ZA935110B - Rapamycin derivatives - Google Patents
Rapamycin derivativesInfo
- Publication number
- ZA935110B ZA935110B ZA935110A ZA935110A ZA935110B ZA 935110 B ZA935110 B ZA 935110B ZA 935110 A ZA935110 A ZA 935110A ZA 935110 A ZA935110 A ZA 935110A ZA 935110 B ZA935110 B ZA 935110B
- Authority
- ZA
- South Africa
- Prior art keywords
- rapamycin derivatives
- rapamycin
- derivatives
- Prior art date
Links
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical class C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
- C07D498/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US91514792A | 1992-07-17 | 1992-07-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA935110B true ZA935110B (en) | 1994-02-04 |
Family
ID=25435302
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA935110A ZA935110B (en) | 1992-07-17 | 1993-07-15 | Rapamycin derivatives |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5661156A (xx) |
| EP (1) | EP0650357B1 (xx) |
| JP (1) | JPH07509248A (xx) |
| CN (1) | CN1087912A (xx) |
| AU (1) | AU4680193A (xx) |
| DE (1) | DE69332582T2 (xx) |
| MX (1) | MX9304361A (xx) |
| WO (1) | WO1994002137A1 (xx) |
| ZA (1) | ZA935110B (xx) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA935111B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
| USRE37421E1 (en) | 1993-07-16 | 2001-10-23 | Smithkline Beecham Corporation | Rapamycin derivatives |
| CA2175215C (en) * | 1993-11-19 | 2008-06-03 | Yat Sun Or | Semisynthetic analogs of rapamycin (macrolides) being immunomodulators |
| US5527907A (en) * | 1993-11-19 | 1996-06-18 | Abbott Laboratories | Macrolide immunomodulators |
| US5525610A (en) * | 1994-03-31 | 1996-06-11 | American Home Products Corporation | 42-Epi-rapamycin and pharmaceutical compositions thereof |
| US5563145A (en) * | 1994-12-07 | 1996-10-08 | American Home Products Corporation | Rapamycin 42-oximes and hydroxylamines |
| US6187757B1 (en) | 1995-06-07 | 2001-02-13 | Ariad Pharmaceuticals, Inc. | Regulation of biological events using novel compounds |
| US6258823B1 (en) | 1996-07-12 | 2001-07-10 | Ariad Pharmaceuticals, Inc. | Materials and method for treating or preventing pathogenic fungal infection |
| US5939750A (en) * | 1998-01-21 | 1999-08-17 | Advanced Micro Devices | Use of implanted ions to reduce oxide-nitride-oxide (ONO) etch residue and polystringers |
| WO2001014387A1 (en) | 1999-08-24 | 2001-03-01 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| US7067526B1 (en) | 1999-08-24 | 2006-06-27 | Ariad Gene Therapeutics, Inc. | 28-epirapalogs |
| WO2004060283A2 (en) | 2002-12-16 | 2004-07-22 | Nitromed, Inc. | Nitrosated and nitrosylated rapamycin compounds, compositions and methods of use |
| AU2003300076C1 (en) | 2002-12-30 | 2010-03-04 | Angiotech International Ag | Drug delivery from rapid gelling polymer composition |
| WO2005010010A1 (en) * | 2003-07-16 | 2005-02-03 | Wyeth | Cci-779 isomer c |
| WO2006115509A2 (en) | 2004-06-24 | 2006-11-02 | Novartis Vaccines And Diagnostics Inc. | Small molecule immunopotentiators and assays for their detection |
| US8021849B2 (en) * | 2004-11-05 | 2011-09-20 | Siemens Healthcare Diagnostics Inc. | Methods and kits for the determination of sirolimus in a sample |
| US7189582B2 (en) * | 2005-04-27 | 2007-03-13 | Dade Behring Inc. | Compositions and methods for detection of sirolimus |
| WO2009089549A1 (en) | 2008-01-11 | 2009-07-16 | Massachusetts Eye & Ear Infirmary | Conditional-stop dimerizable caspase transgenic animals |
| DE102012018013B4 (de) | 2012-09-12 | 2014-09-18 | X-Fab Semiconductor Foundries Ag | Spiralförmige, integrierbare Spulen mit zentrischen Anschlüssen in planarer grabenisolierter Siliziumhalbleitertechnologie |
| WO2014200659A1 (en) | 2013-06-11 | 2014-12-18 | Clontech Laboratories, Inc. | Protein enriched microvesicles and methods of making and using the same |
| CN103739616B (zh) * | 2013-12-27 | 2015-12-30 | 福建省微生物研究所 | 含噻唑基雷帕霉素类衍生物及其应用 |
| HUP1400075A2 (hu) | 2014-02-14 | 2015-08-28 | Druggability Technologies Ip Holdco Jersey Ltd | Sirolimus és származékainak komplexei, elõállítása és gyógyszerészeti kompozíciói |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023263A (en) * | 1990-08-09 | 1991-06-11 | American Home Products Corporation | 42-oxorapamycin |
| US5130307A (en) * | 1990-09-28 | 1992-07-14 | American Home Products Corporation | Aminoesters of rapamycin |
| GB9125660D0 (en) * | 1991-12-03 | 1992-01-29 | Smithkline Beecham Plc | Novel compound |
| JP3140228B2 (ja) * | 1992-02-17 | 2001-03-05 | ファイザー製薬株式会社 | 新規な大環状ラクトンおよびその生産菌 |
| US5284877A (en) * | 1992-06-12 | 1994-02-08 | Merck & Co., Inc. | Alkyl and alkenyl macrolides having immunosuppressive activity |
| ZA935111B (en) * | 1992-07-17 | 1994-02-04 | Smithkline Beecham Corp | Rapamycin derivatives |
| GB9221220D0 (en) * | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
-
1993
- 1993-07-15 ZA ZA935110A patent/ZA935110B/xx unknown
- 1993-07-16 US US08/373,182 patent/US5661156A/en not_active Expired - Fee Related
- 1993-07-16 AU AU46801/93A patent/AU4680193A/en not_active Abandoned
- 1993-07-16 JP JP6504571A patent/JPH07509248A/ja not_active Ceased
- 1993-07-16 EP EP93917213A patent/EP0650357B1/en not_active Expired - Lifetime
- 1993-07-16 DE DE69332582T patent/DE69332582T2/de not_active Expired - Fee Related
- 1993-07-16 WO PCT/US1993/006680 patent/WO1994002137A1/en active IP Right Grant
- 1993-07-17 CN CN93116589A patent/CN1087912A/zh active Pending
- 1993-07-19 MX MX9304361A patent/MX9304361A/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP0650357A1 (en) | 1995-05-03 |
| AU4680193A (en) | 1994-02-14 |
| DE69332582D1 (de) | 2003-01-30 |
| CN1087912A (zh) | 1994-06-15 |
| MX9304361A (es) | 1994-04-29 |
| DE69332582T2 (de) | 2003-11-20 |
| WO1994002137A1 (en) | 1994-02-03 |
| US5661156A (en) | 1997-08-26 |
| EP0650357A4 (en) | 1995-06-14 |
| EP0650357B1 (en) | 2002-12-18 |
| JPH07509248A (ja) | 1995-10-12 |
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