ZA947864B - 2-(1-alkoxy-2-naphthyl)-pyrrole derivatives their preparation and their use as dopamine D3 receptor antagonists - Google Patents

2-(1-alkoxy-2-naphthyl)-pyrrole derivatives their preparation and their use as dopamine D3 receptor antagonists

Info

Publication number
ZA947864B
ZA947864B ZA947864A ZA947864A ZA947864B ZA 947864 B ZA947864 B ZA 947864B ZA 947864 A ZA947864 A ZA 947864A ZA 947864 A ZA947864 A ZA 947864A ZA 947864 B ZA947864 B ZA 947864B
Authority
ZA
South Africa
Prior art keywords
dopamine
naphthyl
alkoxy
preparation
receptor antagonists
Prior art date
Application number
ZA947864A
Inventor
Geoffrey Stemp
Christopher Norbert Johnson
Original Assignee
Smithkline Beecham Plc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Smithkline Beecham Plc filed Critical Smithkline Beecham Plc
Publication of ZA947864B publication Critical patent/ZA947864B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C65/00—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C65/21—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups
    • C07C65/24—Compounds having carboxyl groups bound to carbon atoms of six—membered aromatic rings and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups containing ether groups, groups, groups, or groups polycyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
ZA947864A 1993-10-09 1994-10-07 2-(1-alkoxy-2-naphthyl)-pyrrole derivatives their preparation and their use as dopamine D3 receptor antagonists ZA947864B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB939320855A GB9320855D0 (en) 1993-10-09 1993-10-09 Compounds

Publications (1)

Publication Number Publication Date
ZA947864B true ZA947864B (en) 1996-04-09

Family

ID=10743286

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA947864A ZA947864B (en) 1993-10-09 1994-10-07 2-(1-alkoxy-2-naphthyl)-pyrrole derivatives their preparation and their use as dopamine D3 receptor antagonists

Country Status (4)

Country Link
AU (1) AU7698794A (en)
GB (1) GB9320855D0 (en)
WO (1) WO1995010504A1 (en)
ZA (1) ZA947864B (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9512129D0 (en) * 1995-06-15 1995-08-16 Smithkline Beecham Plc Compounds
GB9810876D0 (en) 1998-05-20 1998-07-22 Smithkline Beecham Plc Compounds
ATE316969T1 (en) 1998-10-08 2006-02-15 Smithkline Beecham Plc TETRAHYDROBENZAZEPINE DERIVATIVES USABLE AS DOPAMINE D3 RECEPTOR MODULATORS (ANTIPSYCHOTIC AGENTS)

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4540814A (en) * 1983-06-24 1985-09-10 Adria Laboratories, Inc. 1,4-Dimethoxy naphthalenecarboxamide anticonvulsants
NZ219380A (en) * 1986-02-27 1990-06-26 Duphar Int Res (n-piperidinyl)- and (n-piperazinyl)-methylazole derivatives and pharmaceutical compositions
PH23898A (en) * 1986-09-12 1989-12-18 Duphar Int Res New phenyl pyrrolidin-2-yl substituted-2-yl substituted 5-ring heterocycles having antipsycotic properties
US5122361A (en) * 1989-04-17 1992-06-16 Trustees Of The University Of Pennsylvania Dopamine receptor ligands and imaging agents
FR2682953B1 (en) * 1991-10-23 1995-04-21 Inst Nat Sante Rech Med NOVEL NAPHTHAMIDE DERIVATIVES, THEIR PREPARATION PROCESS AND THEIR APPLICATION IN THE THERAPEUTIC FIELD.
EP0654023B1 (en) * 1992-08-06 1998-09-16 Smithkline Beecham Plc 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor antagonists

Also Published As

Publication number Publication date
GB9320855D0 (en) 1993-12-01
AU7698794A (en) 1995-05-04
WO1995010504A1 (en) 1995-04-20

Similar Documents

Publication Publication Date Title
IL144851A0 (en) 3-phenylpyridine derivatives and their use as nk-1 receptor antagonists
HUP9701714A3 (en) Indole derivatives neuropeptide y receptor antagonists, use thereof and pharmaceutical compositions containing these compounds
SI1035115T1 (en) 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists
SI1093803T1 (en) Cosmetic composition comprising an antagonist of the neuropeptide Y receptor
AU4396193A (en) 3-benzylamino-2-phenyl-piperidine derivatives as substance p receptor antagonists
SG47877A1 (en) Use of tetrahydrocarbazone derivatives as 5HT receptor agonists
HUP9901245A3 (en) Indole derivatives useful as endothelin receptor antagonists, preparation and use thereof, pharmaceutical compositions containing these compounds
GB9020051D0 (en) Muscarinic receptor antagonists
EP0707581A1 (en) Indoline derivatives as 5ht 2c? antagonists
AU6031001A (en) Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
HU9600589D0 (en) Epibatidine and derivatives thereof as cholinergic receptor agonists and antagonists
IL152701A0 (en) Substituted 1-aminoalkyl-lactams and their use as muscarinic receptor antagonists
HU9503089D0 (en) Use of indole derivatives as 5ht1 antagonists
AU9069191A (en) Use of angiotensin ii receptor antagonists in the prevention of restinosis
ZA941926B (en) Heterocyclic compounds their preparation and use
ZA952410B (en) Substituted heterocyclic carboxamioesters their preparation and their use as pharmaceuticals
AU1919992A (en) Angiotensin ii receptor antagonist thiazole devivatives
PL330708A1 (en) Derivatives of indolydine useful as antagonists of 5-ht-2c receptor
AU2654692A (en) Pyrrolobenzoxazine derivatives as 5-ht agonists and antagonists
AU7186994A (en) Phenyrrole derivatives and their use as dopamine d3 antagonists
ZA947864B (en) 2-(1-alkoxy-2-naphthyl)-pyrrole derivatives their preparation and their use as dopamine D3 receptor antagonists
PL330796A1 (en) Derivatives of indolin useful as antagonists of 5-ht-2c receptor
AU7460194A (en) 2-phenylpyrrole derivatives as dopamine d3 receptor antagonists
AU1809595A (en) Phenylpyrrole derivatives and their use as dopamine d3 antagonists
AU3935897A (en) B1-bradykinin receptor antagonists and use thereof