ZA968170B - Method for transferring genes to the heart using aav vectors - Google Patents
Method for transferring genes to the heart using aav vectorsInfo
- Publication number
- ZA968170B ZA968170B ZA968170A ZA968170A ZA968170B ZA 968170 B ZA968170 B ZA 968170B ZA 968170 A ZA968170 A ZA 968170A ZA 968170 A ZA968170 A ZA 968170A ZA 968170 B ZA968170 B ZA 968170B
- Authority
- ZA
- South Africa
- Prior art keywords
- heart
- aav vectors
- transferring genes
- genes
- transferring
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Physics & Mathematics (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Electrotherapy Devices (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/534,351 US6162796A (en) | 1995-09-27 | 1995-09-27 | Method for transferring genes to the heart using AAV vectors |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA968170B true ZA968170B (en) | 1997-07-21 |
Family
ID=24129676
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA968170A ZA968170B (en) | 1995-09-27 | 1996-09-27 | Method for transferring genes to the heart using aav vectors |
Country Status (7)
Country | Link |
---|---|
US (1) | US6162796A (xx) |
EP (1) | EP0859853A1 (xx) |
JP (1) | JPH11512608A (xx) |
AU (1) | AU727835B2 (xx) |
CA (1) | CA2233167A1 (xx) |
WO (1) | WO1997012050A1 (xx) |
ZA (1) | ZA968170B (xx) |
Families Citing this family (39)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6306830B1 (en) | 1996-09-05 | 2001-10-23 | The Regents Of The University Of California | Gene therapy for congestive heart failure |
US6752987B1 (en) | 1995-02-28 | 2004-06-22 | The Regents Of The University Of California | Adenovirus encoding human adenylylcyclase (AC) VI |
US7745416B2 (en) * | 1995-04-11 | 2010-06-29 | The Regents Of The University Of California | Method for in vivo regulation of cardiac muscle contractility |
US6506379B1 (en) | 1995-06-07 | 2003-01-14 | Ariad Gene Therapeutics, Inc. | Intramuscular delivery of recombinant AAV |
US20030206891A1 (en) * | 1995-06-07 | 2003-11-06 | Ariad Gene Therapeutics, Inc. | Rapamycin-based biological regulation |
WO1996040272A1 (en) * | 1995-06-07 | 1996-12-19 | University Of North Carolina At Chapel Hill | Aav transduction of myoblasts |
US5846528A (en) * | 1996-01-18 | 1998-12-08 | Avigen, Inc. | Treating anemia using recombinant adeno-associated virus virions comprising an EPO DNA sequence |
US5962313A (en) * | 1996-01-18 | 1999-10-05 | Avigen, Inc. | Adeno-associated virus vectors comprising a gene encoding a lyosomal enzyme |
US5858351A (en) | 1996-01-18 | 1999-01-12 | Avigen, Inc. | Methods for delivering DNA to muscle cells using recombinant adeno-associated virus vectors |
EP0906440A1 (en) * | 1996-03-04 | 1999-04-07 | Targeted Genetics Corporation | Methods for transducing cells in blood vessels using recombinant aav vectors |
IL128779A0 (en) * | 1996-09-06 | 2000-01-31 | Univ Pennsylvania | Method for recombinant adeno-associated virus-directed gene therapy |
US20020037867A1 (en) * | 1999-02-26 | 2002-03-28 | James M. Wilson | Method for recombinant adeno-associated virus-directed gene therapy |
EP1017421B1 (en) | 1997-03-07 | 2005-05-25 | The Wistar Institute Of Anatomy And Biology | Use of adenoviral vectors expressing VEGF or PDGF FOR HEALING TISSUE DEFECTS AND INDUCING HYPERVASCULARITY IN MAMMALIAN TISSUE |
US6995006B2 (en) * | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
US6953690B1 (en) | 1998-03-20 | 2005-10-11 | The Trustees Of The University Of Pennsylvania | Compositions and methods for helper-free production of recombinant adeno-associated viruses |
US6129757A (en) * | 1998-05-18 | 2000-10-10 | Scimed Life Systems | Implantable members for receiving therapeutically useful compositions |
AU763049B2 (en) * | 1998-12-28 | 2003-07-10 | Arch Development Corporation | Efficient and stable (in vivo) gene transfer to cardiomyocytes using recombinantadeno-associated virus vectors |
US7078387B1 (en) | 1998-12-28 | 2006-07-18 | Arch Development Corp. | Efficient and stable in vivo gene transfer to cardiomyocytes using recombinant adeno-associated virus vectors |
JP4693244B2 (ja) | 1999-03-18 | 2011-06-01 | ザ・トラステイーズ・オブ・ザ・ユニバーシテイ・オブ・ペンシルベニア | 組換えアデノ随伴ウイルスのヘルパー無しの生産のための組成物および方法 |
WO2001048164A2 (en) | 1999-12-27 | 2001-07-05 | The Regents Of The University Of California | Modified adenylylcyclase type vi useful in gene therapy for congestive heart failure |
AU2001260214A1 (en) * | 2000-04-13 | 2001-10-30 | D. Collen Research Foudation Vzw | Use of inhibition of a gas6 function or of a gas6 receptor for preventing and treating a cardiovascular disease |
ATE366319T1 (de) * | 2000-08-17 | 2007-07-15 | Keiya Ozawa | Adeno-assoziierte virus-vermittelte übertragung von angiogenesefaktoren |
EP1870473A1 (en) * | 2000-08-17 | 2007-12-26 | Keiya Ozawa | Adeno-associated virus-mediated delivery of angiogenic factors |
US20030064025A1 (en) * | 2001-04-05 | 2003-04-03 | Xiaoming Yang | Imaging systems for in vivo protocols |
AU2002303243A1 (en) * | 2001-04-05 | 2002-10-21 | The Johns Hopkins University | Imaging nucleic acid delivery |
AU2002331669A1 (en) | 2001-08-23 | 2003-03-10 | The Wistar Institute Of Anatomy And Biology | An organotypic intestinal culture and methods of use thereof |
AU2003228410A1 (en) * | 2002-04-01 | 2003-10-20 | The Johns Hopkins University School Of Medicine | Device, systems and methods for heating of a vessel in combination with mr/nmr imaging |
US20040009151A1 (en) * | 2002-04-04 | 2004-01-15 | Kay Mark A. | Methods for delivering recombinant adeno-associated virus virions to the liver of a mammal |
EP1486567A1 (en) * | 2003-06-11 | 2004-12-15 | Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts | Improved adeno-associated virus (AAV) vector for gene therapy |
US20060258980A1 (en) * | 2003-09-19 | 2006-11-16 | The Trustees Of The University Of Pennsylvania | Global myocardial perfusion catheter |
US20050244377A1 (en) * | 2003-12-24 | 2005-11-03 | Daniel Sigg | Methods of treating cardiac disorders by suppressing the expression of the potassium inwardly-rectifying channel |
US8859273B2 (en) * | 2003-12-24 | 2014-10-14 | Medtronic, Inc. | Methods of using HCN genes to treat cardiac arrhythmias |
US20060128647A1 (en) * | 2003-12-24 | 2006-06-15 | Daniel Sigg | Novel oligonucleotides and treating cardiac disorders by using the same |
US20050281786A1 (en) * | 2004-06-18 | 2005-12-22 | David Poulsen | AAV mediated gene delivery to cochlear cells |
CN1286981C (zh) * | 2004-11-30 | 2006-11-29 | 华中科技大学同济医学院附属同济医院 | 表达人类cyp2j2反义基因的重组腺相关病毒及其制备方法 |
AU2007277392A1 (en) * | 2006-07-25 | 2008-01-31 | Celladon Corporation | Extended antegrade epicardial coronary infusion of adeno-associated viral vectors for gene therapy |
AU2008350903B2 (en) | 2008-02-19 | 2015-04-02 | Celladon Corporation | Compositions for enhanced uptake of viral vectors in the myocardium |
US9644205B2 (en) | 2012-04-25 | 2017-05-09 | The Regents Of The University Of California | Synthetic promoter for modulating gene expression |
WO2016133917A1 (en) | 2015-02-16 | 2016-08-25 | University Of Florida Research Foundation | Raav vector compositions, methods for targeting vascular endothelial cells and use in treatment of type i diabetes |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5139941A (en) * | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
US5252479A (en) * | 1991-11-08 | 1993-10-12 | Research Corporation Technologies, Inc. | Safe vector for gene therapy |
US5478745A (en) * | 1992-12-04 | 1995-12-26 | University Of Pittsburgh | Recombinant viral vector system |
WO1995012681A1 (en) * | 1993-11-05 | 1995-05-11 | New York University | Methods relating to ir-95 |
ATE272123T1 (de) * | 1993-11-09 | 2004-08-15 | Ohio Med College | Stabile zellinie, die in der lage ist, das replikationsgen des adenoassoziertenvirus zu exprimieren |
US5693531A (en) * | 1993-11-24 | 1997-12-02 | The United States Of America As Represented By The Department Of Health And Human Services | Vector systems for the generation of adeno-associated virus particles |
US5580766A (en) * | 1994-01-14 | 1996-12-03 | Alexion Pharmaceuticals, Inc. | Retroviral vector particles for transducing non-proliferating cells |
FR2716682B1 (fr) * | 1994-01-28 | 1996-04-26 | Centre Nat Rech Scient | Procédé de préparation de virus adéno-associés (AAV) recombinants et utilisations. |
DE9416814U1 (de) * | 1994-10-19 | 1996-02-15 | Poeting Gmbh & Co Kg | Vorrichtung zur Herstellung von Glasformlingen nach dem Preßverfahren |
EA001616B1 (ru) * | 1995-02-28 | 2001-06-25 | Зе Риджентс Оф Зи Юнивесити Оф Кэлифоньэ | Способ лечения болезни сердца, способ лечения недостаточности периферических сосудов и способ ограничения доставки и экспрессии трансгенной конструкции в определенном органе или структуре |
US5797870A (en) * | 1995-06-07 | 1998-08-25 | Indiana University Foundation | Pericardial delivery of therapeutic and diagnostic agents |
-
1995
- 1995-09-27 US US08/534,351 patent/US6162796A/en not_active Expired - Lifetime
-
1996
- 1996-09-26 CA CA002233167A patent/CA2233167A1/en not_active Abandoned
- 1996-09-26 EP EP96933912A patent/EP0859853A1/en not_active Withdrawn
- 1996-09-26 WO PCT/US1996/015446 patent/WO1997012050A1/en not_active Application Discontinuation
- 1996-09-26 AU AU72467/96A patent/AU727835B2/en not_active Ceased
- 1996-09-26 JP JP9513637A patent/JPH11512608A/ja not_active Abandoned
- 1996-09-27 ZA ZA968170A patent/ZA968170B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US6162796A (en) | 2000-12-19 |
CA2233167A1 (en) | 1997-04-03 |
AU7246796A (en) | 1997-04-17 |
JPH11512608A (ja) | 1999-11-02 |
EP0859853A1 (en) | 1998-08-26 |
AU727835B2 (en) | 2001-01-04 |
WO1997012050A1 (en) | 1997-04-03 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ZA968170B (en) | Method for transferring genes to the heart using aav vectors | |
EP0688358A4 (en) | IMPROVED VECTORS FOR GENTHERAPY | |
GB9524973D0 (en) | Viral vectors | |
HUP0001650A3 (en) | Improved expression vectors | |
IL117309A0 (en) | Gene transfer-mediated angiogenesis therapy | |
AU2552795A (en) | Safe vectors for gene therapy | |
GB9408982D0 (en) | Propulsion system | |
IL114517A0 (en) | Heart assist system | |
AU8672198A (en) | Method enabling readministration of aav vector via immunosuppression of host | |
EP0845457A4 (en) | 2,2-DIDEUTERO-5-AMINOLEVULINIC ACID | |
NZ286622A (en) | Fluorophenylalkenylcarboxylic acid guanidides | |
GB2305614B (en) | Modulator system for golf clubs | |
AU2404395A (en) | Image-transfer process | |
GB9602388D0 (en) | Improvements relating to merchandising apparatus | |
ZA9710114B (en) | Method for the expression of genes. | |
ZA958381B (en) | Regulated genes by stimulation of chondrocytes with 1l-1beta | |
GB9422495D0 (en) | DNA transfer method | |
GB9503805D0 (en) | Improvements relating to trolley transfer apparatus | |
EP0690360A3 (en) | Polarizable transfer members made of polyurethane | |
AU4941096A (en) | Self-deleting vectors for gene therapy | |
AU4369596A (en) | Sperm as vaccine vectors | |
GB9518997D0 (en) | Improvements relating to trolleys | |
PL317305A1 (en) | Method of regenerating slip-rings | |
GB9517494D0 (en) | Recominent DNA expression system | |
GB9519871D0 (en) | Collapsible trolley |