ES2128052T3 - Procedimiento para la preparacion de 4-amino-delta 4-3-cetoesteroides pasando por 4-nitro-delta 4-3-cetoesteroides. - Google Patents

Procedimiento para la preparacion de 4-amino-delta 4-3-cetoesteroides pasando por 4-nitro-delta 4-3-cetoesteroides.

Info

Publication number
ES2128052T3
ES2128052T3 ES95915628T ES95915628T ES2128052T3 ES 2128052 T3 ES2128052 T3 ES 2128052T3 ES 95915628 T ES95915628 T ES 95915628T ES 95915628 T ES95915628 T ES 95915628T ES 2128052 T3 ES2128052 T3 ES 2128052T3
Authority
ES
Spain
Prior art keywords
cetoesteroides
delta
hydrogen
alkyl
nitro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95915628T
Other languages
English (en)
Inventor
Philip M Weintraub
Cynthia A Gates
Michael R Angelastro
Timothy T Curran
Gary A Flynn
Chi-Hsin R King
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aventis Pharmaceuticals Inc
Original Assignee
Merrell Dow Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharmaceuticals Inc filed Critical Merrell Dow Pharmaceuticals Inc
Application granted granted Critical
Publication of ES2128052T3 publication Critical patent/ES2128052T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0011—Unsubstituted amino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0066—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 the 17-beta position being substituted by a carbon atom forming part of an amide group

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

LA PRESENTE INVENCION PROPORCIONA 4-NITRO- DL 4 -3CETOESTEROIDES, SU UTILIZACION COMO LIASA DE ESTEROIDES C{SUB,1720} E INHIBIDORES DE LA 5{AL}-REDUCTASA, Y A UN NUEVO PROCESO PARA PREPARAR EL COMPUESTO DE FORMULA (I), QUE COMPRENDE SECUENCIALMENTE: A) HACER REACCIONAR UN COMPUESTO DE BASE DE FORMULA (II) CON UNA CANTIDAD EFECTIVA DE UNA BASE FUERTE A TEMPERATURA ELEVADA O APROPIADA, PARA CREAR EL CORRESPONDIENTE DIENOLATO TERMODINAMICO, SEGUIDO DE LA ADICION DE UN AGENTE NITRATANTE NEUTRAL, PARA PRODUCIR EL 4-NITRO-ESTEROIDE; Y A CONTINUACION, B) HACER REACCIONAR EL 4-NITROESTEROIDE CON UN AGENTE REDUCTOR APROPIADO.
ES95915628T 1994-05-02 1995-04-11 Procedimiento para la preparacion de 4-amino-delta 4-3-cetoesteroides pasando por 4-nitro-delta 4-3-cetoesteroides. Expired - Lifetime ES2128052T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US23143394A 1994-05-02 1994-05-02

Publications (1)

Publication Number Publication Date
ES2128052T3 true ES2128052T3 (es) 1999-05-01

Family

ID=22869232

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95915628T Expired - Lifetime ES2128052T3 (es) 1994-05-02 1995-04-11 Procedimiento para la preparacion de 4-amino-delta 4-3-cetoesteroides pasando por 4-nitro-delta 4-3-cetoesteroides.

Country Status (18)

Country Link
US (4) US5750744A (es)
EP (1) EP0758340B1 (es)
JP (1) JPH09512547A (es)
CN (1) CN1042540C (es)
AT (1) ATE175419T1 (es)
AU (1) AU686793B2 (es)
CA (1) CA2188760A1 (es)
DE (1) DE69507139T2 (es)
DK (1) DK0758340T3 (es)
ES (1) ES2128052T3 (es)
FI (1) FI964410A (es)
GR (1) GR3029433T3 (es)
HU (1) HUT75523A (es)
IL (1) IL113532A (es)
NO (1) NO964627L (es)
NZ (1) NZ283974A (es)
WO (1) WO1995029932A1 (es)
ZA (1) ZA953357B (es)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2330611A1 (en) 1998-05-22 1999-12-02 The Board Of Trustees Of The Leland Stanford Junior University Bifunctional molecules and therapies based thereon
ATE445838T1 (de) 2001-07-25 2009-10-15 Raptor Pharmaceutical Inc Zusammensetzungen und verfahren zur modulation des transports durch die blut-hirn-schranke
EP1562975A2 (en) * 2002-10-25 2005-08-17 Yissum Research Development Company Of The Hebrew University Of Jerusalem Steroid compounds comprising superoxide dismutase mimic groups and nitric oxide donor groups, and their use in the preparation of medicaments
EP2671508B1 (en) 2005-04-28 2020-09-16 Proteus Digital Health, Inc. Pharma-informatics system
JP2009508494A (ja) 2005-09-16 2009-03-05 ラプトール ファーマシューティカル インコーポレイテッド Ｃｒを含むタンパク質に対して特異的な受容体−結合タンパク質（ｒａｐ）変異体を含む組成物およびその使用
HUE059078T2 (hu) 2009-02-20 2022-10-28 Enhanx Biopharm Inc Glutation-alapú hatóanyagszállító rendszer
JP2012526144A (ja) 2009-05-06 2012-10-25 ラボラトリー スキン ケア インコーポレイテッド 活性物質−リン酸カルシウム粒子複合体を含む経皮送達組成物およびその使用方法

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB892620A (en) * 1957-07-20 1962-03-28 Syntex Sa Cyclopentanophenanthrene derivatives
US3014632A (en) * 1961-03-06 1961-12-26 American Can Co Divider
US3159622A (en) * 1963-03-22 1964-12-01 Searle & Co 17 alpha-(2-carboxyethyl)-17 belta-hydroxy-6-nitroandrost-4-en-3-one gamma-lactones
GB8503940D0 (en) * 1985-02-15 1985-03-20 Erba Farmitalia 4-substituted androstendione derivatives
US5120840A (en) * 1990-08-01 1992-06-09 Merrell Dow Pharmaceuticals Inc. 4-amino-4-ene-steroids and their use as 5α-reductase inhibitors
NZ239141A (en) * 1990-08-01 1994-04-27 Merrell Dow Pharma 4-amino-delta-4,6-steroids; preparatory processes and pharmaceutical compositions
US5143909A (en) * 1991-03-19 1992-09-01 Merrell Dow Pharmaceuticals Inc. Aminosteroids in a method for inhibiting c17-20 lyase
US5218110A (en) * 1990-08-01 1993-06-08 Merrell Dow Pharmaceuticals 4-amino-Δ4 -steroids and their use as 5α-reductase inhibitors

Also Published As

Publication number Publication date
US5990328A (en) 1999-11-23
FI964410A0 (fi) 1996-11-01
ATE175419T1 (de) 1999-01-15
NZ283974A (en) 1998-02-26
ZA953357B (en) 1996-01-17
WO1995029932A1 (en) 1995-11-09
NO964627L (no) 1997-01-02
EP0758340A1 (en) 1997-02-19
NO964627D0 (no) 1996-11-01
AU2244995A (en) 1995-11-29
CN1042540C (zh) 1999-03-17
CN1147258A (zh) 1997-04-09
JPH09512547A (ja) 1997-12-16
US5965550A (en) 1999-10-12
HU9603035D0 (en) 1997-01-28
US5750744A (en) 1998-05-12
IL113532A (en) 2000-02-17
HUT75523A (en) 1997-05-28
GR3029433T3 (en) 1999-05-28
CA2188760A1 (en) 1995-11-09
FI964410A (fi) 1996-11-01
EP0758340B1 (en) 1999-01-07
DE69507139D1 (de) 1999-02-18
DE69507139T2 (de) 1999-09-30
IL113532A0 (en) 1995-07-31
US5869475A (en) 1999-02-09
DK0758340T3 (da) 1999-08-30
AU686793B2 (en) 1998-02-12

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