ZA941128B - Polysubstituted 2-amino-thiazole derivatives - Google Patents

Polysubstituted 2-amino-thiazole derivatives

Info

Publication number
ZA941128B
ZA941128B ZA941128A ZA941128A ZA941128B ZA 941128 B ZA941128 B ZA 941128B ZA 941128 A ZA941128 A ZA 941128A ZA 941128 A ZA941128 A ZA 941128A ZA 941128 B ZA941128 B ZA 941128B
Authority
ZA
South Africa
Prior art keywords
polysubstituted
amino
thiazole derivatives
thiazole
derivatives
Prior art date
Application number
ZA941128A
Other languages
English (en)
Inventor
Robert Boigegrain
Roger Brodin
Daniel Frehel
Danielle Gully
Jean-Charles Molimard
Dominique Olliero
Original Assignee
Sanofi Elf
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sanofi Elf filed Critical Sanofi Elf
Publication of ZA941128B publication Critical patent/ZA941128B/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/427—Thiazoles not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Diabetes (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
ZA941128A 1993-02-19 1994-02-18 Polysubstituted 2-amino-thiazole derivatives ZA941128B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9301941A FR2701708B1 (fr) 1993-02-19 1993-02-19 Dérivés de 2-amido-4-phénylthiazoles polysubstitués, procédé de préparation, composition pharmaceutique et utilisation de ces dérivés pour la préparation d'un médicament.

Publications (1)

Publication Number Publication Date
ZA941128B true ZA941128B (en) 1995-08-18

Family

ID=9444247

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA941128A ZA941128B (en) 1993-02-19 1994-02-18 Polysubstituted 2-amino-thiazole derivatives

Country Status (16)

Country Link
US (1) US5656648A (de)
EP (1) EP0611766A1 (de)
JP (1) JPH06298761A (de)
KR (1) KR940019706A (de)
CN (1) CN1107158A (de)
AU (1) AU680213B2 (de)
CA (1) CA2115805A1 (de)
FI (1) FI940769A (de)
FR (1) FR2701708B1 (de)
HU (1) HUT70158A (de)
IL (1) IL108636A (de)
MX (1) MX9401209A (de)
NO (1) NO940558D0 (de)
NZ (1) NZ250907A (de)
RU (1) RU2125569C1 (de)
ZA (1) ZA941128B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
FR2763337B1 (fr) * 1997-05-13 1999-08-20 Sanofi Sa Nouveaux derives du triazole, un procede pour leur preparation et compositions pharmaceutiques les contenant
FR2768737B1 (fr) * 1997-09-19 2000-05-19 Sanofi Sa Derives de carboxamidothiazoles, leur preparation, les compositions pharmaceutiques en contenant
CO4970713A1 (es) * 1997-09-19 2000-11-07 Sanofi Synthelabo Derivados de carboxamidotiazoles, su preparacion, composiciones farmaceuticas que los contienen
TWI271406B (en) 1999-12-13 2007-01-21 Eisai Co Ltd Tricyclic condensed heterocyclic compounds, preparation method of the same and pharmaceuticals comprising the same
US6768024B1 (en) 2000-08-04 2004-07-27 Lion Bioscience Ag Triamine derivative melanocortin receptor ligands and methods of using same
PL365328A1 (en) * 2000-10-26 2004-12-27 Sanofi-Synthelabo Triazole derivatives and pharmaceutical compositions comprising them
FR2815963B1 (fr) * 2000-10-26 2003-02-28 Sanofi Synthelabo Nouveaux derives du triazole et les compositions pharmaceutiques les contenant
GB0102668D0 (en) * 2001-02-02 2001-03-21 Glaxo Group Ltd Compounds
TWI312347B (en) 2001-02-08 2009-07-21 Eisai R&D Man Co Ltd Bicyclic nitrogen-containing condensed ring compounds
US7091215B2 (en) 2001-04-27 2006-08-15 Eisai Co., Ltd. Pyrazolo[1,5-a]pyridines and medicines containing the same
PL213633B1 (pl) 2002-10-22 2013-04-30 Eisai R&D Management Co Ltd Pochodne 7-fenylopirazolopirydyny, srodek terapeutyczny lub profilaktyczny i zastosowanie
US7176216B2 (en) 2002-10-22 2007-02-13 Eisai Co., Ltd. 7-phenylpyrazolopyridine compounds
FR2872813B1 (fr) 2004-07-09 2007-01-19 Sanofi Synthelabo Derives de 2-carbamide-4-phenylthiazole, leur preparation et leur application en therapeutique
CN101096363B (zh) * 2006-06-27 2011-05-11 中国人民解放军军事医学科学院毒物药物研究所 2,4,5-三取代噻唑类化合物、其制备方法、药物组合物及其制药用途
WO2009128383A1 (ja) 2008-04-15 2009-10-22 エーザイ・アール・アンド・ディー・マネジメント株式会社 ３－フェニルピラゾロ［５，１－ｂ］チアゾール化合物
US8541431B2 (en) * 2008-05-19 2013-09-24 The University Of Tennessee Research Foundation Pyrimidine non-classical cannabinoid compounds and related methods of use
EP2299819A4 (de) * 2008-05-19 2011-07-20 Univ Tennessee Res Foundation Nichtklassische pyridin-cannabinoidverbindungen und damit zusammenhängende verfahren zu ihrer verwendung
AR078521A1 (es) 2009-10-08 2011-11-16 Eisai R&D Man Co Ltd Compuesto pirazolotiazol
RU2576036C2 (ru) 2010-03-17 2016-02-27 Тайвекс Терапьютикс Корпорейшн Модуляторы активности нес1 и способы для них
US11071736B2 (en) 2011-11-21 2021-07-27 Taivex Therapeutics Corporation Modulators of HEC1 activity and methods therefor

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1526074A (fr) * 1967-03-22 1968-05-24 Rech S Ind S O R I Soc D Méthoxy-phényl-amino-2-thiazoles, leurs amides et leurs procédés de préparation
FR2566405B1 (fr) * 1984-06-25 1986-09-26 Roussel Uclaf Nouveaux derives de l'acide 4-hydroxy 3-quinoleine carboxylique substitues en 2 par une fonction aminee, leur preparation, leur application comme medicaments, les compositions les renfermant et les intermediaires nouveaux obtenus
DE3705934A1 (de) * 1987-02-25 1988-09-08 Nattermann A & Cie Indolyl-derivate, verfahren zu ihrer herstellung und ihre verwendung als arzneimittel
US4971978A (en) * 1987-09-21 1990-11-20 Nadzan Alex M Derivatives of D-glutamic acid and D-aspartic acid
IE68593B1 (en) * 1989-12-06 1996-06-26 Sanofi Sa Heterocyclic substituted acylaminothiazoles their preparation and pharmaceutical compositions containing them
FR2677356B1 (fr) * 1991-06-05 1995-03-17 Sanofi Sa Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant.

Also Published As

Publication number Publication date
NO940558L (de) 1994-08-22
AU680213B2 (en) 1997-07-24
KR940019706A (ko) 1994-09-14
CA2115805A1 (en) 1994-08-20
EP0611766A1 (de) 1994-08-24
AU5516294A (en) 1994-08-25
IL108636A (en) 1999-04-11
IL108636A0 (en) 1994-05-30
NZ250907A (en) 1996-01-26
CN1107158A (zh) 1995-08-23
FR2701708A1 (fr) 1994-08-26
FI940769A0 (fi) 1994-02-18
RU2125569C1 (ru) 1999-01-27
NO940558D0 (no) 1994-02-18
MX9401209A (es) 1994-08-31
FR2701708B1 (fr) 1995-05-19
HUT70158A (en) 1995-09-28
HU9400474D0 (en) 1994-05-30
JPH06298761A (ja) 1994-10-25
FI940769A (fi) 1994-08-20
US5656648A (en) 1997-08-12

Similar Documents

Publication Publication Date Title
IL122339A0 (en) Thiohydantoine derivatives
AU7159994A (en) 3-aryl-4-hydroxy-delta3-dihydrofuranone derivatives
ZA941128B (en) Polysubstituted 2-amino-thiazole derivatives
GB9309716D0 (en) Heterocyclic derivatives
HU9400724D0 (en) 2-thio-substituted carbapeneme derivatives
LTIP1874A (en) Substituted azolone derivatives
GB9408473D0 (en) Heterocyclic derivatives
ZA945504B (en) Benzocarbocyclic derivatives
GB9311562D0 (en) Heterocyclic derivatives
ZA947258B (en) Novel triaryl-ethylene derivatives
ZA947183B (en) 3-aryl-4-hydroxy-Delta3-dihydrofuranone derivatives
ZA945589B (en) 2-phenylpyrrole derivatives
AU3709593A (en) N-methyldeacetylcolchiceinamide derivatives
ZA947128B (en) Hydroxyethyl-azolyl derivatives
HU9402534D0 (en) New naphtoxazine derivatives
ZA945588B (en) 2-Phenylpyrrole derivatives
GB2274282B (en) Piperazine-and piperidine-isoxazole derivatives
IL110280A0 (en) Thiazole derivatives
GB9304440D0 (en) 2-acyloxycephem derivatives
GB9311613D0 (en) Thienylthiazole derivatives
IL110645A0 (en) Azoxycyanobenzodioxane derivatives
AU7864291A (en) Azacyclic derivatives
ZA945250B (en) Thiazole derivatives
GB9316777D0 (en) Heterocyclic derivatives
GB9308065D0 (en) Heterocyclic derivatives