ZA946815B - Difluoro statone antiviral analogs. - Google Patents

Difluoro statone antiviral analogs.

Info

Publication number
ZA946815B
ZA946815B ZA946815A ZA946815A ZA946815B ZA 946815 B ZA946815 B ZA 946815B ZA 946815 A ZA946815 A ZA 946815A ZA 946815 A ZA946815 A ZA 946815A ZA 946815 B ZA946815 B ZA 946815B
Authority
ZA
South Africa
Prior art keywords
antiviral
statone
analogs
difluoro
antiviral analogs
Prior art date
Application number
ZA946815A
Other languages
English (en)
Inventor
Viviane Van Dorsselaar
Daniel Schirlin
Celine Tarnus
Original Assignee
Merrell Dow Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merrell Dow Pharma filed Critical Merrell Dow Pharma
Publication of ZA946815B publication Critical patent/ZA946815B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/28—Radicals substituted by singly-bound oxygen or sulphur atoms
    • C07D213/30—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/08—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms
    • C07C271/10—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C271/22—Esters of carbamic acids having oxygen atoms of carbamate groups bound to acyclic carbon atoms with the nitrogen atoms of the carbamate groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of hydrocarbon radicals substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/54—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/56—Amides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Steroid Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Epoxy Compounds (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
ZA946815A 1993-09-09 1994-09-05 Difluoro statone antiviral analogs. ZA946815B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP93402194 1993-09-09

Publications (1)

Publication Number Publication Date
ZA946815B true ZA946815B (en) 1995-04-24

Family

ID=8214747

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA946815A ZA946815B (en) 1993-09-09 1994-09-05 Difluoro statone antiviral analogs.

Country Status (20)

Country Link
US (2) US5831094A (forum.php)
EP (1) EP0717731B1 (forum.php)
JP (1) JPH09502437A (forum.php)
KR (1) KR100308839B1 (forum.php)
CN (1) CN1130898A (forum.php)
AT (1) ATE179167T1 (forum.php)
AU (1) AU683927B2 (forum.php)
CA (1) CA2170607C (forum.php)
DE (1) DE69418050T2 (forum.php)
DK (1) DK0717731T3 (forum.php)
ES (1) ES2133573T3 (forum.php)
FI (1) FI961105A0 (forum.php)
GR (1) GR3030352T3 (forum.php)
HU (1) HUT74569A (forum.php)
IL (1) IL110865A (forum.php)
NO (1) NO960849D0 (forum.php)
NZ (1) NZ271825A (forum.php)
TW (1) TW282449B (forum.php)
WO (1) WO1995007257A1 (forum.php)
ZA (1) ZA946815B (forum.php)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1085980C (zh) * 1995-08-30 2002-06-05 G·D·瑟尔公司 间－胍基、脲基、硫脲基或氮杂环氨基苯甲酸衍生物用作整合素拮抗剂
KR100440643B1 (ko) * 1999-01-28 2004-07-21 쥬가이 세이야쿠 가부시키가이샤 치환 페네틸아민 유도체

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5066643A (en) * 1985-02-19 1991-11-19 Sandoz Ltd. Fluorine and chlorine statine or statone containing peptides and method of use
CH672792A5 (forum.php) * 1985-02-19 1989-12-29 Sandoz Ag
WO1986006379A1 (en) * 1985-04-19 1986-11-06 The Upjohn Company Dihalo-statine substituted renin inhibitors
GB8619182D0 (en) * 1986-08-06 1986-09-17 Sandoz Ltd Peptides & derivatives
NZ223148A (en) * 1987-01-16 1989-10-27 Merrell Dow Pharma Peptide derivatives having peptidase inhibition activity
BE1002213A5 (fr) * 1987-04-23 1990-10-16 Sandoz Sa Nouveaux derives peptidiques, leur preparation et leur utilisation comme medicaments.
GB2212158A (en) * 1987-12-15 1989-07-19 Sandoz Ltd Trialkylsilymethyl-substituted peptides; renin inhibitors
IL90872A0 (en) * 1988-07-08 1990-02-09 Smithkline Beckman Corp Retroviral protease binding peptides
JPH03505875A (ja) * 1988-07-08 1991-12-19 スミスクライン・ベックマン・コーポレイション レトロウイルス・プロテアーゼ結合ペプチド
CA2010531A1 (en) * 1989-03-06 1990-09-06 Werner Neidhart Amino acid derivatives
US5151438A (en) * 1989-05-23 1992-09-29 Abbott Laboratories Retroviral protease inhibiting compounds
KR100220876B1 (ko) * 1991-01-02 1999-10-01 슈테펜엘.네스비트 항 바이러스 화합물
JP3198416B2 (ja) * 1991-01-02 2001-08-13 メレルダウファーマスーティカルズ インコーポレイテッド 抗ウイルス化合物類
SK114094A3 (en) * 1992-03-25 1995-04-12 Pfizer Peptides, method of their producing, their using and pharmaceutical preparation on their base
GB9210744D0 (en) * 1992-05-20 1992-07-08 Pfizer Ltd Antiviral peptides
WO1993023379A1 (en) * 1992-05-21 1993-11-25 Monsanto Company Retroviral protease inhibitors
NZ268202A (en) * 1993-07-08 1997-09-22 Merrell Pharma Inc 2,2-difluoro-4-aminobutanoic acid amide and 2,2-difluoro-5,7-diazaoctan-1,8-dioic acid-1-amide derivatives (statone analogues); pharmaceutical compositions
EP0773926A1 (en) * 1994-07-15 1997-05-21 Merrell Pharmaceuticals Inc. Difluorostatone antiviral agents

Also Published As

Publication number Publication date
AU7560694A (en) 1995-03-27
US5831094A (en) 1998-11-03
CN1130898A (zh) 1996-09-11
FI961105L (fi) 1996-03-08
EP0717731A1 (en) 1996-06-26
ES2133573T3 (es) 1999-09-16
ATE179167T1 (de) 1999-05-15
EP0717731B1 (en) 1999-04-21
IL110865A (en) 1999-07-14
DE69418050T2 (de) 1999-11-25
HU9600601D0 (en) 1996-05-28
CA2170607C (en) 2000-02-22
HUT74569A (en) 1997-01-28
TW282449B (forum.php) 1996-08-01
GR3030352T3 (en) 1999-09-30
WO1995007257A1 (en) 1995-03-16
NZ271825A (en) 1997-11-24
KR960704838A (ko) 1996-10-09
FI961105A7 (fi) 1996-03-08
US5948778A (en) 1999-09-07
DK0717731T3 (da) 1999-11-01
DE69418050D1 (de) 1999-05-27
NO960849L (no) 1996-03-01
FI961105A0 (fi) 1996-03-08
KR100308839B1 (ko) 2002-10-04
NO960849D0 (no) 1996-03-01
JPH09502437A (ja) 1997-03-11
IL110865A0 (en) 1994-11-28
CA2170607A1 (en) 1995-03-16
AU683927B2 (en) 1997-11-27

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