
AU7295196A (en) 1997-05-29
WO1997017317A1 (en) 1997-05-15
GB9522615D0 (en) 1996-01-03
JP2000500743A (ja) 2000-01-25

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