ZA953357B - Process for the preparation of 4-amino-delta4-3-ketosteroids via 4-nitro-delta4-3-ketosteroids - Google Patents

Process for the preparation of 4-amino-delta4-3-ketosteroids via 4-nitro-delta4-3-ketosteroids

Info

Publication number
ZA953357B
ZA953357B ZA953357A ZA953357A ZA953357B ZA 953357 B ZA953357 B ZA 953357B ZA 953357 A ZA953357 A ZA 953357A ZA 953357 A ZA953357 A ZA 953357A ZA 953357 B ZA953357 B ZA 953357B
Authority
ZA
South Africa
Prior art keywords
ketosteroids
delta4
hydrogen
alkyl
nitro
Prior art date
Application number
ZA953357A
Other languages
English (en)
Inventor
Philip Marvin Weintraub
Michael Richard Angelastro
Gary Alan Flynn
Cynthia Ann Gates
Timothy Thomas Curran
Chi-Hsin Richard King
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA953357B publication Critical patent/ZA953357B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
ZA953357A 1994-05-02 1995-04-25 Process for the preparation of 4-amino-delta4-3-ketosteroids via 4-nitro-delta4-3-ketosteroids ZA953357B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23143394A 1994-05-02 1994-05-02

Publications (1)

Publication Number Publication Date
ZA953357B true ZA953357B (en) 1996-01-17

Family

ID=22869232

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA953357A ZA953357B (en) 1994-05-02 1995-04-25 Process for the preparation of 4-amino-delta4-3-ketosteroids via 4-nitro-delta4-3-ketosteroids

Country Status (18)

Country Link
US (4) US5750744A (fi)
EP (1) EP0758340B1 (fi)
JP (1) JPH09512547A (fi)
CN (1) CN1042540C (fi)
AT (1) ATE175419T1 (fi)
AU (1) AU686793B2 (fi)
CA (1) CA2188760A1 (fi)
DE (1) DE69507139T2 (fi)
DK (1) DK0758340T3 (fi)
ES (1) ES2128052T3 (fi)
FI (1) FI964410A (fi)
GR (1) GR3029433T3 (fi)
HU (1) HUT75523A (fi)
IL (1) IL113532A (fi)
NO (1) NO964627L (fi)
NZ (1) NZ283974A (fi)
WO (1) WO1995029932A1 (fi)
ZA (1) ZA953357B (fi)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1999061055A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
EP1554572B1 (en) 2001-07-25 2009-10-14 Raptor Pharmaceutical Inc. Compositions and methods for modulating blood-brain barrier transport
EP1562975A2 (en) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
CN101287411B (zh) 2005-04-28 2013-03-06 普罗秋斯生物医学公司 药物信息系统及其用途
WO2007035716A2 (en) 2005-09-16 2007-03-29 Raptor Pharmaceutical Inc. Compositions comprising receptor-associated protein (rap) variants specific for cr-containing proteins and uses thereof
NZ594310A (en) 2009-02-20 2014-02-28 To Bbb Holding B V Glutathione-based drug delivery system
MX2011011833A (es) 2009-05-06 2012-01-27 Lab Skin Care Inc Composiciones de administración dérmica que comprenden complejos de partículas de fosfato de calcio-agente activo y métodos para utilizar las mismas.

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB892620A (en) * 1957-07-20 1962-03-28 Syntex Sa Cyclopentanophenanthrene derivatives
US3014632A (en) * 1961-03-06 1961-12-26 American Can Co Divider
US3159622A (en) * 1963-03-22 1964-12-01 Searle & Co 17 alpha-(2-carboxyethyl)-17 belta-hydroxy-6-nitroandrost-4-en-3-one gamma-lactones
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
NZ239141A (en) * 1990-08-01 1994-04-27 Merrell Dow Pharma 4-amino-delta-4,6-steroids; preparatory processes and pharmaceutical compositions
US5218110A (en) * 1990-08-01 1993-06-08 Merrell Dow Pharmaceuticals 4-amino-Δ4 -steroids and their use as 5α-reductase inhibitors
US5143909A (en) * 1991-03-19 1992-09-01 Merrell Dow Pharmaceuticals Inc. Aminosteroids in a method for inhibiting c17-20 lyase
US5120840A (en) * 1990-08-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors

Also Published As

Publication number Publication date
IL113532A (en) 2000-02-17
US5965550A (en) 1999-10-12
EP0758340A1 (en) 1997-02-19
DE69507139D1 (de) 1999-02-18
US5990328A (en) 1999-11-23
CN1147258A (zh) 1997-04-09
CN1042540C (zh) 1999-03-17
AU686793B2 (en) 1998-02-12
ES2128052T3 (es) 1999-05-01
JPH09512547A (ja) 1997-12-16
NZ283974A (en) 1998-02-26
HUT75523A (en) 1997-05-28
HU9603035D0 (en) 1997-01-28
DK0758340T3 (da) 1999-08-30
AU2244995A (en) 1995-11-29
FI964410A0 (fi) 1996-11-01
US5869475A (en) 1999-02-09
US5750744A (en) 1998-05-12
EP0758340B1 (en) 1999-01-07
IL113532A0 (en) 1995-07-31
DE69507139T2 (de) 1999-09-30
FI964410A (fi) 1996-11-01
NO964627D0 (no) 1996-11-01
GR3029433T3 (en) 1999-05-28
ATE175419T1 (de) 1999-01-15
CA2188760A1 (en) 1995-11-09
WO1995029932A1 (en) 1995-11-09
NO964627L (no) 1997-01-02

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