ZA948024B - Methods for the treatment of peri-menopausal syndrome - Google Patents
Methods for the treatment of peri-menopausal syndromeInfo
- Publication number
- ZA948024B ZA948024B ZA948024A ZA948024A ZA948024B ZA 948024 B ZA948024 B ZA 948024B ZA 948024 A ZA948024 A ZA 948024A ZA 948024 A ZA948024 A ZA 948024A ZA 948024 B ZA948024 B ZA 948024B
- Authority
- ZA
- South Africa
- Prior art keywords
- peri
- treatment
- methods
- menopausal syndrome
- substd
- Prior art date
Links
- 206010027304 Menopausal symptoms Diseases 0.000 title abstract 2
- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 abstract 2
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000587 piperidin-1-yl group Chemical group [H]C1([H])N(*)C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 125000002112 pyrrolidino group Chemical group [*]N1C([H])([H])C([H])([H])C([H])([H])C1([H])[H] 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000012453 solvate Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/4535—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a heterocyclic ring having sulfur as a ring hetero atom, e.g. pizotifen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Diabetes (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Endocrinology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
- Saccharide Compounds (AREA)
- Steroid Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US08/138,287 US5391557A (en) | 1993-10-15 | 1993-10-15 | Methods for the treatment of peri-menopausal syndrome |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA948024B true ZA948024B (en) | 1996-04-15 |
Family
ID=22481346
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA948024A ZA948024B (en) | 1993-10-15 | 1994-10-13 | Methods for the treatment of peri-menopausal syndrome |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US5391557A (de) |
| EP (1) | EP0652001B1 (de) |
| JP (1) | JPH07196499A (de) |
| KR (1) | KR950010890A (de) |
| CN (1) | CN1107157A (de) |
| AT (1) | ATE153240T1 (de) |
| AU (1) | AU670394B2 (de) |
| CA (1) | CA2118093A1 (de) |
| CZ (1) | CZ253394A3 (de) |
| DE (1) | DE69403305T2 (de) |
| DK (1) | DK0652001T3 (de) |
| ES (1) | ES2104285T3 (de) |
| GR (1) | GR3023603T3 (de) |
| HU (1) | HUT71229A (de) |
| IL (1) | IL111290A (de) |
| NO (1) | NO943876L (de) |
| NZ (1) | NZ264673A (de) |
| PH (1) | PH31262A (de) |
| RU (1) | RU94036758A (de) |
| ZA (1) | ZA948024B (de) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6515009B1 (en) | 1991-09-27 | 2003-02-04 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5811447A (en) * | 1993-01-28 | 1998-09-22 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US6251920B1 (en) | 1993-05-13 | 2001-06-26 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US6395494B1 (en) * | 1993-05-13 | 2002-05-28 | Neorx Corporation | Method to determine TGF-β |
| US5770609A (en) | 1993-01-28 | 1998-06-23 | Neorx Corporation | Prevention and treatment of cardiovascular pathologies |
| US5595722A (en) * | 1993-01-28 | 1997-01-21 | Neorx Corporation | Method for identifying an agent which increases TGF-beta levels |
| US6491938B2 (en) | 1993-05-13 | 2002-12-10 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| WO1994026303A1 (en) * | 1993-05-13 | 1994-11-24 | Neorx Corporation | Prevention and treatment of pathologies associated with abnormally proliferative smooth muscle cells |
| US6417198B1 (en) * | 1993-12-21 | 2002-07-09 | Eli Lilly And Company | Methods of inhibiting CNS problems in post-menopausal women |
| US5534526A (en) * | 1993-12-21 | 1996-07-09 | Eli Lilly And Company | Methods for inhibiting vasomotor symptoms and attending psychological disturbances surrounding post-menopausal syndrome |
| US20030083733A1 (en) * | 1997-10-10 | 2003-05-01 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| US5514704A (en) * | 1995-03-13 | 1996-05-07 | Eli Lilly And Company | Benzothiophenes to inhibit leukotrienes |
| US5837313A (en) * | 1995-04-19 | 1998-11-17 | Schneider (Usa) Inc | Drug release stent coating process |
| US6099562A (en) * | 1996-06-13 | 2000-08-08 | Schneider (Usa) Inc. | Drug coating with topcoat |
| US20020091433A1 (en) * | 1995-04-19 | 2002-07-11 | Ni Ding | Drug release coated stent |
| CA2215902A1 (en) * | 1995-04-21 | 1996-10-24 | Charles David Jones | Benzothiophenes with novel basic side chains |
| JPH11510479A (ja) * | 1995-06-07 | 1999-09-14 | ネオルックス コーポレイション | タモキシフェン類似体による心臓血管疾病の予防及び治療 |
| DK0842169T3 (da) * | 1995-06-26 | 2001-01-29 | Lilly Co Eli | Benzothiophenforbindelser |
| NZ331085A (en) * | 1996-01-29 | 2000-06-23 | Lilly Co Eli | use of 2-phenyl-3-benzoyl-benzo[b]thiophene derivatives for increasing sphincter competence |
| IL120266A (en) * | 1996-02-28 | 2005-05-17 | Pfizer | Use of estrogen antagonists and estrogen agonists in the preparation of medicaments for inhibiting pathological conditions |
| TW442286B (en) * | 1996-02-28 | 2001-06-23 | Pfizer | New therapeutic uses of estrogen agonists |
| WO1998046588A2 (en) * | 1997-04-11 | 1998-10-22 | Neorx Corporation | Compounds and therapies for the prevention of vascular and non-vascular pathologies |
| US6008232A (en) * | 1997-08-20 | 1999-12-28 | Eli Lilly And Company | Methods for preventing headaches |
| WO1999008526A1 (en) * | 1997-08-21 | 1999-02-25 | Eli Lilly And Company | Methods for inhibiting temporomandibular disorders |
| US6103740A (en) * | 1997-08-21 | 2000-08-15 | Eli Lilly And Company | Methods for lowering platelet counts |
| AU9105598A (en) * | 1997-08-21 | 1999-03-08 | Eli Lilly And Company | Methods for inhibiting fibrous inflammatory disease and riedel's thyroiditis |
| US6096781A (en) | 1997-11-14 | 2000-08-01 | Eli Lilly And Company | 2-arylbenzo[B]thiophenes useful for the treatment of estrogen deprivation syndrome |
| FR2777784B1 (fr) * | 1998-04-27 | 2004-03-19 | Arepa | Composition pharmaceutique a base d'estrogene et de progesterone |
| US7005428B1 (en) | 1998-06-11 | 2006-02-28 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US6465445B1 (en) * | 1998-06-11 | 2002-10-15 | Endorecherche, Inc. | Medical uses of a selective estrogen receptor modulator in combination with sex steroid precursors |
| US6258826B1 (en) | 1998-10-13 | 2001-07-10 | Eli Lilly And Company | Pharmaceutical formulations and applications thereof for the treatment of estrogen deprivation syndrome |
| UA75339C2 (en) | 1999-08-31 | 2006-04-17 | Schering Ag | Use of mesoprogestins (progesterone receptor modulators) as pharmaceutical components for manufacture of medicament for hormone replacement therapy (hrt) |
| EP1216037A2 (de) | 1999-09-21 | 2002-06-26 | Emory University | Verfahren und zusammensetzungen zur behandlung von bluttplätchen-zusammenhängenden krankheiten, mit mpl hemmenden agenten |
| IL145838A (en) * | 2000-10-16 | 2008-11-03 | Pfizer Prod Inc | Use of an estrogen agonist/antagonist for the manufacture of a medicament for treating vaginitis |
| ES2233570T3 (es) * | 2000-11-30 | 2005-06-16 | Pfizer Products Inc. | Composicion que contiene agonistas/antagosnistas de estrogenos y testosterona para tratar un descenso en el nivel de la hormona testosterona. |
| AU781168B2 (en) * | 2001-01-26 | 2005-05-12 | Pfizer Products Inc. | Method of treating certain cancers using an estrogen agonist/antagonist |
| US6613083B2 (en) * | 2001-05-02 | 2003-09-02 | Eckhard Alt | Stent device and method |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4133814A (en) * | 1975-10-28 | 1979-01-09 | Eli Lilly And Company | 2-Phenyl-3-aroylbenzothiophenes useful as antifertility agents |
| US4380635A (en) * | 1981-04-03 | 1983-04-19 | Eli Lilly And Company | Synthesis of acylated benzothiophenes |
| US4418068A (en) * | 1981-04-03 | 1983-11-29 | Eli Lilly And Company | Antiestrogenic and antiandrugenic benzothiophenes |
| US5075321A (en) * | 1987-03-24 | 1991-12-24 | University Of Pennsylvania | Methods of treating diseases characterized by interactions of IgG-containing immune complexes with macrophage Fc receptors using antiestrogenic benzothiophenes |
| DE4122484A1 (de) * | 1991-07-06 | 1993-01-07 | Teves Gmbh Alfred | Schaltungsanordnung zur erkennung von radsensordefekten |
| JP3157882B2 (ja) * | 1991-11-15 | 2001-04-16 | 帝国臓器製薬株式会社 | 新規なベンゾチオフエン誘導体 |
-
1993
- 1993-10-15 US US08/138,287 patent/US5391557A/en not_active Expired - Fee Related
-
1994
- 1994-10-12 CN CN94117127A patent/CN1107157A/zh active Pending
- 1994-10-13 NO NO943876A patent/NO943876L/no not_active Application Discontinuation
- 1994-10-13 CZ CZ942533A patent/CZ253394A3/cs unknown
- 1994-10-13 JP JP6247747A patent/JPH07196499A/ja active Pending
- 1994-10-13 DK DK94307524.2T patent/DK0652001T3/da active
- 1994-10-13 DE DE69403305T patent/DE69403305T2/de not_active Expired - Fee Related
- 1994-10-13 ES ES94307524T patent/ES2104285T3/es not_active Expired - Lifetime
- 1994-10-13 EP EP94307524A patent/EP0652001B1/de not_active Expired - Lifetime
- 1994-10-13 NZ NZ264673A patent/NZ264673A/xx unknown
- 1994-10-13 PH PH49188A patent/PH31262A/en unknown
- 1994-10-13 KR KR1019940026161A patent/KR950010890A/ko not_active Ceased
- 1994-10-13 RU RU94036758/14A patent/RU94036758A/ru unknown
- 1994-10-13 AT AT94307524T patent/ATE153240T1/de not_active IP Right Cessation
- 1994-10-13 IL IL11129094A patent/IL111290A/xx not_active IP Right Cessation
- 1994-10-13 ZA ZA948024A patent/ZA948024B/xx unknown
- 1994-10-13 AU AU75790/94A patent/AU670394B2/en not_active Ceased
- 1994-10-13 CA CA002118093A patent/CA2118093A1/en not_active Abandoned
- 1994-10-13 HU HU9402956A patent/HUT71229A/hu unknown
-
1997
- 1997-05-30 GR GR970401247T patent/GR3023603T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU670394B2 (en) | 1996-07-11 |
| RU94036758A (ru) | 1996-08-27 |
| ES2104285T3 (es) | 1997-10-01 |
| PH31262A (en) | 1998-06-18 |
| NO943876D0 (no) | 1994-10-13 |
| DE69403305D1 (de) | 1997-06-26 |
| NZ264673A (en) | 1999-08-30 |
| IL111290A0 (en) | 1994-12-29 |
| US5391557A (en) | 1995-02-21 |
| GR3023603T3 (en) | 1997-08-29 |
| CA2118093A1 (en) | 1995-04-16 |
| NO943876L (no) | 1995-04-18 |
| KR950010890A (ko) | 1995-05-15 |
| CN1107157A (zh) | 1995-08-23 |
| DK0652001T3 (da) | 1997-09-15 |
| AU7579094A (en) | 1995-05-04 |
| EP0652001B1 (de) | 1997-05-21 |
| HU9402956D0 (en) | 1995-02-28 |
| EP0652001A1 (de) | 1995-05-10 |
| HUT71229A (en) | 1995-11-28 |
| CZ253394A3 (en) | 1995-05-17 |
| ATE153240T1 (de) | 1997-06-15 |
| JPH07196499A (ja) | 1995-08-01 |
| DE69403305T2 (de) | 1997-09-25 |
| IL111290A (en) | 1999-04-11 |
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